G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMU2_LEIBR

TriTrypDb:

LbrM.34.2660 , LBRM2903_340034800

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.747
CLV_C14_Caspase3-7	360	364	PF00656	0.618
CLV_C14_Caspase3-7	613	617	PF00656	0.747
CLV_NRD_NRD_1	142	144	PF00675	0.276
CLV_NRD_NRD_1	246	248	PF00675	0.435
CLV_NRD_NRD_1	51	53	PF00675	0.618
CLV_NRD_NRD_1	513	515	PF00675	0.610
CLV_NRD_NRD_1	519	521	PF00675	0.636
CLV_PCSK_KEX2_1	142	144	PF00082	0.276
CLV_PCSK_KEX2_1	50	52	PF00082	0.623
CLV_PCSK_KEX2_1	513	515	PF00082	0.610
CLV_PCSK_KEX2_1	614	616	PF00082	0.660
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.690
CLV_PCSK_PC7_1	46	52	PF00082	0.623
CLV_PCSK_SKI1_1	125	129	PF00082	0.276
CLV_PCSK_SKI1_1	248	252	PF00082	0.324
CLV_PCSK_SKI1_1	446	450	PF00082	0.518
CLV_PCSK_SKI1_1	454	458	PF00082	0.548
CLV_PCSK_SKI1_1	63	67	PF00082	0.725
DEG_APCC_DBOX_1	453	461	PF00400	0.635
DEG_Nend_Nbox_1	1	3	PF02207	0.473
DEG_SPOP_SBC_1	394	398	PF00917	0.509
DEG_SPOP_SBC_1	424	428	PF00917	0.718
DOC_CKS1_1	105	110	PF01111	0.504
DOC_CYCLIN_RxL_1	120	130	PF00134	0.500
DOC_CYCLIN_RxL_1	242	254	PF00134	0.302
DOC_CYCLIN_RxL_1	449	461	PF00134	0.637
DOC_MAPK_DCC_7	306	316	PF00069	0.734
DOC_MAPK_gen_1	139	148	PF00069	0.479
DOC_MAPK_MEF2A_6	185	192	PF00069	0.517
DOC_MAPK_MEF2A_6	72	79	PF00069	0.346
DOC_PP1_RVXF_1	530	537	PF00149	0.630
DOC_PP2B_LxvP_1	623	626	PF13499	0.652
DOC_PP2B_LxvP_1	644	647	PF13499	0.748
DOC_PP4_FxxP_1	128	131	PF00568	0.389
DOC_PP4_FxxP_1	512	515	PF00568	0.626
DOC_USP7_MATH_1	393	397	PF00917	0.794
DOC_USP7_MATH_1	424	428	PF00917	0.710
DOC_USP7_MATH_1	519	523	PF00917	0.777
DOC_USP7_UBL2_3	521	525	PF12436	0.718
DOC_WW_Pin1_4	104	109	PF00397	0.519
DOC_WW_Pin1_4	127	132	PF00397	0.389
DOC_WW_Pin1_4	19	24	PF00397	0.637
DOC_WW_Pin1_4	461	466	PF00397	0.521
LIG_14-3-3_CanoR_1	117	127	PF00244	0.548
LIG_14-3-3_CanoR_1	236	246	PF00244	0.546
LIG_14-3-3_CanoR_1	26	32	PF00244	0.510
LIG_14-3-3_CanoR_1	289	298	PF00244	0.547
LIG_14-3-3_CanoR_1	301	308	PF00244	0.536
LIG_14-3-3_CanoR_1	370	376	PF00244	0.765
LIG_14-3-3_CanoR_1	446	452	PF00244	0.619
LIG_14-3-3_CanoR_1	520	528	PF00244	0.753
LIG_14-3-3_CanoR_1	89	99	PF00244	0.574
LIG_Actin_WH2_2	401	419	PF00022	0.487
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.416
LIG_FHA_1	105	111	PF00498	0.497
LIG_FHA_1	119	125	PF00498	0.517
LIG_FHA_1	13	19	PF00498	0.487
LIG_FHA_1	169	175	PF00498	0.509
LIG_FHA_1	222	228	PF00498	0.476
LIG_FHA_1	285	291	PF00498	0.576
LIG_FHA_1	397	403	PF00498	0.737
LIG_FHA_1	603	609	PF00498	0.547
LIG_FHA_2	226	232	PF00498	0.476
LIG_FHA_2	289	295	PF00498	0.546
LIG_FHA_2	363	369	PF00498	0.768
LIG_HP1_1	108	112	PF01393	0.443
LIG_IBAR_NPY_1	495	497	PF08397	0.525
LIG_LIR_Apic_2	463	469	PF02991	0.516
LIG_LIR_Apic_2	509	515	PF02991	0.572
LIG_LIR_Gen_1	167	178	PF02991	0.473
LIG_LIR_Gen_1	249	260	PF02991	0.389
LIG_LIR_Gen_1	272	282	PF02991	0.480
LIG_LIR_Gen_1	640	649	PF02991	0.489
LIG_LIR_Nem_3	167	173	PF02991	0.473
LIG_LIR_Nem_3	249	255	PF02991	0.430
LIG_LIR_Nem_3	272	278	PF02991	0.470
LIG_LIR_Nem_3	373	379	PF02991	0.504
LIG_LIR_Nem_3	640	644	PF02991	0.498
LIG_LYPXL_SIV_4	443	451	PF13949	0.633
LIG_PCNA_yPIPBox_3	446	460	PF02747	0.540
LIG_Pex14_2	637	641	PF04695	0.508
LIG_SH2_CRK	275	279	PF00017	0.509
LIG_SH2_CRK	541	545	PF00017	0.580
LIG_SH2_NCK_1	541	545	PF00017	0.580
LIG_SH2_NCK_1	584	588	PF00017	0.652
LIG_SH2_PTP2	503	506	PF00017	0.405
LIG_SH2_SRC	459	462	PF00017	0.644
LIG_SH2_STAP1	2	6	PF00017	0.434
LIG_SH2_STAP1	275	279	PF00017	0.474
LIG_SH2_STAP1	444	448	PF00017	0.613
LIG_SH2_STAT3	497	500	PF00017	0.552
LIG_SH2_STAT5	195	198	PF00017	0.477
LIG_SH2_STAT5	206	209	PF00017	0.456
LIG_SH2_STAT5	27	30	PF00017	0.486
LIG_SH2_STAT5	459	462	PF00017	0.539
LIG_SH2_STAT5	497	500	PF00017	0.552
LIG_SH2_STAT5	503	506	PF00017	0.527
LIG_SH2_STAT5	511	514	PF00017	0.582
LIG_SH2_STAT5	541	544	PF00017	0.571
LIG_SH2_STAT5	545	548	PF00017	0.560
LIG_SH3_1	527	533	PF00018	0.662
LIG_SH3_1	541	547	PF00018	0.566
LIG_SH3_3	102	108	PF00018	0.488
LIG_SH3_3	155	161	PF00018	0.487
LIG_SH3_3	487	493	PF00018	0.545
LIG_SH3_3	527	533	PF00018	0.648
LIG_SH3_3	541	547	PF00018	0.550
LIG_SH3_3	623	629	PF00018	0.722
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.487
LIG_SUMO_SIM_anti_2	73	78	PF11976	0.343
LIG_SUMO_SIM_par_1	223	228	PF11976	0.476
LIG_SUMO_SIM_par_1	257	263	PF11976	0.406
LIG_SxIP_EBH_1	424	436	PF03271	0.721
LIG_TRAF2_1	364	367	PF00917	0.769
LIG_TRAF2_1	398	401	PF00917	0.690
LIG_TRAF2_1	610	613	PF00917	0.482
LIG_TRAF2_2	318	323	PF00917	0.684
LIG_TYR_ITIM	250	255	PF00017	0.542
LIG_TYR_ITIM	273	278	PF00017	0.501
MOD_CDC14_SPxK_1	464	467	PF00782	0.515
MOD_CDK_SPK_2	127	132	PF00069	0.207
MOD_CDK_SPxK_1	461	467	PF00069	0.522
MOD_CDK_SPxxK_3	19	26	PF00069	0.490
MOD_CK1_1	17	23	PF00069	0.538
MOD_CK1_1	25	31	PF00069	0.533
MOD_CK1_1	396	402	PF00069	0.693
MOD_CK1_1	425	431	PF00069	0.614
MOD_CK2_1	127	133	PF00069	0.413
MOD_CK2_1	288	294	PF00069	0.554
MOD_CK2_1	301	307	PF00069	0.532
MOD_CK2_1	362	368	PF00069	0.757
MOD_CK2_1	369	375	PF00069	0.712
MOD_CK2_1	394	400	PF00069	0.740
MOD_CK2_1	61	67	PF00069	0.706
MOD_GlcNHglycan	10	13	PF01048	0.504
MOD_GlcNHglycan	262	265	PF01048	0.406
MOD_GlcNHglycan	298	301	PF01048	0.649
MOD_GlcNHglycan	633	637	PF01048	0.713
MOD_GlcNHglycan	92	95	PF01048	0.532
MOD_GSK3_1	164	171	PF00069	0.328
MOD_GSK3_1	221	228	PF00069	0.328
MOD_GSK3_1	284	291	PF00069	0.559
MOD_GSK3_1	385	392	PF00069	0.652
MOD_GSK3_1	422	429	PF00069	0.626
MOD_GSK3_1	8	15	PF00069	0.481
MOD_N-GLC_1	181	186	PF02516	0.248
MOD_N-GLC_1	221	226	PF02516	0.328
MOD_NEK2_1	14	19	PF00069	0.484
MOD_NEK2_1	163	168	PF00069	0.209
MOD_NEK2_1	260	265	PF00069	0.387
MOD_NEK2_1	422	427	PF00069	0.536
MOD_NEK2_1	637	642	PF00069	0.505
MOD_NEK2_2	269	274	PF00069	0.455
MOD_PIKK_1	301	307	PF00454	0.562
MOD_PIKK_1	316	322	PF00454	0.593
MOD_PIKK_1	520	526	PF00454	0.753
MOD_PKA_1	520	526	PF00069	0.667
MOD_PKA_2	25	31	PF00069	0.621
MOD_PKA_2	288	294	PF00069	0.570
MOD_PKA_2	296	302	PF00069	0.548
MOD_PKA_2	369	375	PF00069	0.765
MOD_PKA_2	519	525	PF00069	0.692
MOD_PKA_2	631	637	PF00069	0.635
MOD_PKB_1	42	50	PF00069	0.708
MOD_Plk_1	221	227	PF00069	0.323
MOD_Plk_1	306	312	PF00069	0.666
MOD_Plk_1	343	349	PF00069	0.626
MOD_Plk_1	44	50	PF00069	0.712
MOD_Plk_1	632	638	PF00069	0.516
MOD_Plk_2-3	288	294	PF00069	0.554
MOD_Plk_2-3	344	350	PF00069	0.480
MOD_Plk_2-3	357	363	PF00069	0.694
MOD_Plk_4	119	125	PF00069	0.328
MOD_Plk_4	2	8	PF00069	0.438
MOD_Plk_4	357	363	PF00069	0.714
MOD_ProDKin_1	104	110	PF00069	0.510
MOD_ProDKin_1	127	133	PF00069	0.207
MOD_ProDKin_1	19	25	PF00069	0.638
MOD_ProDKin_1	461	467	PF00069	0.522
TRG_DiLeu_BaEn_1	494	499	PF01217	0.421
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.630
TRG_ENDOCYTIC_2	194	197	PF00928	0.322
TRG_ENDOCYTIC_2	252	255	PF00928	0.547
TRG_ENDOCYTIC_2	275	278	PF00928	0.506
TRG_ENDOCYTIC_2	444	447	PF00928	0.574
TRG_ER_diArg_1	141	143	PF00400	0.344
TRG_ER_diArg_1	451	454	PF00400	0.641
TRG_ER_diArg_1	50	52	PF00400	0.640
TRG_ER_diArg_1	512	514	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	139	144	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	214	219	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.668

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF63	Leptomonas seymouri	70%	99%
A0A0S4JFQ6	Bodo saltans	45%	99%
A0A1X0P5I3	Trypanosomatidae	56%	100%
A0A3Q8IJ54	Leishmania donovani	84%	100%
A0A3R7RSH5	Trypanosoma rangeli	56%	100%
A4IBE4	Leishmania infantum	84%	100%
C9ZZ76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AFA0	Leishmania major	83%	100%
E9B6F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5C303	Trypanosoma cruzi	55%	96%