QA-SNARE protein putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania braziliensis

UniProt:

A4HMT8_LEIBR

TriTrypDb:

LbrM.34.2610 , LBRM2903_340034300

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	1
GO:0016020	membrane	2	11
GO:0031201	SNARE complex	3	13
GO:0032991	protein-containing complex	1	13
GO:0098796	membrane protein complex	2	13
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

A4HMT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT8

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0006886	intracellular protein transport	4	13
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	13
GO:0009987	cellular process	1	13
GO:0015031	protein transport	4	13
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0016192	vesicle-mediated transport	4	12

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Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.598
CLV_NRD_NRD_1	152	154	PF00675	0.332
CLV_NRD_NRD_1	19	21	PF00675	0.470
CLV_NRD_NRD_1	66	68	PF00675	0.308
CLV_PCSK_FUR_1	17	21	PF00082	0.490
CLV_PCSK_KEX2_1	152	154	PF00082	0.333
CLV_PCSK_KEX2_1	19	21	PF00082	0.470
CLV_PCSK_PC7_1	148	154	PF00082	0.330
CLV_PCSK_SKI1_1	104	108	PF00082	0.336
CLV_PCSK_SKI1_1	130	134	PF00082	0.322

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I246	Leptomonas seymouri	26%	100%
A0A0N1IMN0	Leptomonas seymouri	91%	100%
A0A0S4J7F1	Bodo saltans	27%	100%
A0A0S4JKJ1	Bodo saltans	54%	100%
A0A1X0P0Y0	Trypanosomatidae	29%	100%
A0A1X0P5S4	Trypanosomatidae	71%	100%
A0A3Q8IK46	Leishmania donovani	25%	100%
A0A3R7MIN3	Trypanosoma rangeli	27%	100%
A0A3S7X9G5	Leishmania donovani	94%	100%
A0A422P2Q8	Trypanosoma rangeli	74%	100%

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