MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMU7_LEIBR

TriTrypDb:

LbrM.34.2710 , LBRM2903_340035700

Length:

710

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HMU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.668
CLV_C14_Caspase3-7	417	421	PF00656	0.680
CLV_NRD_NRD_1	109	111	PF00675	0.353
CLV_NRD_NRD_1	212	214	PF00675	0.566
CLV_NRD_NRD_1	539	541	PF00675	0.292
CLV_NRD_NRD_1	696	698	PF00675	0.333
CLV_NRD_NRD_1	700	702	PF00675	0.354
CLV_PCSK_KEX2_1	109	111	PF00082	0.312
CLV_PCSK_KEX2_1	539	541	PF00082	0.292
CLV_PCSK_KEX2_1	696	698	PF00082	0.333
CLV_PCSK_KEX2_1	700	702	PF00082	0.354
CLV_PCSK_PC7_1	696	702	PF00082	0.314
CLV_PCSK_SKI1_1	214	218	PF00082	0.509
CLV_PCSK_SKI1_1	467	471	PF00082	0.388
CLV_PCSK_SKI1_1	472	476	PF00082	0.371
CLV_PCSK_SKI1_1	585	589	PF00082	0.350
CLV_PCSK_SKI1_1	686	690	PF00082	0.304
DEG_MDM2_SWIB_1	587	595	PF02201	0.356
DEG_SPOP_SBC_1	383	387	PF00917	0.643
DOC_CKS1_1	630	635	PF01111	0.356
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.291
DOC_MAPK_DCC_7	213	223	PF00069	0.309
DOC_MAPK_FxFP_2	254	257	PF00069	0.493
DOC_MAPK_gen_1	244	254	PF00069	0.488
DOC_MAPK_gen_1	416	426	PF00069	0.664
DOC_MAPK_gen_1	539	547	PF00069	0.469
DOC_MAPK_gen_1	671	680	PF00069	0.537
DOC_MAPK_HePTP_8	211	223	PF00069	0.219
DOC_MAPK_MEF2A_6	214	223	PF00069	0.309
DOC_MAPK_MEF2A_6	244	252	PF00069	0.488
DOC_MAPK_MEF2A_6	476	483	PF00069	0.565
DOC_MAPK_MEF2A_6	674	682	PF00069	0.526
DOC_MAPK_NFAT4_5	476	484	PF00069	0.474
DOC_PP2B_LxvP_1	323	326	PF13499	0.658
DOC_PP4_FxxP_1	254	257	PF00568	0.606
DOC_PP4_FxxP_1	354	357	PF00568	0.636
DOC_PP4_FxxP_1	470	473	PF00568	0.625
DOC_USP7_MATH_1	171	175	PF00917	0.337
DOC_USP7_MATH_1	194	198	PF00917	0.318
DOC_USP7_MATH_1	283	287	PF00917	0.724
DOC_USP7_MATH_1	319	323	PF00917	0.665
DOC_USP7_MATH_1	383	387	PF00917	0.783
DOC_USP7_MATH_1	563	567	PF00917	0.446
DOC_USP7_MATH_1	705	709	PF00917	0.570
DOC_WW_Pin1_4	32	37	PF00397	0.625
DOC_WW_Pin1_4	629	634	PF00397	0.356
LIG_14-3-3_CanoR_1	318	324	PF00244	0.618
LIG_14-3-3_CanoR_1	382	391	PF00244	0.760
LIG_Actin_WH2_2	58	73	PF00022	0.356
LIG_BRCT_BRCA1_1	114	118	PF00533	0.399
LIG_CaM_NSCaTE_8	698	705	PF13499	0.528
LIG_EH1_1	176	184	PF00400	0.337
LIG_eIF4E_1	177	183	PF01652	0.337
LIG_eIF4E_1	80	86	PF01652	0.420
LIG_FHA_1	233	239	PF00498	0.405
LIG_FHA_1	315	321	PF00498	0.660
LIG_FHA_1	475	481	PF00498	0.574
LIG_FHA_1	520	526	PF00498	0.318
LIG_FHA_1	55	61	PF00498	0.462
LIG_FHA_1	563	569	PF00498	0.511
LIG_FHA_1	6	12	PF00498	0.620
LIG_FHA_2	282	288	PF00498	0.720
LIG_FHA_2	369	375	PF00498	0.715
LIG_FHA_2	670	676	PF00498	0.612
LIG_Integrin_isoDGR_2	414	416	PF01839	0.442
LIG_Integrin_RGD_1	368	370	PF01839	0.446
LIG_LIR_Apic_2	353	357	PF02991	0.635
LIG_LIR_Gen_1	119	129	PF02991	0.230
LIG_LIR_Gen_1	333	341	PF02991	0.804
LIG_LIR_Gen_1	456	466	PF02991	0.663
LIG_LIR_Nem_3	119	125	PF02991	0.442
LIG_LIR_Nem_3	333	339	PF02991	0.683
LIG_LIR_Nem_3	456	461	PF02991	0.723
LIG_LIR_Nem_3	590	596	PF02991	0.344
LIG_LIR_Nem_3	97	103	PF02991	0.437
LIG_LYPXL_S_1	255	259	PF13949	0.373
LIG_MYND_1	215	219	PF01753	0.427
LIG_NRBOX	569	575	PF00104	0.301
LIG_Pex14_2	118	122	PF04695	0.230
LIG_Pex14_2	43	47	PF04695	0.230
LIG_Pex14_2	587	591	PF04695	0.377
LIG_RPA_C_Fungi	669	681	PF08784	0.368
LIG_SH2_CRK	226	230	PF00017	0.361
LIG_SH2_CRK	336	340	PF00017	0.501
LIG_SH2_CRK	482	486	PF00017	0.398
LIG_SH2_CRK	593	597	PF00017	0.500
LIG_SH2_GRB2like	226	229	PF00017	0.361
LIG_SH2_GRB2like	541	544	PF00017	0.437
LIG_SH2_NCK_1	226	230	PF00017	0.299
LIG_SH2_PTP2	458	461	PF00017	0.431
LIG_SH2_STAP1	336	340	PF00017	0.501
LIG_SH2_STAT5	226	229	PF00017	0.361
LIG_SH2_STAT5	458	461	PF00017	0.576
LIG_SH2_STAT5	518	521	PF00017	0.364
LIG_SH2_STAT5	541	544	PF00017	0.475
LIG_SH2_STAT5	664	667	PF00017	0.400
LIG_SH2_STAT5	80	83	PF00017	0.395
LIG_SH3_3	627	633	PF00018	0.379
LIG_SH3_3	7	13	PF00018	0.717
LIG_SUMO_SIM_anti_2	422	427	PF11976	0.533
LIG_SUMO_SIM_anti_2	558	563	PF11976	0.360
LIG_SUMO_SIM_anti_2	675	682	PF11976	0.374
LIG_SUMO_SIM_par_1	422	427	PF11976	0.533
LIG_SUMO_SIM_par_1	687	694	PF11976	0.337
LIG_TRAF2_1	428	431	PF00917	0.516
LIG_TRAF2_1	491	494	PF00917	0.405
LIG_TYR_ITIM	480	485	PF00017	0.420
LIG_UBA3_1	156	163	PF00899	0.316
LIG_WRC_WIRS_1	233	238	PF05994	0.430
LIG_WRC_WIRS_1	461	466	PF05994	0.353
MOD_CK1_1	303	309	PF00069	0.645
MOD_CK1_1	362	368	PF00069	0.595
MOD_CK1_1	385	391	PF00069	0.684
MOD_CK1_1	53	59	PF00069	0.378
MOD_CK1_1	638	644	PF00069	0.365
MOD_CK1_1	656	662	PF00069	0.234
MOD_CK2_1	281	287	PF00069	0.690
MOD_CK2_1	350	356	PF00069	0.594
MOD_CK2_1	368	374	PF00069	0.586
MOD_CK2_1	669	675	PF00069	0.454
MOD_CK2_1	71	77	PF00069	0.356
MOD_Cter_Amidation	107	110	PF01082	0.420
MOD_GlcNHglycan	114	117	PF01048	0.303
MOD_GlcNHglycan	119	122	PF01048	0.303
MOD_GlcNHglycan	197	200	PF01048	0.381
MOD_GlcNHglycan	305	308	PF01048	0.785
MOD_GlcNHglycan	326	329	PF01048	0.643
MOD_GlcNHglycan	374	377	PF01048	0.635
MOD_GlcNHglycan	485	488	PF01048	0.400
MOD_GlcNHglycan	602	605	PF01048	0.484
MOD_GlcNHglycan	640	643	PF01048	0.494
MOD_GlcNHglycan	655	658	PF01048	0.466
MOD_GlcNHglycan	661	664	PF01048	0.361
MOD_GlcNHglycan	81	84	PF01048	0.420
MOD_GSK3_1	112	119	PF00069	0.294
MOD_GSK3_1	183	190	PF00069	0.356
MOD_GSK3_1	279	286	PF00069	0.642
MOD_GSK3_1	368	375	PF00069	0.777
MOD_GSK3_1	50	57	PF00069	0.465
MOD_GSK3_1	553	560	PF00069	0.450
MOD_GSK3_1	600	607	PF00069	0.521
MOD_GSK3_1	637	644	PF00069	0.425
MOD_GSK3_1	669	676	PF00069	0.471
MOD_GSK3_1	703	710	PF00069	0.438
MOD_LATS_1	69	75	PF00433	0.356
MOD_N-GLC_1	195	200	PF02516	0.356
MOD_N-GLC_1	279	284	PF02516	0.600
MOD_N-GLC_1	289	294	PF02516	0.627
MOD_N-GLC_1	372	377	PF02516	0.540
MOD_N-GLC_1	5	10	PF02516	0.551
MOD_N-GLC_1	50	55	PF02516	0.361
MOD_NEK2_1	117	122	PF00069	0.357
MOD_NEK2_1	127	132	PF00069	0.361
MOD_NEK2_1	187	192	PF00069	0.230
MOD_NEK2_1	224	229	PF00069	0.420
MOD_NEK2_1	232	237	PF00069	0.425
MOD_NEK2_1	384	389	PF00069	0.587
MOD_NEK2_1	407	412	PF00069	0.625
MOD_NEK2_1	483	488	PF00069	0.327
MOD_NEK2_1	50	55	PF00069	0.395
MOD_NEK2_1	521	526	PF00069	0.418
MOD_NEK2_1	553	558	PF00069	0.468
MOD_NEK2_1	580	585	PF00069	0.434
MOD_NEK2_1	587	592	PF00069	0.513
MOD_NEK2_1	635	640	PF00069	0.465
MOD_NEK2_1	653	658	PF00069	0.418
MOD_NEK2_2	619	624	PF00069	0.230
MOD_PIKK_1	357	363	PF00454	0.600
MOD_PK_1	419	425	PF00069	0.536
MOD_PK_1	71	77	PF00069	0.356
MOD_PKA_2	300	306	PF00069	0.566
MOD_PKA_2	673	679	PF00069	0.392
MOD_Plk_1	195	201	PF00069	0.370
MOD_Plk_1	289	295	PF00069	0.573
MOD_Plk_1	5	11	PF00069	0.512
MOD_Plk_1	50	56	PF00069	0.361
MOD_Plk_2-3	350	356	PF00069	0.563
MOD_Plk_4	11	17	PF00069	0.554
MOD_Plk_4	129	135	PF00069	0.379
MOD_Plk_4	152	158	PF00069	0.523
MOD_Plk_4	187	193	PF00069	0.365
MOD_Plk_4	206	212	PF00069	0.594
MOD_Plk_4	217	223	PF00069	0.246
MOD_Plk_4	232	238	PF00069	0.419
MOD_Plk_4	350	356	PF00069	0.641
MOD_Plk_4	419	425	PF00069	0.573
MOD_Plk_4	54	60	PF00069	0.462
MOD_Plk_4	557	563	PF00069	0.383
MOD_Plk_4	594	600	PF00069	0.420
MOD_Plk_4	608	614	PF00069	0.420
MOD_Plk_4	664	670	PF00069	0.413
MOD_Plk_4	673	679	PF00069	0.429
MOD_ProDKin_1	32	38	PF00069	0.504
MOD_ProDKin_1	629	635	PF00069	0.356
MOD_SUMO_rev_2	456	464	PF00179	0.527
TRG_DiLeu_BaEn_2	349	355	PF01217	0.528
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.255
TRG_ENDOCYTIC_2	226	229	PF00928	0.361
TRG_ENDOCYTIC_2	256	259	PF00928	0.439
TRG_ENDOCYTIC_2	336	339	PF00928	0.504
TRG_ENDOCYTIC_2	458	461	PF00928	0.576
TRG_ENDOCYTIC_2	482	485	PF00928	0.381
TRG_ENDOCYTIC_2	518	521	PF00928	0.344
TRG_ENDOCYTIC_2	593	596	PF00928	0.517
TRG_ER_diArg_1	109	111	PF00400	0.361
TRG_ER_diArg_1	539	541	PF00400	0.332
TRG_ER_diArg_1	695	697	PF00400	0.385
TRG_ER_diArg_1	700	702	PF00400	0.415
TRG_NES_CRM1_1	41	52	PF08389	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	44%	100%
A0A3Q8II42	Leishmania donovani	30%	100%
A0A3Q8IPN7	Leishmania donovani	64%	100%
A4HMU9	Leishmania braziliensis	30%	100%
A4IBH0	Leishmania infantum	64%	100%
A4IBH1	Leishmania infantum	30%	100%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
E9AFA5	Leishmania major	63%	100%
E9AFA6	Leishmania major	30%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
E9B6G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%