Putative phosphoinositide-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Autophagy-related protein 24

Species:

Leishmania braziliensis

UniProt:

A4HMR6_LEIBR

TriTrypDb:

LbrM.34.2370 , LBRM2903_340031200

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005768	endosome	7	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMR6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0006898	receptor-mediated endocytosis	6	1
GO:0006914	autophagy	3	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0061919	process utilizing autophagic mechanism	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005543	phospholipid binding	3	12
GO:0008289	lipid binding	2	12
GO:0035091	phosphatidylinositol binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.334
CLV_NRD_NRD_1	110	112	PF00675	0.304
CLV_NRD_NRD_1	237	239	PF00675	0.298
CLV_NRD_NRD_1	273	275	PF00675	0.419
CLV_NRD_NRD_1	47	49	PF00675	0.303
CLV_PCSK_FUR_1	235	239	PF00082	0.417
CLV_PCSK_KEX2_1	105	107	PF00082	0.417
CLV_PCSK_KEX2_1	110	112	PF00082	0.417
CLV_PCSK_KEX2_1	237	239	PF00082	0.303
CLV_PCSK_KEX2_1	47	49	PF00082	0.290
CLV_PCSK_PC7_1	106	112	PF00082	0.417
CLV_PCSK_SKI1_1	110	114	PF00082	0.297
CLV_PCSK_SKI1_1	226	230	PF00082	0.451
CLV_PCSK_SKI1_1	385	389	PF00082	0.285
CLV_PCSK_SKI1_1	410	414	PF00082	0.562
DEG_APCC_DBOX_1	109	117	PF00400	0.300
DEG_APCC_DBOX_1	225	233	PF00400	0.320
DEG_APCC_DBOX_1	305	313	PF00400	0.300
DEG_APCC_DBOX_1	315	323	PF00400	0.300
DEG_APCC_DBOX_1	409	417	PF00400	0.560
DOC_CYCLIN_yClb5_NLxxxL_5	226	232	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.314
DOC_MAPK_gen_1	389	396	PF00069	0.417
DOC_MAPK_gen_1	80	89	PF00069	0.315
DOC_MAPK_MEF2A_6	389	398	PF00069	0.417
DOC_PP2B_LxvP_1	23	26	PF13499	0.355
DOC_USP7_MATH_1	152	156	PF00917	0.537
DOC_USP7_MATH_1	165	169	PF00917	0.688
DOC_USP7_MATH_1	174	178	PF00917	0.723
DOC_USP7_MATH_1	180	184	PF00917	0.639
DOC_USP7_MATH_1	193	197	PF00917	0.413
DOC_USP7_UBL2_3	385	389	PF12436	0.285
LIG_14-3-3_CanoR_1	105	110	PF00244	0.383
LIG_14-3-3_CanoR_1	149	159	PF00244	0.580
LIG_14-3-3_CanoR_1	235	243	PF00244	0.321
LIG_14-3-3_CanoR_1	290	296	PF00244	0.407
LIG_14-3-3_CanoR_1	335	344	PF00244	0.407
LIG_14-3-3_CanoR_1	47	55	PF00244	0.396
LIG_APCC_ABBA_1	373	378	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.567
LIG_BRCT_BRCA1_1	369	373	PF00533	0.421
LIG_FHA_1	287	293	PF00498	0.344
LIG_FHA_1	31	37	PF00498	0.399
LIG_FHA_2	366	372	PF00498	0.387
LIG_FHA_2	48	54	PF00498	0.421
LIG_FHA_2	93	99	PF00498	0.421
LIG_LIR_Gen_1	370	378	PF02991	0.419
LIG_LIR_Gen_1	405	413	PF02991	0.405
LIG_LIR_Gen_1	50	59	PF02991	0.285
LIG_LIR_Gen_1	62	72	PF02991	0.283
LIG_LIR_Nem_3	103	107	PF02991	0.417
LIG_LIR_Nem_3	24	30	PF02991	0.450
LIG_LIR_Nem_3	248	253	PF02991	0.376
LIG_LIR_Nem_3	370	376	PF02991	0.424
LIG_LIR_Nem_3	405	409	PF02991	0.296
LIG_LIR_Nem_3	50	55	PF02991	0.285
LIG_LIR_Nem_3	62	68	PF02991	0.283
LIG_Pex14_2	246	250	PF04695	0.285
LIG_Pex14_2	369	373	PF04695	0.412
LIG_SH2_CRK	104	108	PF00017	0.417
LIG_SH2_CRK	118	122	PF00017	0.417
LIG_SH2_CRK	65	69	PF00017	0.344
LIG_SH2_PTP2	28	31	PF00017	0.468
LIG_SH2_SRC	28	31	PF00017	0.463
LIG_SH2_STAP1	280	284	PF00017	0.375
LIG_SH2_STAT5	214	217	PF00017	0.294
LIG_SH2_STAT5	28	31	PF00017	0.463
LIG_SH2_STAT5	298	301	PF00017	0.344
LIG_SH2_STAT5	318	321	PF00017	0.124
LIG_SH2_STAT5	49	52	PF00017	0.437
LIG_SH2_STAT5	65	68	PF00017	0.213
LIG_SH3_2	144	149	PF14604	0.577
LIG_SH3_2	69	74	PF14604	0.285
LIG_SH3_3	141	147	PF00018	0.586
LIG_SH3_3	66	72	PF00018	0.291
LIG_SH3_3	8	14	PF00018	0.386
LIG_SUMO_SIM_par_1	392	397	PF11976	0.417
LIG_TRAF2_1	155	158	PF00917	0.636
LIG_TYR_ITIM	102	107	PF00017	0.417
LIG_TYR_ITIM	116	121	PF00017	0.417
LIG_WW_3	146	150	PF00397	0.566
MOD_CK1_1	183	189	PF00069	0.598
MOD_CK1_1	196	202	PF00069	0.518
MOD_CK1_1	241	247	PF00069	0.442
MOD_CK1_1	286	292	PF00069	0.427
MOD_CK1_1	293	299	PF00069	0.407
MOD_CK2_1	151	157	PF00069	0.552
MOD_CK2_1	365	371	PF00069	0.410
MOD_CK2_1	394	400	PF00069	0.417
MOD_CK2_1	47	53	PF00069	0.303
MOD_CK2_1	92	98	PF00069	0.194
MOD_Cter_Amidation	272	275	PF01082	0.417
MOD_GlcNHglycan	165	168	PF01048	0.658
MOD_GlcNHglycan	169	172	PF01048	0.690
MOD_GlcNHglycan	176	179	PF01048	0.578
MOD_GlcNHglycan	182	185	PF01048	0.615
MOD_GlcNHglycan	195	198	PF01048	0.463
MOD_GlcNHglycan	240	243	PF01048	0.417
MOD_GlcNHglycan	313	316	PF01048	0.334
MOD_GlcNHglycan	331	334	PF01048	0.332
MOD_GlcNHglycan	337	340	PF01048	0.459
MOD_GSK3_1	1	8	PF00069	0.633
MOD_GSK3_1	159	166	PF00069	0.591
MOD_GSK3_1	183	190	PF00069	0.543
MOD_GSK3_1	204	211	PF00069	0.519
MOD_GSK3_1	241	248	PF00069	0.357
MOD_GSK3_1	286	293	PF00069	0.392
MOD_GSK3_1	394	401	PF00069	0.421
MOD_GSK3_1	47	54	PF00069	0.403
MOD_LATS_1	236	242	PF00433	0.421
MOD_NEK2_1	1	6	PF00069	0.489
MOD_NEK2_1	150	155	PF00069	0.503
MOD_NEK2_1	246	251	PF00069	0.368
MOD_NEK2_1	291	296	PF00069	0.401
MOD_NEK2_1	329	334	PF00069	0.464
MOD_NEK2_1	394	399	PF00069	0.385
MOD_NEK2_1	412	417	PF00069	0.565
MOD_NEK2_1	59	64	PF00069	0.421
MOD_NEK2_2	318	323	PF00069	0.288
MOD_PIKK_1	12	18	PF00454	0.540
MOD_PIKK_1	185	191	PF00454	0.608
MOD_PIKK_1	196	202	PF00454	0.461
MOD_PIKK_1	323	329	PF00454	0.325
MOD_PKA_1	105	111	PF00069	0.417
MOD_PKA_1	47	53	PF00069	0.300
MOD_PKA_2	105	111	PF00069	0.417
MOD_PKA_2	236	242	PF00069	0.207
MOD_PKA_2	305	311	PF00069	0.285
MOD_PKA_2	47	53	PF00069	0.359
MOD_Plk_1	204	210	PF00069	0.457
MOD_Plk_1	286	292	PF00069	0.417
MOD_Plk_1	365	371	PF00069	0.417
MOD_Plk_1	394	400	PF00069	0.418
MOD_Plk_2-3	73	79	PF00069	0.417
MOD_Plk_4	293	299	PF00069	0.417
MOD_Plk_4	59	65	PF00069	0.421
MOD_SUMO_for_1	402	405	PF00179	0.417
MOD_SUMO_rev_2	378	387	PF00179	0.297
TRG_DiLeu_BaEn_1	287	292	PF01217	0.417
TRG_DiLeu_BaEn_4	257	263	PF01217	0.417
TRG_ENDOCYTIC_2	104	107	PF00928	0.417
TRG_ENDOCYTIC_2	118	121	PF00928	0.417
TRG_ENDOCYTIC_2	298	301	PF00928	0.285
TRG_ENDOCYTIC_2	49	52	PF00928	0.285
TRG_ENDOCYTIC_2	65	68	PF00928	0.285
TRG_ER_diArg_1	104	106	PF00400	0.285
TRG_ER_diArg_1	109	111	PF00400	0.285
TRG_ER_diArg_1	235	238	PF00400	0.311
TRG_ER_diArg_1	47	49	PF00400	0.414
TRG_NES_CRM1_1	386	400	PF08389	0.417
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBS5	Leptomonas seymouri	75%	98%
A0A0S4KLA7	Bodo saltans	33%	100%
A0A1X0P5K9	Trypanosomatidae	33%	100%
A0A3Q8IV97	Leishmania donovani	92%	100%
A0A3R7L2W7	Trypanosoma rangeli	35%	99%
A4IBF2	Leishmania infantum	92%	100%
C9ZZB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AF66	Leishmania major	93%	100%
E9B6C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O60749	Homo sapiens	22%	81%
P0C220	Macaca fascicularis	21%	80%
Q5R9A9	Pongo abelii	21%	80%
Q8L5Z7	Arabidopsis thaliana	21%	71%
Q9C0U7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	73%
Q9CWK8	Mus musculus	22%	81%
V5B3T2	Trypanosoma cruzi	35%	99%