Pecanex_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMS3_LEIBR

TriTrypDb:

LbrM.34.2440 , LBRM2903_340032000

Length:

554

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.458
CLV_C14_Caspase3-7	450	454	PF00656	0.797
CLV_C14_Caspase3-7	83	87	PF00656	0.421
CLV_NRD_NRD_1	186	188	PF00675	0.628
CLV_NRD_NRD_1	210	212	PF00675	0.631
CLV_NRD_NRD_1	382	384	PF00675	0.370
CLV_NRD_NRD_1	499	501	PF00675	0.301
CLV_NRD_NRD_1	98	100	PF00675	0.724
CLV_PCSK_KEX2_1	212	214	PF00082	0.612
CLV_PCSK_KEX2_1	382	384	PF00082	0.370
CLV_PCSK_KEX2_1	469	471	PF00082	0.532
CLV_PCSK_KEX2_1	499	501	PF00082	0.301
CLV_PCSK_KEX2_1	98	100	PF00082	0.756
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.665
CLV_PCSK_PC1ET2_1	469	471	PF00082	0.532
CLV_PCSK_SKI1_1	127	131	PF00082	0.574
CLV_PCSK_SKI1_1	423	427	PF00082	0.450
CLV_PCSK_SKI1_1	436	440	PF00082	0.448
DEG_APCC_DBOX_1	364	372	PF00400	0.548
DEG_SPOP_SBC_1	321	325	PF00917	0.452
DOC_CKS1_1	47	52	PF01111	0.659
DOC_CYCLIN_yCln2_LP_2	173	179	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	41	44	PF00134	0.683
DOC_MAPK_gen_1	98	106	PF00069	0.607
DOC_PP1_RVXF_1	409	415	PF00149	0.374
DOC_PP2B_LxvP_1	41	44	PF13499	0.653
DOC_PP4_FxxP_1	286	289	PF00568	0.619
DOC_USP7_MATH_1	129	133	PF00917	0.622
DOC_USP7_MATH_1	155	159	PF00917	0.515
DOC_USP7_MATH_1	194	198	PF00917	0.711
DOC_USP7_MATH_1	300	304	PF00917	0.627
DOC_USP7_MATH_1	321	325	PF00917	0.508
DOC_USP7_MATH_1	539	543	PF00917	0.726
DOC_USP7_MATH_1	65	69	PF00917	0.658
DOC_USP7_MATH_1	85	89	PF00917	0.382
DOC_WW_Pin1_4	198	203	PF00397	0.775
DOC_WW_Pin1_4	226	231	PF00397	0.648
DOC_WW_Pin1_4	294	299	PF00397	0.590
DOC_WW_Pin1_4	322	327	PF00397	0.571
DOC_WW_Pin1_4	46	51	PF00397	0.603
LIG_14-3-3_CanoR_1	101	107	PF00244	0.437
LIG_14-3-3_CanoR_1	27	32	PF00244	0.586
LIG_14-3-3_CanoR_1	280	290	PF00244	0.588
LIG_14-3-3_CanoR_1	335	345	PF00244	0.484
LIG_14-3-3_CanoR_1	432	440	PF00244	0.487
LIG_Actin_WH2_2	405	421	PF00022	0.295
LIG_APCC_ABBA_1	35	40	PF00400	0.499
LIG_BIR_II_1	1	5	PF00653	0.598
LIG_BRCT_BRCA1_1	157	161	PF00533	0.454
LIG_BRCT_BRCA1_1	196	200	PF00533	0.674
LIG_CSL_BTD_1	225	228	PF09270	0.604
LIG_deltaCOP1_diTrp_1	224	233	PF00928	0.611
LIG_eIF4E_1	36	42	PF01652	0.500
LIG_EVH1_1	42	46	PF00568	0.573
LIG_FHA_1	282	288	PF00498	0.631
LIG_FHA_1	290	296	PF00498	0.594
LIG_FHA_1	391	397	PF00498	0.480
LIG_FHA_1	47	53	PF00498	0.564
LIG_FHA_1	473	479	PF00498	0.448
LIG_FHA_1	73	79	PF00498	0.676
LIG_FHA_2	191	197	PF00498	0.688
LIG_FHA_2	233	239	PF00498	0.544
LIG_FHA_2	252	258	PF00498	0.493
LIG_FHA_2	263	269	PF00498	0.497
LIG_FHA_2	27	33	PF00498	0.549
LIG_FHA_2	402	408	PF00498	0.532
LIG_LIR_Apic_2	268	273	PF02991	0.547
LIG_LIR_Apic_2	28	34	PF02991	0.523
LIG_LIR_Apic_2	284	289	PF02991	0.598
LIG_LIR_Gen_1	158	166	PF02991	0.443
LIG_LIR_Nem_3	158	164	PF02991	0.450
LIG_LIR_Nem_3	328	334	PF02991	0.623
LIG_LIR_Nem_3	339	345	PF02991	0.500
LIG_MYND_1	39	43	PF01753	0.521
LIG_PCNA_PIPBox_1	514	523	PF02747	0.473
LIG_Pex14_1	477	481	PF04695	0.371
LIG_SH2_CRK	343	347	PF00017	0.449
LIG_SH2_SRC	31	34	PF00017	0.524
LIG_SH2_STAP1	343	347	PF00017	0.449
LIG_SH2_STAP1	474	478	PF00017	0.483
LIG_SH2_STAT5	330	333	PF00017	0.561
LIG_SH2_STAT5	36	39	PF00017	0.495
LIG_SH2_STAT5	374	377	PF00017	0.500
LIG_SH2_STAT5	402	405	PF00017	0.522
LIG_SH2_STAT5	474	477	PF00017	0.486
LIG_SH3_3	284	290	PF00018	0.690
LIG_SH3_3	292	298	PF00018	0.671
LIG_SH3_3	40	46	PF00018	0.553
LIG_SH3_3	414	420	PF00018	0.486
LIG_SH3_3	47	53	PF00018	0.585
LIG_SH3_5	326	330	PF00018	0.527
LIG_SUMO_SIM_anti_2	505	512	PF11976	0.510
LIG_SUMO_SIM_par_1	102	108	PF11976	0.634
LIG_SUMO_SIM_par_1	345	352	PF11976	0.299
LIG_SUMO_SIM_par_1	505	512	PF11976	0.510
LIG_TRAF2_1	149	152	PF00917	0.643
LIG_TRAF2_1	189	192	PF00917	0.555
LIG_WW_1	33	36	PF00397	0.477
LIG_WW_2	50	53	PF00397	0.652
MOD_CK1_1	131	137	PF00069	0.389
MOD_CK1_1	26	32	PF00069	0.700
MOD_CK1_1	324	330	PF00069	0.581
MOD_CK1_1	348	354	PF00069	0.445
MOD_CK1_1	540	546	PF00069	0.776
MOD_CK2_1	146	152	PF00069	0.632
MOD_CK2_1	190	196	PF00069	0.751
MOD_CK2_1	232	238	PF00069	0.659
MOD_CK2_1	251	257	PF00069	0.559
MOD_CK2_1	26	32	PF00069	0.553
MOD_CK2_1	262	268	PF00069	0.633
MOD_CK2_1	401	407	PF00069	0.531
MOD_CK2_1	431	437	PF00069	0.474
MOD_CK2_1	443	449	PF00069	0.776
MOD_GlcNHglycan	131	134	PF01048	0.532
MOD_GlcNHglycan	196	199	PF01048	0.713
MOD_GlcNHglycan	351	354	PF01048	0.642
MOD_GlcNHglycan	356	359	PF01048	0.683
MOD_GlcNHglycan	378	381	PF01048	0.447
MOD_GSK3_1	1	8	PF00069	0.514
MOD_GSK3_1	134	141	PF00069	0.589
MOD_GSK3_1	190	197	PF00069	0.726
MOD_GSK3_1	198	205	PF00069	0.718
MOD_GSK3_1	23	30	PF00069	0.696
MOD_GSK3_1	289	296	PF00069	0.584
MOD_GSK3_1	320	327	PF00069	0.680
MOD_GSK3_1	345	352	PF00069	0.307
MOD_GSK3_1	533	540	PF00069	0.737
MOD_N-GLC_1	293	298	PF02516	0.514
MOD_N-GLC_1	537	542	PF02516	0.753
MOD_NEK2_1	23	28	PF00069	0.623
MOD_NEK2_1	239	244	PF00069	0.567
MOD_NEK2_1	262	267	PF00069	0.491
MOD_NEK2_1	521	526	PF00069	0.391
MOD_PIKK_1	200	206	PF00454	0.501
MOD_PIKK_1	72	78	PF00454	0.588
MOD_PKA_1	211	217	PF00069	0.654
MOD_PKA_2	239	245	PF00069	0.622
MOD_PKA_2	26	32	PF00069	0.588
MOD_PKA_2	376	382	PF00069	0.476
MOD_PKA_2	431	437	PF00069	0.470
MOD_Plk_1	369	375	PF00069	0.486
MOD_Plk_1	537	543	PF00069	0.718
MOD_Plk_1	72	78	PF00069	0.524
MOD_Plk_1	85	91	PF00069	0.657
MOD_Plk_2-3	449	455	PF00069	0.658
MOD_Plk_4	105	111	PF00069	0.499
MOD_Plk_4	131	137	PF00069	0.480
MOD_Plk_4	370	376	PF00069	0.552
MOD_Plk_4	391	397	PF00069	0.323
MOD_Plk_4	472	478	PF00069	0.455
MOD_ProDKin_1	198	204	PF00069	0.774
MOD_ProDKin_1	226	232	PF00069	0.648
MOD_ProDKin_1	294	300	PF00069	0.582
MOD_ProDKin_1	322	328	PF00069	0.570
MOD_ProDKin_1	46	52	PF00069	0.603
MOD_SUMO_for_1	546	549	PF00179	0.608
MOD_SUMO_rev_2	183	189	PF00179	0.660
TRG_DiLeu_BaEn_3	151	157	PF01217	0.586
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.602
TRG_ENDOCYTIC_2	343	346	PF00928	0.451
TRG_ER_diArg_1	210	213	PF00400	0.530
TRG_ER_diArg_1	381	383	PF00400	0.353
TRG_ER_diArg_1	498	500	PF00400	0.322
TRG_ER_diArg_1	98	101	PF00400	0.663
TRG_NLS_MonoExtC_3	210	215	PF00514	0.719
TRG_NLS_MonoExtN_4	208	215	PF00514	0.720
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG0	Leptomonas seymouri	60%	100%
A0A1X0P5K7	Trypanosomatidae	33%	100%
A0A3Q8IJ29	Leishmania donovani	80%	100%
A0A3R7KY71	Trypanosoma rangeli	36%	100%
A4IBF9	Leishmania infantum	80%	100%
C9ZZA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AF73	Leishmania major	80%	100%
E9B6C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
V5DK90	Trypanosoma cruzi	36%	100%