LeishMANIAdb
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Putative cytochrome P450 reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cytochrome P450 reductase
Gene product:
cytochrome P450 reductase, putative
Species:
Leishmania braziliensis
UniProt:
A4HMS7_LEIBR
TriTrypDb:
LbrM.34.2490 , LBRM2903_340032600
Length:
832

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic CYP450 reductases.. For some reason, these proteins duplicated in Kinetoplastids. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 4
GO:0005829 cytosol 2 2

Expansion

Sequence features

A4HMS7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMS7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 19
GO:0003824 catalytic activity 1 19
GO:0005488 binding 1 19
GO:0010181 FMN binding 4 19
GO:0016491 oxidoreductase activity 2 19
GO:0032553 ribonucleotide binding 3 19
GO:0036094 small molecule binding 2 19
GO:0043167 ion binding 2 19
GO:0043168 anion binding 3 19
GO:0097159 organic cyclic compound binding 2 19
GO:0097367 carbohydrate derivative binding 2 19
GO:1901265 nucleoside phosphate binding 3 19
GO:1901363 heterocyclic compound binding 2 19
GO:0003958 NADPH-hemoprotein reductase activity 5 7
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 7
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4 7
GO:0050660 flavin adenine dinucleotide binding 4 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.779
CLV_NRD_NRD_1 194 196 PF00675 0.337
CLV_NRD_NRD_1 24 26 PF00675 0.445
CLV_NRD_NRD_1 33 35 PF00675 0.450
CLV_NRD_NRD_1 546 548 PF00675 0.271
CLV_NRD_NRD_1 668 670 PF00675 0.324
CLV_NRD_NRD_1 725 727 PF00675 0.515
CLV_NRD_NRD_1 819 821 PF00675 0.350
CLV_PCSK_FUR_1 31 35 PF00082 0.373
CLV_PCSK_KEX2_1 127 129 PF00082 0.394
CLV_PCSK_KEX2_1 194 196 PF00082 0.337
CLV_PCSK_KEX2_1 24 26 PF00082 0.303
CLV_PCSK_KEX2_1 33 35 PF00082 0.518
CLV_PCSK_KEX2_1 4 6 PF00082 0.635
CLV_PCSK_KEX2_1 725 727 PF00082 0.515
CLV_PCSK_KEX2_1 819 821 PF00082 0.367
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.394
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.582
CLV_PCSK_SKI1_1 194 198 PF00082 0.345
CLV_PCSK_SKI1_1 243 247 PF00082 0.303
CLV_PCSK_SKI1_1 283 287 PF00082 0.400
CLV_PCSK_SKI1_1 39 43 PF00082 0.529
CLV_PCSK_SKI1_1 400 404 PF00082 0.301
CLV_PCSK_SKI1_1 451 455 PF00082 0.262
CLV_PCSK_SKI1_1 476 480 PF00082 0.290
CLV_PCSK_SKI1_1 490 494 PF00082 0.220
CLV_PCSK_SKI1_1 521 525 PF00082 0.210
CLV_PCSK_SKI1_1 603 607 PF00082 0.332
CLV_PCSK_SKI1_1 643 647 PF00082 0.326
CLV_PCSK_SKI1_1 664 668 PF00082 0.294
CLV_PCSK_SKI1_1 765 769 PF00082 0.280
CLV_PCSK_SKI1_1 826 830 PF00082 0.302
DEG_APCC_DBOX_1 475 483 PF00400 0.480
DEG_SCF_TRCP1_1 63 68 PF00400 0.578
DEG_SPOP_SBC_1 321 325 PF00917 0.657
DEG_SPOP_SBC_1 357 361 PF00917 0.611
DEG_SPOP_SBC_1 370 374 PF00917 0.663
DEG_SPOP_SBC_1 541 545 PF00917 0.362
DOC_CYCLIN_yCln2_LP_2 132 138 PF00134 0.662
DOC_CYCLIN_yCln2_LP_2 378 384 PF00134 0.578
DOC_MAPK_DCC_7 158 167 PF00069 0.594
DOC_MAPK_gen_1 253 260 PF00069 0.452
DOC_MAPK_gen_1 4 12 PF00069 0.262
DOC_MAPK_gen_1 502 510 PF00069 0.463
DOC_MAPK_HePTP_8 2 14 PF00069 0.162
DOC_MAPK_MEF2A_6 158 167 PF00069 0.567
DOC_MAPK_MEF2A_6 301 310 PF00069 0.659
DOC_MAPK_MEF2A_6 5 14 PF00069 0.225
DOC_MAPK_MEF2A_6 597 604 PF00069 0.537
DOC_MAPK_RevD_3 10 25 PF00069 0.290
DOC_PP1_RVXF_1 260 266 PF00149 0.537
DOC_PP1_SILK_1 476 481 PF00149 0.411
DOC_PP2B_LxvP_1 378 381 PF13499 0.582
DOC_PP2B_LxvP_1 456 459 PF13499 0.504
DOC_PP2B_LxvP_1 528 531 PF13499 0.452
DOC_PP4_FxxP_1 382 385 PF00568 0.744
DOC_PP4_FxxP_1 633 636 PF00568 0.495
DOC_USP7_MATH_1 157 161 PF00917 0.552
DOC_USP7_MATH_1 17 21 PF00917 0.319
DOC_USP7_MATH_1 322 326 PF00917 0.738
DOC_USP7_MATH_1 340 344 PF00917 0.775
DOC_USP7_MATH_1 357 361 PF00917 0.692
DOC_USP7_MATH_1 362 366 PF00917 0.780
DOC_USP7_MATH_1 410 414 PF00917 0.535
DOC_USP7_MATH_1 503 507 PF00917 0.432
DOC_USP7_MATH_1 541 545 PF00917 0.551
DOC_USP7_MATH_1 724 728 PF00917 0.720
DOC_USP7_UBL2_3 148 152 PF12436 0.674
DOC_WW_Pin1_4 137 142 PF00397 0.686
DOC_WW_Pin1_4 150 155 PF00397 0.757
DOC_WW_Pin1_4 158 163 PF00397 0.668
DOC_WW_Pin1_4 324 329 PF00397 0.701
DOC_WW_Pin1_4 441 446 PF00397 0.404
LIG_14-3-3_CanoR_1 115 119 PF00244 0.590
LIG_14-3-3_CanoR_1 194 201 PF00244 0.452
LIG_14-3-3_CanoR_1 243 252 PF00244 0.529
LIG_14-3-3_CanoR_1 356 364 PF00244 0.585
LIG_14-3-3_CanoR_1 502 511 PF00244 0.476
LIG_14-3-3_CanoR_1 542 549 PF00244 0.519
LIG_14-3-3_CanoR_1 591 598 PF00244 0.537
LIG_14-3-3_CanoR_1 688 694 PF00244 0.507
LIG_14-3-3_CanoR_1 700 704 PF00244 0.520
LIG_14-3-3_CanoR_1 725 735 PF00244 0.715
LIG_Actin_WH2_2 466 482 PF00022 0.533
LIG_Actin_WH2_2 814 831 PF00022 0.532
LIG_APCC_ABBA_1 183 188 PF00400 0.504
LIG_BRCT_BRCA1_1 378 382 PF00533 0.697
LIG_CtBP_PxDLS_1 445 449 PF00389 0.537
LIG_eIF4E_1 662 668 PF01652 0.490
LIG_EVH1_1 380 384 PF00568 0.748
LIG_FHA_1 16 22 PF00498 0.341
LIG_FHA_1 196 202 PF00498 0.532
LIG_FHA_1 246 252 PF00498 0.504
LIG_FHA_1 505 511 PF00498 0.546
LIG_FHA_1 514 520 PF00498 0.506
LIG_FHA_1 604 610 PF00498 0.526
LIG_FHA_1 677 683 PF00498 0.561
LIG_FHA_1 730 736 PF00498 0.624
LIG_FHA_1 756 762 PF00498 0.489
LIG_FHA_1 76 82 PF00498 0.537
LIG_FHA_2 170 176 PF00498 0.435
LIG_FHA_2 463 469 PF00498 0.513
LIG_FHA_2 552 558 PF00498 0.463
LIG_FHA_2 594 600 PF00498 0.481
LIG_FHA_2 739 745 PF00498 0.527
LIG_FHA_2 98 104 PF00498 0.510
LIG_GBD_Chelix_1 601 609 PF00786 0.337
LIG_HCF-1_HBM_1 824 827 PF13415 0.587
LIG_LIR_Apic_2 379 385 PF02991 0.747
LIG_LIR_Apic_2 631 636 PF02991 0.506
LIG_LIR_Gen_1 114 124 PF02991 0.573
LIG_LIR_Gen_1 179 189 PF02991 0.500
LIG_LIR_Gen_1 522 532 PF02991 0.520
LIG_LIR_Gen_1 622 633 PF02991 0.601
LIG_LIR_Nem_3 179 185 PF02991 0.498
LIG_LIR_Nem_3 220 226 PF02991 0.467
LIG_LIR_Nem_3 235 241 PF02991 0.460
LIG_LIR_Nem_3 307 313 PF02991 0.624
LIG_LIR_Nem_3 522 527 PF02991 0.505
LIG_LIR_Nem_3 622 628 PF02991 0.551
LIG_LIR_Nem_3 766 772 PF02991 0.506
LIG_NRBOX 798 804 PF00104 0.520
LIG_NRBOX 8 14 PF00104 0.283
LIG_Pex14_2 182 186 PF04695 0.481
LIG_PTAP_UEV_1 341 346 PF05743 0.583
LIG_PTB_Apo_2 222 229 PF02174 0.519
LIG_PTB_Phospho_1 222 228 PF10480 0.519
LIG_SH2_CRK 769 773 PF00017 0.499
LIG_SH2_GRB2like 124 127 PF00017 0.585
LIG_SH2_NCK_1 585 589 PF00017 0.479
LIG_SH2_PTP2 166 169 PF00017 0.506
LIG_SH2_PTP2 496 499 PF00017 0.492
LIG_SH2_PTP2 627 630 PF00017 0.587
LIG_SH2_SRC 122 125 PF00017 0.561
LIG_SH2_STAP1 452 456 PF00017 0.362
LIG_SH2_STAT3 40 43 PF00017 0.699
LIG_SH2_STAT5 122 125 PF00017 0.602
LIG_SH2_STAT5 166 169 PF00017 0.502
LIG_SH2_STAT5 241 244 PF00017 0.480
LIG_SH2_STAT5 40 43 PF00017 0.678
LIG_SH2_STAT5 419 422 PF00017 0.424
LIG_SH2_STAT5 496 499 PF00017 0.463
LIG_SH2_STAT5 514 517 PF00017 0.463
LIG_SH2_STAT5 558 561 PF00017 0.474
LIG_SH2_STAT5 6 9 PF00017 0.443
LIG_SH2_STAT5 613 616 PF00017 0.521
LIG_SH2_STAT5 627 630 PF00017 0.531
LIG_SH2_STAT5 692 695 PF00017 0.524
LIG_SH2_STAT5 756 759 PF00017 0.518
LIG_SH2_STAT5 817 820 PF00017 0.544
LIG_SH2_STAT5 827 830 PF00017 0.513
LIG_SH3_3 135 141 PF00018 0.641
LIG_SH3_3 208 214 PF00018 0.491
LIG_SH3_3 300 306 PF00018 0.594
LIG_SH3_3 339 345 PF00018 0.683
LIG_SH3_3 378 384 PF00018 0.695
LIG_SH3_3 439 445 PF00018 0.484
LIG_SH3_4 305 312 PF00018 0.651
LIG_SUMO_SIM_anti_2 596 602 PF11976 0.492
LIG_SUMO_SIM_par_1 284 290 PF11976 0.516
LIG_TRAF2_1 287 290 PF00917 0.572
LIG_TYR_ITIM 164 169 PF00017 0.489
LIG_TYR_ITIM 767 772 PF00017 0.490
LIG_UBA3_1 132 137 PF00899 0.619
LIG_UBA3_1 285 291 PF00899 0.525
LIG_UBA3_1 527 534 PF00899 0.418
MOD_CDK_SPxK_1 150 156 PF00069 0.787
MOD_CK1_1 114 120 PF00069 0.546
MOD_CK1_1 140 146 PF00069 0.746
MOD_CK1_1 202 208 PF00069 0.434
MOD_CK1_1 413 419 PF00069 0.500
MOD_CK1_1 425 431 PF00069 0.495
MOD_CK1_1 586 592 PF00069 0.463
MOD_CK1_1 593 599 PF00069 0.463
MOD_CK1_1 61 67 PF00069 0.726
MOD_CK1_1 738 744 PF00069 0.572
MOD_CK2_1 114 120 PF00069 0.552
MOD_CK2_1 169 175 PF00069 0.443
MOD_CK2_1 363 369 PF00069 0.713
MOD_CK2_1 462 468 PF00069 0.514
MOD_CK2_1 593 599 PF00069 0.474
MOD_GlcNHglycan 215 218 PF01048 0.278
MOD_GlcNHglycan 243 246 PF01048 0.252
MOD_GlcNHglycan 314 317 PF01048 0.414
MOD_GlcNHglycan 342 345 PF01048 0.431
MOD_GlcNHglycan 373 376 PF01048 0.537
MOD_GlcNHglycan 544 547 PF01048 0.235
MOD_GlcNHglycan 58 61 PF01048 0.546
MOD_GlcNHglycan 63 66 PF01048 0.568
MOD_GlcNHglycan 630 633 PF01048 0.355
MOD_GlcNHglycan 73 78 PF01048 0.402
MOD_GlcNHglycan 775 778 PF01048 0.369
MOD_GlcNHglycan 784 787 PF01048 0.306
MOD_GlcNHglycan 86 89 PF01048 0.343
MOD_GSK3_1 136 143 PF00069 0.766
MOD_GSK3_1 195 202 PF00069 0.553
MOD_GSK3_1 241 248 PF00069 0.522
MOD_GSK3_1 312 319 PF00069 0.663
MOD_GSK3_1 320 327 PF00069 0.715
MOD_GSK3_1 336 343 PF00069 0.762
MOD_GSK3_1 358 365 PF00069 0.675
MOD_GSK3_1 410 417 PF00069 0.483
MOD_GSK3_1 536 543 PF00069 0.433
MOD_GSK3_1 586 593 PF00069 0.451
MOD_GSK3_1 61 68 PF00069 0.716
MOD_GSK3_1 724 731 PF00069 0.713
MOD_GSK3_1 782 789 PF00069 0.514
MOD_NEK2_1 15 20 PF00069 0.301
MOD_NEK2_1 233 238 PF00069 0.473
MOD_NEK2_1 294 299 PF00069 0.661
MOD_NEK2_1 312 317 PF00069 0.679
MOD_NEK2_1 358 363 PF00069 0.676
MOD_NEK2_1 469 474 PF00069 0.424
MOD_NEK2_1 609 614 PF00069 0.553
MOD_NEK2_1 735 740 PF00069 0.553
MOD_NEK2_1 771 776 PF00069 0.536
MOD_NEK2_1 97 102 PF00069 0.573
MOD_NEK2_2 256 261 PF00069 0.362
MOD_PIKK_1 200 206 PF00454 0.362
MOD_PIKK_1 402 408 PF00454 0.497
MOD_PIKK_1 577 583 PF00454 0.452
MOD_PIKK_1 58 64 PF00454 0.645
MOD_PK_1 454 460 PF00069 0.452
MOD_PK_1 583 589 PF00069 0.463
MOD_PKA_1 194 200 PF00069 0.452
MOD_PKA_1 504 510 PF00069 0.495
MOD_PKA_2 114 120 PF00069 0.552
MOD_PKA_2 194 200 PF00069 0.452
MOD_PKA_2 410 416 PF00069 0.490
MOD_PKA_2 541 547 PF00069 0.362
MOD_PKA_2 590 596 PF00069 0.537
MOD_PKA_2 687 693 PF00069 0.502
MOD_PKA_2 699 705 PF00069 0.519
MOD_PKA_2 724 730 PF00069 0.737
MOD_PKB_1 398 406 PF00069 0.522
MOD_Plk_1 234 240 PF00069 0.471
MOD_Plk_1 463 469 PF00069 0.397
MOD_Plk_1 786 792 PF00069 0.539
MOD_Plk_4 17 23 PF00069 0.381
MOD_Plk_4 247 253 PF00069 0.537
MOD_Plk_4 389 395 PF00069 0.614
MOD_Plk_4 414 420 PF00069 0.456
MOD_Plk_4 609 615 PF00069 0.524
MOD_Plk_4 676 682 PF00069 0.582
MOD_Plk_4 735 741 PF00069 0.524
MOD_Plk_4 756 762 PF00069 0.608
MOD_ProDKin_1 137 143 PF00069 0.687
MOD_ProDKin_1 150 156 PF00069 0.756
MOD_ProDKin_1 158 164 PF00069 0.657
MOD_ProDKin_1 324 330 PF00069 0.702
MOD_ProDKin_1 441 447 PF00069 0.404
MOD_SUMO_for_1 304 307 PF00179 0.636
TRG_DiLeu_BaEn_4 289 295 PF01217 0.551
TRG_ENDOCYTIC_2 166 169 PF00928 0.485
TRG_ENDOCYTIC_2 227 230 PF00928 0.465
TRG_ENDOCYTIC_2 496 499 PF00928 0.463
TRG_ENDOCYTIC_2 584 587 PF00928 0.481
TRG_ENDOCYTIC_2 6 9 PF00928 0.418
TRG_ENDOCYTIC_2 627 630 PF00928 0.587
TRG_ENDOCYTIC_2 769 772 PF00928 0.574
TRG_ER_diArg_1 193 195 PF00400 0.537
TRG_ER_diArg_1 23 25 PF00400 0.396
TRG_ER_diArg_1 398 401 PF00400 0.484
TRG_ER_diArg_1 818 820 PF00400 0.566
TRG_NLS_MonoCore_2 546 551 PF00514 0.469
TRG_NLS_MonoExtC_3 546 551 PF00514 0.362
TRG_NLS_MonoExtN_4 547 554 PF00514 0.537
TRG_Pf-PMV_PEXEL_1 603 607 PF00026 0.281
TRG_Pf-PMV_PEXEL_1 826 830 PF00026 0.312

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7X2 Leptomonas seymouri 30% 100%
A0A0N1IBR8 Leptomonas seymouri 67% 100%
A0A1X0P5U2 Trypanosomatidae 41% 100%
A0A2U1KZS6 Artemisia annua 24% 100%
A0A3Q8II21 Leishmania donovani 85% 100%
A0A3R7K908 Trypanosoma rangeli 42% 100%
A0A3S7X1H9 Leishmania donovani 29% 100%
A0A422N1R6 Trypanosoma rangeli 29% 100%
A2AI05 Mus musculus 23% 100%
A4HAY4 Leishmania braziliensis 23% 100%
A4HGH1 Leishmania braziliensis 28% 100%
A4I3K3 Leishmania infantum 30% 100%
A4IBG5 Leishmania infantum 85% 100%
C5YJG8 Sorghum bicolor 25% 100%
C9ZZA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
D0A7U1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
D0A835 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AF79 Leishmania major 84% 100%
E9AZU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6D5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
P0CP12 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 24% 100%
P0CP13 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 24% 100%
P16603 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P29473 Bos taurus 22% 69%
P29477 Mus musculus 23% 73%
P37116 Vigna radiata var. radiata 23% 100%
P37201 Candida tropicalis 21% 100%
P70313 Mus musculus 22% 69%
Q05001 Catharanthus roseus 25% 100%
Q07994 Musca domestica 25% 100%
Q0J705 Oryza sativa subsp. japonica 24% 100%
Q1JPJ0 Bos taurus 24% 100%
Q28969 Sus scrofa 21% 69%
Q4JIJ2 Bos taurus 26% 100%
Q4Q2S8 Leishmania major 23% 96%
Q4Q8E2 Leishmania major 37% 100%
Q5BB41 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 23% 100%
Q62600 Rattus norvegicus 22% 69%
Q6NRG5 Xenopus laevis 23% 100%
Q6PFP6 Danio rerio 22% 100%
Q7X7K8 Oryza sativa subsp. japonica 25% 100%
Q8C1A3 Mus musculus 23% 100%
Q9SB48 Arabidopsis thaliana 22% 100%
Q9UBK8 Homo sapiens 23% 100%
Q9UHB4 Homo sapiens 24% 100%
Q9US28 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS