FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TFIIF-stimulated CTD phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMT1_LEIBR

TriTrypDb:

LbrM.34.2540 , LBRM2903_340033100

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.742
CLV_NRD_NRD_1	247	249	PF00675	0.658
CLV_NRD_NRD_1	304	306	PF00675	0.580
CLV_NRD_NRD_1	311	313	PF00675	0.609
CLV_NRD_NRD_1	37	39	PF00675	0.491
CLV_PCSK_FUR_1	245	249	PF00082	0.614
CLV_PCSK_FUR_1	302	306	PF00082	0.504
CLV_PCSK_KEX2_1	245	247	PF00082	0.569
CLV_PCSK_KEX2_1	302	304	PF00082	0.533
CLV_PCSK_KEX2_1	36	38	PF00082	0.507
CLV_PCSK_KEX2_1	58	60	PF00082	0.494
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.575
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.438
CLV_PCSK_SKI1_1	109	113	PF00082	0.319
CLV_PCSK_SKI1_1	252	256	PF00082	0.404
CLV_PCSK_SKI1_1	258	262	PF00082	0.409
CLV_PCSK_SKI1_1	85	89	PF00082	0.279
DEG_APCC_DBOX_1	257	265	PF00400	0.432
DEG_APCC_DBOX_1	80	88	PF00400	0.279
DEG_COP1_1	186	195	PF00400	0.517
DOC_ANK_TNKS_1	227	234	PF00023	0.520
DOC_ANK_TNKS_1	282	289	PF00023	0.306
DOC_CKS1_1	192	197	PF01111	0.725
DOC_CKS1_1	336	341	PF01111	0.526
DOC_CYCLIN_RxL_1	252	263	PF00134	0.435
DOC_MAPK_gen_1	36	44	PF00069	0.524
DOC_MAPK_gen_1	58	64	PF00069	0.279
DOC_MAPK_gen_1	89	99	PF00069	0.281
DOC_PP2B_LxvP_1	49	52	PF13499	0.433
DOC_PP2B_LxvP_1	8	11	PF13499	0.504
DOC_USP7_MATH_1	12	16	PF00917	0.573
DOC_USP7_MATH_1	165	169	PF00917	0.360
DOC_USP7_MATH_1	226	230	PF00917	0.746
DOC_USP7_MATH_1	339	343	PF00917	0.687
DOC_USP7_MATH_1	351	355	PF00917	0.752
DOC_USP7_MATH_1	361	365	PF00917	0.798
DOC_WW_Pin1_4	1	6	PF00397	0.648
DOC_WW_Pin1_4	154	159	PF00397	0.318
DOC_WW_Pin1_4	187	192	PF00397	0.699
DOC_WW_Pin1_4	239	244	PF00397	0.705
DOC_WW_Pin1_4	330	335	PF00397	0.804
DOC_WW_Pin1_4	367	372	PF00397	0.643
LIG_14-3-3_CanoR_1	245	255	PF00244	0.495
LIG_14-3-3_CanoR_1	273	281	PF00244	0.457
LIG_14-3-3_CanoR_1	283	287	PF00244	0.365
LIG_14-3-3_CanoR_1	59	63	PF00244	0.414
LIG_Actin_WH2_2	250	268	PF00022	0.287
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.566
LIG_EH1_1	118	126	PF00400	0.322
LIG_FHA_1	136	142	PF00498	0.279
LIG_FHA_1	149	155	PF00498	0.289
LIG_FHA_1	187	193	PF00498	0.614
LIG_FHA_1	213	219	PF00498	0.636
LIG_FHA_1	251	257	PF00498	0.427
LIG_FHA_1	39	45	PF00498	0.609
LIG_FHA_2	178	184	PF00498	0.622
LIG_FHA_2	206	212	PF00498	0.656
LIG_FHA_2	336	342	PF00498	0.629
LIG_FHA_2	99	105	PF00498	0.279
LIG_LIR_Gen_1	147	158	PF02991	0.284
LIG_LIR_Gen_1	172	178	PF02991	0.410
LIG_LIR_Gen_1	57	66	PF02991	0.322
LIG_LIR_Gen_1	93	102	PF02991	0.297
LIG_LIR_Nem_3	172	177	PF02991	0.410
LIG_LIR_Nem_3	57	63	PF02991	0.322
LIG_LIR_Nem_3	86	91	PF02991	0.308
LIG_LIR_Nem_3	93	98	PF02991	0.290
LIG_MYND_1	6	10	PF01753	0.635
LIG_NRBOX	256	262	PF00104	0.425
LIG_RPA_C_Fungi	314	326	PF08784	0.488
LIG_SH2_CRK	60	64	PF00017	0.279
LIG_SH2_NCK_1	60	64	PF00017	0.398
LIG_SH2_NCK_1	79	83	PF00017	0.161
LIG_SH2_STAP1	107	111	PF00017	0.279
LIG_SH2_STAP1	137	141	PF00017	0.279
LIG_SH2_STAP1	150	154	PF00017	0.279
LIG_SH2_STAP1	60	64	PF00017	0.279
LIG_SH2_STAP1	79	83	PF00017	0.279
LIG_SH2_STAT5	137	140	PF00017	0.302
LIG_SH2_STAT5	150	153	PF00017	0.279
LIG_SH2_STAT5	60	63	PF00017	0.279
LIG_SH2_STAT5	83	86	PF00017	0.279
LIG_SH3_3	185	191	PF00018	0.679
LIG_SH3_3	192	198	PF00018	0.618
LIG_SH3_3	368	374	PF00018	0.709
LIG_SUMO_SIM_par_1	150	155	PF11976	0.281
LIG_TRAF2_1	180	183	PF00917	0.579
LIG_TRAF2_2	199	204	PF00917	0.531
LIG_UBA3_1	260	266	PF00899	0.457
LIG_UBA3_1	87	92	PF00899	0.279
LIG_WW_3	377	381	PF00397	0.514
MOD_CDC14_SPxK_1	242	245	PF00782	0.717
MOD_CDC14_SPxK_1	4	7	PF00782	0.620
MOD_CDK_SPxK_1	1	7	PF00069	0.647
MOD_CDK_SPxK_1	239	245	PF00069	0.713
MOD_CDK_SPxxK_3	239	246	PF00069	0.670
MOD_CK1_1	186	192	PF00069	0.610
MOD_CK1_1	237	243	PF00069	0.758
MOD_CK1_1	267	273	PF00069	0.371
MOD_CK1_1	282	288	PF00069	0.382
MOD_CK1_1	289	295	PF00069	0.434
MOD_CK1_1	335	341	PF00069	0.724
MOD_CK1_1	354	360	PF00069	0.755
MOD_CK1_1	363	369	PF00069	0.763
MOD_CK1_1	54	60	PF00069	0.483
MOD_CK2_1	177	183	PF00069	0.603
MOD_CK2_1	205	211	PF00069	0.662
MOD_CK2_1	226	232	PF00069	0.612
MOD_CK2_1	335	341	PF00069	0.655
MOD_CK2_1	98	104	PF00069	0.279
MOD_Cter_Amidation	45	48	PF01082	0.548
MOD_GlcNHglycan	14	17	PF01048	0.589
MOD_GlcNHglycan	228	231	PF01048	0.773
MOD_GlcNHglycan	236	239	PF01048	0.743
MOD_GlcNHglycan	266	269	PF01048	0.372
MOD_GlcNHglycan	322	325	PF01048	0.608
MOD_GlcNHglycan	341	344	PF01048	0.681
MOD_GlcNHglycan	365	369	PF01048	0.795
MOD_GlcNHglycan	374	377	PF01048	0.700
MOD_GSK3_1	183	190	PF00069	0.662
MOD_GSK3_1	246	253	PF00069	0.552
MOD_GSK3_1	260	267	PF00069	0.399
MOD_GSK3_1	282	289	PF00069	0.456
MOD_GSK3_1	335	342	PF00069	0.740
MOD_GSK3_1	360	367	PF00069	0.739
MOD_GSK3_1	54	61	PF00069	0.485
MOD_N-GLC_1	12	17	PF02516	0.474
MOD_N-GLC_1	148	153	PF02516	0.410
MOD_NEK2_1	148	153	PF00069	0.410
MOD_NEK2_1	218	223	PF00069	0.492
MOD_NEK2_1	260	265	PF00069	0.492
MOD_NEK2_1	66	71	PF00069	0.279
MOD_PIKK_1	237	243	PF00454	0.740
MOD_PIKK_1	332	338	PF00454	0.693
MOD_PKA_1	246	252	PF00069	0.613
MOD_PKA_1	58	64	PF00069	0.357
MOD_PKA_2	246	252	PF00069	0.638
MOD_PKA_2	282	288	PF00069	0.404
MOD_PKA_2	58	64	PF00069	0.410
MOD_PKB_1	245	253	PF00069	0.551
MOD_Plk_1	148	154	PF00069	0.410
MOD_Plk_1	250	256	PF00069	0.377
MOD_Plk_1	345	351	PF00069	0.698
MOD_Plk_1	66	72	PF00069	0.279
MOD_Plk_4	148	154	PF00069	0.401
MOD_Plk_4	165	171	PF00069	0.246
MOD_Plk_4	260	266	PF00069	0.493
MOD_Plk_4	282	288	PF00069	0.374
MOD_Plk_4	38	44	PF00069	0.510
MOD_Plk_4	58	64	PF00069	0.150
MOD_Plk_4	66	72	PF00069	0.279
MOD_ProDKin_1	1	7	PF00069	0.639
MOD_ProDKin_1	154	160	PF00069	0.318
MOD_ProDKin_1	187	193	PF00069	0.698
MOD_ProDKin_1	239	245	PF00069	0.696
MOD_ProDKin_1	330	336	PF00069	0.803
MOD_ProDKin_1	367	373	PF00069	0.643
MOD_SUMO_rev_2	210	215	PF00179	0.496
TRG_DiLeu_BaEn_1	39	44	PF01217	0.500
TRG_DiLeu_BaEn_4	398	404	PF01217	0.508
TRG_ENDOCYTIC_2	150	153	PF00928	0.279
TRG_ENDOCYTIC_2	60	63	PF00928	0.279
TRG_ER_diArg_1	244	247	PF00400	0.713
TRG_ER_diArg_1	302	305	PF00400	0.545
TRG_NES_CRM1_1	143	155	PF08389	0.355
TRG_Pf-PMV_PEXEL_1	142	147	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.209

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1T4	Leptomonas seymouri	69%	97%
A0A1X0P5T3	Trypanosomatidae	53%	100%
A0A3R7P338	Trypanosoma rangeli	53%	100%
A0A3S7X9F4	Leishmania donovani	80%	100%
A4IBC9	Leishmania infantum	80%	100%
C9ZZ90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AF85	Leishmania major	79%	99%
E9B6E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BY89	Trypanosoma cruzi	52%	100%