Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HMS5_LEIBR

TriTrypDb:

LbrM.34.2470 , LBRM2903_340032400

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HMS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMS5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.421
CLV_C14_Caspase3-7	3	7	PF00656	0.589
CLV_NRD_NRD_1	37	39	PF00675	0.612
CLV_PCSK_SKI1_1	134	138	PF00082	0.433
CLV_PCSK_SKI1_1	93	97	PF00082	0.791
DEG_Nend_Nbox_1	1	3	PF02207	0.785
DOC_MAPK_gen_1	124	132	PF00069	0.760
DOC_MAPK_MEF2A_6	134	142	PF00069	0.530
DOC_MAPK_MEF2A_6	4	12	PF00069	0.455
DOC_USP7_MATH_1	57	61	PF00917	0.584
DOC_USP7_MATH_1	77	81	PF00917	0.415
DOC_USP7_MATH_2	63	69	PF00917	0.441
DOC_WW_Pin1_4	199	204	PF00397	0.476
DOC_WW_Pin1_4	25	30	PF00397	0.530
DOC_WW_Pin1_4	59	64	PF00397	0.480
LIG_14-3-3_CanoR_1	134	139	PF00244	0.377
LIG_14-3-3_CanoR_1	78	84	PF00244	0.603
LIG_14-3-3_CanoR_1	93	101	PF00244	0.259
LIG_BRCT_BRCA1_1	182	186	PF00533	0.435
LIG_BRCT_BRCA1_1	70	74	PF00533	0.430
LIG_FHA_1	135	141	PF00498	0.351
LIG_FHA_1	17	23	PF00498	0.322
LIG_FHA_1	3	9	PF00498	0.623
LIG_FHA_1	53	59	PF00498	0.417
LIG_FHA_1	94	100	PF00498	0.427
LIG_FHA_2	170	176	PF00498	0.423
LIG_GBD_Chelix_1	142	150	PF00786	0.261
LIG_IRF3_LxIS_1	110	115	PF10401	0.277
LIG_LIR_Gen_1	13	22	PF02991	0.374
LIG_LIR_Gen_1	133	144	PF02991	0.456
LIG_LIR_Gen_1	183	194	PF02991	0.530
LIG_LIR_Gen_1	96	106	PF02991	0.530
LIG_LIR_LC3C_4	115	118	PF02991	0.277
LIG_LIR_Nem_3	13	17	PF02991	0.374
LIG_LIR_Nem_3	133	139	PF02991	0.456
LIG_LIR_Nem_3	183	189	PF02991	0.530
LIG_LIR_Nem_3	96	101	PF02991	0.530
LIG_MLH1_MIPbox_1	182	186	PF16413	0.435
LIG_SH2_CRK	14	18	PF00017	0.530
LIG_SH2_CRK	49	53	PF00017	0.589
LIG_SH2_NCK_1	49	53	PF00017	0.589
LIG_SH2_STAP1	14	18	PF00017	0.530
LIG_SH2_STAT5	11	14	PF00017	0.530
LIG_SH2_STAT5	98	101	PF00017	0.530
LIG_SH3_3	135	141	PF00018	0.384
LIG_SH3_3	23	29	PF00018	0.530
LIG_SUMO_SIM_anti_2	108	115	PF11976	0.530
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.277
LIG_SUMO_SIM_par_1	128	133	PF11976	0.604
LIG_TRFH_1	49	53	PF08558	0.408
LIG_Vh1_VBS_1	99	117	PF01044	0.296
MOD_CK1_1	25	31	PF00069	0.400
MOD_CK1_1	64	70	PF00069	0.552
MOD_CK1_1	89	95	PF00069	0.597
MOD_CK2_1	31	37	PF00069	0.604
MOD_CK2_1	59	65	PF00069	0.437
MOD_GlcNHglycan	182	185	PF01048	0.636
MOD_GSK3_1	108	115	PF00069	0.290
MOD_GSK3_1	130	137	PF00069	0.713
MOD_GSK3_1	167	174	PF00069	0.474
MOD_GSK3_1	176	183	PF00069	0.550
MOD_GSK3_1	199	206	PF00069	0.364
MOD_GSK3_1	57	64	PF00069	0.513
MOD_GSK3_1	85	92	PF00069	0.522
MOD_N-GLC_1	68	73	PF02516	0.631
MOD_NEK2_1	10	15	PF00069	0.530
MOD_NEK2_1	112	117	PF00069	0.389
MOD_NEK2_1	185	190	PF00069	0.516
MOD_NEK2_1	194	199	PF00069	0.265
MOD_PIKK_1	68	74	PF00454	0.440
MOD_PK_1	4	10	PF00069	0.455
MOD_PKA_2	77	83	PF00069	0.582
MOD_Plk_4	108	114	PF00069	0.522
MOD_Plk_4	22	28	PF00069	0.356
MOD_Plk_4	4	10	PF00069	0.501
MOD_ProDKin_1	199	205	PF00069	0.476
MOD_ProDKin_1	25	31	PF00069	0.530
MOD_ProDKin_1	59	65	PF00069	0.481
MOD_SUMO_rev_2	34	40	PF00179	0.424
TRG_ENDOCYTIC_2	14	17	PF00928	0.530
TRG_ENDOCYTIC_2	161	164	PF00928	0.599
TRG_ENDOCYTIC_2	98	101	PF00928	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7Z5	Leishmania donovani	67%	97%
A4IBG3	Leishmania infantum	67%	97%
E9AF77	Leishmania major	65%	100%
E9B6D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	97%