Palmitoyltransferase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMS9_LEIBR

TriTrypDb:

LbrM.34.2520 , LBRM2903_340032900

Length:

279

Annotations

LeishMANIAdb annotations

Related to many other eukaryotic palmitoyltransferases (e.g. mammalian ZDHHC4/9/14/24)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HMS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMS9

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016409	palmitoyltransferase activity	5	10
GO:0016417	S-acyltransferase activity	5	10
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	10
GO:0019707	protein-cysteine S-acyltransferase activity	3	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	262	264	PF00675	0.377
CLV_PCSK_KEX2_1	146	148	PF00082	0.265
CLV_PCSK_KEX2_1	262	264	PF00082	0.350
CLV_PCSK_KEX2_1	9	11	PF00082	0.391
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.265
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.391
CLV_PCSK_SKI1_1	262	266	PF00082	0.343
CLV_PCSK_SKI1_1	9	13	PF00082	0.397
DOC_CDC14_PxL_1	32	40	PF14671	0.455
DOC_CYCLIN_RxL_1	259	266	PF00134	0.505
DOC_MAPK_gen_1	9	17	PF00069	0.669
DOC_PP1_RVXF_1	14	20	PF00149	0.666
DOC_PP2B_LxvP_1	115	118	PF13499	0.460
DOC_PP2B_LxvP_1	208	211	PF13499	0.455
DOC_USP7_MATH_1	221	225	PF00917	0.562
DOC_USP7_MATH_1	85	89	PF00917	0.605
DOC_WW_Pin1_4	263	268	PF00397	0.615
LIG_14-3-3_CanoR_1	116	125	PF00244	0.482
LIG_14-3-3_CanoR_1	169	175	PF00244	0.205
LIG_deltaCOP1_diTrp_1	26	32	PF00928	0.527
LIG_deltaCOP1_diTrp_1	53	59	PF00928	0.362
LIG_FHA_1	109	115	PF00498	0.454
LIG_FHA_1	157	163	PF00498	0.343
LIG_FHA_1	40	46	PF00498	0.455
LIG_FHA_1	67	73	PF00498	0.421
LIG_FHA_2	223	229	PF00498	0.454
LIG_LIR_Gen_1	159	168	PF02991	0.386
LIG_LIR_Gen_1	170	179	PF02991	0.402
LIG_LIR_Gen_1	26	36	PF02991	0.561
LIG_LIR_Gen_1	42	50	PF02991	0.259
LIG_LIR_Gen_1	56	65	PF02991	0.219
LIG_LIR_Nem_3	148	152	PF02991	0.465
LIG_LIR_Nem_3	159	164	PF02991	0.318
LIG_LIR_Nem_3	170	174	PF02991	0.402
LIG_LIR_Nem_3	26	31	PF02991	0.561
LIG_LIR_Nem_3	42	47	PF02991	0.259
LIG_LIR_Nem_3	53	57	PF02991	0.213
LIG_PDZ_Class_2	274	279	PF00595	0.611
LIG_Pex14_1	28	32	PF04695	0.455
LIG_Pex14_2	151	155	PF04695	0.318
LIG_Pex14_2	40	44	PF04695	0.455
LIG_Pex14_2	59	63	PF04695	0.147
LIG_SH2_PTP2	165	168	PF00017	0.375
LIG_SH2_PTP2	216	219	PF00017	0.482
LIG_SH2_STAT5	165	168	PF00017	0.375
LIG_SH2_STAT5	216	219	PF00017	0.477
LIG_SH2_STAT5	256	259	PF00017	0.569
LIG_SH2_STAT5	57	60	PF00017	0.343
LIG_SH3_3	30	36	PF00018	0.455
LIG_SH3_3	44	50	PF00018	0.395
LIG_SH3_3	88	94	PF00018	0.569
LIG_Sin3_3	206	213	PF02671	0.205
LIG_SUMO_SIM_anti_2	170	178	PF11976	0.397
LIG_SUMO_SIM_par_1	71	76	PF11976	0.420
LIG_SUMO_SIM_par_1	95	100	PF11976	0.462
LIG_WRC_WIRS_1	158	163	PF05994	0.455
LIG_WRC_WIRS_1	168	173	PF05994	0.293
LIG_WW_3	116	120	PF00397	0.465
MOD_CDK_SPxxK_3	263	270	PF00069	0.628
MOD_CK1_1	170	176	PF00069	0.369
MOD_CK2_1	222	228	PF00069	0.454
MOD_Cter_Amidation	144	147	PF01082	0.362
MOD_GlcNHglycan	219	222	PF01048	0.327
MOD_GlcNHglycan	237	240	PF01048	0.352
MOD_GlcNHglycan	99	102	PF01048	0.264
MOD_GSK3_1	170	177	PF00069	0.303
MOD_GSK3_1	217	224	PF00069	0.519
MOD_GSK3_1	229	236	PF00069	0.606
MOD_GSK3_1	39	46	PF00069	0.429
MOD_GSK3_1	53	60	PF00069	0.260
MOD_N-GLC_1	222	227	PF02516	0.254
MOD_N-GLC_2	255	257	PF02516	0.401
MOD_NEK2_1	156	161	PF00069	0.343
MOD_NEK2_1	167	172	PF00069	0.343
MOD_NEK2_1	191	196	PF00069	0.369
MOD_NEK2_1	219	224	PF00069	0.509
MOD_NEK2_1	39	44	PF00069	0.411
MOD_NEK2_1	63	68	PF00069	0.344
MOD_NEK2_1	71	76	PF00069	0.328
MOD_NEK2_2	145	150	PF00069	0.465
MOD_OFUCOSY	106	112	PF10250	0.282
MOD_OFUCOSY	137	143	PF10250	0.282
MOD_PIKK_1	229	235	PF00454	0.617
MOD_PIKK_1	83	89	PF00454	0.646
MOD_PKA_2	118	124	PF00069	0.465
MOD_Plk_1	177	183	PF00069	0.184
MOD_Plk_1	222	228	PF00069	0.527
MOD_Plk_4	157	163	PF00069	0.381
MOD_Plk_4	256	262	PF00069	0.443
MOD_Plk_4	39	45	PF00069	0.382
MOD_Plk_4	53	59	PF00069	0.201
MOD_ProDKin_1	263	269	PF00069	0.618
TRG_ENDOCYTIC_2	165	168	PF00928	0.375
TRG_ENDOCYTIC_2	216	219	PF00928	0.477
TRG_ER_diArg_1	14	17	PF00400	0.614
TRG_ER_diArg_1	261	263	PF00400	0.589
TRG_ER_diArg_1	270	273	PF00400	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	24%	69%
A0A0N1HZ19	Leptomonas seymouri	28%	79%
A0A0S4IT15	Bodo saltans	30%	79%
A0A0S4IWS3	Bodo saltans	27%	100%
A0A0S4IXZ6	Bodo saltans	28%	100%
A0A0S4JRL4	Bodo saltans	30%	78%
A0A0S4KJ22	Bodo saltans	35%	91%
A0A1X0NUX2	Trypanosomatidae	24%	76%
A0A1X0NY23	Trypanosomatidae	24%	93%
A0A1X0NY30	Trypanosomatidae	31%	92%
A0A1X0P5Q8	Trypanosomatidae	42%	87%
A0A3Q8ICY2	Leishmania donovani	31%	79%
A0A3Q8IIC8	Leishmania donovani	79%	100%
A0A3R7P4J6	Trypanosoma rangeli	33%	93%
A0A422NE16	Trypanosoma rangeli	44%	86%
A4HG63	Leishmania braziliensis	30%	78%
A4I395	Leishmania infantum	31%	79%
A4IBG8	Leishmania infantum	78%	100%
B3DN87	Arabidopsis thaliana	27%	83%
C9ZKD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	91%
D0A7S1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	91%
E9AF82	Leishmania major	80%	100%
E9AZI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	78%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O74384	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	80%
O80685	Arabidopsis thaliana	27%	68%
P0C7U3	Homo sapiens	25%	75%
Q2TGJ1	Rattus norvegicus	32%	72%
Q3EBC2	Arabidopsis thaliana	28%	70%
Q4Q8P8	Leishmania major	31%	79%
Q5FWL7	Xenopus laevis	26%	83%
Q5PNZ1	Arabidopsis thaliana	27%	68%
Q5Y5T2	Mus musculus	32%	73%
Q6BHT4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	26%	75%
Q7ZVN4	Danio rerio	30%	72%
Q8R173	Mus musculus	25%	93%
Q8VYS8	Arabidopsis thaliana	26%	69%
Q9ESG8	Mus musculus	25%	77%
Q9FLM3	Arabidopsis thaliana	32%	68%
Q9H8X9	Homo sapiens	25%	68%
Q9NUE0	Homo sapiens	34%	72%
Q9SB58	Arabidopsis thaliana	29%	69%
V5BCH8	Trypanosoma cruzi	33%	93%
V5C316	Trypanosoma cruzi	42%	84%