Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMR7_LEIBR

TriTrypDb:

LbrM.34.2380 , LBRM2903_340031300

Length:

783

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 2
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HMR7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMR7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.763
CLV_C14_Caspase3-7	164	168	PF00656	0.651
CLV_C14_Caspase3-7	241	245	PF00656	0.645
CLV_C14_Caspase3-7	278	282	PF00656	0.691
CLV_C14_Caspase3-7	31	35	PF00656	0.469
CLV_C14_Caspase3-7	542	546	PF00656	0.810
CLV_C14_Caspase3-7	629	633	PF00656	0.695
CLV_C14_Caspase3-7	647	651	PF00656	0.621
CLV_C14_Caspase3-7	732	736	PF00656	0.659
CLV_NRD_NRD_1	126	128	PF00675	0.461
CLV_NRD_NRD_1	242	244	PF00675	0.469
CLV_NRD_NRD_1	560	562	PF00675	0.489
CLV_NRD_NRD_1	768	770	PF00675	0.398
CLV_PCSK_FUR_1	571	575	PF00082	0.617
CLV_PCSK_KEX2_1	126	128	PF00082	0.518
CLV_PCSK_KEX2_1	242	244	PF00082	0.461
CLV_PCSK_KEX2_1	560	562	PF00082	0.489
CLV_PCSK_KEX2_1	573	575	PF00082	0.558
CLV_PCSK_KEX2_1	591	593	PF00082	0.531
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.558
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.531
CLV_PCSK_SKI1_1	47	51	PF00082	0.662
CLV_PCSK_SKI1_1	519	523	PF00082	0.620
CLV_PCSK_SKI1_1	664	668	PF00082	0.559
CLV_PCSK_SKI1_1	762	766	PF00082	0.448
CLV_PCSK_SKI1_1	770	774	PF00082	0.450
CLV_PCSK_SKI1_1	89	93	PF00082	0.605
DEG_APCC_DBOX_1	591	599	PF00400	0.640
DEG_APCC_DBOX_1	768	776	PF00400	0.611
DEG_APCC_DBOX_1	88	96	PF00400	0.251
DEG_Kelch_Keap1_1	131	136	PF01344	0.636
DEG_SPOP_SBC_1	256	260	PF00917	0.807
DEG_SPOP_SBC_1	609	613	PF00917	0.698
DOC_CKS1_1	204	209	PF01111	0.621
DOC_CKS1_1	385	390	PF01111	0.661
DOC_MAPK_MEF2A_6	752	759	PF00069	0.719
DOC_MAPK_RevD_3	230	243	PF00069	0.656
DOC_MAPK_RevD_3	755	770	PF00069	0.696
DOC_PP2B_LxvP_1	586	589	PF13499	0.647
DOC_PP2B_LxvP_1	607	610	PF13499	0.809
DOC_USP7_MATH_1	175	179	PF00917	0.794
DOC_USP7_MATH_1	262	266	PF00917	0.806
DOC_USP7_MATH_1	279	283	PF00917	0.628
DOC_USP7_MATH_1	298	302	PF00917	0.632
DOC_USP7_MATH_1	337	341	PF00917	0.656
DOC_USP7_MATH_1	365	369	PF00917	0.759
DOC_USP7_MATH_1	475	479	PF00917	0.801
DOC_USP7_MATH_1	482	486	PF00917	0.717
DOC_USP7_MATH_1	547	551	PF00917	0.656
DOC_USP7_MATH_1	622	626	PF00917	0.664
DOC_USP7_MATH_1	677	681	PF00917	0.816
DOC_USP7_MATH_1	73	77	PF00917	0.446
DOC_USP7_MATH_1	736	740	PF00917	0.696
DOC_USP7_UBL2_3	569	573	PF12436	0.764
DOC_WW_Pin1_4	203	208	PF00397	0.745
DOC_WW_Pin1_4	333	338	PF00397	0.718
DOC_WW_Pin1_4	381	386	PF00397	0.678
DOC_WW_Pin1_4	396	401	PF00397	0.761
DOC_WW_Pin1_4	705	710	PF00397	0.749
DOC_WW_Pin1_4	718	723	PF00397	0.785
LIG_14-3-3_CanoR_1	126	131	PF00244	0.662
LIG_14-3-3_CanoR_1	261	269	PF00244	0.770
LIG_14-3-3_CanoR_1	339	348	PF00244	0.647
LIG_14-3-3_CanoR_1	450	456	PF00244	0.641
LIG_14-3-3_CanoR_1	483	490	PF00244	0.675
LIG_14-3-3_CanoR_1	571	579	PF00244	0.762
LIG_14-3-3_CanoR_1	656	666	PF00244	0.734
LIG_14-3-3_CanoR_1	711	716	PF00244	0.656
LIG_14-3-3_CanoR_1	89	95	PF00244	0.284
LIG_BRCT_BRCA1_1	244	248	PF00533	0.650
LIG_BRCT_BRCA1_1	706	710	PF00533	0.703
LIG_deltaCOP1_diTrp_1	244	248	PF00928	0.650
LIG_deltaCOP1_diTrp_1	332	338	PF00928	0.655
LIG_eIF4E_1	438	444	PF01652	0.644
LIG_EVH1_1	511	515	PF00568	0.653
LIG_FHA_1	105	111	PF00498	0.271
LIG_FHA_1	219	225	PF00498	0.758
LIG_FHA_1	404	410	PF00498	0.731
LIG_FHA_1	439	445	PF00498	0.645
LIG_FHA_1	554	560	PF00498	0.812
LIG_FHA_1	6	12	PF00498	0.488
LIG_FHA_1	663	669	PF00498	0.771
LIG_FHA_1	677	683	PF00498	0.755
LIG_FHA_1	698	704	PF00498	0.796
LIG_FHA_1	761	767	PF00498	0.744
LIG_FHA_1	777	783	PF00498	0.687
LIG_FHA_1	94	100	PF00498	0.390
LIG_FHA_2	276	282	PF00498	0.741
LIG_FHA_2	355	361	PF00498	0.727
LIG_FHA_2	645	651	PF00498	0.659
LIG_FHA_2	727	733	PF00498	0.667
LIG_LIR_Apic_2	156	162	PF02991	0.651
LIG_LIR_Apic_2	462	468	PF02991	0.650
LIG_LIR_Apic_2	576	582	PF02991	0.745
LIG_LIR_Apic_2	768	774	PF02991	0.761
LIG_LIR_Gen_1	93	102	PF02991	0.304
LIG_LIR_Nem_3	332	338	PF02991	0.655
LIG_LIR_Nem_3	508	514	PF02991	0.660
LIG_LIR_Nem_3	581	586	PF02991	0.688
LIG_LIR_Nem_3	76	81	PF02991	0.477
LIG_LIR_Nem_3	93	97	PF02991	0.207
LIG_LYPXL_yS_3	511	514	PF13949	0.656
LIG_MYND_1	585	589	PF01753	0.731
LIG_Pex14_2	351	355	PF04695	0.799
LIG_PTAP_UEV_1	698	703	PF05743	0.648
LIG_PTB_Apo_2	349	356	PF02174	0.646
LIG_SH2_CRK	377	381	PF00017	0.659
LIG_SH2_CRK	465	469	PF00017	0.646
LIG_SH2_GRB2like	350	353	PF00017	0.649
LIG_SH2_PTP2	94	97	PF00017	0.282
LIG_SH2_STAP1	87	91	PF00017	0.452
LIG_SH2_STAT5	103	106	PF00017	0.360
LIG_SH2_STAT5	350	353	PF00017	0.710
LIG_SH2_STAT5	36	39	PF00017	0.458
LIG_SH2_STAT5	438	441	PF00017	0.642
LIG_SH2_STAT5	465	468	PF00017	0.645
LIG_SH2_STAT5	526	529	PF00017	0.727
LIG_SH2_STAT5	553	556	PF00017	0.655
LIG_SH2_STAT5	94	97	PF00017	0.332
LIG_SH3_1	465	471	PF00018	0.646
LIG_SH3_1	579	585	PF00018	0.733
LIG_SH3_3	214	220	PF00018	0.675
LIG_SH3_3	318	324	PF00018	0.796
LIG_SH3_3	382	388	PF00018	0.676
LIG_SH3_3	397	403	PF00018	0.736
LIG_SH3_3	431	437	PF00018	0.727
LIG_SH3_3	465	471	PF00018	0.800
LIG_SH3_3	487	493	PF00018	0.696
LIG_SH3_3	509	515	PF00018	0.712
LIG_SH3_3	579	585	PF00018	0.733
LIG_SH3_3	696	702	PF00018	0.735
LIG_SH3_3	706	712	PF00018	0.737
LIG_SH3_3	716	722	PF00018	0.585
LIG_SUMO_SIM_par_1	14	21	PF11976	0.701
LIG_SUMO_SIM_par_1	714	721	PF11976	0.660
LIG_SUMO_SIM_par_1	760	768	PF11976	0.698
LIG_SxIP_EBH_1	547	561	PF03271	0.659
LIG_TRAF2_1	134	137	PF00917	0.638
LIG_TRAF2_1	758	761	PF00917	0.687
LIG_TYR_ITIM	101	106	PF00017	0.234
LIG_TYR_ITIM	92	97	PF00017	0.282
LIG_WRC_WIRS_1	4	9	PF05994	0.683
MOD_CDC14_SPxK_1	336	339	PF00782	0.658
MOD_CDC14_SPxK_1	708	711	PF00782	0.655
MOD_CDK_SPxK_1	333	339	PF00069	0.656
MOD_CDK_SPxK_1	705	711	PF00069	0.659
MOD_CK1_1	179	185	PF00069	0.695
MOD_CK1_1	257	263	PF00069	0.779
MOD_CK1_1	280	286	PF00069	0.773
MOD_CK1_1	308	314	PF00069	0.724
MOD_CK1_1	368	374	PF00069	0.663
MOD_CK1_1	386	392	PF00069	0.744
MOD_CK1_1	396	402	PF00069	0.736
MOD_CK1_1	414	420	PF00069	0.796
MOD_CK1_1	48	54	PF00069	0.557
MOD_CK1_1	494	500	PF00069	0.830
MOD_CK1_1	546	552	PF00069	0.655
MOD_CK1_1	60	66	PF00069	0.490
MOD_CK1_1	605	611	PF00069	0.810
MOD_CK1_1	645	651	PF00069	0.779
MOD_CK1_1	689	695	PF00069	0.673
MOD_CK1_1	718	724	PF00069	0.716
MOD_CK2_1	130	136	PF00069	0.781
MOD_CK2_1	361	367	PF00069	0.712
MOD_CK2_1	452	458	PF00069	0.660
MOD_CK2_1	482	488	PF00069	0.791
MOD_CK2_1	591	597	PF00069	0.640
MOD_CK2_1	692	698	PF00069	0.648
MOD_CK2_1	755	761	PF00069	0.694
MOD_Cter_Amidation	571	574	PF01082	0.472
MOD_GlcNHglycan	131	136	PF01048	0.503
MOD_GlcNHglycan	14	17	PF01048	0.603
MOD_GlcNHglycan	155	158	PF01048	0.478
MOD_GlcNHglycan	169	172	PF01048	0.451
MOD_GlcNHglycan	262	265	PF01048	0.588
MOD_GlcNHglycan	296	299	PF01048	0.458
MOD_GlcNHglycan	352	355	PF01048	0.448
MOD_GlcNHglycan	363	366	PF01048	0.472
MOD_GlcNHglycan	370	373	PF01048	0.469
MOD_GlcNHglycan	38	41	PF01048	0.721
MOD_GlcNHglycan	388	391	PF01048	0.501
MOD_GlcNHglycan	413	416	PF01048	0.579
MOD_GlcNHglycan	472	475	PF01048	0.610
MOD_GlcNHglycan	545	548	PF01048	0.454
MOD_GlcNHglycan	575	578	PF01048	0.466
MOD_GlcNHglycan	607	610	PF01048	0.454
MOD_GlcNHglycan	713	716	PF01048	0.495
MOD_GSK3_1	126	133	PF00069	0.697
MOD_GSK3_1	175	182	PF00069	0.680
MOD_GSK3_1	242	249	PF00069	0.765
MOD_GSK3_1	252	259	PF00069	0.699
MOD_GSK3_1	275	282	PF00069	0.728
MOD_GSK3_1	294	301	PF00069	0.789
MOD_GSK3_1	32	39	PF00069	0.597
MOD_GSK3_1	333	340	PF00069	0.747
MOD_GSK3_1	350	357	PF00069	0.640
MOD_GSK3_1	361	368	PF00069	0.649
MOD_GSK3_1	376	383	PF00069	0.720
MOD_GSK3_1	466	473	PF00069	0.742
MOD_GSK3_1	48	55	PF00069	0.460
MOD_GSK3_1	482	489	PF00069	0.766
MOD_GSK3_1	543	550	PF00069	0.695
MOD_GSK3_1	56	63	PF00069	0.523
MOD_GSK3_1	599	606	PF00069	0.800
MOD_GSK3_1	645	652	PF00069	0.762
MOD_GSK3_1	658	665	PF00069	0.655
MOD_GSK3_1	677	684	PF00069	0.673
MOD_GSK3_1	711	718	PF00069	0.708
MOD_GSK3_1	731	738	PF00069	0.676
MOD_GSK3_1	751	758	PF00069	0.549
MOD_GSK3_1	81	88	PF00069	0.368
MOD_N-GLC_1	246	251	PF02516	0.538
MOD_N-GLC_1	515	520	PF02516	0.465
MOD_N-GLC_1	645	650	PF02516	0.603
MOD_N-GLC_1	755	760	PF02516	0.520
MOD_NEK2_1	104	109	PF00069	0.312
MOD_NEK2_1	12	17	PF00069	0.588
MOD_NEK2_1	210	215	PF00069	0.703
MOD_NEK2_1	274	279	PF00069	0.670
MOD_NEK2_1	361	366	PF00069	0.779
MOD_NEK2_1	376	381	PF00069	0.727
MOD_NEK2_1	411	416	PF00069	0.774
MOD_NEK2_1	426	431	PF00069	0.781
MOD_NEK2_1	476	481	PF00069	0.721
MOD_NEK2_1	58	63	PF00069	0.551
MOD_NEK2_1	662	667	PF00069	0.752
MOD_NEK2_1	765	770	PF00069	0.748
MOD_NEK2_1	81	86	PF00069	0.416
MOD_PIKK_1	370	376	PF00454	0.736
MOD_PK_1	126	132	PF00069	0.625
MOD_PK_1	287	293	PF00069	0.680
MOD_PKA_1	126	132	PF00069	0.625
MOD_PKA_1	242	248	PF00069	0.658
MOD_PKA_1	573	579	PF00069	0.758
MOD_PKA_1	591	597	PF00069	0.759
MOD_PKA_2	126	132	PF00069	0.763
MOD_PKA_2	242	248	PF00069	0.731
MOD_PKA_2	260	266	PF00069	0.652
MOD_PKA_2	274	280	PF00069	0.662
MOD_PKA_2	308	314	PF00069	0.785
MOD_PKA_2	411	417	PF00069	0.786
MOD_PKA_2	449	455	PF00069	0.641
MOD_PKA_2	482	488	PF00069	0.695
MOD_PKA_2	573	579	PF00069	0.803
MOD_PKA_2	591	597	PF00069	0.612
MOD_PKA_2	658	664	PF00069	0.650
MOD_PKA_2	751	757	PF00069	0.632
MOD_Plk_1	252	258	PF00069	0.652
MOD_Plk_1	452	458	PF00069	0.814
MOD_Plk_1	507	513	PF00069	0.662
MOD_Plk_1	689	695	PF00069	0.716
MOD_Plk_1	73	79	PF00069	0.391
MOD_Plk_1	755	761	PF00069	0.706
MOD_Plk_2-3	21	27	PF00069	0.756
MOD_Plk_2-3	623	629	PF00069	0.664
MOD_Plk_4	104	110	PF00069	0.274
MOD_Plk_4	182	188	PF00069	0.754
MOD_Plk_4	60	66	PF00069	0.522
MOD_Plk_4	677	683	PF00069	0.690
MOD_Plk_4	726	732	PF00069	0.724
MOD_Plk_4	90	96	PF00069	0.267
MOD_ProDKin_1	203	209	PF00069	0.744
MOD_ProDKin_1	333	339	PF00069	0.719
MOD_ProDKin_1	381	387	PF00069	0.679
MOD_ProDKin_1	396	402	PF00069	0.758
MOD_ProDKin_1	705	711	PF00069	0.749
MOD_ProDKin_1	718	724	PF00069	0.784
MOD_SUMO_rev_2	314	324	PF00179	0.660
MOD_SUMO_rev_2	48	56	PF00179	0.459
TRG_DiLeu_BaEn_1	760	765	PF01217	0.677
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.643
TRG_DiLeu_BaLyEn_6	771	776	PF01217	0.702
TRG_ENDOCYTIC_2	103	106	PF00928	0.360
TRG_ENDOCYTIC_2	377	380	PF00928	0.661
TRG_ENDOCYTIC_2	511	514	PF00928	0.656
TRG_ENDOCYTIC_2	94	97	PF00928	0.332
TRG_ER_diArg_1	338	341	PF00400	0.658
TRG_ER_diArg_1	559	561	PF00400	0.687
TRG_ER_diArg_1	766	769	PF00400	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFH2	Leptomonas seymouri	26%	100%
A0A3S7X9B2	Leishmania donovani	55%	100%
E9AF67	Leishmania major	54%	100%