Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PHD-like zinc-binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMT2_LEIBR

TriTrypDb:

LbrM.34.2550 , LBRM2903_340033200

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HMT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT2

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	293	297	PF00656	0.515
CLV_C14_Caspase3-7	741	745	PF00656	0.632
CLV_MEL_PAP_1	2	8	PF00089	0.300
CLV_NRD_NRD_1	325	327	PF00675	0.455
CLV_NRD_NRD_1	337	339	PF00675	0.419
CLV_NRD_NRD_1	401	403	PF00675	0.540
CLV_NRD_NRD_1	450	452	PF00675	0.696
CLV_NRD_NRD_1	529	531	PF00675	0.540
CLV_NRD_NRD_1	535	537	PF00675	0.495
CLV_NRD_NRD_1	590	592	PF00675	0.581
CLV_NRD_NRD_1	706	708	PF00675	0.499
CLV_NRD_NRD_1	88	90	PF00675	0.557
CLV_PCSK_FUR_1	533	537	PF00082	0.497
CLV_PCSK_KEX2_1	325	327	PF00082	0.496
CLV_PCSK_KEX2_1	337	339	PF00082	0.452
CLV_PCSK_KEX2_1	450	452	PF00082	0.670
CLV_PCSK_KEX2_1	535	537	PF00082	0.518
CLV_PCSK_KEX2_1	589	591	PF00082	0.558
CLV_PCSK_KEX2_1	705	707	PF00082	0.618
CLV_PCSK_KEX2_1	88	90	PF00082	0.557
CLV_PCSK_KEX2_1	98	100	PF00082	0.670
CLV_PCSK_PC1ET2_1	705	707	PF00082	0.618
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.778
CLV_PCSK_PC7_1	84	90	PF00082	0.548
CLV_PCSK_PC7_1	94	100	PF00082	0.719
CLV_PCSK_SKI1_1	238	242	PF00082	0.536
CLV_PCSK_SKI1_1	258	262	PF00082	0.564
CLV_PCSK_SKI1_1	272	276	PF00082	0.346
CLV_PCSK_SKI1_1	326	330	PF00082	0.519
CLV_Separin_Metazoa	364	368	PF03568	0.547
DEG_APCC_DBOX_1	199	207	PF00400	0.678
DEG_APCC_DBOX_1	271	279	PF00400	0.403
DEG_COP1_1	183	192	PF00400	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.373
DEG_SPOP_SBC_1	182	186	PF00917	0.683
DEG_SPOP_SBC_1	439	443	PF00917	0.722
DOC_ANK_TNKS_1	589	596	PF00023	0.662
DOC_CKS1_1	280	285	PF01111	0.458
DOC_CKS1_1	369	374	PF01111	0.563
DOC_CYCLIN_yCln2_LP_2	690	696	PF00134	0.390
DOC_MAPK_gen_1	22	30	PF00069	0.321
DOC_MAPK_gen_1	281	289	PF00069	0.477
DOC_MAPK_gen_1	3	12	PF00069	0.461
DOC_MAPK_gen_1	322	331	PF00069	0.466
DOC_MAPK_gen_1	337	344	PF00069	0.467
DOC_MAPK_gen_1	356	365	PF00069	0.289
DOC_MAPK_gen_1	483	490	PF00069	0.658
DOC_MAPK_gen_1	530	540	PF00069	0.606
DOC_MAPK_MEF2A_6	272	280	PF00069	0.379
DOC_MAPK_MEF2A_6	281	289	PF00069	0.493
DOC_MAPK_MEF2A_6	3	12	PF00069	0.416
DOC_MAPK_NFAT4_5	5	13	PF00069	0.419
DOC_PP1_RVXF_1	46	52	PF00149	0.414
DOC_PP1_RVXF_1	7	13	PF00149	0.431
DOC_PP4_FxxP_1	280	283	PF00568	0.471
DOC_PP4_FxxP_1	30	33	PF00568	0.487
DOC_USP7_MATH_1	176	180	PF00917	0.601
DOC_USP7_MATH_1	240	244	PF00917	0.698
DOC_USP7_MATH_1	419	423	PF00917	0.715
DOC_USP7_MATH_1	438	442	PF00917	0.646
DOC_USP7_MATH_1	463	467	PF00917	0.700
DOC_USP7_MATH_1	468	472	PF00917	0.627
DOC_USP7_MATH_1	628	632	PF00917	0.597
DOC_USP7_MATH_1	726	730	PF00917	0.610
DOC_WW_Pin1_4	111	116	PF00397	0.766
DOC_WW_Pin1_4	117	122	PF00397	0.671
DOC_WW_Pin1_4	188	193	PF00397	0.773
DOC_WW_Pin1_4	279	284	PF00397	0.440
DOC_WW_Pin1_4	368	373	PF00397	0.529
LIG_14-3-3_CanoR_1	450	455	PF00244	0.659
LIG_14-3-3_CanoR_1	600	608	PF00244	0.512
LIG_14-3-3_CanoR_1	697	703	PF00244	0.573
LIG_Actin_WH2_2	225	240	PF00022	0.520
LIG_AP2alpha_2	687	689	PF02296	0.656
LIG_Clathr_ClatBox_1	354	358	PF01394	0.451
LIG_DCNL_PONY_1	1	4	PF03556	0.348
LIG_eIF4E_1	270	276	PF01652	0.270
LIG_FHA_1	183	189	PF00498	0.620
LIG_FHA_1	249	255	PF00498	0.431
LIG_FHA_1	299	305	PF00498	0.530
LIG_FHA_1	465	471	PF00498	0.736
LIG_FHA_1	540	546	PF00498	0.459
LIG_FHA_1	597	603	PF00498	0.543
LIG_FHA_1	610	616	PF00498	0.405
LIG_FHA_1	697	703	PF00498	0.578
LIG_FHA_2	138	144	PF00498	0.661
LIG_FHA_2	306	312	PF00498	0.406
LIG_FHA_2	381	387	PF00498	0.627
LIG_FHA_2	507	513	PF00498	0.569
LIG_GBD_Chelix_1	639	647	PF00786	0.421
LIG_Integrin_RGD_1	322	324	PF01839	0.543
LIG_LIR_Apic_2	29	33	PF02991	0.492
LIG_LIR_Gen_1	308	317	PF02991	0.533
LIG_LIR_Gen_1	35	45	PF02991	0.434
LIG_LIR_Gen_1	50	59	PF02991	0.473
LIG_LIR_Gen_1	578	586	PF02991	0.529
LIG_LIR_Gen_1	666	676	PF02991	0.423
LIG_LIR_Gen_1	677	688	PF02991	0.502
LIG_LIR_Gen_1	76	87	PF02991	0.540
LIG_LIR_Nem_3	21	27	PF02991	0.544
LIG_LIR_Nem_3	308	312	PF02991	0.538
LIG_LIR_Nem_3	35	41	PF02991	0.336
LIG_LIR_Nem_3	426	431	PF02991	0.708
LIG_LIR_Nem_3	50	54	PF02991	0.464
LIG_LIR_Nem_3	57	62	PF02991	0.439
LIG_LIR_Nem_3	578	582	PF02991	0.532
LIG_LIR_Nem_3	666	672	PF02991	0.424
LIG_LIR_Nem_3	677	683	PF02991	0.484
LIG_LIR_Nem_3	76	82	PF02991	0.388
LIG_Rb_LxCxE_1	155	174	PF01857	0.569
LIG_SH2_CRK	661	665	PF00017	0.411
LIG_SH2_GRB2like	680	683	PF00017	0.501
LIG_SH2_SRC	123	126	PF00017	0.514
LIG_SH2_STAT5	270	273	PF00017	0.484
LIG_SH2_STAT5	335	338	PF00017	0.435
LIG_SH2_STAT5	680	683	PF00017	0.501
LIG_SH2_STAT5	78	81	PF00017	0.460
LIG_SH3_3	10	16	PF00018	0.520
LIG_SH3_3	186	192	PF00018	0.608
LIG_SH3_3	215	221	PF00018	0.516
LIG_SH3_3	243	249	PF00018	0.570
LIG_SH3_3	250	256	PF00018	0.424
LIG_SH3_3	432	438	PF00018	0.620
LIG_SH3_3	493	499	PF00018	0.622
LIG_SH3_3	614	620	PF00018	0.518
LIG_SH3_3	685	691	PF00018	0.553
LIG_SUMO_SIM_par_1	380	386	PF11976	0.658
LIG_SUMO_SIM_par_1	392	397	PF11976	0.669
LIG_TRAF2_1	484	487	PF00917	0.613
LIG_UBA3_1	353	362	PF00899	0.541
LIG_WRC_WIRS_1	27	32	PF05994	0.573
MOD_CDK_SPK_2	279	284	PF00069	0.440
MOD_CK1_1	114	120	PF00069	0.517
MOD_CK1_1	166	172	PF00069	0.685
MOD_CK1_1	183	189	PF00069	0.622
MOD_CK1_1	414	420	PF00069	0.669
MOD_CK1_1	441	447	PF00069	0.724
MOD_CK1_1	457	463	PF00069	0.598
MOD_CK1_1	57	63	PF00069	0.489
MOD_CK2_1	26	32	PF00069	0.572
MOD_CK2_1	305	311	PF00069	0.514
MOD_CK2_1	358	364	PF00069	0.461
MOD_CK2_1	380	386	PF00069	0.623
MOD_CK2_1	417	423	PF00069	0.628
MOD_CK2_1	47	53	PF00069	0.438
MOD_CK2_1	481	487	PF00069	0.639
MOD_CK2_1	628	634	PF00069	0.558
MOD_CK2_1	716	722	PF00069	0.624
MOD_Cter_Amidation	400	403	PF01082	0.539
MOD_GlcNHglycan	127	130	PF01048	0.768
MOD_GlcNHglycan	178	181	PF01048	0.693
MOD_GlcNHglycan	242	245	PF01048	0.532
MOD_GlcNHglycan	389	392	PF01048	0.730
MOD_GlcNHglycan	413	416	PF01048	0.785
MOD_GlcNHglycan	446	449	PF01048	0.546
MOD_GlcNHglycan	459	462	PF01048	0.565
MOD_GlcNHglycan	470	473	PF01048	0.599
MOD_GlcNHglycan	609	612	PF01048	0.566
MOD_GlcNHglycan	626	629	PF01048	0.420
MOD_GlcNHglycan	630	633	PF01048	0.575
MOD_GlcNHglycan	66	70	PF01048	0.500
MOD_GlcNHglycan	676	679	PF01048	0.522
MOD_GlcNHglycan	79	82	PF01048	0.541
MOD_GSK3_1	113	120	PF00069	0.637
MOD_GSK3_1	134	141	PF00069	0.775
MOD_GSK3_1	171	178	PF00069	0.715
MOD_GSK3_1	236	243	PF00069	0.724
MOD_GSK3_1	298	305	PF00069	0.484
MOD_GSK3_1	410	417	PF00069	0.773
MOD_GSK3_1	419	426	PF00069	0.653
MOD_GSK3_1	438	445	PF00069	0.607
MOD_GSK3_1	450	457	PF00069	0.697
MOD_GSK3_1	464	471	PF00069	0.586
MOD_GSK3_1	603	610	PF00069	0.525
MOD_GSK3_1	624	631	PF00069	0.564
MOD_GSK3_1	73	80	PF00069	0.565
MOD_GSK3_1	88	95	PF00069	0.454
MOD_N-GLC_1	423	428	PF02516	0.708
MOD_N-GLC_2	646	648	PF02516	0.503
MOD_NEK2_1	164	169	PF00069	0.682
MOD_NEK2_1	181	186	PF00069	0.640
MOD_NEK2_1	214	219	PF00069	0.744
MOD_NEK2_1	357	362	PF00069	0.553
MOD_NEK2_1	454	459	PF00069	0.758
MOD_NEK2_1	549	554	PF00069	0.502
MOD_NEK2_1	565	570	PF00069	0.606
MOD_NEK2_1	601	606	PF00069	0.510
MOD_NEK2_1	607	612	PF00069	0.476
MOD_NEK2_1	708	713	PF00069	0.484
MOD_NEK2_2	380	385	PF00069	0.732
MOD_NEK2_2	611	616	PF00069	0.570
MOD_PIKK_1	164	170	PF00454	0.435
MOD_PIKK_1	298	304	PF00454	0.545
MOD_PIKK_1	394	400	PF00454	0.649
MOD_PIKK_1	539	545	PF00454	0.483
MOD_PIKK_1	571	577	PF00454	0.429
MOD_PIKK_1	601	607	PF00454	0.355
MOD_PIKK_1	696	702	PF00454	0.528
MOD_PKA_1	450	456	PF00069	0.772
MOD_PKA_1	88	94	PF00069	0.536
MOD_PKA_2	358	364	PF00069	0.485
MOD_PKA_2	449	455	PF00069	0.693
MOD_PKA_2	571	577	PF00069	0.676
MOD_PKA_2	696	702	PF00069	0.553
MOD_PKA_2	88	94	PF00069	0.536
MOD_Plk_1	34	40	PF00069	0.501
MOD_Plk_1	394	400	PF00069	0.693
MOD_Plk_1	57	63	PF00069	0.438
MOD_Plk_1	641	647	PF00069	0.508
MOD_Plk_1	716	722	PF00069	0.598
MOD_Plk_1	92	98	PF00069	0.602
MOD_Plk_2-3	143	149	PF00069	0.693
MOD_Plk_2-3	26	32	PF00069	0.457
MOD_Plk_2-3	34	40	PF00069	0.469
MOD_Plk_4	106	112	PF00069	0.519
MOD_Plk_4	114	120	PF00069	0.485
MOD_Plk_4	214	220	PF00069	0.631
MOD_Plk_4	603	609	PF00069	0.559
MOD_ProDKin_1	111	117	PF00069	0.766
MOD_ProDKin_1	188	194	PF00069	0.774
MOD_ProDKin_1	279	285	PF00069	0.449
MOD_ProDKin_1	368	374	PF00069	0.532
MOD_SUMO_rev_2	208	214	PF00179	0.497
MOD_SUMO_rev_2	40	50	PF00179	0.457
MOD_SUMO_rev_2	588	598	PF00179	0.660
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.475
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.514
TRG_ENDOCYTIC_2	38	41	PF00928	0.426
TRG_ENDOCYTIC_2	661	664	PF00928	0.437
TRG_ENDOCYTIC_2	680	683	PF00928	0.546
TRG_ER_diArg_1	2	5	PF00400	0.471
TRG_ER_diArg_1	336	338	PF00400	0.488
TRG_ER_diArg_1	449	451	PF00400	0.761
TRG_ER_diArg_1	482	485	PF00400	0.534
TRG_ER_diArg_1	532	535	PF00400	0.616
TRG_ER_diArg_1	589	591	PF00400	0.574
TRG_ER_diArg_1	706	708	PF00400	0.499
TRG_ER_diArg_1	8	11	PF00400	0.434
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	600	605	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF9	Leptomonas seymouri	68%	100%
A0A1X0P5J9	Trypanosomatidae	46%	100%
A0A3S7X9C0	Leishmania donovani	81%	100%
A4IBD0	Leishmania infantum	81%	100%
C9ZZ89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AF86	Leishmania major	81%	99%
E9B6E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
V5DUV4	Trypanosoma cruzi	49%	100%