BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMT5_LEIBR

TriTrypDb:

LbrM.34.2580 , LBRM2903_340034000

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT5

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	13
GO:0016043	cellular component organization	3	13
GO:0022607	cellular component assembly	4	13
GO:0043933	protein-containing complex organization	4	13
GO:0051259	protein complex oligomerization	6	13
GO:0051260	protein homooligomerization	7	13
GO:0065003	protein-containing complex assembly	5	13
GO:0071840	cellular component organization or biogenesis	2	13

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.423
CLV_NRD_NRD_1	286	288	PF00675	0.432
CLV_NRD_NRD_1	319	321	PF00675	0.444
CLV_NRD_NRD_1	329	331	PF00675	0.367
CLV_NRD_NRD_1	353	355	PF00675	0.427
CLV_PCSK_FUR_1	327	331	PF00082	0.527
CLV_PCSK_KEX2_1	175	177	PF00082	0.417
CLV_PCSK_KEX2_1	329	331	PF00082	0.518
CLV_PCSK_KEX2_1	352	354	PF00082	0.518
CLV_PCSK_SKI1_1	12	16	PF00082	0.577
CLV_PCSK_SKI1_1	175	179	PF00082	0.380
CLV_PCSK_SKI1_1	332	336	PF00082	0.449
DEG_APCC_DBOX_1	213	221	PF00400	0.615
DEG_APCC_DBOX_1	351	359	PF00400	0.518
DOC_CDC14_PxL_1	183	191	PF14671	0.423
DOC_CYCLIN_RxL_1	326	336	PF00134	0.504
DOC_MAPK_gen_1	216	225	PF00069	0.451
DOC_MAPK_gen_1	317	325	PF00069	0.460
DOC_MAPK_gen_1	329	339	PF00069	0.375
DOC_PP1_RVXF_1	327	334	PF00149	0.355
DOC_PP4_FxxP_1	105	108	PF00568	0.299
DOC_SPAK_OSR1_1	104	108	PF12202	0.346
DOC_USP7_MATH_1	44	48	PF00917	0.603
DOC_USP7_MATH_1	84	88	PF00917	0.597
DOC_USP7_UBL2_3	317	321	PF12436	0.388
DOC_WW_Pin1_4	17	22	PF00397	0.757
DOC_WW_Pin1_4	202	207	PF00397	0.603
DOC_WW_Pin1_4	208	213	PF00397	0.489
DOC_WW_Pin1_4	353	358	PF00397	0.572
LIG_14-3-3_CanoR_1	104	108	PF00244	0.428
LIG_14-3-3_CanoR_1	12	21	PF00244	0.675
LIG_14-3-3_CanoR_1	235	241	PF00244	0.355
LIG_14-3-3_CanoR_1	320	326	PF00244	0.489
LIG_14-3-3_CanoR_1	332	338	PF00244	0.344
LIG_Actin_WH2_2	318	334	PF00022	0.416
LIG_BIR_III_4	23	27	PF00653	0.639
LIG_BRCT_BRCA1_1	15	19	PF00533	0.773
LIG_BRCT_BRCA1_1	275	279	PF00533	0.381
LIG_deltaCOP1_diTrp_1	128	137	PF00928	0.346
LIG_eIF4E_1	163	169	PF01652	0.376
LIG_eIF4E_1	184	190	PF01652	0.346
LIG_eIF4E_1	247	253	PF01652	0.327
LIG_FHA_1	104	110	PF00498	0.335
LIG_FHA_1	128	134	PF00498	0.346
LIG_FHA_1	141	147	PF00498	0.299
LIG_FHA_1	237	243	PF00498	0.355
LIG_FHA_1	300	306	PF00498	0.433
LIG_FHA_1	334	340	PF00498	0.474
LIG_FHA_1	6	12	PF00498	0.488
LIG_FHA_2	258	264	PF00498	0.459
LIG_FHA_2	62	68	PF00498	0.521
LIG_LIR_Apic_2	103	108	PF02991	0.301
LIG_LIR_Apic_2	129	135	PF02991	0.346
LIG_LIR_Gen_1	261	272	PF02991	0.492
LIG_LIR_Gen_1	299	307	PF02991	0.338
LIG_LIR_Gen_1	90	100	PF02991	0.461
LIG_LIR_Nem_3	151	156	PF02991	0.264
LIG_LIR_Nem_3	180	186	PF02991	0.282
LIG_LIR_Nem_3	246	250	PF02991	0.331
LIG_LIR_Nem_3	261	267	PF02991	0.505
LIG_LIR_Nem_3	299	303	PF02991	0.342
LIG_LIR_Nem_3	308	314	PF02991	0.313
LIG_LIR_Nem_3	90	95	PF02991	0.525
LIG_NRBOX	65	71	PF00104	0.493
LIG_PTB_Apo_2	279	286	PF02174	0.508
LIG_PTB_Apo_2	294	301	PF02174	0.509
LIG_PTB_Phospho_1	279	285	PF10480	0.502
LIG_RPA_C_Fungi	37	49	PF08784	0.518
LIG_SH2_CRK	184	188	PF00017	0.346
LIG_SH2_GRB2like	165	168	PF00017	0.349
LIG_SH2_GRB2like	280	283	PF00017	0.354
LIG_SH2_STAP1	240	244	PF00017	0.482
LIG_SH2_STAT5	120	123	PF00017	0.299
LIG_SH2_STAT5	155	158	PF00017	0.289
LIG_SH2_STAT5	159	162	PF00017	0.253
LIG_SH2_STAT5	165	168	PF00017	0.244
LIG_SH2_STAT5	247	250	PF00017	0.302
LIG_SH2_STAT5	280	283	PF00017	0.478
LIG_SH2_STAT5	311	314	PF00017	0.328
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.450
LIG_TRAF2_1	260	263	PF00917	0.411
LIG_TRAF2_1	347	350	PF00917	0.427
LIG_TRAF2_1	361	364	PF00917	0.431
MOD_CDC14_SPxK_1	211	214	PF00782	0.551
MOD_CDK_SPxK_1	208	214	PF00069	0.544
MOD_CK1_1	127	133	PF00069	0.354
MOD_CK1_1	13	19	PF00069	0.684
MOD_CK1_1	230	236	PF00069	0.533
MOD_CK1_1	5	11	PF00069	0.738
MOD_CK1_1	54	60	PF00069	0.516
MOD_CK2_1	257	263	PF00069	0.420
MOD_CK2_1	358	364	PF00069	0.531
MOD_CK2_1	84	90	PF00069	0.495
MOD_GlcNHglycan	275	278	PF01048	0.419
MOD_GSK3_1	103	110	PF00069	0.423
MOD_GSK3_1	13	20	PF00069	0.722
MOD_GSK3_1	230	237	PF00069	0.458
MOD_GSK3_1	253	260	PF00069	0.452
MOD_GSK3_1	26	33	PF00069	0.560
MOD_GSK3_1	61	68	PF00069	0.489
MOD_GSK3_1	84	91	PF00069	0.684
MOD_NEK2_1	10	15	PF00069	0.721
MOD_NEK2_1	316	321	PF00069	0.354
MOD_NEK2_1	333	338	PF00069	0.270
MOD_NEK2_1	38	43	PF00069	0.612
MOD_NEK2_1	61	66	PF00069	0.396
MOD_PIKK_1	73	79	PF00454	0.499
MOD_PKA_2	103	109	PF00069	0.397
MOD_PKA_2	197	203	PF00069	0.431
MOD_PKA_2	234	240	PF00069	0.385
MOD_PKB_1	330	338	PF00069	0.490
MOD_Plk_1	170	176	PF00069	0.423
MOD_Plk_1	227	233	PF00069	0.453
MOD_Plk_4	108	114	PF00069	0.296
MOD_Plk_4	140	146	PF00069	0.395
MOD_Plk_4	227	233	PF00069	0.453
MOD_Plk_4	65	71	PF00069	0.489
MOD_Plk_4	88	94	PF00069	0.571
MOD_ProDKin_1	17	23	PF00069	0.759
MOD_ProDKin_1	202	208	PF00069	0.597
MOD_ProDKin_1	353	359	PF00069	0.565
MOD_SUMO_for_1	137	140	PF00179	0.423
MOD_SUMO_for_1	78	81	PF00179	0.556
TRG_DiLeu_BaEn_2	295	301	PF01217	0.503
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.477
TRG_ENDOCYTIC_2	120	123	PF00928	0.299
TRG_ENDOCYTIC_2	163	166	PF00928	0.318
TRG_ENDOCYTIC_2	183	186	PF00928	0.141
TRG_ENDOCYTIC_2	247	250	PF00928	0.302
TRG_ENDOCYTIC_2	92	95	PF00928	0.532
TRG_ER_diArg_1	174	176	PF00400	0.423
TRG_ER_diArg_1	214	217	PF00400	0.501
TRG_ER_diArg_1	327	330	PF00400	0.460
TRG_ER_diArg_1	342	345	PF00400	0.386
TRG_ER_diArg_1	351	354	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C7	Leptomonas seymouri	71%	79%
A0A0S4J5F7	Bodo saltans	43%	98%
A0A0S4JC91	Bodo saltans	43%	98%
A0A1X0P5J3	Trypanosomatidae	49%	70%
A0A3Q8II33	Leishmania donovani	94%	88%
A0A422P2R6	Trypanosoma rangeli	47%	71%
A4IBD6	Leishmania infantum	94%	88%
C9ZZ82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	70%
E9AF92	Leishmania major	95%	100%
E9B6E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	88%
V5DUU9	Trypanosoma cruzi	48%	71%