Putative acyl-CoA dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMU0_LEIBR

TriTrypDb:

LbrM.34.2630 , LBRM2903_340034500

Length:

421

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMU0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMU0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003995	acyl-CoA dehydrogenase activity	5	10
GO:0005488	binding	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0050660	flavin adenine dinucleotide binding	4	10
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.325
CLV_NRD_NRD_1	11	13	PF00675	0.597
CLV_NRD_NRD_1	136	138	PF00675	0.506
CLV_NRD_NRD_1	296	298	PF00675	0.338
CLV_NRD_NRD_1	332	334	PF00675	0.325
CLV_NRD_NRD_1	57	59	PF00675	0.254
CLV_PCSK_KEX2_1	11	13	PF00082	0.597
CLV_PCSK_KEX2_1	136	138	PF00082	0.502
CLV_PCSK_SKI1_1	142	146	PF00082	0.437
CLV_PCSK_SKI1_1	207	211	PF00082	0.330
CLV_PCSK_SKI1_1	383	387	PF00082	0.347
CLV_PCSK_SKI1_1	404	408	PF00082	0.430
CLV_PCSK_SKI1_1	72	76	PF00082	0.381
DEG_APCC_DBOX_1	136	144	PF00400	0.422
DEG_Nend_Nbox_1	1	3	PF02207	0.510
DOC_CKS1_1	82	87	PF01111	0.386
DOC_MAPK_gen_1	11	17	PF00069	0.674
DOC_MAPK_gen_1	259	267	PF00069	0.386
DOC_MAPK_MEF2A_6	107	116	PF00069	0.325
DOC_MAPK_MEF2A_6	259	267	PF00069	0.350
DOC_PP1_RVXF_1	360	367	PF00149	0.325
DOC_USP7_MATH_1	16	20	PF00917	0.689
DOC_USP7_MATH_1	220	224	PF00917	0.346
DOC_USP7_MATH_1	283	287	PF00917	0.440
DOC_USP7_MATH_1	5	9	PF00917	0.704
DOC_USP7_UBL2_3	138	142	PF12436	0.440
DOC_USP7_UBL2_3	171	175	PF12436	0.431
DOC_USP7_UBL2_3	298	302	PF12436	0.440
DOC_WW_Pin1_4	216	221	PF00397	0.407
DOC_WW_Pin1_4	412	417	PF00397	0.711
DOC_WW_Pin1_4	81	86	PF00397	0.386
LIG_14-3-3_CanoR_1	11	17	PF00244	0.615
LIG_14-3-3_CanoR_1	234	243	PF00244	0.373
LIG_14-3-3_CanoR_1	46	51	PF00244	0.386
LIG_BRCT_BRCA1_1	159	163	PF00533	0.325
LIG_BRCT_BRCA1_1	180	184	PF00533	0.269
LIG_CaM_IQ_9	396	411	PF13499	0.422
LIG_Clathr_ClatBox_1	79	83	PF01394	0.325
LIG_deltaCOP1_diTrp_1	365	372	PF00928	0.350
LIG_FHA_1	113	119	PF00498	0.440
LIG_FHA_1	143	149	PF00498	0.328
LIG_FHA_1	208	214	PF00498	0.325
LIG_FHA_1	217	223	PF00498	0.325
LIG_FHA_1	236	242	PF00498	0.224
LIG_FHA_1	392	398	PF00498	0.325
LIG_FHA_1	49	55	PF00498	0.489
LIG_FHA_2	33	39	PF00498	0.386
LIG_FHA_2	82	88	PF00498	0.386
LIG_LIR_Gen_1	240	249	PF02991	0.313
LIG_LIR_Gen_1	94	102	PF02991	0.325
LIG_LIR_Nem_3	203	209	PF02991	0.325
LIG_LIR_Nem_3	240	246	PF02991	0.313
LIG_LIR_Nem_3	94	99	PF02991	0.325
LIG_Pex14_1	190	194	PF04695	0.422
LIG_Pex14_2	372	376	PF04695	0.386
LIG_PTB_Apo_2	121	128	PF02174	0.325
LIG_SH2_CRK	206	210	PF00017	0.325
LIG_SH2_GRB2like	410	413	PF00017	0.411
LIG_SH2_SRC	410	413	PF00017	0.509
LIG_SH2_STAP1	314	318	PF00017	0.350
LIG_SH2_STAT3	293	296	PF00017	0.325
LIG_SH2_STAT5	139	142	PF00017	0.405
LIG_SH2_STAT5	194	197	PF00017	0.442
LIG_SH2_STAT5	293	296	PF00017	0.325
LIG_SH2_STAT5	350	353	PF00017	0.454
LIG_SH3_3	24	30	PF00018	0.616
LIG_SH3_3	243	249	PF00018	0.306
LIG_SUMO_SIM_anti_2	286	291	PF11976	0.440
LIG_SUMO_SIM_par_1	98	104	PF11976	0.325
LIG_TRAF2_1	101	104	PF00917	0.325
LIG_UBA3_1	1	7	PF00899	0.591
LIG_UBA3_1	396	404	PF00899	0.350
LIG_WRC_WIRS_1	45	50	PF05994	0.321
MOD_CK1_1	157	163	PF00069	0.321
MOD_CK1_1	18	24	PF00069	0.625
MOD_CK1_1	216	222	PF00069	0.453
MOD_CK1_1	414	420	PF00069	0.682
MOD_CK2_1	234	240	PF00069	0.325
MOD_CK2_1	32	38	PF00069	0.325
MOD_GlcNHglycan	157	160	PF01048	0.325
MOD_GlcNHglycan	18	21	PF01048	0.691
MOD_GlcNHglycan	416	419	PF01048	0.689
MOD_GSK3_1	151	158	PF00069	0.350
MOD_GSK3_1	167	174	PF00069	0.357
MOD_GSK3_1	196	203	PF00069	0.386
MOD_GSK3_1	216	223	PF00069	0.201
MOD_GSK3_1	410	417	PF00069	0.604
MOD_GSK3_1	44	51	PF00069	0.260
MOD_GSK3_1	91	98	PF00069	0.325
MOD_N-GLC_1	178	183	PF02516	0.325
MOD_N-GLC_1	337	342	PF02516	0.349
MOD_N-GLC_1	411	416	PF02516	0.454
MOD_N-GLC_2	330	332	PF02516	0.240
MOD_NEK2_1	183	188	PF00069	0.397
MOD_NEK2_1	41	46	PF00069	0.325
MOD_NEK2_1	48	53	PF00069	0.444
MOD_NEK2_1	95	100	PF00069	0.325
MOD_NEK2_2	91	96	PF00069	0.350
MOD_PKA_1	171	177	PF00069	0.440
MOD_PKA_2	10	16	PF00069	0.595
MOD_PKA_2	167	173	PF00069	0.253
MOD_PKA_2	233	239	PF00069	0.373
MOD_Plk_1	337	343	PF00069	0.290
MOD_Plk_4	118	124	PF00069	0.345
MOD_Plk_4	220	226	PF00069	0.440
MOD_Plk_4	337	343	PF00069	0.269
MOD_Plk_4	350	356	PF00069	0.450
MOD_Plk_4	392	398	PF00069	0.359
MOD_Plk_4	91	97	PF00069	0.325
MOD_ProDKin_1	216	222	PF00069	0.407
MOD_ProDKin_1	412	418	PF00069	0.714
MOD_ProDKin_1	81	87	PF00069	0.386
MOD_SUMO_rev_2	223	231	PF00179	0.410
MOD_SUMO_rev_2	36	41	PF00179	0.431
MOD_SUMO_rev_2	379	387	PF00179	0.325
TRG_ENDOCYTIC_2	194	197	PF00928	0.310
TRG_ENDOCYTIC_2	206	209	PF00928	0.350
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3D6	Leptomonas seymouri	24%	67%
A0A0N1HXP9	Leptomonas seymouri	37%	100%
A0A0N1I6H4	Leptomonas seymouri	31%	100%
A0A0N1IMF9	Leptomonas seymouri	86%	100%
A0A0S4IM43	Bodo saltans	33%	100%
A0A0S4IY66	Bodo saltans	29%	100%
A0A0S4J7W1	Bodo saltans	34%	100%
A0A0S4JFP0	Bodo saltans	69%	100%
A0A0S4KIH4	Bodo saltans	35%	100%
A0A1X0NL04	Trypanosomatidae	34%	100%
A0A1X0NQM6	Trypanosomatidae	26%	67%
A0A1X0P4C4	Trypanosomatidae	34%	100%
A0A1X0P5J1	Trypanosomatidae	68%	99%
A0A3Q8IIB9	Leishmania donovani	25%	67%
A0A3Q8IVB5	Leishmania donovani	92%	100%
A0A3R7LB59	Trypanosoma rangeli	31%	100%
A0A3R7LXK2	Trypanosoma rangeli	28%	100%
A0A3S5H5T1	Leishmania donovani	36%	100%
A0A3S7X0K3	Leishmania donovani	33%	100%
A0A422N1U9	Trypanosoma rangeli	32%	100%
A0A422NKY7	Trypanosoma rangeli	26%	67%
A4H4Q0	Leishmania braziliensis	36%	100%
A4H4Q2	Leishmania braziliensis	36%	100%
A4HFL6	Leishmania braziliensis	33%	100%
A4HGV3	Leishmania braziliensis	24%	67%
A4HSY0	Leishmania infantum	36%	100%
A4I353	Leishmania infantum	33%	100%
A4I3Y3	Leishmania infantum	25%	67%
A4IBE1	Leishmania infantum	92%	100%
A5A6I0	Pan troglodytes	34%	100%
A8WP91	Caenorhabditis briggsae	33%	100%
A8XNF0	Caenorhabditis briggsae	35%	100%
B1WC61	Rattus norvegicus	38%	67%
B2AM55	Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)	23%	98%
B2CML6	Mycobacterium goodii	22%	100%
B9U6P5	Variovorax paradoxus	29%	100%
C3UVB0	Desulfococcus multivorans	35%	100%
D0A5U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
D3JV03	Cereibacter sphaeroides	30%	77%
E9AD70	Leishmania major	33%	99%
E9AF97	Leishmania major	91%	100%
E9AKW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AYZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B073	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	67%
E9B6F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
F8GVD3	Cupriavidus necator (strain ATCC 43291 / DSM 13513 / CCUG 52238 / LMG 8453 / N-1)	29%	100%
G3KIM8	Anaerotignum propionicum	37%	100%
H6LGM6	Acetobacterium woodii (strain ATCC 29683 / DSM 1030 / JCM 2381 / KCTC 1655 / WB1)	35%	100%
I6Y3Q0	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	22%	100%
J7TF92	Clostridium sporogenes (strain ATCC 15579)	37%	100%
K4L7X3	Advenella mimigardefordensis (strain DSM 17166 / LMG 22922 / DPN7)	30%	100%
O32176	Bacillus subtilis (strain 168)	33%	71%
O34421	Bacillus subtilis (strain 168)	37%	100%
O53666	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	69%
O54143	Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)	31%	100%
P08503	Rattus norvegicus	35%	100%
P0A9U8	Escherichia coli (strain K12)	28%	100%
P0A9U9	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	28%	100%
P0A9V0	Escherichia coli O157:H7	28%	100%
P11310	Homo sapiens	34%	100%
P12007	Rattus norvegicus	32%	99%
P15650	Rattus norvegicus	28%	98%
P15651	Rattus norvegicus	39%	100%
P16219	Homo sapiens	38%	100%
P26440	Homo sapiens	32%	99%
P28330	Homo sapiens	29%	98%
P34275	Caenorhabditis elegans	30%	100%
P41367	Sus scrofa	34%	100%
P45857	Bacillus subtilis (strain 168)	42%	100%
P45867	Bacillus subtilis (strain 168)	40%	100%
P45952	Mus musculus	34%	100%
P45954	Homo sapiens	51%	97%
P46703	Mycobacterium leprae (strain TN)	38%	100%
P51174	Mus musculus	29%	98%
P52042	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	39%	100%
P63428	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	37%	100%
P70584	Rattus norvegicus	50%	97%
P71857	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	23%	100%
P79273	Sus scrofa	39%	100%
P79274	Sus scrofa	30%	98%
P81140	Sus scrofa	28%	100%
P96608	Bacillus subtilis (strain 168)	24%	100%
P96831	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	28%	100%
P9WQG0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	37%	100%
P9WQG1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	37%	100%
P9WQG2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	27%	100%
P9WQG3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	27%	100%
Q06319	Megasphaera elsdenii	41%	100%
Q07417	Mus musculus	39%	100%
Q0AVA8	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	27%	69%
Q0AVM4	Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)	27%	69%
Q0NXR6	Bos taurus	32%	100%
Q13PC1	Paraburkholderia xenovorans (strain LB400)	30%	100%
Q1BBA3	Mycobacterium sp. (strain MCS)	24%	100%
Q20772	Caenorhabditis elegans	27%	100%
Q22347	Caenorhabditis elegans	34%	100%
Q2KHZ9	Bos taurus	29%	96%
Q2LQN9	Syntrophus aciditrophicus (strain SB)	36%	100%
Q2LQP0	Syntrophus aciditrophicus (strain SB)	30%	100%
Q3L887	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	26%	69%
Q3SZB4	Bos taurus	34%	100%
Q3SZI8	Bos taurus	33%	99%
Q3ZBF6	Bos taurus	38%	100%
Q4KCY6	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	30%	100%
Q4Q812	Leishmania major	25%	67%
Q4QIY9	Leishmania major	37%	100%
Q50LG2	Alternaria alternata	26%	97%
Q54IM8	Dictyostelium discoideum	37%	100%
Q54R47	Dictyostelium discoideum	30%	100%
Q54RR5	Dictyostelium discoideum	53%	100%
Q5EAD4	Bos taurus	51%	97%
Q5LLW7	Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3)	27%	72%
Q5RAS0	Pongo abelii	39%	100%
Q5RBD5	Pongo abelii	32%	100%
Q5RF40	Pongo abelii	51%	97%
Q5W271	Serratia sp. (strain ATCC 39006)	25%	100%
Q60759	Mus musculus	28%	96%
Q60HI0	Macaca fascicularis	29%	98%
Q73ZP8	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	24%	100%
Q75IM9	Oryza sativa subsp. japonica	34%	100%
Q7U0Y2	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	27%	100%
Q8HXX8	Macaca fascicularis	27%	96%
Q8HXY8	Macaca fascicularis	34%	100%
Q8JZN5	Mus musculus	38%	67%
Q8X1D8	Fusarium oxysporum	21%	96%
Q92947	Homo sapiens	28%	96%
Q96329	Arabidopsis thaliana	29%	97%
Q9D7B6	Mus musculus	31%	100%
Q9DBL1	Mus musculus	52%	97%
Q9DBS4	Mus musculus	22%	67%
Q9FS87	Solanum tuberosum	33%	100%
Q9FS88	Solanum tuberosum	35%	100%
Q9H845	Homo sapiens	37%	68%
Q9JHI5	Mus musculus	33%	99%
Q9KJE8	Thauera aromatica	28%	100%
Q9NUZ1	Homo sapiens	22%	77%
Q9SWG0	Arabidopsis thaliana	34%	100%
Q9UKU7	Homo sapiens	32%	100%
Q9VSA3	Drosophila melanogaster	35%	100%
V5B8K6	Trypanosoma cruzi	33%	100%
V5BKL8	Trypanosoma cruzi	30%	100%
V5BY79	Trypanosoma cruzi	68%	100%
V5DCV2	Trypanosoma cruzi	25%	67%
V5DPQ5	Trypanosoma cruzi	33%	100%