SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMR1_LEIBR

TriTrypDb:

LbrM.34.2320 , LBRM2903_340030700

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMR1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.470
CLV_C14_Caspase3-7	464	468	PF00656	0.549
CLV_C14_Caspase3-7	581	585	PF00656	0.740
CLV_NRD_NRD_1	13	15	PF00675	0.635
CLV_NRD_NRD_1	136	138	PF00675	0.456
CLV_NRD_NRD_1	636	638	PF00675	0.497
CLV_NRD_NRD_1	643	645	PF00675	0.546
CLV_PCSK_FUR_1	416	420	PF00082	0.753
CLV_PCSK_KEX2_1	13	15	PF00082	0.635
CLV_PCSK_KEX2_1	136	138	PF00082	0.456
CLV_PCSK_KEX2_1	418	420	PF00082	0.607
CLV_PCSK_KEX2_1	635	637	PF00082	0.512
CLV_PCSK_KEX2_1	643	645	PF00082	0.546
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.761
CLV_PCSK_SKI1_1	13	17	PF00082	0.609
CLV_PCSK_SKI1_1	33	37	PF00082	0.287
CLV_PCSK_SKI1_1	643	647	PF00082	0.543
CLV_PCSK_SKI1_1	684	688	PF00082	0.396
DEG_APCC_DBOX_1	169	177	PF00400	0.727
DEG_APCC_DBOX_1	591	599	PF00400	0.754
DEG_APCC_DBOX_1	634	642	PF00400	0.504
DEG_Nend_UBRbox_2	1	3	PF02207	0.560
DEG_SCF_FBW7_1	345	352	PF00400	0.537
DEG_SPOP_SBC_1	344	348	PF00917	0.733
DEG_SPOP_SBC_1	69	73	PF00917	0.373
DOC_CDC14_PxL_1	527	535	PF14671	0.777
DOC_CKS1_1	59	64	PF01111	0.455
DOC_CYCLIN_RxL_1	637	647	PF00134	0.523
DOC_CYCLIN_yClb1_LxF_4	542	547	PF00134	0.786
DOC_CYCLIN_yCln2_LP_2	679	685	PF00134	0.401
DOC_MAPK_gen_1	170	179	PF00069	0.581
DOC_MAPK_gen_1	722	730	PF00069	0.548
DOC_MAPK_MEF2A_6	684	693	PF00069	0.327
DOC_MAPK_MEF2A_6	722	730	PF00069	0.400
DOC_PP1_RVXF_1	542	548	PF00149	0.548
DOC_PP2B_LxvP_1	679	682	PF13499	0.402
DOC_PP4_FxxP_1	458	461	PF00568	0.560
DOC_PP4_FxxP_1	685	688	PF00568	0.390
DOC_SPAK_OSR1_1	558	562	PF12202	0.528
DOC_USP7_MATH_1	132	136	PF00917	0.565
DOC_USP7_MATH_1	178	182	PF00917	0.620
DOC_USP7_MATH_1	192	196	PF00917	0.536
DOC_USP7_MATH_1	205	209	PF00917	0.729
DOC_USP7_MATH_1	220	224	PF00917	0.632
DOC_USP7_MATH_1	230	234	PF00917	0.632
DOC_USP7_MATH_1	259	263	PF00917	0.548
DOC_USP7_MATH_1	344	348	PF00917	0.707
DOC_USP7_MATH_1	394	398	PF00917	0.600
DOC_USP7_MATH_1	426	430	PF00917	0.682
DOC_USP7_MATH_1	450	454	PF00917	0.720
DOC_USP7_MATH_1	487	491	PF00917	0.638
DOC_USP7_MATH_1	770	774	PF00917	0.418
DOC_USP7_MATH_1	794	798	PF00917	0.316
DOC_WW_Pin1_4	155	160	PF00397	0.539
DOC_WW_Pin1_4	194	199	PF00397	0.682
DOC_WW_Pin1_4	305	310	PF00397	0.444
DOC_WW_Pin1_4	319	324	PF00397	0.463
DOC_WW_Pin1_4	345	350	PF00397	0.643
DOC_WW_Pin1_4	438	443	PF00397	0.701
DOC_WW_Pin1_4	457	462	PF00397	0.499
DOC_WW_Pin1_4	521	526	PF00397	0.639
DOC_WW_Pin1_4	532	537	PF00397	0.584
DOC_WW_Pin1_4	538	543	PF00397	0.561
DOC_WW_Pin1_4	58	63	PF00397	0.448
DOC_WW_Pin1_4	590	595	PF00397	0.502
DOC_WW_Pin1_4	625	630	PF00397	0.453
DOC_WW_Pin1_4	784	789	PF00397	0.609
LIG_14-3-3_CanoR_1	136	146	PF00244	0.518
LIG_14-3-3_CanoR_1	154	161	PF00244	0.525
LIG_14-3-3_CanoR_1	270	279	PF00244	0.430
LIG_14-3-3_CanoR_1	315	320	PF00244	0.478
LIG_14-3-3_CanoR_1	33	38	PF00244	0.455
LIG_14-3-3_CanoR_1	419	424	PF00244	0.760
LIG_14-3-3_CanoR_1	550	559	PF00244	0.536
LIG_14-3-3_CanoR_1	592	598	PF00244	0.630
LIG_14-3-3_CanoR_1	613	619	PF00244	0.481
LIG_14-3-3_CanoR_1	673	683	PF00244	0.439
LIG_14-3-3_CanoR_1	725	729	PF00244	0.548
LIG_14-3-3_CanoR_1	77	82	PF00244	0.451
LIG_Actin_WH2_2	680	696	PF00022	0.329
LIG_APCC_ABBA_1	473	478	PF00400	0.573
LIG_BIR_III_4	337	341	PF00653	0.615
LIG_BIR_III_4	783	787	PF00653	0.579
LIG_BRCT_BRCA1_1	232	236	PF00533	0.509
LIG_BRCT_BRCA1_1	361	365	PF00533	0.790
LIG_CaM_IQ_9	599	615	PF13499	0.704
LIG_deltaCOP1_diTrp_1	371	378	PF00928	0.623
LIG_DLG_GKlike_1	126	133	PF00625	0.460
LIG_eIF4E_1	24	30	PF01652	0.440
LIG_eIF4E_1	43	49	PF01652	0.434
LIG_FHA_1	129	135	PF00498	0.422
LIG_FHA_1	199	205	PF00498	0.542
LIG_FHA_1	306	312	PF00498	0.458
LIG_FHA_1	527	533	PF00498	0.710
LIG_FHA_1	600	606	PF00498	0.721
LIG_FHA_1	640	646	PF00498	0.529
LIG_FHA_2	480	486	PF00498	0.583
LIG_FHA_2	599	605	PF00498	0.732
LIG_FHA_2	716	722	PF00498	0.545
LIG_LIR_Apic_2	456	461	PF02991	0.578
LIG_LIR_Gen_1	128	134	PF02991	0.434
LIG_LIR_Gen_1	158	168	PF02991	0.529
LIG_LIR_Gen_1	233	242	PF02991	0.493
LIG_LIR_Gen_1	64	70	PF02991	0.443
LIG_LIR_LC3C_4	606	610	PF02991	0.580
LIG_LIR_LC3C_4	727	730	PF02991	0.381
LIG_LIR_Nem_3	128	133	PF02991	0.439
LIG_LIR_Nem_3	158	163	PF02991	0.514
LIG_LIR_Nem_3	233	239	PF02991	0.510
LIG_LIR_Nem_3	61	66	PF02991	0.414
LIG_LIR_Nem_3	80	86	PF02991	0.454
LIG_MAD2	621	629	PF02301	0.479
LIG_NRBOX	315	321	PF00104	0.471
LIG_Pex14_2	66	70	PF04695	0.451
LIG_SH2_STAP1	90	94	PF00017	0.391
LIG_SH2_STAT3	627	630	PF00017	0.670
LIG_SH2_STAT5	408	411	PF00017	0.625
LIG_SH2_STAT5	597	600	PF00017	0.753
LIG_SH2_STAT5	659	662	PF00017	0.441
LIG_SH2_STAT5	736	739	PF00017	0.432
LIG_SH2_STAT5	79	82	PF00017	0.439
LIG_SH3_3	174	180	PF00018	0.546
LIG_SH3_3	35	41	PF00018	0.461
LIG_SH3_3	374	380	PF00018	0.615
LIG_SH3_3	56	62	PF00018	0.313
LIG_SUMO_SIM_anti_2	518	524	PF11976	0.720
LIG_SUMO_SIM_anti_2	606	612	PF11976	0.586
LIG_SUMO_SIM_anti_2	724	731	PF11976	0.406
LIG_SUMO_SIM_par_1	315	322	PF11976	0.475
LIG_SUMO_SIM_par_1	528	535	PF11976	0.539
LIG_SUMO_SIM_par_1	778	783	PF11976	0.378
LIG_SxIP_EBH_1	51	60	PF03271	0.420
LIG_TRAF2_1	141	144	PF00917	0.573
LIG_TRAF2_1	212	215	PF00917	0.542
LIG_TRAF2_1	25	28	PF00917	0.450
LIG_TRAF2_1	482	485	PF00917	0.584
LIG_TRAF2_1	601	604	PF00917	0.581
LIG_TRAF2_2	380	385	PF00917	0.592
LIG_WRC_WIRS_1	179	184	PF05994	0.719
LIG_WRC_WIRS_1	716	721	PF05994	0.557
MOD_CDC14_SPxK_1	541	544	PF00782	0.776
MOD_CDK_SPK_2	305	310	PF00069	0.444
MOD_CDK_SPxK_1	538	544	PF00069	0.775
MOD_CK1_1	318	324	PF00069	0.466
MOD_CK1_1	355	361	PF00069	0.705
MOD_CK1_1	364	370	PF00069	0.686
MOD_CK1_1	453	459	PF00069	0.802
MOD_CK1_1	462	468	PF00069	0.614
MOD_CK1_1	480	486	PF00069	0.521
MOD_CK1_1	492	498	PF00069	0.618
MOD_CK1_1	500	506	PF00069	0.712
MOD_CK1_1	535	541	PF00069	0.639
MOD_CK1_1	579	585	PF00069	0.685
MOD_CK1_1	593	599	PF00069	0.515
MOD_CK1_1	617	623	PF00069	0.595
MOD_CK1_1	700	706	PF00069	0.553
MOD_CK1_1	73	79	PF00069	0.478
MOD_CK2_1	137	143	PF00069	0.437
MOD_CK2_1	235	241	PF00069	0.657
MOD_CK2_1	287	293	PF00069	0.407
MOD_CK2_1	394	400	PF00069	0.603
MOD_CK2_1	419	425	PF00069	0.513
MOD_CK2_1	479	485	PF00069	0.576
MOD_CK2_1	598	604	PF00069	0.738
MOD_CK2_1	674	680	PF00069	0.479
MOD_CMANNOS	381	384	PF00535	0.592
MOD_GlcNHglycan	117	120	PF01048	0.428
MOD_GlcNHglycan	139	142	PF01048	0.486
MOD_GlcNHglycan	155	158	PF01048	0.528
MOD_GlcNHglycan	187	190	PF01048	0.719
MOD_GlcNHglycan	194	197	PF01048	0.620
MOD_GlcNHglycan	207	210	PF01048	0.730
MOD_GlcNHglycan	222	225	PF01048	0.695
MOD_GlcNHglycan	230	233	PF01048	0.662
MOD_GlcNHglycan	245	248	PF01048	0.505
MOD_GlcNHglycan	341	344	PF01048	0.639
MOD_GlcNHglycan	354	357	PF01048	0.794
MOD_GlcNHglycan	494	497	PF01048	0.706
MOD_GlcNHglycan	537	540	PF01048	0.728
MOD_GlcNHglycan	552	555	PF01048	0.593
MOD_GlcNHglycan	584	587	PF01048	0.520
MOD_GlcNHglycan	63	66	PF01048	0.426
MOD_GlcNHglycan	699	702	PF01048	0.666
MOD_GlcNHglycan	755	758	PF01048	0.643
MOD_GSK3_1	128	135	PF00069	0.458
MOD_GSK3_1	194	201	PF00069	0.608
MOD_GSK3_1	243	250	PF00069	0.557
MOD_GSK3_1	266	273	PF00069	0.643
MOD_GSK3_1	315	322	PF00069	0.532
MOD_GSK3_1	339	346	PF00069	0.742
MOD_GSK3_1	355	362	PF00069	0.738
MOD_GSK3_1	363	370	PF00069	0.654
MOD_GSK3_1	394	401	PF00069	0.606
MOD_GSK3_1	449	456	PF00069	0.677
MOD_GSK3_1	462	469	PF00069	0.791
MOD_GSK3_1	485	492	PF00069	0.604
MOD_GSK3_1	49	56	PF00069	0.455
MOD_GSK3_1	494	501	PF00069	0.608
MOD_GSK3_1	521	528	PF00069	0.601
MOD_GSK3_1	534	541	PF00069	0.630
MOD_GSK3_1	548	555	PF00069	0.781
MOD_GSK3_1	572	579	PF00069	0.725
MOD_GSK3_1	593	600	PF00069	0.616
MOD_GSK3_1	625	632	PF00069	0.548
MOD_GSK3_1	69	76	PF00069	0.317
MOD_GSK3_1	724	731	PF00069	0.406
MOD_GSK3_1	744	751	PF00069	0.361
MOD_LATS_1	396	402	PF00433	0.608
MOD_N-GLC_1	115	120	PF02516	0.428
MOD_N-GLC_1	228	233	PF02516	0.510
MOD_N-GLC_1	257	262	PF02516	0.532
MOD_N-GLC_1	498	503	PF02516	0.567
MOD_N-GLC_1	753	758	PF02516	0.440
MOD_N-GLC_2	676	678	PF02516	0.639
MOD_NEK2_1	359	364	PF00069	0.698
MOD_NEK2_1	49	54	PF00069	0.569
MOD_NEK2_1	598	603	PF00069	0.728
MOD_NEK2_1	611	616	PF00069	0.487
MOD_NEK2_1	623	628	PF00069	0.636
MOD_NEK2_1	70	75	PF00069	0.484
MOD_NEK2_1	753	758	PF00069	0.440
MOD_OFUCOSY	672	678	PF10250	0.507
MOD_PIKK_1	281	287	PF00454	0.406
MOD_PIKK_1	323	329	PF00454	0.451
MOD_PIKK_1	349	355	PF00454	0.635
MOD_PIKK_1	398	404	PF00454	0.618
MOD_PIKK_1	576	582	PF00454	0.532
MOD_PIKK_1	599	605	PF00454	0.583
MOD_PK_1	419	425	PF00069	0.753
MOD_PKA_2	153	159	PF00069	0.551
MOD_PKA_2	492	498	PF00069	0.684
MOD_PKA_2	582	588	PF00069	0.579
MOD_PKA_2	672	678	PF00069	0.477
MOD_PKA_2	724	730	PF00069	0.532
MOD_Plk_1	477	483	PF00069	0.691
MOD_Plk_1	548	554	PF00069	0.751
MOD_Plk_1	623	629	PF00069	0.555
MOD_Plk_2-3	235	241	PF00069	0.510
MOD_Plk_4	388	394	PF00069	0.579
MOD_Plk_4	55	61	PF00069	0.440
MOD_Plk_4	593	599	PF00069	0.606
MOD_Plk_4	629	635	PF00069	0.611
MOD_Plk_4	655	661	PF00069	0.436
MOD_Plk_4	724	730	PF00069	0.397
MOD_ProDKin_1	155	161	PF00069	0.538
MOD_ProDKin_1	194	200	PF00069	0.684
MOD_ProDKin_1	305	311	PF00069	0.448
MOD_ProDKin_1	319	325	PF00069	0.455
MOD_ProDKin_1	345	351	PF00069	0.643
MOD_ProDKin_1	438	444	PF00069	0.703
MOD_ProDKin_1	457	463	PF00069	0.500
MOD_ProDKin_1	521	527	PF00069	0.641
MOD_ProDKin_1	532	538	PF00069	0.584
MOD_ProDKin_1	58	64	PF00069	0.453
MOD_ProDKin_1	590	596	PF00069	0.500
MOD_ProDKin_1	625	631	PF00069	0.442
MOD_ProDKin_1	784	790	PF00069	0.600
MOD_SUMO_for_1	212	215	PF00179	0.634
TRG_AP2beta_CARGO_1	128	137	PF09066	0.435
TRG_DiLeu_BaEn_1	518	523	PF01217	0.742
TRG_DiLeu_BaEn_1	604	609	PF01217	0.537
TRG_DiLeu_BaEn_4	518	524	PF01217	0.744
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.380
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.777
TRG_DiLeu_BaLyEn_6	800	805	PF01217	0.445
TRG_ENDOCYTIC_2	100	103	PF00928	0.559
TRG_ENDOCYTIC_2	63	66	PF00928	0.426
TRG_ER_diArg_1	13	15	PF00400	0.635
TRG_ER_diArg_1	169	172	PF00400	0.563
TRG_ER_diArg_1	634	637	PF00400	0.497
TRG_ER_diArg_1	643	645	PF00400	0.546
TRG_ER_diArg_1	664	667	PF00400	0.411
TRG_ER_diArg_1	670	673	PF00400	0.483
TRG_ER_diArg_1	689	692	PF00400	0.569
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P946	Leptomonas seymouri	51%	87%
A0A3Q8IMA4	Leishmania donovani	78%	98%
A4IBE7	Leishmania infantum	78%	98%
E9AF61	Leishmania major	76%	100%
E9B6B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	98%