Ribosome biogenesis protein NOP53

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nop53 (60S ribosomal biogenesis), putative

Species:

Leishmania braziliensis

UniProt:

A4HMS1_LEIBR

TriTrypDb:

LbrM.34.2420 , LBRM2903_340031800

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	10
GO:0005730	nucleolus	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HMS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMS1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	10
GO:0022613	ribonucleoprotein complex biogenesis	4	9
GO:0042254	ribosome biogenesis	5	9
GO:0044085	cellular component biogenesis	3	9
GO:0071840	cellular component organization or biogenesis	2	10
GO:0000027	ribosomal large subunit assembly	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0008097	5S rRNA binding	6	1
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.399
CLV_NRD_NRD_1	210	212	PF00675	0.284
CLV_NRD_NRD_1	238	240	PF00675	0.269
CLV_NRD_NRD_1	246	248	PF00675	0.290
CLV_NRD_NRD_1	315	317	PF00675	0.505
CLV_NRD_NRD_1	47	49	PF00675	0.285
CLV_PCSK_FUR_1	243	247	PF00082	0.300
CLV_PCSK_FUR_1	326	330	PF00082	0.555
CLV_PCSK_KEX2_1	204	206	PF00082	0.339
CLV_PCSK_KEX2_1	210	212	PF00082	0.293
CLV_PCSK_KEX2_1	238	240	PF00082	0.289
CLV_PCSK_KEX2_1	245	247	PF00082	0.298
CLV_PCSK_KEX2_1	315	317	PF00082	0.505
CLV_PCSK_KEX2_1	328	330	PF00082	0.531
CLV_PCSK_KEX2_1	46	48	PF00082	0.284
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.415
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.308
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.505
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.531
CLV_PCSK_SKI1_1	100	104	PF00082	0.377
CLV_PCSK_SKI1_1	138	142	PF00082	0.295
CLV_PCSK_SKI1_1	184	188	PF00082	0.331
CLV_PCSK_SKI1_1	247	251	PF00082	0.319
CLV_PCSK_SKI1_1	316	320	PF00082	0.515
CLV_PCSK_SKI1_1	91	95	PF00082	0.412
DEG_SCF_FBW7_1	160	165	PF00400	0.199
DOC_CKS1_1	263	268	PF01111	0.393
DOC_MAPK_gen_1	245	256	PF00069	0.317
DOC_MAPK_gen_1	315	327	PF00069	0.519
DOC_MAPK_MEF2A_6	58	65	PF00069	0.341
DOC_PP4_FxxP_1	288	291	PF00568	0.423
DOC_USP7_MATH_1	162	166	PF00917	0.412
DOC_USP7_MATH_1	336	340	PF00917	0.515
DOC_USP7_UBL2_3	133	137	PF12436	0.349
DOC_USP7_UBL2_3	184	188	PF12436	0.288
DOC_USP7_UBL2_3	190	194	PF12436	0.281
DOC_USP7_UBL2_3	90	94	PF12436	0.289
DOC_WW_Pin1_4	158	163	PF00397	0.273
DOC_WW_Pin1_4	262	267	PF00397	0.276
DOC_WW_Pin1_4	269	274	PF00397	0.276
LIG_14-3-3_CanoR_1	100	105	PF00244	0.330
LIG_14-3-3_CanoR_1	24	28	PF00244	0.336
LIG_14-3-3_CanoR_1	295	300	PF00244	0.401
LIG_14-3-3_CanoR_1	308	314	PF00244	0.472
LIG_BRCT_BRCA1_1	284	288	PF00533	0.364
LIG_FHA_1	14	20	PF00498	0.404
LIG_FHA_1	220	226	PF00498	0.393
LIG_FHA_1	263	269	PF00498	0.324
LIG_FHA_2	117	123	PF00498	0.312
LIG_FHA_2	231	237	PF00498	0.199
LIG_FHA_2	270	276	PF00498	0.393
LIG_LIR_Apic_2	285	291	PF02991	0.496
LIG_LIR_Gen_1	95	104	PF02991	0.300
LIG_LIR_LC3C_4	265	269	PF02991	0.272
LIG_LIR_Nem_3	69	73	PF02991	0.350
LIG_MYND_1	35	39	PF01753	0.341
LIG_NRBOX	224	230	PF00104	0.393
LIG_PDZ_Class_1	335	340	PF00595	0.541
LIG_RPA_C_Fungi	234	246	PF08784	0.199
LIG_SH2_CRK	263	267	PF00017	0.393
LIG_SH2_CRK	50	54	PF00017	0.335
LIG_SH2_NCK_1	70	74	PF00017	0.225
LIG_SH2_SRC	50	53	PF00017	0.300
LIG_SH2_STAT5	110	113	PF00017	0.341
LIG_SH3_1	49	55	PF00018	0.335
LIG_SH3_2	42	47	PF14604	0.300
LIG_SH3_3	16	22	PF00018	0.349
LIG_SH3_3	315	321	PF00018	0.566
LIG_SH3_3	36	42	PF00018	0.293
LIG_SH3_3	49	55	PF00018	0.236
LIG_SH3_4	320	327	PF00018	0.447
LIG_SUMO_SIM_par_1	265	270	PF11976	0.276
LIG_TRAF2_1	119	122	PF00917	0.299
LIG_TRAF2_1	298	301	PF00917	0.404
LIG_UBA3_1	101	109	PF00899	0.393
MOD_CDK_SPxxK_3	269	276	PF00069	0.393
MOD_CK2_1	116	122	PF00069	0.316
MOD_CK2_1	230	236	PF00069	0.199
MOD_CK2_1	295	301	PF00069	0.410
MOD_GlcNHglycan	114	117	PF01048	0.289
MOD_GlcNHglycan	128	131	PF01048	0.276
MOD_GlcNHglycan	150	153	PF01048	0.453
MOD_GlcNHglycan	162	165	PF01048	0.185
MOD_GlcNHglycan	284	287	PF01048	0.544
MOD_GSK3_1	108	115	PF00069	0.316
MOD_GSK3_1	124	131	PF00069	0.155
MOD_GSK3_1	143	150	PF00069	0.176
MOD_GSK3_1	158	165	PF00069	0.421
MOD_N-GLC_1	112	117	PF02516	0.271
MOD_NEK2_1	228	233	PF00069	0.199
MOD_NEK2_1	277	282	PF00069	0.300
MOD_NEK2_1	309	314	PF00069	0.498
MOD_PIKK_1	131	137	PF00454	0.295
MOD_PKA_1	108	114	PF00069	0.481
MOD_PKA_1	192	198	PF00069	0.307
MOD_PKA_2	23	29	PF00069	0.199
MOD_PKA_2	309	315	PF00069	0.499
MOD_PKB_1	106	114	PF00069	0.199
MOD_Plk_1	116	122	PF00069	0.276
MOD_ProDKin_1	158	164	PF00069	0.273
MOD_ProDKin_1	262	268	PF00069	0.276
MOD_ProDKin_1	269	275	PF00069	0.276
MOD_SUMO_for_1	327	330	PF00179	0.528
MOD_SUMO_for_1	93	96	PF00179	0.393
MOD_SUMO_rev_2	117	127	PF00179	0.240
MOD_SUMO_rev_2	201	206	PF00179	0.319
MOD_SUMO_rev_2	89	99	PF00179	0.265
TRG_DiLeu_BaEn_1	224	229	PF01217	0.393
TRG_DiLeu_BaEn_1	300	305	PF01217	0.436
TRG_ENDOCYTIC_2	50	53	PF00928	0.300
TRG_ENDOCYTIC_2	70	73	PF00928	0.155
TRG_ER_diArg_1	45	48	PF00400	0.276
TRG_NLS_MonoCore_2	189	194	PF00514	0.213
TRG_NLS_MonoExtC_3	186	191	PF00514	0.278
TRG_NLS_MonoExtC_3	192	197	PF00514	0.276
TRG_NLS_MonoExtC_3	89	94	PF00514	0.341
TRG_NLS_MonoExtN_4	184	191	PF00514	0.277
TRG_NLS_MonoExtN_4	192	197	PF00514	0.275
TRG_NLS_MonoExtN_4	243	249	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R6	Leptomonas seymouri	66%	100%
A0A0S4KHQ3	Bodo saltans	45%	100%
A0A1X0P5V5	Trypanosomatidae	54%	97%
A0A3Q8IF61	Leishmania donovani	79%	100%
A0A422NEC3	Trypanosoma rangeli	54%	100%
A4IBF7	Leishmania infantum	79%	100%
E9AF71	Leishmania major	79%	99%
E9B6C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%