LeishMANIAdb
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MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HMU8_LEIBR
TriTrypDb:
LbrM.34.2720 , LBRM2903_340035700
Length:
266

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 1
NetGPI no yes: 0, no: 1
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HMU8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU8

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0022857 transmembrane transporter activity 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 182 184 PF00675 0.585
CLV_NRD_NRD_1 238 240 PF00675 0.595
CLV_NRD_NRD_1 250 252 PF00675 0.406
CLV_NRD_NRD_1 65 67 PF00675 0.424
CLV_PCSK_KEX2_1 182 184 PF00082 0.585
CLV_PCSK_KEX2_1 238 240 PF00082 0.595
CLV_PCSK_KEX2_1 249 251 PF00082 0.420
CLV_PCSK_KEX2_1 65 67 PF00082 0.424
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.558
DEG_SCF_FBW7_1 162 167 PF00400 0.524
DOC_CYCLIN_yCln2_LP_2 173 179 PF00134 0.524
DOC_MAPK_gen_1 238 246 PF00069 0.779
DOC_MAPK_gen_1 249 255 PF00069 0.616
DOC_MAPK_MEF2A_6 214 222 PF00069 0.779
DOC_MAPK_MEF2A_6 239 248 PF00069 0.772
DOC_MIT_MIM_1 247 255 PF04212 0.755
DOC_PP1_RVXF_1 169 175 PF00149 0.524
DOC_SPAK_OSR1_1 188 192 PF12202 0.811
DOC_USP7_MATH_1 127 131 PF00917 0.524
DOC_USP7_MATH_1 165 169 PF00917 0.524
DOC_USP7_MATH_1 200 204 PF00917 0.820
DOC_WW_Pin1_4 160 165 PF00397 0.424
DOC_WW_Pin1_4 172 177 PF00397 0.314
LIG_14-3-3_CanoR_1 238 246 PF00244 0.779
LIG_14-3-3_CanoR_1 250 256 PF00244 0.604
LIG_Actin_WH2_2 14 29 PF00022 0.524
LIG_BIR_II_1 1 5 PF00653 0.674
LIG_BRCT_BRCA1_1 70 74 PF00533 0.524
LIG_Clathr_ClatBox_1 215 219 PF01394 0.782
LIG_CSL_BTD_1 173 176 PF09270 0.524
LIG_EH1_1 132 140 PF00400 0.524
LIG_eIF4E_1 133 139 PF01652 0.524
LIG_eIF4E_1 36 42 PF01652 0.424
LIG_FHA_1 11 17 PF00498 0.524
LIG_FHA_1 161 167 PF00498 0.524
LIG_FHA_1 168 174 PF00498 0.401
LIG_FHA_1 239 245 PF00498 0.781
LIG_LIR_Gen_1 75 85 PF02991 0.524
LIG_LIR_Nem_3 146 152 PF02991 0.524
LIG_LIR_Nem_3 53 59 PF02991 0.524
LIG_LIR_Nem_3 75 81 PF02991 0.524
LIG_PDZ_Class_1 261 266 PF00595 0.808
LIG_Pex14_2 149 153 PF04695 0.424
LIG_Pex14_2 74 78 PF04695 0.524
LIG_SH2_PTP2 217 220 PF00017 0.775
LIG_SH2_SRC 217 220 PF00017 0.775
LIG_SH2_STAT5 207 210 PF00017 0.798
LIG_SH2_STAT5 217 220 PF00017 0.650
LIG_SH2_STAT5 36 39 PF00017 0.424
LIG_SH3_3 194 200 PF00018 0.819
LIG_SH3_3 215 221 PF00018 0.774
LIG_SUMO_SIM_par_1 241 247 PF11976 0.769
LIG_TYR_ITIM 215 220 PF00017 0.779
LIG_UBA3_1 112 119 PF00899 0.524
LIG_UBA3_1 243 249 PF00899 0.764
MOD_CK1_1 160 166 PF00069 0.424
MOD_CK1_1 9 15 PF00069 0.524
MOD_CK2_1 27 33 PF00069 0.424
MOD_Cter_Amidation 63 66 PF01082 0.424
MOD_GlcNHglycan 158 162 PF01048 0.761
MOD_GlcNHglycan 198 203 PF01048 0.620
MOD_GlcNHglycan 37 40 PF01048 0.624
MOD_GlcNHglycan 70 73 PF01048 0.524
MOD_GlcNHglycan 75 78 PF01048 0.436
MOD_GSK3_1 139 146 PF00069 0.524
MOD_GSK3_1 153 160 PF00069 0.373
MOD_GSK3_1 221 228 PF00069 0.771
MOD_GSK3_1 238 245 PF00069 0.571
MOD_GSK3_1 6 13 PF00069 0.624
MOD_GSK3_1 68 75 PF00069 0.624
MOD_LATS_1 25 31 PF00433 0.424
MOD_N-GLC_1 6 11 PF02516 0.458
MOD_NEK2_1 143 148 PF00069 0.524
MOD_NEK2_1 152 157 PF00069 0.421
MOD_NEK2_1 253 258 PF00069 0.761
MOD_NEK2_1 6 11 PF00069 0.658
MOD_NEK2_1 73 78 PF00069 0.524
MOD_NEK2_1 83 88 PF00069 0.349
MOD_PIKK_1 200 206 PF00454 0.819
MOD_PIKK_1 253 259 PF00454 0.763
MOD_PK_1 27 33 PF00069 0.424
MOD_PKA_1 238 244 PF00069 0.785
MOD_PKA_2 231 237 PF00069 0.793
MOD_PKA_2 238 244 PF00069 0.697
MOD_Plk_1 6 12 PF00069 0.624
MOD_Plk_4 10 16 PF00069 0.524
MOD_Plk_4 108 114 PF00069 0.524
MOD_Plk_4 85 91 PF00069 0.524
MOD_ProDKin_1 160 166 PF00069 0.424
MOD_ProDKin_1 172 178 PF00069 0.314
TRG_DiLeu_BaLyEn_6 65 70 PF01217 0.624
TRG_ENDOCYTIC_2 217 220 PF00928 0.775
TRG_ER_diArg_1 229 232 PF00400 0.799
TRG_ER_diArg_1 250 252 PF00400 0.756
TRG_ER_diArg_1 65 67 PF00400 0.624
TRG_NLS_Bipartite_1 238 253 PF00514 0.769

Homologs

Protein Taxonomy Sequence identity Coverage
B4EYY4 Proteus mirabilis (strain HI4320) 26% 66%
P40760 Bacillus subtilis (strain 168) 26% 68%
P51564 Pasteurella multocida 29% 66%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS