Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMV4_LEIBR

TriTrypDb:

LbrM.34.2780 , LBRM2903_340036300

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMV4

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.523
CLV_C14_Caspase3-7	203	207	PF00656	0.447
CLV_C14_Caspase3-7	494	498	PF00656	0.443
CLV_NRD_NRD_1	102	104	PF00675	0.573
CLV_NRD_NRD_1	217	219	PF00675	0.455
CLV_NRD_NRD_1	405	407	PF00675	0.313
CLV_NRD_NRD_1	51	53	PF00675	0.556
CLV_NRD_NRD_1	727	729	PF00675	0.548
CLV_NRD_NRD_1	730	732	PF00675	0.533
CLV_PCSK_FUR_1	100	104	PF00082	0.535
CLV_PCSK_KEX2_1	102	104	PF00082	0.544
CLV_PCSK_KEX2_1	210	212	PF00082	0.450
CLV_PCSK_KEX2_1	214	216	PF00082	0.458
CLV_PCSK_KEX2_1	405	407	PF00082	0.392
CLV_PCSK_KEX2_1	51	53	PF00082	0.544
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.444
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.450
CLV_PCSK_SKI1_1	211	215	PF00082	0.485
CLV_PCSK_SKI1_1	32	36	PF00082	0.441
CLV_PCSK_SKI1_1	496	500	PF00082	0.512
CLV_PCSK_SKI1_1	545	549	PF00082	0.464
CLV_PCSK_SKI1_1	596	600	PF00082	0.607
CLV_PCSK_SKI1_1	733	737	PF00082	0.598
DEG_APCC_DBOX_1	372	380	PF00400	0.357
DEG_APCC_DBOX_1	405	413	PF00400	0.427
DEG_SCF_FBW7_1	41	46	PF00400	0.514
DEG_SPOP_SBC_1	179	183	PF00917	0.514
DEG_SPOP_SBC_1	287	291	PF00917	0.544
DEG_SPOP_SBC_1	75	79	PF00917	0.631
DEG_SPOP_SBC_1	83	87	PF00917	0.543
DOC_CKS1_1	147	152	PF01111	0.534
DOC_CKS1_1	489	494	PF01111	0.569
DOC_CKS1_1	571	576	PF01111	0.477
DOC_MAPK_DCC_7	416	426	PF00069	0.390
DOC_MAPK_gen_1	259	267	PF00069	0.345
DOC_MAPK_gen_1	405	413	PF00069	0.438
DOC_MAPK_MEF2A_6	229	238	PF00069	0.323
DOC_MAPK_MEF2A_6	259	267	PF00069	0.424
DOC_MAPK_RevD_3	247	260	PF00069	0.332
DOC_MAPK_RevD_3	90	103	PF00069	0.600
DOC_PP1_RVXF_1	619	625	PF00149	0.500
DOC_PP2B_LxvP_1	123	126	PF13499	0.498
DOC_PP2B_LxvP_1	41	44	PF13499	0.532
DOC_USP7_MATH_1	142	146	PF00917	0.576
DOC_USP7_MATH_1	175	179	PF00917	0.569
DOC_USP7_MATH_1	448	452	PF00917	0.527
DOC_USP7_MATH_1	457	461	PF00917	0.592
DOC_USP7_MATH_1	532	536	PF00917	0.541
DOC_USP7_MATH_1	716	720	PF00917	0.618
DOC_USP7_MATH_1	84	88	PF00917	0.504
DOC_USP7_MATH_2	306	312	PF00917	0.464
DOC_USP7_UBL2_3	210	214	PF12436	0.539
DOC_USP7_UBL2_3	729	733	PF12436	0.569
DOC_WW_Pin1_4	121	126	PF00397	0.634
DOC_WW_Pin1_4	146	151	PF00397	0.594
DOC_WW_Pin1_4	39	44	PF00397	0.501
DOC_WW_Pin1_4	399	404	PF00397	0.418
DOC_WW_Pin1_4	427	432	PF00397	0.604
DOC_WW_Pin1_4	446	451	PF00397	0.439
DOC_WW_Pin1_4	488	493	PF00397	0.506
DOC_WW_Pin1_4	533	538	PF00397	0.510
DOC_WW_Pin1_4	570	575	PF00397	0.476
DOC_WW_Pin1_4	634	639	PF00397	0.431
DOC_WW_Pin1_4	655	660	PF00397	0.455
LIG_14-3-3_CanoR_1	266	275	PF00244	0.470
LIG_14-3-3_CanoR_1	32	37	PF00244	0.440
LIG_14-3-3_CanoR_1	458	464	PF00244	0.634
LIG_14-3-3_CanoR_1	533	537	PF00244	0.516
LIG_14-3-3_CanoR_1	714	723	PF00244	0.499
LIG_AP2alpha_1	495	499	PF02296	0.564
LIG_BIR_II_1	1	5	PF00653	0.532
LIG_BRCT_BRCA1_1	414	418	PF00533	0.392
LIG_BRCT_BRCA1_1	61	65	PF00533	0.516
LIG_BRCT_BRCA1_2	414	420	PF00533	0.468
LIG_Clathr_ClatBox_1	189	193	PF01394	0.517
LIG_CtBP_PxDLS_1	537	541	PF00389	0.566
LIG_FHA_1	117	123	PF00498	0.525
LIG_FHA_1	287	293	PF00498	0.507
LIG_FHA_1	300	306	PF00498	0.711
LIG_FHA_1	428	434	PF00498	0.369
LIG_FHA_1	44	50	PF00498	0.670
LIG_FHA_1	571	577	PF00498	0.466
LIG_FHA_1	589	595	PF00498	0.566
LIG_FHA_1	599	605	PF00498	0.472
LIG_FHA_1	645	651	PF00498	0.443
LIG_FHA_1	696	702	PF00498	0.611
LIG_FHA_1	716	722	PF00498	0.380
LIG_FHA_1	75	81	PF00498	0.638
LIG_FHA_2	433	439	PF00498	0.441
LIG_FHA_2	601	607	PF00498	0.500
LIG_FHA_2	647	653	PF00498	0.390
LIG_FHA_2	83	89	PF00498	0.562
LIG_LIR_Gen_1	181	192	PF02991	0.459
LIG_LIR_Gen_1	415	426	PF02991	0.390
LIG_LIR_Gen_1	556	564	PF02991	0.395
LIG_LIR_Gen_1	609	620	PF02991	0.422
LIG_LIR_LC3C_4	367	371	PF02991	0.369
LIG_LIR_Nem_3	181	187	PF02991	0.473
LIG_LIR_Nem_3	25	29	PF02991	0.530
LIG_LIR_Nem_3	415	421	PF02991	0.351
LIG_LIR_Nem_3	556	561	PF02991	0.485
LIG_LIR_Nem_3	579	584	PF02991	0.468
LIG_LIR_Nem_3	609	615	PF02991	0.416
LIG_LIR_Nem_3	72	76	PF02991	0.565
LIG_NRBOX	230	236	PF00104	0.314
LIG_NRBOX	408	414	PF00104	0.436
LIG_PCNA_PIPBox_1	605	614	PF02747	0.558
LIG_Pex14_2	495	499	PF04695	0.564
LIG_RPA_C_Fungi	224	236	PF08784	0.312
LIG_SH2_CRK	26	30	PF00017	0.523
LIG_SH2_CRK	558	562	PF00017	0.383
LIG_SH2_CRK	581	585	PF00017	0.413
LIG_SH2_PTP2	73	76	PF00017	0.569
LIG_SH2_SRC	195	198	PF00017	0.491
LIG_SH2_SRC	204	207	PF00017	0.345
LIG_SH2_STAP1	118	122	PF00017	0.548
LIG_SH2_STAP1	204	208	PF00017	0.387
LIG_SH2_STAT3	118	121	PF00017	0.545
LIG_SH2_STAT3	36	39	PF00017	0.609
LIG_SH2_STAT5	118	121	PF00017	0.514
LIG_SH2_STAT5	195	198	PF00017	0.508
LIG_SH2_STAT5	73	76	PF00017	0.569
LIG_SH3_1	700	706	PF00018	0.541
LIG_SH3_3	102	108	PF00018	0.499
LIG_SH3_3	119	125	PF00018	0.660
LIG_SH3_3	166	172	PF00018	0.583
LIG_SH3_3	17	23	PF00018	0.501
LIG_SH3_3	241	247	PF00018	0.349
LIG_SH3_3	262	268	PF00018	0.426
LIG_SH3_3	310	316	PF00018	0.515
LIG_SH3_3	423	429	PF00018	0.434
LIG_SH3_3	700	706	PF00018	0.532
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.539
LIG_SUMO_SIM_anti_2	367	374	PF11976	0.481
LIG_SUMO_SIM_anti_2	378	386	PF11976	0.372
LIG_SUMO_SIM_anti_2	390	397	PF11976	0.279
LIG_SUMO_SIM_anti_2	550	556	PF11976	0.505
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.457
LIG_SUMO_SIM_par_1	188	194	PF11976	0.517
LIG_SUMO_SIM_par_1	367	374	PF11976	0.481
LIG_SUMO_SIM_par_1	646	652	PF11976	0.398
LIG_TYR_ITIM	71	76	PF00017	0.563
LIG_WRC_WIRS_1	503	508	PF05994	0.480
LIG_WW_3	150	154	PF00397	0.660
MOD_CDC14_SPxK_1	402	405	PF00782	0.435
MOD_CDK_SPK_2	488	493	PF00069	0.424
MOD_CDK_SPxK_1	399	405	PF00069	0.422
MOD_CDK_SPxxK_3	146	153	PF00069	0.538
MOD_CDK_SPxxK_3	399	406	PF00069	0.415
MOD_CK1_1	124	130	PF00069	0.659
MOD_CK1_1	145	151	PF00069	0.581
MOD_CK1_1	178	184	PF00069	0.543
MOD_CK1_1	297	303	PF00069	0.562
MOD_CK1_1	360	366	PF00069	0.536
MOD_CK1_1	449	455	PF00069	0.529
MOD_CK1_1	536	542	PF00069	0.452
MOD_CK1_1	566	572	PF00069	0.508
MOD_CK1_1	57	63	PF00069	0.621
MOD_CK1_1	600	606	PF00069	0.419
MOD_CK1_1	64	70	PF00069	0.683
MOD_CK1_1	691	697	PF00069	0.481
MOD_CK2_1	382	388	PF00069	0.421
MOD_CK2_1	394	400	PF00069	0.359
MOD_CK2_1	432	438	PF00069	0.460
MOD_CK2_1	53	59	PF00069	0.541
MOD_CK2_1	600	606	PF00069	0.502
MOD_CK2_1	646	652	PF00069	0.398
MOD_CK2_1	660	666	PF00069	0.503
MOD_CK2_1	691	697	PF00069	0.729
MOD_CK2_1	82	88	PF00069	0.600
MOD_GlcNHglycan	1	4	PF01048	0.607
MOD_GlcNHglycan	161	164	PF01048	0.820
MOD_GlcNHglycan	177	180	PF01048	0.581
MOD_GlcNHglycan	269	272	PF01048	0.478
MOD_GlcNHglycan	337	340	PF01048	0.323
MOD_GlcNHglycan	517	521	PF01048	0.543
MOD_GlcNHglycan	56	59	PF01048	0.646
MOD_GlcNHglycan	66	69	PF01048	0.576
MOD_GlcNHglycan	661	665	PF01048	0.614
MOD_GlcNHglycan	683	686	PF01048	0.531
MOD_GlcNHglycan	718	721	PF01048	0.412
MOD_GSK3_1	142	149	PF00069	0.642
MOD_GSK3_1	159	166	PF00069	0.804
MOD_GSK3_1	175	182	PF00069	0.567
MOD_GSK3_1	294	301	PF00069	0.567
MOD_GSK3_1	378	385	PF00069	0.355
MOD_GSK3_1	39	46	PF00069	0.538
MOD_GSK3_1	459	466	PF00069	0.704
MOD_GSK3_1	487	494	PF00069	0.560
MOD_GSK3_1	502	509	PF00069	0.480
MOD_GSK3_1	518	525	PF00069	0.537
MOD_GSK3_1	53	60	PF00069	0.533
MOD_GSK3_1	532	539	PF00069	0.519
MOD_GSK3_1	562	569	PF00069	0.559
MOD_GSK3_1	596	603	PF00069	0.545
MOD_GSK3_1	632	639	PF00069	0.473
MOD_GSK3_1	673	680	PF00069	0.586
MOD_GSK3_1	691	698	PF00069	0.436
MOD_GSK3_1	84	91	PF00069	0.742
MOD_N-GLC_1	463	468	PF02516	0.508
MOD_N-GLC_1	677	682	PF02516	0.545
MOD_N-GLC_1	695	700	PF02516	0.430
MOD_N-GLC_1	716	721	PF02516	0.537
MOD_NEK2_1	180	185	PF00069	0.580
MOD_NEK2_1	286	291	PF00069	0.466
MOD_NEK2_1	394	399	PF00069	0.371
MOD_NEK2_1	412	417	PF00069	0.459
MOD_NEK2_1	487	492	PF00069	0.559
MOD_NEK2_1	5	10	PF00069	0.556
MOD_NEK2_1	502	507	PF00069	0.479
MOD_NEK2_1	516	521	PF00069	0.487
MOD_NEK2_1	615	620	PF00069	0.410
MOD_NEK2_1	644	649	PF00069	0.515
MOD_NEK2_1	660	665	PF00069	0.556
MOD_NEK2_1	677	682	PF00069	0.507
MOD_NEK2_1	722	727	PF00069	0.568
MOD_NEK2_1	76	81	PF00069	0.579
MOD_NEK2_2	439	444	PF00069	0.351
MOD_PIKK_1	527	533	PF00454	0.625
MOD_PKA_1	405	411	PF00069	0.401
MOD_PKA_2	405	411	PF00069	0.401
MOD_PKA_2	457	463	PF00069	0.610
MOD_PKA_2	532	538	PF00069	0.514
MOD_Plk_1	319	325	PF00069	0.422
MOD_Plk_1	475	481	PF00069	0.532
MOD_Plk_1	673	679	PF00069	0.549
MOD_Plk_1	695	701	PF00069	0.472
MOD_Plk_1	716	722	PF00069	0.536
MOD_Plk_2-3	197	203	PF00069	0.395
MOD_Plk_2-3	646	652	PF00069	0.426
MOD_Plk_2-3	673	679	PF00069	0.549
MOD_Plk_2-3	88	94	PF00069	0.463
MOD_Plk_4	142	148	PF00069	0.587
MOD_Plk_4	378	384	PF00069	0.334
MOD_Plk_4	475	481	PF00069	0.525
MOD_Plk_4	502	508	PF00069	0.476
MOD_Plk_4	600	606	PF00069	0.497
MOD_Plk_4	688	694	PF00069	0.495
MOD_Plk_4	69	75	PF00069	0.576
MOD_Plk_4	722	728	PF00069	0.536
MOD_ProDKin_1	121	127	PF00069	0.638
MOD_ProDKin_1	146	152	PF00069	0.595
MOD_ProDKin_1	39	45	PF00069	0.504
MOD_ProDKin_1	399	405	PF00069	0.422
MOD_ProDKin_1	427	433	PF00069	0.593
MOD_ProDKin_1	446	452	PF00069	0.451
MOD_ProDKin_1	488	494	PF00069	0.500
MOD_ProDKin_1	533	539	PF00069	0.503
MOD_ProDKin_1	570	576	PF00069	0.478
MOD_ProDKin_1	634	640	PF00069	0.433
MOD_ProDKin_1	655	661	PF00069	0.462
MOD_SUMO_for_1	613	616	PF00179	0.525
TRG_DiLeu_BaEn_1	378	383	PF01217	0.336
TRG_ENDOCYTIC_2	26	29	PF00928	0.528
TRG_ENDOCYTIC_2	558	561	PF00928	0.466
TRG_ENDOCYTIC_2	581	584	PF00928	0.485
TRG_ENDOCYTIC_2	73	76	PF00928	0.569
TRG_ER_diArg_1	263	266	PF00400	0.341
TRG_ER_diArg_1	405	407	PF00400	0.313
TRG_ER_diArg_1	424	427	PF00400	0.415
TRG_ER_diArg_1	99	102	PF00400	0.530
TRG_NLS_MonoExtC_3	727	732	PF00514	0.583
TRG_NLS_MonoExtN_4	728	735	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.715
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	592	597	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG5	Leptomonas seymouri	36%	98%
A0A3Q8IVC2	Leishmania donovani	62%	100%
A4IBH5	Leishmania infantum	62%	100%
E9AFB1	Leishmania major	63%	100%
E9B6G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%