FAA_hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fumarylacetoacetate (FAA) hydrolase family, putative

Species:

Leishmania braziliensis

UniProt:

A4HMR8_LEIBR

TriTrypDb:

LbrM.34.2390 , LBRM2903_340031400

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMR8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	4
GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds	3	1
GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	4	1
GO:0018773	acetylpyruvate hydrolase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.296
CLV_NRD_NRD_1	254	256	PF00675	0.410
CLV_NRD_NRD_1	28	30	PF00675	0.360
CLV_PCSK_KEX2_1	143	145	PF00082	0.298
CLV_PCSK_KEX2_1	254	256	PF00082	0.410
CLV_PCSK_KEX2_1	28	30	PF00082	0.360
CLV_PCSK_SKI1_1	176	180	PF00082	0.230
CLV_PCSK_SKI1_1	18	22	PF00082	0.590
DEG_APCC_DBOX_1	142	150	PF00400	0.610
DEG_APCC_DBOX_1	212	220	PF00400	0.568
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.340
DOC_MAPK_JIP1_4	237	243	PF00069	0.513
DOC_PP1_RVXF_1	19	26	PF00149	0.561
DOC_PP4_FxxP_1	186	189	PF00568	0.582
DOC_PP4_FxxP_1	56	59	PF00568	0.507
DOC_USP7_MATH_1	163	167	PF00917	0.474
DOC_USP7_UBL2_3	151	155	PF12436	0.537
DOC_WW_Pin1_4	167	172	PF00397	0.477
DOC_WW_Pin1_4	185	190	PF00397	0.574
DOC_WW_Pin1_4	243	248	PF00397	0.507
DOC_WW_Pin1_4	69	74	PF00397	0.610
LIG_14-3-3_CanoR_1	211	219	PF00244	0.540
LIG_14-3-3_CanoR_1	9	13	PF00244	0.475
LIG_Actin_WH2_2	223	239	PF00022	0.566
LIG_AP2alpha_2	52	54	PF02296	0.430
LIG_BIR_II_1	1	5	PF00653	0.544
LIG_BRCT_BRCA1_1	2	6	PF00533	0.524
LIG_CtBP_PxDLS_1	138	144	PF00389	0.507
LIG_FHA_1	192	198	PF00498	0.609
LIG_FHA_1	266	272	PF00498	0.569
LIG_FHA_1	58	64	PF00498	0.587
LIG_FHA_1	74	80	PF00498	0.507
LIG_FHA_2	140	146	PF00498	0.507
LIG_Integrin_RGD_1	255	257	PF01839	0.410
LIG_LIR_Apic_2	184	189	PF02991	0.457
LIG_LIR_Gen_1	117	128	PF02991	0.610
LIG_LIR_Gen_1	201	210	PF02991	0.587
LIG_LIR_Gen_1	231	241	PF02991	0.587
LIG_LIR_LC3C_4	91	96	PF02991	0.499
LIG_LIR_Nem_3	201	206	PF02991	0.587
LIG_LIR_Nem_3	231	236	PF02991	0.587
LIG_LIR_Nem_3	51	57	PF02991	0.609
LIG_LIR_Nem_3	78	84	PF02991	0.562
LIG_LYPXL_yS_3	81	84	PF13949	0.582
LIG_REV1ctd_RIR_1	52	58	PF16727	0.537
LIG_SH2_GRB2like	120	123	PF00017	0.587
LIG_SH2_PTP2	233	236	PF00017	0.587
LIG_SH2_SRC	133	136	PF00017	0.610
LIG_SH2_STAP1	37	41	PF00017	0.507
LIG_SH2_STAT5	233	236	PF00017	0.593
LIG_SH2_STAT5	24	27	PF00017	0.421
LIG_SH2_STAT5	31	34	PF00017	0.514
LIG_SH3_3	165	171	PF00018	0.550
LIG_SUMO_SIM_anti_2	91	96	PF11976	0.521
LIG_SUMO_SIM_par_1	170	175	PF11976	0.587
LIG_TYR_ITIM	79	84	PF00017	0.582
LIG_UBA3_1	226	232	PF00899	0.559
MOD_CDC14_SPxK_1	188	191	PF00782	0.430
MOD_CDK_SPxK_1	185	191	PF00069	0.457
MOD_CK1_1	109	115	PF00069	0.601
MOD_CK1_1	198	204	PF00069	0.615
MOD_CK1_1	248	254	PF00069	0.578
MOD_GlcNHglycan	108	111	PF01048	0.406
MOD_GlcNHglycan	164	168	PF01048	0.257
MOD_GlcNHglycan	198	201	PF01048	0.317
MOD_GlcNHglycan	247	250	PF01048	0.309
MOD_GlcNHglycan	73	76	PF01048	0.286
MOD_GSK3_1	163	170	PF00069	0.439
MOD_GSK3_1	191	198	PF00069	0.606
MOD_GSK3_1	241	248	PF00069	0.494
MOD_GSK3_1	4	11	PF00069	0.455
MOD_GSK3_1	69	76	PF00069	0.587
MOD_N-GLC_1	48	53	PF02516	0.382
MOD_N-GLC_1	68	73	PF02516	0.335
MOD_NEK2_1	139	144	PF00069	0.518
MOD_NEK2_1	241	246	PF00069	0.537
MOD_NEK2_1	4	9	PF00069	0.513
MOD_NEK2_2	265	270	PF00069	0.610
MOD_PIKK_1	109	115	PF00454	0.572
MOD_PKA_2	8	14	PF00069	0.477
MOD_Plk_4	198	204	PF00069	0.569
MOD_Plk_4	8	14	PF00069	0.480
MOD_ProDKin_1	167	173	PF00069	0.477
MOD_ProDKin_1	185	191	PF00069	0.574
MOD_ProDKin_1	243	249	PF00069	0.507
MOD_ProDKin_1	69	75	PF00069	0.610
MOD_SUMO_for_1	123	126	PF00179	0.556
MOD_SUMO_rev_2	175	181	PF00179	0.573
TRG_DiLeu_BaEn_3	126	132	PF01217	0.541
TRG_ENDOCYTIC_2	120	123	PF00928	0.513
TRG_ENDOCYTIC_2	233	236	PF00928	0.587
TRG_ENDOCYTIC_2	24	27	PF00928	0.297
TRG_ENDOCYTIC_2	81	84	PF00928	0.582
TRG_ER_diArg_1	253	255	PF00400	0.610
TRG_ER_diArg_1	27	29	PF00400	0.415
TRG_NES_CRM1_1	225	240	PF08389	0.539
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.230

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S1	Leptomonas seymouri	63%	100%
A0A0S4IKX8	Bodo saltans	37%	100%
A0A0S4JYH7	Bodo saltans	24%	100%
A0A1X0P5X5	Trypanosomatidae	50%	99%
A0A3R7MDA1	Trypanosoma rangeli	49%	100%
A0A3S7X9E6	Leishmania donovani	80%	100%
A0B3M8	Burkholderia cenocepacia (strain HI2424)	26%	97%
A3AJ77	Oryza sativa subsp. japonica	31%	100%
A4IBF4	Leishmania infantum	80%	100%
A9ALD1	Burkholderia multivorans (strain ATCC 17616 / 249)	27%	97%
B1K3Y3	Burkholderia cenocepacia (strain MC0-3)	26%	97%
B1Z1Y2	Burkholderia ambifaria (strain MC40-6)	26%	97%
B2RYW9	Rattus norvegicus	25%	88%
B4EKX6	Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610)	26%	97%
E9AF68	Leishmania major	78%	100%
E9B6C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
I6Y276	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
O06724	Bacillus subtilis (strain 168)	28%	91%
O28058	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O58377	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	33%	100%
O86042	Ralstonia sp.	35%	100%
P34673	Caenorhabditis elegans	32%	100%
P53889	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P76004	Escherichia coli (strain K12)	32%	100%
Q0B628	Burkholderia ambifaria (strain ATCC BAA-244 / AMMD)	26%	97%
Q0QFQ3	Pseudomonas alcaligenes	26%	95%
Q10B63	Oryza sativa subsp. japonica	32%	100%
Q1BJJ1	Burkholderia cenocepacia (strain AU 1054)	26%	97%
Q2FIA7	Staphylococcus aureus (strain USA300)	27%	91%
Q2FZT4	Staphylococcus aureus (strain NCTC 8325 / PS 47)	27%	91%
Q2HJ98	Bos taurus	31%	100%
Q2KIB0	Bos taurus	27%	87%
Q2YWW3	Staphylococcus aureus (strain bovine RF122 / ET3-1)	27%	91%
Q39BA7	Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383)	26%	97%
Q3TC72	Mus musculus	26%	88%
Q49WA8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	28%	91%
Q4L4Y4	Staphylococcus haemolyticus (strain JCSC1435)	27%	91%
Q54BF3	Dictyostelium discoideum	29%	90%
Q59050	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	29%	100%
Q5HHB6	Staphylococcus aureus (strain COL)	27%	91%
Q5HQJ3	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	28%	91%
Q5RCX5	Pongo abelii	26%	87%
Q5RDW0	Pongo abelii	32%	100%
Q6AYQ8	Rattus norvegicus	32%	100%
Q6GAV8	Staphylococcus aureus (strain MSSA476)	27%	91%
Q6GIC0	Staphylococcus aureus (strain MRSA252)	27%	91%
Q6GLT8	Xenopus laevis	30%	86%
Q6P2I3	Homo sapiens	26%	87%
Q6P587	Homo sapiens	32%	100%
Q7A1B6	Staphylococcus aureus (strain MW2)	27%	91%
Q7A6H3	Staphylococcus aureus (strain N315)	27%	91%
Q86I22	Dictyostelium discoideum	31%	100%
Q8CPT8	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	91%
Q8R0F8	Mus musculus	31%	100%
Q93ZE5	Arabidopsis thaliana	32%	100%
Q96GK7	Homo sapiens	25%	87%
Q99VC2	Staphylococcus aureus (strain Mu50 / ATCC 700699)	27%	91%
Q9LUR3	Arabidopsis thaliana	31%	100%
Q9P7L4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
Q9UYW0	Pyrococcus abyssi (strain GE5 / Orsay)	34%	100%
V5BTF7	Trypanosoma cruzi	47%	99%