Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMT7_LEIBR

TriTrypDb:

LbrM.34.2600 , LBRM2903_340034200

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.610
CLV_NRD_NRD_1	153	155	PF00675	0.398
CLV_NRD_NRD_1	8	10	PF00675	0.563
CLV_PCSK_KEX2_1	450	452	PF00082	0.667
CLV_PCSK_KEX2_1	460	462	PF00082	0.775
CLV_PCSK_KEX2_1	8	10	PF00082	0.396
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.667
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.775
CLV_PCSK_SKI1_1	139	143	PF00082	0.575
CLV_PCSK_SKI1_1	157	161	PF00082	0.602
CLV_PCSK_SKI1_1	219	223	PF00082	0.549
CLV_PCSK_SKI1_1	282	286	PF00082	0.418
CLV_PCSK_SKI1_1	29	33	PF00082	0.517
CLV_PCSK_SKI1_1	310	314	PF00082	0.517
CLV_PCSK_SKI1_1	323	327	PF00082	0.418
CLV_PCSK_SKI1_1	451	455	PF00082	0.722
CLV_PCSK_SKI1_1	498	502	PF00082	0.539
CLV_PCSK_SKI1_1	55	59	PF00082	0.653
CLV_PCSK_SKI1_1	8	12	PF00082	0.442
DEG_APCC_DBOX_1	309	317	PF00400	0.574
DEG_APCC_DBOX_1	365	373	PF00400	0.582
DEG_APCC_DBOX_1	7	15	PF00400	0.434
DEG_Nend_UBRbox_1	1	4	PF02207	0.633
DEG_SPOP_SBC_1	220	224	PF00917	0.660
DEG_SPOP_SBC_1	452	456	PF00917	0.559
DEG_SPOP_SBC_1	50	54	PF00917	0.727
DOC_CYCLIN_RxL_1	136	146	PF00134	0.538
DOC_CYCLIN_RxL_1	154	163	PF00134	0.643
DOC_MAPK_gen_1	137	144	PF00069	0.537
DOC_MAPK_gen_1	8	16	PF00069	0.329
DOC_PP1_RVXF_1	137	144	PF00149	0.459
DOC_PP1_RVXF_1	362	368	PF00149	0.528
DOC_PP2B_LxvP_1	205	208	PF13499	0.528
DOC_USP7_MATH_1	185	189	PF00917	0.532
DOC_USP7_MATH_1	228	232	PF00917	0.738
DOC_USP7_MATH_1	239	243	PF00917	0.573
DOC_USP7_MATH_1	444	448	PF00917	0.711
DOC_USP7_MATH_1	477	481	PF00917	0.590
DOC_USP7_MATH_1	50	54	PF00917	0.658
DOC_USP7_MATH_1	68	72	PF00917	0.802
DOC_WW_Pin1_4	183	188	PF00397	0.584
DOC_WW_Pin1_4	197	202	PF00397	0.607
DOC_WW_Pin1_4	232	237	PF00397	0.536
DOC_WW_Pin1_4	370	375	PF00397	0.579
DOC_WW_Pin1_4	46	51	PF00397	0.550
DOC_WW_Pin1_4	73	78	PF00397	0.626
LIG_14-3-3_CanoR_1	29	35	PF00244	0.528
LIG_14-3-3_CanoR_1	320	326	PF00244	0.462
LIG_14-3-3_CanoR_1	364	370	PF00244	0.475
LIG_14-3-3_CanoR_1	481	486	PF00244	0.506
LIG_14-3-3_CanoR_1	55	65	PF00244	0.769
LIG_14-3-3_CanoR_1	93	101	PF00244	0.659
LIG_BRCT_BRCA1_1	422	426	PF00533	0.436
LIG_BRCT_BRCA1_1	479	483	PF00533	0.545
LIG_FHA_1	101	107	PF00498	0.542
LIG_FHA_1	154	160	PF00498	0.565
LIG_FHA_1	197	203	PF00498	0.648
LIG_FHA_1	221	227	PF00498	0.777
LIG_FHA_1	295	301	PF00498	0.467
LIG_FHA_1	58	64	PF00498	0.522
LIG_FHA_2	169	175	PF00498	0.573
LIG_FHA_2	233	239	PF00498	0.651
LIG_FHA_2	297	303	PF00498	0.559
LIG_FHA_2	324	330	PF00498	0.568
LIG_FHA_2	344	350	PF00498	0.300
LIG_FHA_2	375	381	PF00498	0.612
LIG_FHA_2	454	460	PF00498	0.779
LIG_IRF3_LxIS_1	160	167	PF10401	0.704
LIG_LIR_Gen_1	389	399	PF02991	0.427
LIG_LIR_Gen_1	423	434	PF02991	0.658
LIG_LIR_LC3C_4	383	387	PF02991	0.559
LIG_LIR_Nem_3	389	394	PF02991	0.425
LIG_LIR_Nem_3	423	429	PF02991	0.605
LIG_LIR_Nem_3	480	486	PF02991	0.539
LIG_MLH1_MIPbox_1	483	487	PF16413	0.528
LIG_NRBOX	496	502	PF00104	0.528
LIG_PCNA_yPIPBox_3	139	152	PF02747	0.607
LIG_Pex14_2	291	295	PF04695	0.537
LIG_Pex14_2	30	34	PF04695	0.633
LIG_Pex14_2	363	367	PF04695	0.412
LIG_Pex14_2	483	487	PF04695	0.419
LIG_PTB_Apo_2	385	392	PF02174	0.454
LIG_SH2_CRK	138	142	PF00017	0.576
LIG_SH2_CRK	7	11	PF00017	0.432
LIG_SH2_SRC	407	410	PF00017	0.539
LIG_SH2_STAP1	341	345	PF00017	0.634
LIG_SH2_STAP1	422	426	PF00017	0.436
LIG_SH2_STAT5	24	27	PF00017	0.559
LIG_SH2_STAT5	345	348	PF00017	0.578
LIG_SH2_STAT5	355	358	PF00017	0.527
LIG_SH2_STAT5	390	393	PF00017	0.405
LIG_SH2_STAT5	407	410	PF00017	0.539
LIG_SH2_STAT5	486	489	PF00017	0.497
LIG_SH3_3	368	374	PF00018	0.487
LIG_SUMO_SIM_anti_2	383	389	PF11976	0.531
LIG_SUMO_SIM_par_1	296	302	PF11976	0.496
LIG_SUMO_SIM_par_1	383	389	PF11976	0.557
LIG_TRAF2_1	255	258	PF00917	0.561
LIG_TRFH_1	367	371	PF08558	0.447
LIG_TYR_ITIM	136	141	PF00017	0.576
LIG_TYR_ITIM	500	505	PF00017	0.532
MOD_CK1_1	153	159	PF00069	0.535
MOD_CK1_1	186	192	PF00069	0.729
MOD_CK1_1	197	203	PF00069	0.770
MOD_CK1_1	464	470	PF00069	0.767
MOD_CK1_1	49	55	PF00069	0.733
MOD_CK1_1	59	65	PF00069	0.644
MOD_CK1_1	71	77	PF00069	0.512
MOD_CK2_1	227	233	PF00069	0.539
MOD_CK2_1	296	302	PF00069	0.575
MOD_CK2_1	343	349	PF00069	0.606
MOD_CK2_1	374	380	PF00069	0.711
MOD_Cter_Amidation	448	451	PF01082	0.526
MOD_GlcNHglycan	189	192	PF01048	0.764
MOD_GlcNHglycan	230	233	PF01048	0.776
MOD_GlcNHglycan	265	268	PF01048	0.635
MOD_GlcNHglycan	43	46	PF01048	0.717
MOD_GlcNHglycan	431	434	PF01048	0.628
MOD_GSK3_1	160	167	PF00069	0.706
MOD_GSK3_1	183	190	PF00069	0.703
MOD_GSK3_1	192	199	PF00069	0.726
MOD_GSK3_1	211	218	PF00069	0.673
MOD_GSK3_1	228	235	PF00069	0.699
MOD_GSK3_1	323	330	PF00069	0.483
MOD_GSK3_1	370	377	PF00069	0.665
MOD_GSK3_1	420	427	PF00069	0.490
MOD_GSK3_1	451	458	PF00069	0.711
MOD_GSK3_1	459	466	PF00069	0.782
MOD_GSK3_1	46	53	PF00069	0.647
MOD_GSK3_1	477	484	PF00069	0.536
MOD_N-GLC_1	183	188	PF02516	0.660
MOD_N-GLC_1	488	493	PF02516	0.556
MOD_NEK2_1	159	164	PF00069	0.633
MOD_NEK2_1	227	232	PF00069	0.669
MOD_NEK2_1	30	35	PF00069	0.534
MOD_NEK2_1	36	41	PF00069	0.568
MOD_NEK2_1	429	434	PF00069	0.690
MOD_NEK2_1	51	56	PF00069	0.474
MOD_NEK2_1	57	62	PF00069	0.500
MOD_PKA_2	153	159	PF00069	0.565
MOD_PKA_2	215	221	PF00069	0.725
MOD_PKA_2	365	371	PF00069	0.536
MOD_PKA_2	92	98	PF00069	0.703
MOD_PKB_1	418	426	PF00069	0.427
MOD_Plk_1	101	107	PF00069	0.614
MOD_Plk_4	102	108	PF00069	0.607
MOD_Plk_4	386	392	PF00069	0.434
MOD_ProDKin_1	183	189	PF00069	0.590
MOD_ProDKin_1	197	203	PF00069	0.604
MOD_ProDKin_1	232	238	PF00069	0.539
MOD_ProDKin_1	370	376	PF00069	0.590
MOD_ProDKin_1	46	52	PF00069	0.550
MOD_ProDKin_1	73	79	PF00069	0.625
TRG_DiLeu_BaEn_1	397	402	PF01217	0.540
TRG_DiLeu_BaEn_4	403	409	PF01217	0.590
TRG_ENDOCYTIC_2	111	114	PF00928	0.570
TRG_ENDOCYTIC_2	138	141	PF00928	0.573
TRG_ENDOCYTIC_2	502	505	PF00928	0.413
TRG_ENDOCYTIC_2	7	10	PF00928	0.440
TRG_ER_diArg_1	279	282	PF00400	0.568
TRG_ER_diArg_1	363	366	PF00400	0.558
TRG_ER_diArg_1	7	9	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	415	419	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	9	13	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBR0	Leptomonas seymouri	50%	100%
A0A1X0P6J4	Trypanosomatidae	21%	100%
A0A3S7X9M3	Leishmania donovani	75%	100%
A0A422P2R2	Trypanosoma rangeli	26%	100%
A4IBD8	Leishmania infantum	75%	100%
C9ZZ79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF94	Leishmania major	72%	97%
E9B6E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
V5BTJ6	Trypanosoma cruzi	27%	100%