SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SpoU rRNA Methylase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HMV6_LEIBR

TriTrypDb:

LbrM.34.2800 , LBRM2903_340036500

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMV6

PDB structure(s): 7am2_BX , 7am2_BY

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006396	RNA processing	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003723	RNA binding	4	9
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	9
GO:0008168	methyltransferase activity	4	10
GO:0008173	RNA methyltransferase activity	4	9
GO:0016740	transferase activity	2	10
GO:0016741	transferase activity, transferring one-carbon groups	3	10
GO:0097159	organic cyclic compound binding	2	9
GO:0140098	catalytic activity, acting on RNA	3	9
GO:0140640	catalytic activity, acting on a nucleic acid	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.526
CLV_C14_Caspase3-7	56	60	PF00656	0.326
CLV_NRD_NRD_1	280	282	PF00675	0.434
CLV_NRD_NRD_1	383	385	PF00675	0.478
CLV_NRD_NRD_1	402	404	PF00675	0.426
CLV_NRD_NRD_1	409	411	PF00675	0.439
CLV_NRD_NRD_1	414	416	PF00675	0.432
CLV_PCSK_FUR_1	381	385	PF00082	0.432
CLV_PCSK_KEX2_1	275	277	PF00082	0.418
CLV_PCSK_KEX2_1	280	282	PF00082	0.410
CLV_PCSK_KEX2_1	383	385	PF00082	0.433
CLV_PCSK_KEX2_1	402	404	PF00082	0.442
CLV_PCSK_KEX2_1	409	411	PF00082	0.438
CLV_PCSK_KEX2_1	414	416	PF00082	0.434
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.418
CLV_PCSK_PC7_1	276	282	PF00082	0.422
CLV_PCSK_PC7_1	410	416	PF00082	0.511
CLV_PCSK_SKI1_1	276	280	PF00082	0.597
CLV_PCSK_SKI1_1	281	285	PF00082	0.566
CLV_PCSK_SKI1_1	292	296	PF00082	0.390
CLV_PCSK_SKI1_1	423	427	PF00082	0.717
CLV_PCSK_SKI1_1	447	451	PF00082	0.493
CLV_Separin_Metazoa	378	382	PF03568	0.497
DEG_APCC_DBOX_1	162	170	PF00400	0.365
DEG_APCC_DBOX_1	275	283	PF00400	0.598
DEG_APCC_DBOX_1	291	299	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.273
DEG_SPOP_SBC_1	226	230	PF00917	0.511
DOC_CKS1_1	67	72	PF01111	0.515
DOC_CYCLIN_RxL_1	80	93	PF00134	0.398
DOC_MAPK_gen_1	285	295	PF00069	0.462
DOC_MAPK_JIP1_4	19	25	PF00069	0.474
DOC_MAPK_MEF2A_6	344	352	PF00069	0.533
DOC_PP4_FxxP_1	252	255	PF00568	0.437
DOC_PP4_FxxP_1	269	272	PF00568	0.472
DOC_PP4_FxxP_1	65	68	PF00568	0.374
DOC_USP7_MATH_1	226	230	PF00917	0.586
DOC_USP7_MATH_1	234	238	PF00917	0.432
DOC_USP7_MATH_1	299	303	PF00917	0.555
DOC_USP7_MATH_1	418	422	PF00917	0.412
DOC_WW_Pin1_4	297	302	PF00397	0.549
DOC_WW_Pin1_4	66	71	PF00397	0.428
LIG_14-3-3_CanoR_1	204	208	PF00244	0.609
LIG_14-3-3_CanoR_1	354	364	PF00244	0.604
LIG_14-3-3_CanoR_1	442	446	PF00244	0.626
LIG_eIF4E_1	18	24	PF01652	0.292
LIG_FHA_1	175	181	PF00498	0.506
LIG_FHA_1	289	295	PF00498	0.395
LIG_FHA_1	304	310	PF00498	0.452
LIG_FHA_1	336	342	PF00498	0.527
LIG_FHA_1	38	44	PF00498	0.436
LIG_FHA_1	420	426	PF00498	0.435
LIG_FHA_2	142	148	PF00498	0.529
LIG_FHA_2	176	182	PF00498	0.571
LIG_FHA_2	302	308	PF00498	0.516
LIG_IRF3_LxIS_1	305	311	PF10401	0.449
LIG_LIR_Apic_2	250	255	PF02991	0.426
LIG_LIR_Apic_2	457	463	PF02991	0.575
LIG_LIR_Apic_2	64	68	PF02991	0.372
LIG_LIR_Gen_1	264	272	PF02991	0.482
LIG_LIR_Nem_3	151	157	PF02991	0.359
LIG_LIR_Nem_3	264	269	PF02991	0.483
LIG_NRP_CendR_1	462	465	PF00754	0.591
LIG_PCNA_yPIPBox_3	401	415	PF02747	0.563
LIG_SH2_CRK	110	114	PF00017	0.446
LIG_SH2_CRK	154	158	PF00017	0.353
LIG_SH2_CRK	460	464	PF00017	0.692
LIG_SH2_SRC	327	330	PF00017	0.579
LIG_SH2_STAP1	110	114	PF00017	0.446
LIG_SH2_STAP1	123	127	PF00017	0.446
LIG_SH2_STAP1	171	175	PF00017	0.382
LIG_SH2_STAP1	393	397	PF00017	0.435
LIG_SH2_STAT3	171	174	PF00017	0.437
LIG_SH2_STAT5	143	146	PF00017	0.365
LIG_SH2_STAT5	266	269	PF00017	0.463
LIG_SH2_STAT5	327	330	PF00017	0.424
LIG_SH2_STAT5	61	64	PF00017	0.405
LIG_SH3_2	68	73	PF14604	0.401
LIG_SH3_3	189	195	PF00018	0.669
LIG_SH3_3	210	216	PF00018	0.694
LIG_SH3_3	65	71	PF00018	0.474
LIG_SH3_3	89	95	PF00018	0.426
LIG_SH3_CIN85_PxpxPR_1	214	219	PF14604	0.641
LIG_SUMO_SIM_par_1	85	90	PF11976	0.320
LIG_TRFH_1	317	321	PF08558	0.420
MOD_CDK_SPxxK_3	66	73	PF00069	0.460
MOD_CK1_1	297	303	PF00069	0.497
MOD_CK1_1	53	59	PF00069	0.577
MOD_CK2_1	141	147	PF00069	0.394
MOD_CK2_1	253	259	PF00069	0.540
MOD_GlcNHglycan	105	108	PF01048	0.342
MOD_GlcNHglycan	188	191	PF01048	0.566
MOD_GlcNHglycan	256	259	PF01048	0.674
MOD_GlcNHglycan	263	266	PF01048	0.489
MOD_GlcNHglycan	357	360	PF01048	0.425
MOD_GlcNHglycan	50	53	PF01048	0.407
MOD_GlcNHglycan	55	58	PF01048	0.415
MOD_GSK3_1	250	257	PF00069	0.626
MOD_GSK3_1	284	291	PF00069	0.520
MOD_GSK3_1	297	304	PF00069	0.555
MOD_GSK3_1	46	53	PF00069	0.494
MOD_GSK3_1	97	104	PF00069	0.282
MOD_LATS_1	452	458	PF00433	0.568
MOD_N-GLC_1	90	95	PF02516	0.230
MOD_N-GLC_2	117	119	PF02516	0.282
MOD_NEK2_1	101	106	PF00069	0.315
MOD_NEK2_1	203	208	PF00069	0.670
MOD_NEK2_1	294	299	PF00069	0.559
MOD_NEK2_1	308	313	PF00069	0.541
MOD_NEK2_1	355	360	PF00069	0.423
MOD_NEK2_2	141	146	PF00069	0.385
MOD_NEK2_2	227	232	PF00069	0.546
MOD_PIKK_1	234	240	PF00454	0.666
MOD_PK_1	344	350	PF00069	0.474
MOD_PKA_2	203	209	PF00069	0.610
MOD_PKA_2	220	226	PF00069	0.610
MOD_PKA_2	253	259	PF00069	0.545
MOD_PKA_2	284	290	PF00069	0.438
MOD_PKA_2	355	361	PF00069	0.555
MOD_PKA_2	388	394	PF00069	0.582
MOD_PKA_2	441	447	PF00069	0.629
MOD_Plk_1	240	246	PF00069	0.475
MOD_Plk_1	334	340	PF00069	0.604
MOD_Plk_1	426	432	PF00069	0.413
MOD_Plk_4	203	209	PF00069	0.643
MOD_Plk_4	310	316	PF00069	0.447
MOD_Plk_4	97	103	PF00069	0.282
MOD_ProDKin_1	297	303	PF00069	0.551
MOD_ProDKin_1	66	72	PF00069	0.431
MOD_SUMO_for_1	145	148	PF00179	0.410
MOD_SUMO_rev_2	256	264	PF00179	0.394
TRG_DiLeu_BaEn_1	162	167	PF01217	0.464
TRG_DiLeu_BaEn_4	334	340	PF01217	0.395
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.503
TRG_ENDOCYTIC_2	110	113	PF00928	0.282
TRG_ENDOCYTIC_2	154	157	PF00928	0.354
TRG_ENDOCYTIC_2	266	269	PF00928	0.483
TRG_ER_diArg_1	218	221	PF00400	0.556
TRG_ER_diArg_1	279	281	PF00400	0.434
TRG_ER_diArg_1	319	322	PF00400	0.473
TRG_ER_diArg_1	354	357	PF00400	0.503
TRG_ER_diArg_1	382	384	PF00400	0.463
TRG_ER_diArg_1	402	404	PF00400	0.315
TRG_ER_diArg_1	408	410	PF00400	0.442
TRG_ER_diArg_1	414	416	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.282

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEE8	Leptomonas seymouri	70%	76%
A0A1X0P5S3	Trypanosomatidae	50%	80%
A0A3S7X9F7	Leishmania donovani	82%	77%
A0A422P2S4	Trypanosoma rangeli	48%	82%
A4IBH7	Leishmania infantum	82%	77%
C9ZZ65	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	79%
E9AFB3	Leishmania major	80%	100%
E9B6G8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	77%