AB hydrolase-1 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HMU6_LEIBR

TriTrypDb:

LbrM.34.2700 , LBRM2903_340035600

Length:

400

Annotations

LeishMANIAdb annotations

A catalytically active hydrolase 4 domain associated with a multi-pass membrane domain. Probably recognizes membrane-associated substrates.. Distant Eukaryotic relatives typically have signal-anchors and are luminal

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HMU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.501
CLV_NRD_NRD_1	141	143	PF00675	0.418
CLV_NRD_NRD_1	151	153	PF00675	0.235
CLV_NRD_NRD_1	330	332	PF00675	0.363
CLV_PCSK_FUR_1	139	143	PF00082	0.392
CLV_PCSK_KEX2_1	141	143	PF00082	0.379
CLV_PCSK_SKI1_1	185	189	PF00082	0.268
CLV_PCSK_SKI1_1	256	260	PF00082	0.255
CLV_PCSK_SKI1_1	308	312	PF00082	0.378
CLV_PCSK_SKI1_1	332	336	PF00082	0.337
CLV_PCSK_SKI1_1	93	97	PF00082	0.612
DEG_COP1_1	157	166	PF00400	0.638
DEG_Nend_Nbox_1	1	3	PF02207	0.654
DEG_ODPH_VHL_1	29	42	PF01847	0.339
DEG_SCF_FBW7_1	302	307	PF00400	0.609
DOC_CKS1_1	181	186	PF01111	0.442
DOC_CYCLIN_RxL_1	326	337	PF00134	0.592
DOC_MAPK_gen_1	326	335	PF00069	0.532
DOC_PP1_RVXF_1	254	261	PF00149	0.457
DOC_PP1_RVXF_1	75	82	PF00149	0.497
DOC_PP2B_LxvP_1	28	31	PF13499	0.475
DOC_PP2B_LxvP_1	370	373	PF13499	0.458
DOC_USP7_MATH_1	103	107	PF00917	0.396
DOC_USP7_MATH_1	279	283	PF00917	0.521
DOC_USP7_MATH_1	351	355	PF00917	0.446
DOC_USP7_UBL2_3	252	256	PF12436	0.497
DOC_USP7_UBL2_3	328	332	PF12436	0.551
DOC_WW_Pin1_4	180	185	PF00397	0.450
DOC_WW_Pin1_4	300	305	PF00397	0.556
LIG_14-3-3_CanoR_1	141	147	PF00244	0.518
LIG_14-3-3_CanoR_1	287	293	PF00244	0.482
LIG_Actin_WH2_2	61	79	PF00022	0.490
LIG_eIF4E_1	278	284	PF01652	0.562
LIG_FHA_1	102	108	PF00498	0.386
LIG_FHA_1	172	178	PF00498	0.570
LIG_FHA_1	225	231	PF00498	0.534
LIG_FHA_1	301	307	PF00498	0.562
LIG_FHA_1	69	75	PF00498	0.529
LIG_LIR_Gen_1	286	297	PF02991	0.482
LIG_LIR_Gen_1	385	394	PF02991	0.597
LIG_LIR_Gen_1	62	70	PF02991	0.475
LIG_LIR_LC3C_4	174	177	PF02991	0.573
LIG_LIR_Nem_3	114	119	PF02991	0.423
LIG_LIR_Nem_3	183	189	PF02991	0.485
LIG_LIR_Nem_3	383	387	PF02991	0.575
LIG_LIR_Nem_3	62	68	PF02991	0.407
LIG_MAD2	365	373	PF02301	0.447
LIG_SH2_CRK	181	185	PF00017	0.448
LIG_SH2_GRB2like	376	379	PF00017	0.591
LIG_SH2_SRC	21	24	PF00017	0.653
LIG_SH2_SRC	387	390	PF00017	0.621
LIG_SH2_STAP1	50	54	PF00017	0.298
LIG_SH2_STAT5	181	184	PF00017	0.535
LIG_SH2_STAT5	189	192	PF00017	0.471
LIG_SH2_STAT5	21	24	PF00017	0.647
LIG_SH2_STAT5	229	232	PF00017	0.509
LIG_SH2_STAT5	247	250	PF00017	0.526
LIG_SH3_3	92	98	PF00018	0.379
LIG_SUMO_SIM_anti_2	106	111	PF11976	0.297
LIG_WRC_WIRS_1	381	386	PF05994	0.589
LIG_WW_1	373	376	PF00397	0.599
MOD_CDK_SPK_2	180	185	PF00069	0.450
MOD_CK1_1	290	296	PF00069	0.477
MOD_CK1_1	300	306	PF00069	0.536
MOD_CK1_1	346	352	PF00069	0.510
MOD_GlcNHglycan	16	19	PF01048	0.330
MOD_GlcNHglycan	4	7	PF01048	0.356
MOD_GSK3_1	142	149	PF00069	0.571
MOD_GSK3_1	167	174	PF00069	0.594
MOD_GSK3_1	224	231	PF00069	0.534
MOD_GSK3_1	300	307	PF00069	0.589
MOD_GSK3_1	372	379	PF00069	0.544
MOD_GSK3_1	64	71	PF00069	0.475
MOD_N-GLC_1	14	19	PF02516	0.428
MOD_N-GLC_1	343	348	PF02516	0.336
MOD_NEK2_1	1	6	PF00069	0.496
MOD_NEK2_1	197	202	PF00069	0.523
MOD_NEK2_1	261	266	PF00069	0.537
MOD_NEK2_1	285	290	PF00069	0.476
MOD_NEK2_1	345	350	PF00069	0.570
MOD_NEK2_1	36	41	PF00069	0.298
MOD_NEK2_1	59	64	PF00069	0.364
MOD_NEK2_1	68	73	PF00069	0.543
MOD_NEK2_1	83	88	PF00069	0.389
MOD_PIKK_1	334	340	PF00454	0.523
MOD_PIKK_1	351	357	PF00454	0.541
MOD_PK_1	142	148	PF00069	0.467
MOD_PKA_2	351	357	PF00069	0.535
MOD_Plk_1	197	203	PF00069	0.461
MOD_Plk_1	285	291	PF00069	0.476
MOD_Plk_1	343	349	PF00069	0.553
MOD_Plk_4	146	152	PF00069	0.593
MOD_Plk_4	171	177	PF00069	0.553
MOD_Plk_4	279	285	PF00069	0.538
MOD_Plk_4	317	323	PF00069	0.589
MOD_Plk_4	36	42	PF00069	0.277
MOD_Plk_4	376	382	PF00069	0.590
MOD_Plk_4	59	65	PF00069	0.393
MOD_ProDKin_1	180	186	PF00069	0.445
MOD_ProDKin_1	300	306	PF00069	0.553
MOD_SUMO_rev_2	165	171	PF00179	0.659
MOD_SUMO_rev_2	249	258	PF00179	0.400
TRG_ENDOCYTIC_2	387	390	PF00928	0.602
TRG_ER_diArg_1	139	142	PF00400	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q9	Leptomonas seymouri	60%	100%
A0A0S4JC83	Bodo saltans	29%	93%
A0A1X0P6X8	Trypanosomatidae	35%	99%
A0A3S5H7Z7	Leishmania donovani	77%	100%
A0A422P2Q7	Trypanosoma rangeli	34%	99%
A4IBE6	Leishmania infantum	77%	100%
C9ZZ74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	95%
E9AFA4	Leishmania major	78%	100%
E9B6F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BD21	Trypanosoma cruzi	34%	98%