DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMV7_LEIBR

TriTrypDb:

LbrM.34.2810 , LBRM2903_340036600

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	536	540	PF00656	0.587
CLV_MEL_PAP_1	585	591	PF00089	0.537
CLV_NRD_NRD_1	15	17	PF00675	0.454
CLV_NRD_NRD_1	187	189	PF00675	0.536
CLV_NRD_NRD_1	202	204	PF00675	0.571
CLV_NRD_NRD_1	281	283	PF00675	0.613
CLV_NRD_NRD_1	291	293	PF00675	0.706
CLV_NRD_NRD_1	312	314	PF00675	0.721
CLV_NRD_NRD_1	587	589	PF00675	0.748
CLV_NRD_NRD_1	657	659	PF00675	0.734
CLV_PCSK_KEX2_1	15	17	PF00082	0.454
CLV_PCSK_KEX2_1	187	189	PF00082	0.536
CLV_PCSK_KEX2_1	202	204	PF00082	0.571
CLV_PCSK_KEX2_1	280	282	PF00082	0.654
CLV_PCSK_KEX2_1	291	293	PF00082	0.720
CLV_PCSK_KEX2_1	312	314	PF00082	0.577
CLV_PCSK_KEX2_1	587	589	PF00082	0.737
CLV_PCSK_KEX2_1	657	659	PF00082	0.734
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.654
CLV_PCSK_PC7_1	277	283	PF00082	0.504
CLV_PCSK_SKI1_1	225	229	PF00082	0.551
CLV_PCSK_SKI1_1	277	281	PF00082	0.673
CLV_PCSK_SKI1_1	286	290	PF00082	0.479
CLV_PCSK_SKI1_1	292	296	PF00082	0.454
CLV_PCSK_SKI1_1	334	338	PF00082	0.761
CLV_PCSK_SKI1_1	496	500	PF00082	0.601
DEG_APCC_KENBOX_2	667	671	PF00400	0.520
DEG_MDM2_SWIB_1	14	21	PF02201	0.386
DEG_Nend_UBRbox_1	1	4	PF02207	0.650
DEG_SPOP_SBC_1	4	8	PF00917	0.448
DEG_SPOP_SBC_1	420	424	PF00917	0.708
DOC_CDC14_PxL_1	179	187	PF14671	0.603
DOC_CKS1_1	100	105	PF01111	0.332
DOC_CYCLIN_RxL_1	220	229	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	100	106	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.434
DOC_MAPK_gen_1	168	177	PF00069	0.421
DOC_MAPK_HePTP_8	497	509	PF00069	0.616
DOC_MAPK_MEF2A_6	168	177	PF00069	0.421
DOC_MAPK_MEF2A_6	500	509	PF00069	0.627
DOC_MAPK_MEF2A_6	658	667	PF00069	0.718
DOC_PP1_RVXF_1	357	363	PF00149	0.616
DOC_PP2B_LxvP_1	228	231	PF13499	0.533
DOC_PP4_FxxP_1	156	159	PF00568	0.577
DOC_PP4_FxxP_1	207	210	PF00568	0.506
DOC_PP4_FxxP_1	275	278	PF00568	0.685
DOC_PP4_FxxP_1	37	40	PF00568	0.517
DOC_PP4_FxxP_1	395	398	PF00568	0.601
DOC_PP4_FxxP_1	54	57	PF00568	0.547
DOC_SPAK_OSR1_1	638	642	PF12202	0.624
DOC_USP7_MATH_1	316	320	PF00917	0.617
DOC_USP7_MATH_1	4	8	PF00917	0.682
DOC_USP7_MATH_1	486	490	PF00917	0.527
DOC_USP7_UBL2_3	724	728	PF12436	0.622
DOC_WW_Pin1_4	365	370	PF00397	0.616
DOC_WW_Pin1_4	421	426	PF00397	0.759
DOC_WW_Pin1_4	43	48	PF00397	0.542
DOC_WW_Pin1_4	594	599	PF00397	0.700
DOC_WW_Pin1_4	99	104	PF00397	0.333
LIG_14-3-3_CanoR_1	15	23	PF00244	0.569
LIG_14-3-3_CanoR_1	225	231	PF00244	0.552
LIG_14-3-3_CanoR_1	266	275	PF00244	0.671
LIG_14-3-3_CanoR_1	281	289	PF00244	0.694
LIG_14-3-3_CanoR_1	291	300	PF00244	0.719
LIG_14-3-3_CanoR_1	320	329	PF00244	0.621
LIG_14-3-3_CanoR_1	363	369	PF00244	0.446
LIG_14-3-3_CanoR_1	409	413	PF00244	0.585
LIG_14-3-3_CanoR_1	419	425	PF00244	0.628
LIG_14-3-3_CanoR_1	456	460	PF00244	0.524
LIG_14-3-3_CanoR_1	510	520	PF00244	0.604
LIG_14-3-3_CanoR_1	534	538	PF00244	0.615
LIG_14-3-3_CanoR_1	657	662	PF00244	0.748
LIG_14-3-3_CanoR_1	82	91	PF00244	0.466
LIG_Actin_WH2_2	340	358	PF00022	0.564
LIG_Actin_WH2_2	394	411	PF00022	0.457
LIG_Actin_WH2_2	506	521	PF00022	0.605
LIG_Actin_WH2_2	641	659	PF00022	0.492
LIG_AP2alpha_1	373	377	PF02296	0.671
LIG_AP2alpha_2	273	275	PF02296	0.690
LIG_BRCT_BRCA1_1	120	124	PF00533	0.542
LIG_BRCT_BRCA1_1	228	232	PF00533	0.508
LIG_BRCT_BRCA1_1	489	493	PF00533	0.568
LIG_BRCT_BRCA1_1	49	53	PF00533	0.449
LIG_Clathr_ClatBox_1	636	640	PF01394	0.620
LIG_FHA_1	106	112	PF00498	0.549
LIG_FHA_1	216	222	PF00498	0.542
LIG_FHA_1	4	10	PF00498	0.609
LIG_FHA_1	412	418	PF00498	0.594
LIG_FHA_1	482	488	PF00498	0.500
LIG_FHA_1	502	508	PF00498	0.487
LIG_FHA_1	567	573	PF00498	0.724
LIG_FHA_1	57	63	PF00498	0.617
LIG_FHA_1	584	590	PF00498	0.515
LIG_FHA_1	673	679	PF00498	0.587
LIG_FHA_1	85	91	PF00498	0.521
LIG_FHA_2	100	106	PF00498	0.329
LIG_FHA_2	380	386	PF00498	0.674
LIG_FHA_2	472	478	PF00498	0.405
LIG_FHA_2	561	567	PF00498	0.671
LIG_FHA_2	573	579	PF00498	0.724
LIG_FHA_2	627	633	PF00498	0.524
LIG_FHA_2	717	723	PF00498	0.552
LIG_IBAR_NPY_1	389	391	PF08397	0.738
LIG_LIR_Apic_2	153	159	PF02991	0.560
LIG_LIR_Apic_2	205	210	PF02991	0.521
LIG_LIR_Apic_2	273	278	PF02991	0.687
LIG_LIR_Apic_2	35	40	PF02991	0.503
LIG_LIR_Apic_2	52	57	PF02991	0.577
LIG_LIR_Apic_2	593	598	PF02991	0.695
LIG_LIR_Gen_1	118	126	PF02991	0.433
LIG_LIR_Gen_1	20	30	PF02991	0.374
LIG_LIR_Gen_1	263	272	PF02991	0.439
LIG_LIR_Gen_1	371	380	PF02991	0.632
LIG_LIR_Gen_1	606	614	PF02991	0.528
LIG_LIR_Nem_3	118	122	PF02991	0.488
LIG_LIR_Nem_3	13	17	PF02991	0.338
LIG_LIR_Nem_3	20	26	PF02991	0.351
LIG_LIR_Nem_3	263	267	PF02991	0.407
LIG_LIR_Nem_3	29	34	PF02991	0.298
LIG_LIR_Nem_3	371	376	PF02991	0.643
LIG_LIR_Nem_3	460	466	PF02991	0.646
LIG_LIR_Nem_3	50	56	PF02991	0.534
LIG_LIR_Nem_3	606	612	PF02991	0.734
LIG_LIR_Nem_3	676	682	PF02991	0.436
LIG_LIR_Nem_3	89	94	PF02991	0.432
LIG_LYPXL_yS_3	391	394	PF13949	0.611
LIG_MLH1_MIPbox_1	120	124	PF16413	0.503
LIG_NRBOX	95	101	PF00104	0.397
LIG_Pex14_1	119	123	PF04695	0.503
LIG_Pex14_2	14	18	PF04695	0.382
LIG_Pex14_2	146	150	PF04695	0.582
LIG_Pex14_2	232	236	PF04695	0.588
LIG_Pex14_2	37	41	PF04695	0.501
LIG_Pex14_2	373	377	PF04695	0.671
LIG_Pex14_2	476	480	PF04695	0.519
LIG_PTB_Apo_2	608	615	PF02174	0.533
LIG_Rb_LxCxE_1	556	577	PF01857	0.733
LIG_REV1ctd_RIR_1	491	500	PF16727	0.576
LIG_SH2_CRK	463	467	PF00017	0.578
LIG_SH2_CRK	595	599	PF00017	0.698
LIG_SH2_CRK	609	613	PF00017	0.704
LIG_SH2_CRK	712	716	PF00017	0.657
LIG_SH2_GRB2like	609	612	PF00017	0.531
LIG_SH2_NCK_1	609	613	PF00017	0.531
LIG_SH2_SRC	609	612	PF00017	0.531
LIG_SH2_STAP1	195	199	PF00017	0.688
LIG_SH2_STAT3	523	526	PF00017	0.694
LIG_SH2_STAT5	123	126	PF00017	0.506
LIG_SH2_STAT5	195	198	PF00017	0.669
LIG_SH2_STAT5	226	229	PF00017	0.592
LIG_SH2_STAT5	254	257	PF00017	0.559
LIG_SH2_STAT5	264	267	PF00017	0.590
LIG_SH2_STAT5	430	433	PF00017	0.632
LIG_SH2_STAT5	559	562	PF00017	0.699
LIG_SH2_STAT5	643	646	PF00017	0.567
LIG_SH2_STAT5	681	684	PF00017	0.510
LIG_SH2_STAT5	726	729	PF00017	0.682
LIG_SH2_STAT5	85	88	PF00017	0.348
LIG_SH3_1	415	421	PF00018	0.550
LIG_SH3_2	663	668	PF14604	0.512
LIG_SH3_3	415	421	PF00018	0.626
LIG_SH3_3	562	568	PF00018	0.728
LIG_SH3_3	660	666	PF00018	0.525
LIG_SH3_3	701	707	PF00018	0.525
LIG_SUMO_SIM_anti_2	102	109	PF11976	0.313
LIG_SUMO_SIM_par_1	102	109	PF11976	0.529
LIG_SUMO_SIM_par_1	256	263	PF11976	0.390
LIG_SUMO_SIM_par_1	348	354	PF11976	0.595
LIG_SUMO_SIM_par_1	569	580	PF11976	0.523
LIG_TRAF2_1	629	632	PF00917	0.713
LIG_TYR_ITIM	21	26	PF00017	0.346
LIG_WRC_WIRS_1	147	152	PF05994	0.600
LIG_WRC_WIRS_1	204	209	PF05994	0.586
LIG_WRC_WIRS_1	85	90	PF05994	0.336
MOD_CK1_1	118	124	PF00069	0.551
MOD_CK1_1	296	302	PF00069	0.622
MOD_CK1_1	319	325	PF00069	0.781
MOD_CK1_1	351	357	PF00069	0.709
MOD_CK1_1	411	417	PF00069	0.690
MOD_CK1_1	475	481	PF00069	0.575
MOD_CK1_1	626	632	PF00069	0.647
MOD_CK1_1	672	678	PF00069	0.632
MOD_CK2_1	379	385	PF00069	0.677
MOD_CK2_1	471	477	PF00069	0.470
MOD_CK2_1	509	515	PF00069	0.584
MOD_CK2_1	560	566	PF00069	0.691
MOD_CK2_1	573	579	PF00069	0.697
MOD_CK2_1	626	632	PF00069	0.763
MOD_CK2_1	691	697	PF00069	0.657
MOD_CK2_1	99	105	PF00069	0.335
MOD_GlcNHglycan	228	231	PF01048	0.537
MOD_GlcNHglycan	242	246	PF01048	0.567
MOD_GlcNHglycan	295	298	PF01048	0.650
MOD_GlcNHglycan	370	373	PF01048	0.670
MOD_GlcNHglycan	385	389	PF01048	0.666
MOD_GlcNHglycan	437	440	PF01048	0.497
MOD_GlcNHglycan	555	558	PF01048	0.597
MOD_GlcNHglycan	671	674	PF01048	0.627
MOD_GSK3_1	146	153	PF00069	0.530
MOD_GSK3_1	237	244	PF00069	0.670
MOD_GSK3_1	292	299	PF00069	0.537
MOD_GSK3_1	319	326	PF00069	0.613
MOD_GSK3_1	334	341	PF00069	0.541
MOD_GSK3_1	364	371	PF00069	0.524
MOD_GSK3_1	407	414	PF00069	0.615
MOD_GSK3_1	419	426	PF00069	0.653
MOD_GSK3_1	43	50	PF00069	0.505
MOD_GSK3_1	471	478	PF00069	0.536
MOD_GSK3_1	52	59	PF00069	0.550
MOD_GSK3_1	573	580	PF00069	0.639
MOD_GSK3_1	711	718	PF00069	0.629
MOD_N-GLC_1	268	273	PF02516	0.623
MOD_N-GLC_1	365	370	PF02516	0.588
MOD_N-GLC_1	604	609	PF02516	0.636
MOD_N-GLC_1	669	674	PF02516	0.578
MOD_NEK2_1	146	151	PF00069	0.539
MOD_NEK2_1	17	22	PF00069	0.566
MOD_NEK2_1	215	220	PF00069	0.503
MOD_NEK2_1	26	31	PF00069	0.417
MOD_NEK2_1	267	272	PF00069	0.583
MOD_NEK2_1	3	8	PF00069	0.576
MOD_NEK2_1	323	328	PF00069	0.515
MOD_NEK2_1	408	413	PF00069	0.609
MOD_NEK2_1	41	46	PF00069	0.588
MOD_NEK2_1	476	481	PF00069	0.541
MOD_NEK2_1	487	492	PF00069	0.511
MOD_NEK2_1	501	506	PF00069	0.590
MOD_NEK2_1	509	514	PF00069	0.532
MOD_NEK2_1	623	628	PF00069	0.553
MOD_NEK2_1	656	661	PF00069	0.511
MOD_NEK2_1	690	695	PF00069	0.417
MOD_NEK2_1	715	720	PF00069	0.605
MOD_NEK2_1	84	89	PF00069	0.511
MOD_OFUCOSY	650	655	PF10250	0.503
MOD_PIKK_1	106	112	PF00454	0.296
MOD_PIKK_1	626	632	PF00454	0.743
MOD_PK_1	657	663	PF00069	0.502
MOD_PKA_1	280	286	PF00069	0.648
MOD_PKA_1	657	663	PF00069	0.716
MOD_PKA_2	280	286	PF00069	0.648
MOD_PKA_2	311	317	PF00069	0.631
MOD_PKA_2	319	325	PF00069	0.692
MOD_PKA_2	408	414	PF00069	0.615
MOD_PKA_2	455	461	PF00069	0.530
MOD_PKA_2	509	515	PF00069	0.580
MOD_PKA_2	533	539	PF00069	0.591
MOD_PKA_2	656	662	PF00069	0.663
MOD_Plk_1	237	243	PF00069	0.651
MOD_Plk_1	26	32	PF00069	0.377
MOD_Plk_1	476	482	PF00069	0.570
MOD_Plk_1	603	609	PF00069	0.734
MOD_Plk_2-3	604	610	PF00069	0.735
MOD_Plk_2-3	691	697	PF00069	0.667
MOD_Plk_4	115	121	PF00069	0.552
MOD_Plk_4	203	209	PF00069	0.541
MOD_Plk_4	260	266	PF00069	0.485
MOD_Plk_4	408	414	PF00069	0.596
MOD_Plk_4	476	482	PF00069	0.528
MOD_Plk_4	49	55	PF00069	0.579
MOD_Plk_4	604	610	PF00069	0.735
MOD_Plk_4	716	722	PF00069	0.551
MOD_ProDKin_1	365	371	PF00069	0.621
MOD_ProDKin_1	421	427	PF00069	0.758
MOD_ProDKin_1	43	49	PF00069	0.545
MOD_ProDKin_1	594	600	PF00069	0.698
MOD_ProDKin_1	99	105	PF00069	0.335
MOD_SUMO_for_1	695	698	PF00179	0.655
MOD_SUMO_rev_2	163	170	PF00179	0.496
MOD_SUMO_rev_2	718	725	PF00179	0.555
TRG_DiLeu_BaEn_1	632	637	PF01217	0.689
TRG_DiLeu_BaEn_1	698	703	PF01217	0.552
TRG_ENDOCYTIC_2	123	126	PF00928	0.487
TRG_ENDOCYTIC_2	23	26	PF00928	0.551
TRG_ENDOCYTIC_2	264	267	PF00928	0.613
TRG_ENDOCYTIC_2	391	394	PF00928	0.604
TRG_ENDOCYTIC_2	463	466	PF00928	0.586
TRG_ENDOCYTIC_2	609	612	PF00928	0.734
TRG_ENDOCYTIC_2	712	715	PF00928	0.654
TRG_ENDOCYTIC_2	85	88	PF00928	0.475
TRG_ER_diArg_1	14	16	PF00400	0.452
TRG_ER_diArg_1	186	188	PF00400	0.500
TRG_ER_diArg_1	202	204	PF00400	0.573
TRG_ER_diArg_1	290	292	PF00400	0.796
TRG_ER_diArg_1	587	589	PF00400	0.745
TRG_ER_diArg_1	656	658	PF00400	0.619
TRG_NES_CRM1_1	169	180	PF08389	0.463
TRG_NLS_MonoExtN_4	277	284	PF00514	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q5	Leptomonas seymouri	67%	100%
A0A1X0P6X0	Trypanosomatidae	37%	100%
A0A3Q8IF92	Leishmania donovani	77%	94%
A4IBH8	Leishmania infantum	76%	100%
E9AFB4	Leishmania major	76%	99%
E9B6G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%