Trafficking protein particle complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sybindin-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4HMV5_LEIBR

TriTrypDb:

LbrM.34.2790 , LBRM2903_340036400

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0005794	Golgi apparatus	5	11
GO:0030008	TRAPP complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0099023	vesicle tethering complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11

Expansion

Sequence features

A4HMV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMV5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.554
CLV_PCSK_KEX2_1	135	137	PF00082	0.554
CLV_PCSK_KEX2_1	22	24	PF00082	0.385
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.377
CLV_PCSK_SKI1_1	100	104	PF00082	0.316
CLV_PCSK_SKI1_1	105	109	PF00082	0.309
CLV_PCSK_SKI1_1	137	141	PF00082	0.444
CLV_PCSK_SKI1_1	77	81	PF00082	0.331
DOC_CKS1_1	60	65	PF01111	0.313
DOC_WW_Pin1_4	59	64	PF00397	0.313
LIG_Actin_WH2_2	42	60	PF00022	0.355
LIG_Actin_WH2_2	86	102	PF00022	0.407
LIG_APCC_ABBA_1	78	83	PF00400	0.424
LIG_APCC_ABBAyCdc20_2	77	83	PF00400	0.424
LIG_FHA_1	22	28	PF00498	0.368
LIG_FHA_1	52	58	PF00498	0.360
LIG_FHA_1	86	92	PF00498	0.321
LIG_FHA_1	94	100	PF00498	0.327
LIG_FHA_2	120	126	PF00498	0.383
LIG_FHA_2	92	98	PF00498	0.418
LIG_LIR_Nem_3	2	7	PF02991	0.313
LIG_NRBOX	94	100	PF00104	0.457
LIG_PCNA_yPIPBox_3	92	105	PF02747	0.394
LIG_PDZ_Class_2	136	141	PF00595	0.667
LIG_PTB_Apo_2	107	114	PF02174	0.409
LIG_PTB_Phospho_1	107	113	PF10480	0.424
LIG_SH2_STAP1	17	21	PF00017	0.313
LIG_SH2_STAP1	4	8	PF00017	0.313
LIG_SH2_STAP1	69	73	PF00017	0.321
LIG_SH2_STAT3	17	20	PF00017	0.392
LIG_SH2_STAT3	40	43	PF00017	0.313
LIG_SH2_STAT5	40	43	PF00017	0.313
LIG_SH2_STAT5	7	10	PF00017	0.326
LIG_SH3_3	57	63	PF00018	0.332
MOD_CDK_SPxxK_3	59	66	PF00069	0.313
MOD_CK1_1	47	53	PF00069	0.313
MOD_CK2_1	119	125	PF00069	0.383
MOD_CK2_1	91	97	PF00069	0.431
MOD_GlcNHglycan	24	27	PF01048	0.325
MOD_GSK3_1	105	112	PF00069	0.422
MOD_GSK3_1	43	50	PF00069	0.313
MOD_GSK3_1	67	74	PF00069	0.435
MOD_NEK2_1	103	108	PF00069	0.385
MOD_NEK2_1	38	43	PF00069	0.313
MOD_NEK2_1	49	54	PF00069	0.127
MOD_NEK2_2	12	17	PF00069	0.424
MOD_PIKK_1	44	50	PF00454	0.313
MOD_PKA_1	22	28	PF00069	0.385
MOD_PKA_2	22	28	PF00069	0.331
MOD_Plk_1	82	88	PF00069	0.334
MOD_Plk_4	12	18	PF00069	0.295
MOD_Plk_4	2	8	PF00069	0.297
MOD_ProDKin_1	59	65	PF00069	0.313
TRG_DiLeu_BaEn_1	116	121	PF01217	0.457
TRG_ER_diArg_1	134	136	PF00400	0.360
TRG_ER_diLys_1	137	141	PF00400	0.587
TRG_NLS_MonoExtN_4	135	140	PF00514	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G3	Leptomonas seymouri	77%	100%
A0A0S4JI68	Bodo saltans	44%	98%
A0A1X0P5H3	Trypanosomatidae	67%	100%
A0A3S7X9F2	Leishmania donovani	89%	100%
A0A422P2R5	Trypanosoma rangeli	67%	100%
A4IBH6	Leishmania infantum	88%	100%
C9ZZ66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AFB2	Leishmania major	88%	100%
E9B6G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q17QI1	Bos taurus	28%	97%
Q2KMM2	Rattus norvegicus	27%	97%
Q54UU1	Dictyostelium discoideum	28%	100%
Q557G3	Dictyostelium discoideum	30%	99%
Q5NCF2	Mus musculus	27%	97%
Q9UT70	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	91%
Q9Y5R8	Homo sapiens	28%	97%