MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HMU9_LEIBR

TriTrypDb:

LbrM.34.2730 , LBRM2903_340035800

Length:

648

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HMU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	642	648	PF00089	0.389
CLV_NRD_NRD_1	220	222	PF00675	0.371
CLV_NRD_NRD_1	235	237	PF00675	0.467
CLV_NRD_NRD_1	80	82	PF00675	0.429
CLV_PCSK_KEX2_1	220	222	PF00082	0.371
CLV_PCSK_SKI1_1	303	307	PF00082	0.456
CLV_PCSK_SKI1_1	387	391	PF00082	0.461
CLV_PCSK_SKI1_1	446	450	PF00082	0.342
CLV_PCSK_SKI1_1	506	510	PF00082	0.362
DEG_SPOP_SBC_1	551	555	PF00917	0.309
DOC_CDC14_PxL_1	599	607	PF14671	0.229
DOC_CDC14_PxL_1	627	635	PF14671	0.359
DOC_CKS1_1	531	536	PF01111	0.359
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.228
DOC_MAPK_gen_1	474	481	PF00069	0.421
DOC_MAPK_gen_1	78	87	PF00069	0.507
DOC_MAPK_MEF2A_6	78	87	PF00069	0.521
DOC_PP2B_LxvP_1	30	33	PF13499	0.369
DOC_PP2B_PxIxI_1	82	88	PF00149	0.428
DOC_PP4_FxxP_1	440	443	PF00568	0.626
DOC_USP7_MATH_1	178	182	PF00917	0.388
DOC_USP7_MATH_1	225	229	PF00917	0.631
DOC_USP7_MATH_1	305	309	PF00917	0.666
DOC_USP7_MATH_1	323	327	PF00917	0.701
DOC_USP7_MATH_1	359	363	PF00917	0.686
DOC_USP7_MATH_1	392	396	PF00917	0.631
DOC_USP7_MATH_1	441	445	PF00917	0.477
DOC_USP7_MATH_1	498	502	PF00917	0.254
DOC_USP7_MATH_1	93	97	PF00917	0.319
DOC_WW_Pin1_4	332	337	PF00397	0.764
DOC_WW_Pin1_4	388	393	PF00397	0.723
DOC_WW_Pin1_4	530	535	PF00397	0.367
DOC_WW_Pin1_4	99	104	PF00397	0.369
LIG_14-3-3_CanoR_1	236	244	PF00244	0.638
LIG_14-3-3_CanoR_1	321	331	PF00244	0.655
LIG_14-3-3_CanoR_1	352	359	PF00244	0.761
LIG_14-3-3_CanoR_1	426	434	PF00244	0.611
LIG_14-3-3_CanoR_1	595	600	PF00244	0.359
LIG_14-3-3_CterR_2	645	648	PF00244	0.598
LIG_Actin_RPEL_3	71	90	PF02755	0.428
LIG_BIR_III_2	277	281	PF00653	0.632
LIG_BRCT_BRCA1_1	500	504	PF00533	0.369
LIG_BRCT_BRCA1_1	542	546	PF00533	0.431
LIG_BRCT_BRCA1_1	560	564	PF00533	0.215
LIG_BRCT_BRCA1_1	95	99	PF00533	0.457
LIG_eIF4E_1	497	503	PF01652	0.239
LIG_eIF4E_1	52	58	PF01652	0.529
LIG_FHA_1	109	115	PF00498	0.329
LIG_FHA_1	17	23	PF00498	0.483
LIG_FHA_1	205	211	PF00498	0.469
LIG_FHA_1	352	358	PF00498	0.637
LIG_FHA_1	429	435	PF00498	0.561
LIG_FHA_1	445	451	PF00498	0.549
LIG_FHA_1	513	519	PF00498	0.551
LIG_FHA_1	527	533	PF00498	0.322
LIG_FHA_1	553	559	PF00498	0.365
LIG_FHA_1	596	602	PF00498	0.309
LIG_FHA_1	66	72	PF00498	0.369
LIG_FHA_1	89	95	PF00498	0.339
LIG_FHA_2	131	137	PF00498	0.521
LIG_FHA_2	72	78	PF00498	0.521
LIG_IRF3_LxIS_1	194	201	PF10401	0.271
LIG_IRF3_LxIS_1	205	212	PF10401	0.293
LIG_IRF3_LxIS_1	486	493	PF10401	0.369
LIG_IRF3_LxIS_1	53	59	PF10401	0.319
LIG_LIR_Apic_2	438	443	PF02991	0.507
LIG_LIR_Gen_1	224	231	PF02991	0.669
LIG_LIR_Gen_1	501	511	PF02991	0.392
LIG_LIR_Gen_1	520	528	PF02991	0.328
LIG_LIR_Gen_1	561	572	PF02991	0.371
LIG_LIR_Gen_1	9	17	PF02991	0.615
LIG_LIR_Nem_3	224	229	PF02991	0.667
LIG_LIR_Nem_3	433	439	PF02991	0.508
LIG_LIR_Nem_3	501	507	PF02991	0.384
LIG_LIR_Nem_3	520	524	PF02991	0.304
LIG_LIR_Nem_3	543	549	PF02991	0.263
LIG_LIR_Nem_3	561	567	PF02991	0.356
LIG_MLH1_MIPbox_1	95	99	PF16413	0.369
LIG_MYND_1	174	178	PF01753	0.399
LIG_MYND_1	192	196	PF01753	0.410
LIG_NRBOX	362	368	PF00104	0.621
LIG_Pex14_2	226	230	PF04695	0.686
LIG_Pex14_2	327	331	PF04695	0.643
LIG_Pex14_2	436	440	PF04695	0.489
LIG_Pex14_2	564	568	PF04695	0.341
LIG_Pex14_2	619	623	PF04695	0.308
LIG_SH2_CRK	164	168	PF00017	0.228
LIG_SH2_CRK	452	456	PF00017	0.449
LIG_SH2_CRK	621	625	PF00017	0.314
LIG_SH2_GRB2like	11	14	PF00017	0.542
LIG_SH2_NCK_1	497	501	PF00017	0.239
LIG_SH2_STAP1	11	15	PF00017	0.580
LIG_SH2_STAP1	547	551	PF00017	0.351
LIG_SH2_STAT5	11	14	PF00017	0.578
LIG_SH2_STAT5	510	513	PF00017	0.627
LIG_SH2_STAT5	52	55	PF00017	0.410
LIG_SH2_STAT5	538	541	PF00017	0.460
LIG_SH3_3	151	157	PF00018	0.369
LIG_SH3_3	168	174	PF00018	0.304
LIG_SH3_3	186	192	PF00018	0.260
LIG_SH3_3	219	225	PF00018	0.647
LIG_SH3_3	598	604	PF00018	0.410
LIG_SH3_3	610	616	PF00018	0.368
LIG_SH3_4	82	89	PF00018	0.521
LIG_SUMO_SIM_anti_2	201	207	PF11976	0.350
LIG_SUMO_SIM_anti_2	259	268	PF11976	0.729
LIG_SUMO_SIM_par_1	18	25	PF11976	0.354
LIG_SUMO_SIM_par_1	198	204	PF11976	0.295
LIG_SUMO_SIM_par_1	206	212	PF11976	0.295
LIG_SUMO_SIM_par_1	630	635	PF11976	0.359
LIG_TRAF2_1	313	316	PF00917	0.700
LIG_TYR_ITIM	450	455	PF00017	0.529
LIG_UBA3_1	503	509	PF00899	0.295
LIG_UBA3_1	97	106	PF00899	0.369
LIG_WRC_WIRS_1	324	329	PF05994	0.641
LIG_WRC_WIRS_1	633	638	PF05994	0.359
MOD_CDK_SPxxK_3	99	106	PF00069	0.369
MOD_CK1_1	181	187	PF00069	0.405
MOD_CK1_1	201	207	PF00069	0.341
MOD_CK1_1	310	316	PF00069	0.733
MOD_CK1_1	325	331	PF00069	0.694
MOD_CK1_1	335	341	PF00069	0.677
MOD_CK1_1	376	382	PF00069	0.650
MOD_CK1_1	444	450	PF00069	0.448
MOD_CK1_1	457	463	PF00069	0.293
MOD_CK1_1	589	595	PF00069	0.514
MOD_CK1_1	9	15	PF00069	0.598
MOD_CK2_1	130	136	PF00069	0.428
MOD_CK2_1	286	292	PF00069	0.672
MOD_CK2_1	310	316	PF00069	0.750
MOD_CK2_1	392	398	PF00069	0.632
MOD_CK2_1	551	557	PF00069	0.359
MOD_Cter_Amidation	79	82	PF01082	0.435
MOD_GlcNHglycan	182	186	PF01048	0.583
MOD_GlcNHglycan	256	259	PF01048	0.436
MOD_GlcNHglycan	26	29	PF01048	0.369
MOD_GlcNHglycan	286	291	PF01048	0.587
MOD_GlcNHglycan	340	343	PF01048	0.521
MOD_GlcNHglycan	374	378	PF01048	0.481
MOD_GlcNHglycan	421	424	PF01048	0.464
MOD_GlcNHglycan	459	462	PF01048	0.465
MOD_GlcNHglycan	482	485	PF01048	0.499
MOD_GlcNHglycan	520	524	PF01048	0.257
MOD_GlcNHglycan	53	56	PF01048	0.529
MOD_GlcNHglycan	573	576	PF01048	0.464
MOD_GSK3_1	130	137	PF00069	0.521
MOD_GSK3_1	20	27	PF00069	0.358
MOD_GSK3_1	225	232	PF00069	0.696
MOD_GSK3_1	306	313	PF00069	0.744
MOD_GSK3_1	319	326	PF00069	0.666
MOD_GSK3_1	331	338	PF00069	0.731
MOD_GSK3_1	347	354	PF00069	0.739
MOD_GSK3_1	388	395	PF00069	0.670
MOD_GSK3_1	426	433	PF00069	0.633
MOD_GSK3_1	498	505	PF00069	0.369
MOD_GSK3_1	526	533	PF00069	0.463
MOD_GSK3_1	537	544	PF00069	0.384
MOD_GSK3_1	558	565	PF00069	0.414
MOD_GSK3_1	591	598	PF00069	0.367
MOD_GSK3_1	632	639	PF00069	0.382
MOD_GSK3_1	9	16	PF00069	0.581
MOD_NEK2_1	198	203	PF00069	0.422
MOD_NEK2_1	209	214	PF00069	0.455
MOD_NEK2_1	229	234	PF00069	0.689
MOD_NEK2_1	26	31	PF00069	0.455
MOD_NEK2_1	306	311	PF00069	0.720
MOD_NEK2_1	331	336	PF00069	0.684
MOD_NEK2_1	490	495	PF00069	0.450
MOD_NEK2_1	502	507	PF00069	0.400
MOD_NEK2_1	56	61	PF00069	0.332
MOD_NEK2_1	606	611	PF00069	0.524
MOD_NEK2_1	625	630	PF00069	0.215
MOD_NEK2_1	632	637	PF00069	0.407
MOD_NEK2_1	71	76	PF00069	0.468
MOD_NEK2_2	225	230	PF00069	0.683
MOD_NEK2_2	293	298	PF00069	0.671
MOD_NEK2_2	93	98	PF00069	0.319
MOD_OFUCOSY	407	413	PF10250	0.437
MOD_PIKK_1	231	237	PF00454	0.608
MOD_PIKK_1	311	317	PF00454	0.686
MOD_PIKK_1	396	402	PF00454	0.712
MOD_PIKK_1	426	432	PF00454	0.576
MOD_PKA_2	238	244	PF00069	0.740
MOD_PKA_2	351	357	PF00069	0.736
MOD_PKA_2	594	600	PF00069	0.229
MOD_Plk_1	519	525	PF00069	0.359
MOD_Plk_1	540	546	PF00069	0.362
MOD_Plk_4	124	130	PF00069	0.529
MOD_Plk_4	150	156	PF00069	0.391
MOD_Plk_4	16	22	PF00069	0.410
MOD_Plk_4	225	231	PF00069	0.696
MOD_Plk_4	26	32	PF00069	0.378
MOD_Plk_4	359	365	PF00069	0.638
MOD_Plk_4	491	497	PF00069	0.369
MOD_Plk_4	498	504	PF00069	0.340
MOD_Plk_4	541	547	PF00069	0.344
MOD_Plk_4	6	12	PF00069	0.653
MOD_Plk_4	632	638	PF00069	0.391
MOD_Plk_4	93	99	PF00069	0.465
MOD_ProDKin_1	332	338	PF00069	0.765
MOD_ProDKin_1	388	394	PF00069	0.723
MOD_ProDKin_1	530	536	PF00069	0.367
MOD_ProDKin_1	99	105	PF00069	0.369
TRG_DiLeu_BaLyEn_6	296	301	PF01217	0.713
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.359
TRG_ENDOCYTIC_2	11	14	PF00928	0.578
TRG_ENDOCYTIC_2	164	167	PF00928	0.228
TRG_ENDOCYTIC_2	452	455	PF00928	0.529
TRG_ENDOCYTIC_2	621	624	PF00928	0.314
TRG_ER_diArg_1	220	222	PF00400	0.574
TRG_NLS_Bipartite_1	220	240	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II42	Leishmania donovani	71%	100%
A0A3Q8IPN7	Leishmania donovani	30%	92%
A4HMU7	Leishmania braziliensis	30%	100%
A4IBH0	Leishmania infantum	30%	92%
A4IBH1	Leishmania infantum	71%	100%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	92%
E9AFA6	Leishmania major	68%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9B6G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%