LeishMANIAdb
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Membrane-associated protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-associated protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HMU5_LEIBR
TriTrypDb:
LbrM.34.2690 , LBRM2903_340035500
Length:
400

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 0
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HMU5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 380 384 PF00656 0.633
CLV_NRD_NRD_1 372 374 PF00675 0.451
CLV_PCSK_SKI1_1 255 259 PF00082 0.651
CLV_PCSK_SKI1_1 261 265 PF00082 0.608
CLV_PCSK_SKI1_1 339 343 PF00082 0.410
DEG_APCC_DBOX_1 145 153 PF00400 0.420
DEG_Nend_UBRbox_2 1 3 PF02207 0.527
DEG_SCF_FBW7_2 294 301 PF00400 0.607
DOC_CDC14_PxL_1 168 176 PF14671 0.361
DOC_CKS1_1 48 53 PF01111 0.436
DOC_MAPK_DCC_7 300 308 PF00069 0.578
DOC_MAPK_MEF2A_6 300 308 PF00069 0.566
DOC_MAPK_MEF2A_6 365 372 PF00069 0.582
DOC_PP1_RVXF_1 259 266 PF00149 0.415
DOC_PP2B_PxIxI_1 367 373 PF00149 0.614
DOC_PP4_MxPP_1 296 299 PF00568 0.530
DOC_USP7_MATH_1 218 222 PF00917 0.414
DOC_USP7_MATH_1 366 370 PF00917 0.670
DOC_USP7_MATH_1 9 13 PF00917 0.449
DOC_WW_Pin1_4 294 299 PF00397 0.606
DOC_WW_Pin1_4 47 52 PF00397 0.492
LIG_Actin_WH2_2 329 345 PF00022 0.608
LIG_APCC_ABBA_1 232 237 PF00400 0.394
LIG_APCC_ABBAyCdc20_2 231 237 PF00400 0.398
LIG_BRCT_BRCA1_1 237 241 PF00533 0.414
LIG_CORNRBOX 277 285 PF00104 0.247
LIG_CtBP_PxDLS_1 360 364 PF00389 0.580
LIG_deltaCOP1_diTrp_1 262 271 PF00928 0.419
LIG_FHA_1 153 159 PF00498 0.424
LIG_FHA_1 205 211 PF00498 0.455
LIG_FHA_1 247 253 PF00498 0.473
LIG_FHA_1 285 291 PF00498 0.342
LIG_FHA_2 149 155 PF00498 0.413
LIG_FHA_2 378 384 PF00498 0.695
LIG_FHA_2 96 102 PF00498 0.404
LIG_GBD_Chelix_1 277 285 PF00786 0.274
LIG_LIR_Gen_1 223 234 PF02991 0.345
LIG_LIR_Gen_1 268 279 PF02991 0.402
LIG_LIR_Nem_3 105 110 PF02991 0.472
LIG_LIR_Nem_3 144 150 PF02991 0.424
LIG_LIR_Nem_3 169 174 PF02991 0.493
LIG_LIR_Nem_3 223 229 PF02991 0.414
LIG_LIR_Nem_3 230 235 PF02991 0.463
LIG_LIR_Nem_3 238 244 PF02991 0.550
LIG_LIR_Nem_3 268 274 PF02991 0.402
LIG_LIR_Nem_3 50 56 PF02991 0.384
LIG_LYPXL_S_1 170 174 PF13949 0.639
LIG_LYPXL_yS_3 171 174 PF13949 0.439
LIG_PCNA_PIPBox_1 161 170 PF02747 0.419
LIG_Pex14_1 20 24 PF04695 0.513
LIG_Pex14_1 270 274 PF04695 0.322
LIG_SH2_CRK 147 151 PF00017 0.338
LIG_SH2_CRK 291 295 PF00017 0.336
LIG_SH2_CRK 48 52 PF00017 0.435
LIG_SH2_GRB2like 318 321 PF00017 0.681
LIG_SH2_NCK_1 48 52 PF00017 0.462
LIG_SH2_PTP2 226 229 PF00017 0.320
LIG_SH2_SRC 244 247 PF00017 0.447
LIG_SH2_SRC 318 321 PF00017 0.710
LIG_SH2_STAT3 56 59 PF00017 0.415
LIG_SH2_STAT3 74 77 PF00017 0.396
LIG_SH2_STAT5 107 110 PF00017 0.482
LIG_SH2_STAT5 199 202 PF00017 0.463
LIG_SH2_STAT5 226 229 PF00017 0.398
LIG_SH2_STAT5 235 238 PF00017 0.330
LIG_SH2_STAT5 244 247 PF00017 0.383
LIG_SH2_STAT5 291 294 PF00017 0.383
LIG_SH2_STAT5 318 321 PF00017 0.685
LIG_SH2_STAT5 53 56 PF00017 0.447
LIG_SH2_STAT5 74 77 PF00017 0.446
LIG_SH3_3 301 307 PF00018 0.663
LIG_SH3_3 354 360 PF00018 0.628
LIG_SH3_3 36 42 PF00018 0.448
LIG_SUMO_SIM_par_1 148 155 PF11976 0.415
LIG_SUMO_SIM_par_1 281 287 PF11976 0.304
LIG_TRAF2_1 299 302 PF00917 0.633
LIG_TRFH_1 168 172 PF08558 0.429
LIG_TYR_ITIM 242 247 PF00017 0.581
LIG_TYR_ITIM 289 294 PF00017 0.336
MOD_CDK_SPxK_1 294 300 PF00069 0.603
MOD_CK1_1 334 340 PF00069 0.614
MOD_CK1_1 5 11 PF00069 0.417
MOD_CK1_1 66 72 PF00069 0.440
MOD_CK1_1 81 87 PF00069 0.510
MOD_CK2_1 110 116 PF00069 0.400
MOD_CK2_1 95 101 PF00069 0.412
MOD_GlcNHglycan 113 116 PF01048 0.653
MOD_GlcNHglycan 137 140 PF01048 0.553
MOD_GlcNHglycan 220 223 PF01048 0.696
MOD_GlcNHglycan 31 34 PF01048 0.635
MOD_GlcNHglycan 315 318 PF01048 0.465
MOD_GlcNHglycan 339 342 PF01048 0.484
MOD_GlcNHglycan 348 351 PF01048 0.478
MOD_GlcNHglycan 83 86 PF01048 0.653
MOD_GSK3_1 102 109 PF00069 0.487
MOD_GSK3_1 148 155 PF00069 0.356
MOD_GSK3_1 216 223 PF00069 0.538
MOD_GSK3_1 25 32 PF00069 0.462
MOD_GSK3_1 342 349 PF00069 0.634
MOD_GSK3_1 373 380 PF00069 0.600
MOD_GSK3_1 5 12 PF00069 0.514
MOD_N-GLC_1 313 318 PF02516 0.510
MOD_N-GLC_1 334 339 PF02516 0.429
MOD_N-GLC_1 394 399 PF02516 0.459
MOD_NEK2_1 102 107 PF00069 0.473
MOD_NEK2_1 108 113 PF00069 0.506
MOD_NEK2_1 201 206 PF00069 0.421
MOD_NEK2_1 29 34 PF00069 0.623
MOD_NEK2_1 342 347 PF00069 0.639
MOD_NEK2_2 141 146 PF00069 0.394
MOD_PIKK_1 123 129 PF00454 0.430
MOD_PIKK_1 235 241 PF00454 0.540
MOD_PIKK_1 342 348 PF00454 0.605
MOD_PKA_1 373 379 PF00069 0.598
MOD_PKA_2 9 15 PF00069 0.499
MOD_PKB_1 311 319 PF00069 0.572
MOD_Plk_1 216 222 PF00069 0.537
MOD_Plk_1 261 267 PF00069 0.409
MOD_Plk_1 337 343 PF00069 0.666
MOD_Plk_4 148 154 PF00069 0.490
MOD_Plk_4 166 172 PF00069 0.438
MOD_Plk_4 222 228 PF00069 0.494
MOD_Plk_4 237 243 PF00069 0.470
MOD_Plk_4 25 31 PF00069 0.486
MOD_Plk_4 359 365 PF00069 0.766
MOD_Plk_4 366 372 PF00069 0.658
MOD_Plk_4 78 84 PF00069 0.460
MOD_Plk_4 9 15 PF00069 0.558
MOD_ProDKin_1 294 300 PF00069 0.610
MOD_ProDKin_1 47 53 PF00069 0.492
MOD_SUMO_for_1 299 302 PF00179 0.633
MOD_SUMO_rev_2 388 394 PF00179 0.641
TRG_DiLeu_BaEn_2 236 242 PF01217 0.415
TRG_ENDOCYTIC_2 147 150 PF00928 0.342
TRG_ENDOCYTIC_2 167 170 PF00928 0.416
TRG_ENDOCYTIC_2 171 174 PF00928 0.433
TRG_ENDOCYTIC_2 198 201 PF00928 0.418
TRG_ENDOCYTIC_2 226 229 PF00928 0.361
TRG_ENDOCYTIC_2 244 247 PF00928 0.486
TRG_ENDOCYTIC_2 260 263 PF00928 0.336
TRG_ENDOCYTIC_2 291 294 PF00928 0.336

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 31% 85%
A0A0N1I9Y8 Leptomonas seymouri 36% 100%
A0A3S7WSM6 Leishmania donovani 34% 86%
A0A3S7X9E7 Leishmania donovani 77% 100%
A4HVR0 Leishmania infantum 34% 86%
E9AFA3 Leishmania major 76% 100%
E9AHW4 Leishmania infantum 78% 100%
E9APF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 86%
E9B6F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS