Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMV0_LEIBR

TriTrypDb:

LbrM.34.2740 , LBRM2903_340035900

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMV0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.519
CLV_C14_Caspase3-7	430	434	PF00656	0.702
CLV_NRD_NRD_1	136	138	PF00675	0.600
CLV_NRD_NRD_1	173	175	PF00675	0.506
CLV_NRD_NRD_1	292	294	PF00675	0.661
CLV_NRD_NRD_1	347	349	PF00675	0.453
CLV_NRD_NRD_1	397	399	PF00675	0.593
CLV_NRD_NRD_1	523	525	PF00675	0.481
CLV_PCSK_FUR_1	395	399	PF00082	0.594
CLV_PCSK_FUR_1	521	525	PF00082	0.474
CLV_PCSK_KEX2_1	136	138	PF00082	0.600
CLV_PCSK_KEX2_1	292	294	PF00082	0.655
CLV_PCSK_KEX2_1	309	311	PF00082	0.614
CLV_PCSK_KEX2_1	349	351	PF00082	0.461
CLV_PCSK_KEX2_1	380	382	PF00082	0.684
CLV_PCSK_KEX2_1	397	399	PF00082	0.608
CLV_PCSK_KEX2_1	426	428	PF00082	0.557
CLV_PCSK_KEX2_1	523	525	PF00082	0.644
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.647
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.461
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.684
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.557
CLV_PCSK_SKI1_1	137	141	PF00082	0.675
CLV_PCSK_SKI1_1	200	204	PF00082	0.643
CLV_PCSK_SKI1_1	381	385	PF00082	0.652
CLV_PCSK_SKI1_1	427	431	PF00082	0.627
CLV_PCSK_SKI1_1	61	65	PF00082	0.525
DEG_APCC_DBOX_1	122	130	PF00400	0.487
DEG_Nend_UBRbox_4	1	3	PF02207	0.479
DEG_SPOP_SBC_1	303	307	PF00917	0.550
DEG_SPOP_SBC_1	496	500	PF00917	0.502
DEG_SPOP_SBC_1	78	82	PF00917	0.505
DOC_ANK_TNKS_1	448	455	PF00023	0.699
DOC_CYCLIN_RxL_1	232	242	PF00134	0.663
DOC_MAPK_gen_1	233	241	PF00069	0.658
DOC_MAPK_gen_1	309	319	PF00069	0.541
DOC_MAPK_gen_1	395	405	PF00069	0.584
DOC_MAPK_JIP1_4	235	241	PF00069	0.650
DOC_MAPK_MEF2A_6	200	209	PF00069	0.631
DOC_MAPK_MEF2A_6	233	241	PF00069	0.562
DOC_PP2B_LxvP_1	20	23	PF13499	0.545
DOC_PP2B_LxvP_1	317	320	PF13499	0.545
DOC_PP2B_LxvP_1	445	448	PF13499	0.695
DOC_USP7_MATH_1	103	107	PF00917	0.645
DOC_USP7_MATH_1	224	228	PF00917	0.603
DOC_USP7_MATH_1	302	306	PF00917	0.619
DOC_USP7_MATH_1	93	97	PF00917	0.675
DOC_WW_Pin1_4	246	251	PF00397	0.586
DOC_WW_Pin1_4	264	269	PF00397	0.527
DOC_WW_Pin1_4	284	289	PF00397	0.614
DOC_WW_Pin1_4	31	36	PF00397	0.693
DOC_WW_Pin1_4	439	444	PF00397	0.645
DOC_WW_Pin1_4	510	515	PF00397	0.693
DOC_WW_Pin1_4	89	94	PF00397	0.544
LIG_14-3-3_CanoR_1	172	178	PF00244	0.585
LIG_14-3-3_CanoR_1	188	195	PF00244	0.501
LIG_14-3-3_CanoR_1	293	303	PF00244	0.698
LIG_14-3-3_CanoR_1	350	356	PF00244	0.555
LIG_14-3-3_CanoR_1	494	504	PF00244	0.542
LIG_Actin_WH2_2	535	552	PF00022	0.530
LIG_BIR_III_2	220	224	PF00653	0.684
LIG_BIR_III_4	101	105	PF00653	0.477
LIG_BRCT_BRCA1_1	304	308	PF00533	0.628
LIG_BRCT_BRCA1_1	367	371	PF00533	0.524
LIG_deltaCOP1_diTrp_1	257	269	PF00928	0.531
LIG_FHA_1	232	238	PF00498	0.529
LIG_FHA_1	32	38	PF00498	0.586
LIG_FHA_1	415	421	PF00498	0.620
LIG_FHA_1	474	480	PF00498	0.598
LIG_FHA_2	192	198	PF00498	0.679
LIG_FHA_2	25	31	PF00498	0.555
LIG_FHA_2	384	390	PF00498	0.588
LIG_FHA_2	428	434	PF00498	0.666
LIG_FHA_2	539	545	PF00498	0.541
LIG_FHA_2	81	87	PF00498	0.609
LIG_LIR_Gen_1	155	165	PF02991	0.531
LIG_LIR_Gen_1	267	276	PF02991	0.574
LIG_LIR_Gen_1	491	496	PF02991	0.683
LIG_LIR_Nem_3	155	160	PF02991	0.539
LIG_LIR_Nem_3	201	206	PF02991	0.529
LIG_LIR_Nem_3	267	272	PF02991	0.522
LIG_LIR_Nem_3	334	338	PF02991	0.466
LIG_LIR_Nem_3	491	495	PF02991	0.745
LIG_LIR_Nem_3	5	9	PF02991	0.550
LIG_LIR_Nem_3	56	62	PF02991	0.592
LIG_MYND_1	468	472	PF01753	0.699
LIG_NRBOX	401	407	PF00104	0.589
LIG_Pex14_1	262	266	PF04695	0.509
LIG_Pex14_2	46	50	PF04695	0.520
LIG_SH2_GRB2like	110	113	PF00017	0.608
LIG_SH2_SRC	110	113	PF00017	0.448
LIG_SH2_SRC	218	221	PF00017	0.564
LIG_SH2_STAP1	134	138	PF00017	0.597
LIG_SH2_STAP1	338	342	PF00017	0.517
LIG_SH2_STAP1	47	51	PF00017	0.547
LIG_SH2_STAT3	122	125	PF00017	0.654
LIG_SH2_STAT3	338	341	PF00017	0.454
LIG_SH2_STAT5	110	113	PF00017	0.552
LIG_SH2_STAT5	159	162	PF00017	0.530
LIG_SH2_STAT5	218	221	PF00017	0.564
LIG_SH2_STAT5	266	269	PF00017	0.539
LIG_SH2_STAT5	342	345	PF00017	0.440
LIG_SH3_3	19	25	PF00018	0.552
LIG_SH3_3	244	250	PF00018	0.567
LIG_SH3_3	269	275	PF00018	0.491
LIG_SH3_3	437	443	PF00018	0.671
LIG_Sin3_3	203	210	PF02671	0.624
LIG_SUMO_SIM_anti_2	242	249	PF11976	0.481
LIG_SUMO_SIM_par_1	237	242	PF11976	0.548
LIG_SUMO_SIM_par_1	532	538	PF11976	0.538
LIG_TRAF2_1	255	258	PF00917	0.498
LIG_TRAF2_1	386	389	PF00917	0.682
LIG_TRAF2_1	71	74	PF00917	0.650
LIG_WRC_WIRS_1	3	8	PF05994	0.463
MOD_CDK_SPxxK_3	439	446	PF00069	0.699
MOD_CK1_1	187	193	PF00069	0.707
MOD_CK1_1	227	233	PF00069	0.692
MOD_CK1_1	340	346	PF00069	0.454
MOD_CK1_1	354	360	PF00069	0.428
MOD_CK1_1	473	479	PF00069	0.734
MOD_CK1_1	510	516	PF00069	0.566
MOD_CK1_1	538	544	PF00069	0.610
MOD_CK1_1	80	86	PF00069	0.522
MOD_CK2_1	248	254	PF00069	0.677
MOD_CK2_1	383	389	PF00069	0.503
MOD_CK2_1	68	74	PF00069	0.642
MOD_CK2_1	80	86	PF00069	0.558
MOD_GlcNHglycan	161	164	PF01048	0.624
MOD_GlcNHglycan	226	229	PF01048	0.706
MOD_GlcNHglycan	430	433	PF01048	0.636
MOD_GlcNHglycan	515	518	PF01048	0.618
MOD_GlcNHglycan	528	532	PF01048	0.664
MOD_GlcNHglycan	95	98	PF01048	0.696
MOD_GSK3_1	187	194	PF00069	0.677
MOD_GSK3_1	227	234	PF00069	0.570
MOD_GSK3_1	304	311	PF00069	0.673
MOD_GSK3_1	31	38	PF00069	0.674
MOD_GSK3_1	315	322	PF00069	0.594
MOD_GSK3_1	379	386	PF00069	0.549
MOD_GSK3_1	389	396	PF00069	0.598
MOD_GSK3_1	496	503	PF00069	0.571
MOD_GSK3_1	506	513	PF00069	0.682
MOD_GSK3_1	523	530	PF00069	0.625
MOD_GSK3_1	534	541	PF00069	0.543
MOD_GSK3_1	78	85	PF00069	0.516
MOD_GSK3_1	89	96	PF00069	0.588
MOD_N-GLC_1	153	158	PF02516	0.463
MOD_N-GLC_1	414	419	PF02516	0.533
MOD_N-GLC_1	427	432	PF02516	0.580
MOD_NEK2_1	121	126	PF00069	0.640
MOD_NEK2_1	308	313	PF00069	0.578
MOD_NEK2_1	331	336	PF00069	0.645
MOD_NEK2_1	363	368	PF00069	0.633
MOD_NEK2_1	88	93	PF00069	0.611
MOD_PIKK_1	121	127	PF00454	0.614
MOD_PIKK_1	227	233	PF00454	0.692
MOD_PIKK_1	294	300	PF00454	0.641
MOD_PIKK_1	337	343	PF00454	0.617
MOD_PK_1	507	513	PF00069	0.535
MOD_PKA_1	523	529	PF00069	0.493
MOD_PKA_2	173	179	PF00069	0.559
MOD_PKA_2	187	193	PF00069	0.523
MOD_PKA_2	496	502	PF00069	0.507
MOD_PKA_2	506	512	PF00069	0.530
MOD_PKA_2	523	529	PF00069	0.493
MOD_PKB_1	521	529	PF00069	0.487
MOD_Plk_1	153	159	PF00069	0.495
MOD_Plk_1	534	540	PF00069	0.634
MOD_Plk_4	153	159	PF00069	0.496
MOD_Plk_4	279	285	PF00069	0.607
MOD_Plk_4	331	337	PF00069	0.551
MOD_Plk_4	500	506	PF00069	0.618
MOD_Plk_4	538	544	PF00069	0.481
MOD_ProDKin_1	246	252	PF00069	0.588
MOD_ProDKin_1	264	270	PF00069	0.534
MOD_ProDKin_1	284	290	PF00069	0.615
MOD_ProDKin_1	31	37	PF00069	0.692
MOD_ProDKin_1	439	445	PF00069	0.645
MOD_ProDKin_1	510	516	PF00069	0.695
MOD_ProDKin_1	89	95	PF00069	0.546
MOD_SUMO_rev_2	38	46	PF00179	0.680
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.572
TRG_ENDOCYTIC_2	266	269	PF00928	0.522
TRG_ENDOCYTIC_2	47	50	PF00928	0.548
TRG_ER_diArg_1	291	293	PF00400	0.654
TRG_ER_diArg_1	347	350	PF00400	0.461
TRG_ER_diArg_1	395	398	PF00400	0.596
TRG_ER_diArg_1	520	523	PF00400	0.480
TRG_NES_CRM1_1	326	341	PF08389	0.465
TRG_Pf-PMV_PEXEL_1	404	408	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q6	Leptomonas seymouri	37%	89%
A0A3S7X9F0	Leishmania donovani	71%	100%
A4IBH2	Leishmania infantum	71%	91%
E9AFA7	Leishmania major	72%	100%
E9B6G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%