GN3L_Grn1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMV3_LEIBR

TriTrypDb:

LbrM.34.2770 , LBRM2903_340036200

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HMV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.477
CLV_NRD_NRD_1	114	116	PF00675	0.454
CLV_NRD_NRD_1	134	136	PF00675	0.373
CLV_NRD_NRD_1	17	19	PF00675	0.432
CLV_NRD_NRD_1	23	25	PF00675	0.480
CLV_NRD_NRD_1	35	37	PF00675	0.533
CLV_NRD_NRD_1	5	7	PF00675	0.456
CLV_PCSK_FUR_1	135	139	PF00082	0.332
CLV_PCSK_KEX2_1	113	115	PF00082	0.456
CLV_PCSK_KEX2_1	137	139	PF00082	0.391
CLV_PCSK_KEX2_1	14	16	PF00082	0.427
CLV_PCSK_KEX2_1	23	25	PF00082	0.472
CLV_PCSK_KEX2_1	35	37	PF00082	0.511
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.391
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.427
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.441
CLV_PCSK_PC7_1	109	115	PF00082	0.453
CLV_PCSK_PC7_1	31	37	PF00082	0.562
CLV_PCSK_SKI1_1	105	109	PF00082	0.527
CLV_PCSK_SKI1_1	138	142	PF00082	0.435
CLV_PCSK_SKI1_1	6	10	PF00082	0.453
DOC_CKS1_1	96	101	PF01111	0.435
DOC_MAPK_gen_1	132	142	PF00069	0.445
DOC_USP7_MATH_1	67	71	PF00917	0.533
DOC_USP7_MATH_1	78	82	PF00917	0.544
DOC_USP7_UBL2_3	101	105	PF12436	0.505
DOC_USP7_UBL2_3	132	136	PF12436	0.393
DOC_USP7_UBL2_3	137	141	PF12436	0.393
DOC_USP7_UBL2_3	19	23	PF12436	0.421
DOC_USP7_UBL2_3	3	7	PF12436	0.477
DOC_USP7_UBL2_3	9	13	PF12436	0.483
DOC_WW_Pin1_4	95	100	PF00397	0.431
LIG_14-3-3_CanoR_1	18	22	PF00244	0.439
LIG_14-3-3_CanoR_1	66	74	PF00244	0.632
MOD_CDK_SPxK_1	95	101	PF00069	0.433
MOD_CDK_SPxxK_3	95	102	PF00069	0.439
MOD_GSK3_1	123	130	PF00069	0.338
MOD_GSK3_1	34	41	PF00069	0.495
MOD_PIKK_1	38	44	PF00454	0.641
MOD_PKA_2	17	23	PF00069	0.436
MOD_PKA_2	34	40	PF00069	0.546
MOD_ProDKin_1	95	101	PF00069	0.433
TRG_ER_diArg_1	113	115	PF00400	0.363
TRG_NES_CRM1_1	86	97	PF08389	0.365
TRG_NLS_MonoExtC_3	100	105	PF00514	0.428
TRG_NLS_MonoExtN_4	135	140	PF00514	0.336
TRG_NLS_MonoExtN_4	3	10	PF00514	0.486
TRG_NLS_MonoExtN_4	99	105	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S0	Leptomonas seymouri	74%	100%
A0A0S4JBT2	Bodo saltans	44%	93%
A0A1X0P5F8	Trypanosomatidae	53%	96%
A0A3Q8IIF2	Leishmania donovani	81%	100%
A0A3R7MVM6	Trypanosoma rangeli	51%	100%
A4IBH4	Leishmania infantum	80%	100%
C9ZZ68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AFB0	Leishmania major	81%	99%
E9B6G5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%