Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMT0_LEIBR

TriTrypDb:

LbrM.34.2530 , LBRM2903_340033000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMT0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMT0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.489
CLV_NRD_NRD_1	118	120	PF00675	0.650
CLV_NRD_NRD_1	163	165	PF00675	0.814
CLV_NRD_NRD_1	180	182	PF00675	0.514
CLV_NRD_NRD_1	240	242	PF00675	0.479
CLV_NRD_NRD_1	69	71	PF00675	0.679
CLV_NRD_NRD_1	8	10	PF00675	0.784
CLV_NRD_NRD_1	87	89	PF00675	0.712
CLV_PCSK_FUR_1	6	10	PF00082	0.663
CLV_PCSK_KEX2_1	179	181	PF00082	0.713
CLV_PCSK_KEX2_1	239	241	PF00082	0.481
CLV_PCSK_KEX2_1	41	43	PF00082	0.670
CLV_PCSK_KEX2_1	69	71	PF00082	0.729
CLV_PCSK_KEX2_1	8	10	PF00082	0.784
CLV_PCSK_KEX2_1	81	83	PF00082	0.772
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.481
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.670
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.730
CLV_PCSK_PC7_1	37	43	PF00082	0.617
CLV_PCSK_SKI1_1	240	244	PF00082	0.478
CLV_PCSK_SKI1_1	41	45	PF00082	0.717
CLV_PCSK_SKI1_1	52	56	PF00082	0.624
DEG_APCC_DBOX_1	239	247	PF00400	0.487
DEG_Nend_UBRbox_1	1	4	PF02207	0.701
DEG_SCF_FBW7_1	193	200	PF00400	0.506
DEG_SCF_FBW7_1	97	104	PF00400	0.571
DEG_SCF_SKP2-CKS1_1	96	103	PF00560	0.573
DOC_CKS1_1	111	116	PF01111	0.565
DOC_CKS1_1	194	199	PF01111	0.662
DOC_CYCLIN_yCln2_LP_2	281	287	PF00134	0.350
DOC_MAPK_gen_1	239	245	PF00069	0.478
DOC_MAPK_MEF2A_6	239	247	PF00069	0.487
DOC_MAPK_MEF2A_6	70	79	PF00069	0.565
DOC_PP4_FxxP_1	292	295	PF00568	0.554
DOC_USP7_MATH_1	101	105	PF00917	0.647
DOC_USP7_MATH_1	123	127	PF00917	0.585
DOC_USP7_MATH_1	139	143	PF00917	0.572
DOC_USP7_UBL2_3	116	120	PF12436	0.736
DOC_USP7_UBL2_3	153	157	PF12436	0.579
DOC_USP7_UBL2_3	35	39	PF12436	0.678
DOC_USP7_UBL2_3	63	67	PF12436	0.577
DOC_WW_Pin1_4	110	115	PF00397	0.702
DOC_WW_Pin1_4	193	198	PF00397	0.657
DOC_WW_Pin1_4	251	256	PF00397	0.589
DOC_WW_Pin1_4	41	46	PF00397	0.786
DOC_WW_Pin1_4	54	59	PF00397	0.696
DOC_WW_Pin1_4	71	76	PF00397	0.742
DOC_WW_Pin1_4	88	93	PF00397	0.646
DOC_WW_Pin1_4	97	102	PF00397	0.714
LIG_14-3-3_CanoR_1	164	170	PF00244	0.821
LIG_14-3-3_CanoR_1	86	92	PF00244	0.726
LIG_FHA_1	164	170	PF00498	0.819
LIG_FHA_1	194	200	PF00498	0.665
LIG_FHA_1	273	279	PF00498	0.511
LIG_FHA_1	42	48	PF00498	0.598
LIG_FHA_1	63	69	PF00498	0.714
LIG_FHA_2	120	126	PF00498	0.577
LIG_FHA_2	232	238	PF00498	0.444
LIG_GSK3_LRP6_1	110	115	PF00069	0.559
LIG_Integrin_isoDGR_2	267	269	PF01839	0.556
LIG_LIR_Apic_2	288	293	PF02991	0.478
LIG_LIR_Nem_3	223	228	PF02991	0.340
LIG_SH2_STAT5	14	17	PF00017	0.632
LIG_SH2_STAT5	28	31	PF00017	0.644
LIG_SH2_STAT5	290	293	PF00017	0.500
LIG_SH3_1	157	163	PF00018	0.562
LIG_SH3_1	55	61	PF00018	0.571
LIG_SH3_1	69	75	PF00018	0.594
LIG_SH3_1	81	87	PF00018	0.557
LIG_SH3_2	111	116	PF14604	0.565
LIG_SH3_2	160	165	PF14604	0.688
LIG_SH3_2	58	63	PF14604	0.701
LIG_SH3_2	84	89	PF14604	0.584
LIG_SH3_3	108	114	PF00018	0.560
LIG_SH3_3	115	121	PF00018	0.562
LIG_SH3_3	152	158	PF00018	0.709
LIG_SH3_3	185	191	PF00018	0.666
LIG_SH3_3	256	262	PF00018	0.451
LIG_SH3_3	281	287	PF00018	0.350
LIG_SH3_3	55	61	PF00018	0.711
LIG_SH3_3	69	75	PF00018	0.594
LIG_SH3_3	81	87	PF00018	0.557
LIG_SH3_4	35	42	PF00018	0.534
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.479
LIG_WRC_WIRS_1	228	233	PF05994	0.334
LIG_WW_3	158	162	PF00397	0.537
MOD_CDK_SPK_2	54	59	PF00069	0.576
MOD_CDK_SPxK_1	110	116	PF00069	0.617
MOD_CDK_SPxK_1	97	103	PF00069	0.601
MOD_CK1_1	126	132	PF00069	0.622
MOD_CK1_1	211	217	PF00069	0.372
MOD_CK1_1	99	105	PF00069	0.681
MOD_CK2_1	119	125	PF00069	0.582
MOD_CK2_1	197	203	PF00069	0.523
MOD_GlcNHglycan	128	131	PF01048	0.623
MOD_GlcNHglycan	251	254	PF01048	0.613
MOD_GSK3_1	119	126	PF00069	0.592
MOD_GSK3_1	193	200	PF00069	0.525
MOD_GSK3_1	216	223	PF00069	0.482
MOD_GSK3_1	227	234	PF00069	0.343
MOD_GSK3_1	37	44	PF00069	0.671
MOD_GSK3_1	97	104	PF00069	0.662
MOD_N-GLC_1	211	216	PF02516	0.448
MOD_N-GLC_1	220	225	PF02516	0.494
MOD_NEK2_1	216	221	PF00069	0.505
MOD_NEK2_1	231	236	PF00069	0.322
MOD_NEK2_2	123	128	PF00069	0.581
MOD_PKA_1	119	125	PF00069	0.582
MOD_PKA_2	123	129	PF00069	0.659
MOD_PKA_2	163	169	PF00069	0.823
MOD_PKA_2	87	93	PF00069	0.838
MOD_Plk_1	211	217	PF00069	0.501
MOD_Plk_1	231	237	PF00069	0.272
MOD_Plk_4	171	177	PF00069	0.691
MOD_Plk_4	211	217	PF00069	0.487
MOD_Plk_4	231	237	PF00069	0.295
MOD_Plk_4	285	291	PF00069	0.488
MOD_ProDKin_1	110	116	PF00069	0.707
MOD_ProDKin_1	193	199	PF00069	0.661
MOD_ProDKin_1	251	257	PF00069	0.593
MOD_ProDKin_1	41	47	PF00069	0.784
MOD_ProDKin_1	54	60	PF00069	0.695
MOD_ProDKin_1	71	77	PF00069	0.743
MOD_ProDKin_1	88	94	PF00069	0.648
MOD_ProDKin_1	97	103	PF00069	0.715
TRG_ER_diArg_1	179	181	PF00400	0.708
TRG_ER_diArg_1	240	242	PF00400	0.479
TRG_ER_diArg_1	68	70	PF00400	0.691
TRG_NLS_MonoExtC_3	238	244	PF00514	0.466
TRG_NLS_MonoExtC_3	65	70	PF00514	0.576
TRG_NLS_MonoExtN_4	63	70	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF70	Leishmania donovani	61%	91%
A4IBC8	Leishmania infantum	60%	92%
E9AF84	Leishmania major	62%	100%
E9B6D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	91%