Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 9

Species:

Leishmania braziliensis

UniProt:

A4HMS6_LEIBR

TriTrypDb:

LbrM.34.2480 , LBRM2903_340032500

Length:

458

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMS6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.535
CLV_C14_Caspase3-7	386	390	PF00656	0.805
CLV_NRD_NRD_1	140	142	PF00675	0.571
CLV_NRD_NRD_1	363	365	PF00675	0.546
CLV_NRD_NRD_1	367	369	PF00675	0.552
CLV_NRD_NRD_1	380	382	PF00675	0.591
CLV_NRD_NRD_1	423	425	PF00675	0.574
CLV_NRD_NRD_1	47	49	PF00675	0.490
CLV_PCSK_FUR_1	364	368	PF00082	0.545
CLV_PCSK_KEX2_1	140	142	PF00082	0.627
CLV_PCSK_KEX2_1	177	179	PF00082	0.233
CLV_PCSK_KEX2_1	302	304	PF00082	0.264
CLV_PCSK_KEX2_1	363	365	PF00082	0.546
CLV_PCSK_KEX2_1	366	368	PF00082	0.549
CLV_PCSK_KEX2_1	382	384	PF00082	0.587
CLV_PCSK_KEX2_1	423	425	PF00082	0.646
CLV_PCSK_KEX2_1	47	49	PF00082	0.561
CLV_PCSK_KEX2_1	60	62	PF00082	0.548
CLV_PCSK_KEX2_1	78	80	PF00082	0.727
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.233
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.262
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.549
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.587
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.536
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.490
CLV_PCSK_PC7_1	363	369	PF00082	0.595
CLV_PCSK_SKI1_1	118	122	PF00082	0.606
CLV_PCSK_SKI1_1	148	152	PF00082	0.517
CLV_PCSK_SKI1_1	164	168	PF00082	0.238
CLV_PCSK_SKI1_1	182	186	PF00082	0.239
CLV_PCSK_SKI1_1	223	227	PF00082	0.599
CLV_PCSK_SKI1_1	299	303	PF00082	0.217
CLV_PCSK_SKI1_1	354	358	PF00082	0.586
CLV_PCSK_SKI1_1	43	47	PF00082	0.559
CLV_PCSK_SKI1_1	60	64	PF00082	0.514
CLV_PCSK_SKI1_1	96	100	PF00082	0.593
CLV_Separin_Metazoa	93	97	PF03568	0.584
DEG_SPOP_SBC_1	100	104	PF00917	0.658
DEG_SPOP_SBC_1	358	362	PF00917	0.479
DOC_ANK_TNKS_1	110	117	PF00023	0.504
DOC_ANK_TNKS_1	430	437	PF00023	0.552
DOC_MAPK_gen_1	50	59	PF00069	0.469
DOC_PP1_RVXF_1	435	441	PF00149	0.635
DOC_PP4_FxxP_1	403	406	PF00568	0.608
DOC_USP7_MATH_1	14	18	PF00917	0.613
DOC_USP7_MATH_1	271	275	PF00917	0.344
DOC_USP7_MATH_1	359	363	PF00917	0.675
DOC_USP7_MATH_1	82	86	PF00917	0.626
DOC_USP7_MATH_1	98	102	PF00917	0.501
DOC_USP7_UBL2_3	144	148	PF12436	0.518
DOC_USP7_UBL2_3	222	226	PF12436	0.506
DOC_USP7_UBL2_3	437	441	PF12436	0.650
LIG_BRCT_BRCA1_1	399	403	PF00533	0.532
LIG_BRCT_BRCA1_2	399	405	PF00533	0.526
LIG_deltaCOP1_diTrp_1	286	293	PF00928	0.431
LIG_FHA_1	125	131	PF00498	0.505
LIG_FHA_1	163	169	PF00498	0.274
LIG_FHA_1	228	234	PF00498	0.427
LIG_FHA_1	259	265	PF00498	0.585
LIG_FHA_2	121	127	PF00498	0.613
LIG_FHA_2	258	264	PF00498	0.363
LIG_FHA_2	282	288	PF00498	0.444
LIG_FHA_2	29	35	PF00498	0.563
LIG_FHA_2	333	339	PF00498	0.478
LIG_FHA_2	44	50	PF00498	0.474
LIG_Integrin_isoDGR_2	341	343	PF01839	0.244
LIG_Integrin_RGD_1	336	338	PF01839	0.278
LIG_LIR_Apic_2	400	406	PF02991	0.611
LIG_LIR_Gen_1	119	125	PF02991	0.558
LIG_LIR_Gen_1	229	238	PF02991	0.387
LIG_LIR_Gen_1	287	298	PF02991	0.452
LIG_LIR_Nem_3	119	124	PF02991	0.484
LIG_LIR_Nem_3	229	235	PF02991	0.373
LIG_LIR_Nem_3	287	293	PF02991	0.452
LIG_LIR_Nem_3	414	418	PF02991	0.533
LIG_Pex14_2	121	125	PF04695	0.649
LIG_PTB_Apo_2	276	283	PF02174	0.431
LIG_PTB_Phospho_1	276	282	PF10480	0.431
LIG_SH2_STAP1	227	231	PF00017	0.320
LIG_SH2_STAT5	232	235	PF00017	0.360
LIG_SH2_STAT5	320	323	PF00017	0.431
LIG_SH3_2	445	450	PF14604	0.596
LIG_SH3_3	442	448	PF00018	0.579
LIG_TRAF2_1	135	138	PF00917	0.644
LIG_TRAF2_1	157	160	PF00917	0.590
LIG_TRAF2_1	199	202	PF00917	0.469
LIG_TRAF2_1	284	287	PF00917	0.431
LIG_UBA3_1	53	60	PF00899	0.652
MOD_CK1_1	101	107	PF00069	0.590
MOD_CK1_1	186	192	PF00069	0.548
MOD_CK1_1	237	243	PF00069	0.497
MOD_CK1_1	4	10	PF00069	0.589
MOD_CK1_1	85	91	PF00069	0.743
MOD_CK2_1	116	122	PF00069	0.571
MOD_CK2_1	240	246	PF00069	0.489
MOD_CK2_1	281	287	PF00069	0.431
MOD_CK2_1	359	365	PF00069	0.554
MOD_CK2_1	43	49	PF00069	0.481
MOD_Cter_Amidation	138	141	PF01082	0.600
MOD_Cter_Amidation	76	79	PF01082	0.799
MOD_GlcNHglycan	103	106	PF01048	0.624
MOD_GlcNHglycan	236	239	PF01048	0.390
MOD_GlcNHglycan	242	245	PF01048	0.389
MOD_GlcNHglycan	3	6	PF01048	0.555
MOD_GlcNHglycan	86	90	PF01048	0.676
MOD_GlcNHglycan	96	99	PF01048	0.708
MOD_GSK3_1	116	123	PF00069	0.573
MOD_GSK3_1	383	390	PF00069	0.522
MOD_GSK3_1	393	400	PF00069	0.714
MOD_GSK3_1	407	414	PF00069	0.575
MOD_GSK3_1	60	67	PF00069	0.414
MOD_GSK3_1	94	101	PF00069	0.656
MOD_N-GLC_1	350	355	PF02516	0.619
MOD_N-GLC_1	407	412	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	120	125	PF00069	0.652
MOD_NEK2_1	28	33	PF00069	0.672
MOD_NEK2_1	324	329	PF00069	0.496
MOD_NEK2_1	35	40	PF00069	0.704
MOD_NEK2_2	116	121	PF00069	0.562
MOD_NEK2_2	271	276	PF00069	0.344
MOD_PIKK_1	133	139	PF00454	0.541
MOD_PKA_1	143	149	PF00069	0.641
MOD_PKA_1	43	49	PF00069	0.493
MOD_PKA_1	60	66	PF00069	0.481
MOD_PKA_2	309	315	PF00069	0.431
MOD_PKA_2	60	66	PF00069	0.600
MOD_PKA_2	82	88	PF00069	0.722
MOD_PKB_1	141	149	PF00069	0.646
MOD_PKB_1	381	389	PF00069	0.592
MOD_Plk_1	271	277	PF00069	0.346
MOD_Plk_1	85	91	PF00069	0.460
MOD_Plk_2-3	64	70	PF00069	0.440
MOD_Plk_4	120	126	PF00069	0.541
MOD_Plk_4	271	277	PF00069	0.345
MOD_SUMO_rev_2	122	130	PF00179	0.613
MOD_SUMO_rev_2	220	228	PF00179	0.496
MOD_SUMO_rev_2	295	304	PF00179	0.487
MOD_SUMO_rev_2	309	318	PF00179	0.487
MOD_SUMO_rev_2	353	359	PF00179	0.673
MOD_SUMO_rev_2	374	384	PF00179	0.712
MOD_SUMO_rev_2	429	438	PF00179	0.572
MOD_SUMO_rev_2	56	62	PF00179	0.528
MOD_SUMO_rev_2	64	73	PF00179	0.513
TRG_DiLeu_BaEn_1	246	251	PF01217	0.431
TRG_DiLeu_BaEn_2	271	277	PF01217	0.358
TRG_ENDOCYTIC_2	232	235	PF00928	0.379
TRG_ENDOCYTIC_2	320	323	PF00928	0.431
TRG_ER_diArg_1	140	143	PF00400	0.663
TRG_ER_diArg_1	193	196	PF00400	0.454
TRG_ER_diArg_1	303	306	PF00400	0.434
TRG_ER_diArg_1	422	424	PF00400	0.632
TRG_NLS_Bipartite_1	366	386	PF00514	0.665
TRG_NLS_MonoCore_2	403	408	PF00514	0.708
TRG_NLS_MonoExtC_3	381	387	PF00514	0.657
TRG_NLS_MonoExtC_3	403	409	PF00514	0.622
TRG_NLS_MonoExtN_4	299	306	PF00514	0.413
TRG_NLS_MonoExtN_4	381	386	PF00514	0.619
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	132	137	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	215	220	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	431	435	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	52	56	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R8	Leptomonas seymouri	71%	100%
A0A1X0P6L1	Trypanosomatidae	45%	100%
A0A3Q8IPK7	Leishmania donovani	84%	100%
A0A3R7LUT6	Trypanosoma rangeli	46%	100%
C9ZZA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AF78	Leishmania major	85%	100%
E9B6D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BNV3	Trypanosoma cruzi	47%	100%