Spt4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Spt4/RpoE2 zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HMR3_LEIBR

TriTrypDb:

LbrM.34.2340 , LBRM2903_340030900

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6
GO:0008023	transcription elongation factor complex	3	1
GO:0032044	DSIF complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HMR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMR3

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	7
GO:0009889	regulation of biosynthetic process	4	7
GO:0009891	positive regulation of biosynthetic process	5	7
GO:0009893	positive regulation of metabolic process	4	7
GO:0010468	regulation of gene expression	5	7
GO:0010556	regulation of macromolecule biosynthetic process	5	7
GO:0010557	positive regulation of macromolecule biosynthetic process	6	7
GO:0010604	positive regulation of macromolecule metabolic process	5	7
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	7
GO:0019222	regulation of metabolic process	3	7
GO:0031323	regulation of cellular metabolic process	4	7
GO:0031325	positive regulation of cellular metabolic process	5	7
GO:0031326	regulation of cellular biosynthetic process	5	7
GO:0031328	positive regulation of cellular biosynthetic process	6	7
GO:0032784	regulation of DNA-templated transcription elongation	7	7
GO:0032786	positive regulation of DNA-templated transcription, elongation	8	7
GO:0045893	positive regulation of DNA-templated transcription	7	7
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	7
GO:0048518	positive regulation of biological process	3	7
GO:0048522	positive regulation of cellular process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051173	positive regulation of nitrogen compound metabolic process	5	7
GO:0051252	regulation of RNA metabolic process	5	7
GO:0051254	positive regulation of RNA metabolic process	6	7
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0065007	biological regulation	1	7
GO:0080090	regulation of primary metabolic process	4	7
GO:1902680	positive regulation of RNA biosynthetic process	7	7
GO:1903506	regulation of nucleic acid-templated transcription	7	7
GO:1903508	positive regulation of nucleic acid-templated transcription	8	7
GO:2001141	regulation of RNA biosynthetic process	6	7
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006325	chromatin organization	4	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034243	regulation of transcription elongation by RNA polymerase II	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0000993	RNA polymerase II complex binding	5	1
GO:0001098	basal transcription machinery binding	3	1
GO:0001099	basal RNA polymerase II transcription machinery binding	4	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0043175	RNA polymerase core enzyme binding	5	1
GO:0070063	RNA polymerase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.275
CLV_NRD_NRD_1	36	38	PF00675	0.275
CLV_PCSK_FUR_1	34	38	PF00082	0.275
CLV_PCSK_KEX2_1	33	35	PF00082	0.275
CLV_PCSK_KEX2_1	36	38	PF00082	0.275
CLV_PCSK_SKI1_1	36	40	PF00082	0.275
DEG_Nend_UBRbox_1	1	4	PF02207	0.505
DEG_ODPH_VHL_1	79	91	PF01847	0.475
DOC_CKS1_1	67	72	PF01111	0.475
DOC_PP2B_LxvP_1	78	81	PF13499	0.475
DOC_PP4_FxxP_1	67	70	PF00568	0.475
DOC_USP7_MATH_1	81	85	PF00917	0.475
DOC_WW_Pin1_4	66	71	PF00397	0.475
LIG_14-3-3_CanoR_1	36	45	PF00244	0.475
LIG_FHA_1	10	16	PF00498	0.546
LIG_FHA_1	45	51	PF00498	0.475
LIG_FHA_1	95	101	PF00498	0.475
LIG_FHA_2	102	108	PF00498	0.490
LIG_LIR_Apic_2	66	70	PF02991	0.475
LIG_LIR_Gen_1	69	80	PF02991	0.475
LIG_LIR_Nem_3	69	75	PF02991	0.475
LIG_SH3_3	13	19	PF00018	0.549
LIG_SUMO_SIM_par_1	125	134	PF11976	0.519
LIG_TRAF2_1	11	14	PF00917	0.518
LIG_TRAF2_1	110	113	PF00917	0.513
LIG_TRAF2_1	124	127	PF00917	0.661
MOD_CK2_1	103	109	PF00069	0.708
MOD_CK2_1	139	145	PF00069	0.530
MOD_GlcNHglycan	51	55	PF01048	0.274
MOD_NEK2_1	1	6	PF00069	0.775
MOD_NEK2_1	101	106	PF00069	0.571
MOD_PKA_2	1	7	PF00069	0.495
MOD_Plk_2-3	103	109	PF00069	0.515
MOD_Plk_4	81	87	PF00069	0.497
MOD_ProDKin_1	66	72	PF00069	0.475
TRG_DiLeu_BaEn_2	115	121	PF01217	0.511
TRG_DiLeu_BaEn_3	127	133	PF01217	0.519
TRG_DiLeu_BaEn_4	128	134	PF01217	0.524
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.475
TRG_ER_diArg_1	33	36	PF00400	0.475
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.275

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE79	Leptomonas seymouri	85%	70%
A0A3Q8IIB5	Leishmania donovani	84%	100%
A4IBE9	Leishmania infantum	84%	100%
E9AF63	Leishmania major	82%	100%
E9B6B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%