GNAT family N-acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMT3_LEIBR

TriTrypDb:

LbrM.34.2560 , LBRM2903_340033300

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT3

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009451	RNA modification	5	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003824	catalytic activity	1	3
GO:0005488	binding	1	3
GO:0009982	pseudouridine synthase activity	4	3
GO:0016853	isomerase activity	2	3
GO:0016866	intramolecular transferase activity	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.386
CLV_NRD_NRD_1	15	17	PF00675	0.371
CLV_NRD_NRD_1	172	174	PF00675	0.363
CLV_NRD_NRD_1	287	289	PF00675	0.398
CLV_NRD_NRD_1	305	307	PF00675	0.511
CLV_NRD_NRD_1	57	59	PF00675	0.316
CLV_PCSK_KEX2_1	15	17	PF00082	0.371
CLV_PCSK_KEX2_1	172	174	PF00082	0.331
CLV_PCSK_KEX2_1	253	255	PF00082	0.601
CLV_PCSK_KEX2_1	287	289	PF00082	0.398
CLV_PCSK_KEX2_1	305	307	PF00082	0.495
CLV_PCSK_KEX2_1	57	59	PF00082	0.316
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.346
CLV_PCSK_SKI1_1	173	177	PF00082	0.317
CLV_PCSK_SKI1_1	232	236	PF00082	0.323
CLV_PCSK_SKI1_1	305	309	PF00082	0.351
CLV_PCSK_SKI1_1	336	340	PF00082	0.343
CLV_PCSK_SKI1_1	351	355	PF00082	0.405
DEG_ODPH_VHL_1	229	241	PF01847	0.292
DOC_CYCLIN_RxL_1	74	84	PF00134	0.318
DOC_MAPK_DCC_7	74	82	PF00069	0.324
DOC_MAPK_gen_1	101	111	PF00069	0.525
DOC_MAPK_MEF2A_6	232	241	PF00069	0.292
DOC_PP1_SILK_1	276	281	PF00149	0.318
DOC_PP2B_LxvP_1	239	242	PF13499	0.307
DOC_PP4_FxxP_1	308	311	PF00568	0.351
DOC_PP4_FxxP_1	323	326	PF00568	0.322
DOC_USP7_MATH_1	11	15	PF00917	0.364
DOC_USP7_MATH_1	127	131	PF00917	0.391
DOC_USP7_MATH_1	201	205	PF00917	0.369
DOC_USP7_MATH_1	326	330	PF00917	0.396
DOC_USP7_MATH_1	96	100	PF00917	0.286
DOC_USP7_UBL2_3	310	314	PF12436	0.362
DOC_WW_Pin1_4	280	285	PF00397	0.406
DOC_WW_Pin1_4	342	347	PF00397	0.393
DOC_WW_Pin1_4	7	12	PF00397	0.367
LIG_14-3-3_CanoR_1	184	191	PF00244	0.271
LIG_14-3-3_CterR_2	356	358	PF00244	0.443
LIG_APCC_ABBAyCdc20_2	268	274	PF00400	0.294
LIG_BRCT_BRCA1_1	346	350	PF00533	0.390
LIG_FHA_1	184	190	PF00498	0.276
LIG_FHA_1	330	336	PF00498	0.374
LIG_FHA_2	174	180	PF00498	0.295
LIG_LIR_Gen_1	153	162	PF02991	0.356
LIG_LIR_Gen_1	209	219	PF02991	0.307
LIG_LIR_Gen_1	91	100	PF02991	0.524
LIG_LIR_Nem_3	153	157	PF02991	0.349
LIG_LIR_Nem_3	168	174	PF02991	0.335
LIG_LIR_Nem_3	209	215	PF02991	0.371
LIG_LIR_Nem_3	246	250	PF02991	0.336
LIG_LIR_Nem_3	347	353	PF02991	0.663
LIG_LIR_Nem_3	91	97	PF02991	0.520
LIG_PCNA_yPIPBox_3	177	189	PF02747	0.292
LIG_REV1ctd_RIR_1	305	310	PF16727	0.354
LIG_SH2_CRK	171	175	PF00017	0.315
LIG_SH2_CRK	281	285	PF00017	0.369
LIG_SH2_STAP1	31	35	PF00017	0.371
LIG_SH2_STAT3	272	275	PF00017	0.310
LIG_SH2_STAT3	31	34	PF00017	0.368
LIG_SH2_STAT5	248	251	PF00017	0.258
LIG_SH3_3	185	191	PF00018	0.359
LIG_SH3_3	41	47	PF00018	0.391
LIG_SH3_4	310	317	PF00018	0.356
LIG_SUMO_SIM_par_1	78	84	PF11976	0.312
LIG_TRAF2_1	150	153	PF00917	0.379
LIG_TRFH_1	307	311	PF08558	0.355
LIG_UBA3_1	211	217	PF00899	0.352
LIG_WRC_WIRS_1	190	195	PF05994	0.263
MOD_CDK_SPK_2	7	12	PF00069	0.367
MOD_CDK_SPxxK_3	280	287	PF00069	0.361
MOD_CK1_1	10	16	PF00069	0.365
MOD_CK1_1	155	161	PF00069	0.372
MOD_CK1_1	283	289	PF00069	0.418
MOD_CK1_1	329	335	PF00069	0.321
MOD_CK2_1	173	179	PF00069	0.361
MOD_GlcNHglycan	129	132	PF01048	0.382
MOD_GlcNHglycan	148	151	PF01048	0.338
MOD_GlcNHglycan	153	157	PF01048	0.342
MOD_GlcNHglycan	17	21	PF01048	0.329
MOD_GlcNHglycan	332	335	PF01048	0.362
MOD_GlcNHglycan	346	349	PF01048	0.387
MOD_GlcNHglycan	68	71	PF01048	0.363
MOD_GSK3_1	326	333	PF00069	0.352
MOD_GSK3_1	340	347	PF00069	0.520
MOD_GSK3_1	351	358	PF00069	0.419
MOD_GSK3_1	7	14	PF00069	0.357
MOD_N-GLC_1	243	248	PF02516	0.296
MOD_NEK2_1	146	151	PF00069	0.507
MOD_NEK2_1	211	216	PF00069	0.292
MOD_NEK2_1	267	272	PF00069	0.286
MOD_NEK2_1	315	320	PF00069	0.358
MOD_NEK2_1	321	326	PF00069	0.340
MOD_NEK2_1	340	345	PF00069	0.384
MOD_NEK2_2	96	101	PF00069	0.283
MOD_PIKK_1	119	125	PF00454	0.419
MOD_PKA_2	11	17	PF00069	0.366
MOD_PKA_2	183	189	PF00069	0.271
MOD_PKA_2	286	292	PF00069	0.389
MOD_PKA_2	39	45	PF00069	0.399
MOD_Plk_1	152	158	PF00069	0.379
MOD_Plk_1	243	249	PF00069	0.284
MOD_Plk_4	243	249	PF00069	0.293
MOD_Plk_4	267	273	PF00069	0.291
MOD_ProDKin_1	280	286	PF00069	0.402
MOD_ProDKin_1	342	348	PF00069	0.389
MOD_ProDKin_1	7	13	PF00069	0.358
TRG_AP2beta_CARGO_1	91	101	PF09066	0.282
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.285
TRG_DiLeu_BaLyEn_6	348	353	PF01217	0.395
TRG_ENDOCYTIC_2	171	174	PF00928	0.308
TRG_ER_diArg_1	171	173	PF00400	0.351
TRG_ER_diArg_1	305	307	PF00400	0.595
TRG_ER_diArg_1	56	58	PF00400	0.314
TRG_NES_CRM1_1	209	222	PF08389	0.307
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.290
TRG_Pf-PMV_PEXEL_1	78	83	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
V5BD35	Trypanosoma cruzi	41%	100%