Putative ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania braziliensis

UniProt:

A4HMQ8_LEIBR

TriTrypDb:

LbrM.34.2290 , LBRM2903_340030400

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.402
CLV_C14_Caspase3-7	592	596	PF00656	0.340
CLV_C14_Caspase3-7	85	89	PF00656	0.402
CLV_NRD_NRD_1	315	317	PF00675	0.276
CLV_NRD_NRD_1	402	404	PF00675	0.300
CLV_NRD_NRD_1	441	443	PF00675	0.304
CLV_NRD_NRD_1	54	56	PF00675	0.304
CLV_NRD_NRD_1	619	621	PF00675	0.317
CLV_PCSK_KEX2_1	194	196	PF00082	0.202
CLV_PCSK_KEX2_1	315	317	PF00082	0.221
CLV_PCSK_KEX2_1	402	404	PF00082	0.201
CLV_PCSK_KEX2_1	598	600	PF00082	0.450
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.202
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.450
CLV_PCSK_SKI1_1	267	271	PF00082	0.335
CLV_PCSK_SKI1_1	332	336	PF00082	0.221
CLV_PCSK_SKI1_1	432	436	PF00082	0.202
CLV_PCSK_SKI1_1	611	615	PF00082	0.469
CLV_PCSK_SKI1_1	620	624	PF00082	0.398
DEG_Nend_UBRbox_2	1	3	PF02207	0.436
DOC_CKS1_1	221	226	PF01111	0.402
DOC_CYCLIN_RxL_1	351	363	PF00134	0.425
DOC_CYCLIN_RxL_1	429	439	PF00134	0.402
DOC_CYCLIN_yClb5_NLxxxL_5	316	324	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.402
DOC_MAPK_gen_1	267	275	PF00069	0.500
DOC_MAPK_gen_1	315	323	PF00069	0.478
DOC_MAPK_gen_1	55	62	PF00069	0.402
DOC_MAPK_JIP1_4	56	62	PF00069	0.402
DOC_MAPK_MEF2A_6	356	364	PF00069	0.402
DOC_MAPK_MEF2A_6	611	618	PF00069	0.359
DOC_MAPK_MEF2A_6	69	78	PF00069	0.514
DOC_PP1_RVXF_1	441	448	PF00149	0.504
DOC_PP4_FxxP_1	342	345	PF00568	0.402
DOC_USP7_MATH_1	142	146	PF00917	0.402
DOC_USP7_MATH_1	183	187	PF00917	0.568
DOC_USP7_MATH_1	205	209	PF00917	0.457
DOC_USP7_MATH_1	49	53	PF00917	0.504
DOC_USP7_MATH_1	522	526	PF00917	0.496
DOC_USP7_MATH_1	548	552	PF00917	0.470
DOC_USP7_MATH_1	568	572	PF00917	0.520
DOC_USP7_MATH_1	622	626	PF00917	0.274
DOC_USP7_MATH_1	98	102	PF00917	0.410
DOC_USP7_UBL2_3	664	668	PF12436	0.313
DOC_WW_Pin1_4	220	225	PF00397	0.440
DOC_WW_Pin1_4	96	101	PF00397	0.437
LIG_14-3-3_CanoR_1	177	184	PF00244	0.449
LIG_14-3-3_CanoR_1	332	338	PF00244	0.418
LIG_14-3-3_CanoR_1	403	413	PF00244	0.429
LIG_14-3-3_CanoR_1	489	497	PF00244	0.524
LIG_Actin_WH2_2	571	588	PF00022	0.273
LIG_APCC_ABBA_1	11	16	PF00400	0.402
LIG_APCC_ABBA_1	78	83	PF00400	0.504
LIG_BIR_III_4	88	92	PF00653	0.541
LIG_BRCT_BRCA1_1	338	342	PF00533	0.402
LIG_BRCT_BRCA1_1	524	528	PF00533	0.500
LIG_FHA_1	129	135	PF00498	0.504
LIG_FHA_1	217	223	PF00498	0.402
LIG_FHA_1	24	30	PF00498	0.402
LIG_FHA_1	247	253	PF00498	0.506
LIG_FHA_1	264	270	PF00498	0.561
LIG_FHA_1	284	290	PF00498	0.371
LIG_FHA_1	450	456	PF00498	0.411
LIG_FHA_1	486	492	PF00498	0.468
LIG_FHA_1	552	558	PF00498	0.449
LIG_FHA_1	599	605	PF00498	0.457
LIG_FHA_1	627	633	PF00498	0.359
LIG_FHA_2	212	218	PF00498	0.402
LIG_FHA_2	240	246	PF00498	0.468
LIG_FHA_2	80	86	PF00498	0.402
LIG_IRF3_LxIS_1	358	363	PF10401	0.402
LIG_LIR_Apic_2	339	345	PF02991	0.402
LIG_LIR_Gen_1	232	241	PF02991	0.504
LIG_LIR_Gen_1	300	309	PF02991	0.572
LIG_LIR_Gen_1	453	464	PF02991	0.590
LIG_LIR_Gen_1	580	590	PF02991	0.433
LIG_LIR_Gen_1	68	78	PF02991	0.527
LIG_LIR_Gen_1	79	89	PF02991	0.515
LIG_LIR_Nem_3	123	128	PF02991	0.480
LIG_LIR_Nem_3	151	156	PF02991	0.498
LIG_LIR_Nem_3	21	27	PF02991	0.464
LIG_LIR_Nem_3	232	236	PF02991	0.500
LIG_LIR_Nem_3	28	34	PF02991	0.485
LIG_LIR_Nem_3	300	306	PF02991	0.572
LIG_LIR_Nem_3	453	459	PF02991	0.496
LIG_LIR_Nem_3	473	477	PF02991	0.472
LIG_LIR_Nem_3	580	585	PF02991	0.456
LIG_LIR_Nem_3	79	84	PF02991	0.524
LIG_LRP6_Inhibitor_1	171	177	PF00058	0.202
LIG_NRBOX	430	436	PF00104	0.504
LIG_Pex14_2	149	153	PF04695	0.504
LIG_Pex14_2	482	486	PF04695	0.549
LIG_Pex14_2	528	532	PF04695	0.402
LIG_Rb_LxCxE_1	487	504	PF01857	0.402
LIG_SH2_CRK	303	307	PF00017	0.480
LIG_SH2_CRK	582	586	PF00017	0.459
LIG_SH2_GRB2like	575	578	PF00017	0.387
LIG_SH2_SRC	575	578	PF00017	0.250
LIG_SH2_STAP1	125	129	PF00017	0.402
LIG_SH2_STAP1	436	440	PF00017	0.573
LIG_SH2_STAP1	451	455	PF00017	0.423
LIG_SH2_STAP1	575	579	PF00017	0.537
LIG_SH2_STAT3	639	642	PF00017	0.390
LIG_SH2_STAT5	125	128	PF00017	0.402
LIG_SH2_STAT5	155	158	PF00017	0.550
LIG_SH2_STAT5	228	231	PF00017	0.444
LIG_SH2_STAT5	303	306	PF00017	0.402
LIG_SH2_STAT5	354	357	PF00017	0.533
LIG_SH2_STAT5	377	380	PF00017	0.493
LIG_SH2_STAT5	451	454	PF00017	0.504
LIG_SH2_STAT5	523	526	PF00017	0.409
LIG_SH2_STAT5	589	592	PF00017	0.465
LIG_SH2_STAT5	607	610	PF00017	0.388
LIG_SH2_STAT5	61	64	PF00017	0.402
LIG_SH2_STAT5	639	642	PF00017	0.355
LIG_SH3_2	221	226	PF14604	0.402
LIG_SH3_3	218	224	PF00018	0.402
LIG_SH3_3	319	325	PF00018	0.504
LIG_SUMO_SIM_anti_2	357	363	PF11976	0.402
LIG_SUMO_SIM_par_1	25	30	PF11976	0.402
LIG_SUMO_SIM_par_1	333	339	PF11976	0.585
LIG_UBA3_1	334	340	PF00899	0.402
LIG_UBA3_1	657	664	PF00899	0.297
LIG_WRC_WIRS_1	230	235	PF05994	0.500
LIG_WRC_WIRS_1	361	366	PF05994	0.500
LIG_WRC_WIRS_1	471	476	PF05994	0.504
LIG_WRC_WIRS_1	523	528	PF05994	0.421
MOD_CDK_SPxK_1	220	226	PF00069	0.402
MOD_CK1_1	185	191	PF00069	0.402
MOD_CK1_1	23	29	PF00069	0.417
MOD_CK1_1	336	342	PF00069	0.497
MOD_CK1_1	420	426	PF00069	0.454
MOD_CK1_1	473	479	PF00069	0.504
MOD_CK1_1	515	521	PF00069	0.524
MOD_CK1_1	530	536	PF00069	0.405
MOD_CK1_1	538	544	PF00069	0.421
MOD_CK1_1	551	557	PF00069	0.382
MOD_CK1_1	688	694	PF00069	0.560
MOD_CK1_1	79	85	PF00069	0.478
MOD_CK2_1	239	245	PF00069	0.478
MOD_CK2_1	335	341	PF00069	0.526
MOD_CK2_1	489	495	PF00069	0.402
MOD_CK2_1	79	85	PF00069	0.402
MOD_Cter_Amidation	313	316	PF01082	0.265
MOD_GlcNHglycan	104	107	PF01048	0.379
MOD_GlcNHglycan	140	143	PF01048	0.385
MOD_GlcNHglycan	144	147	PF01048	0.379
MOD_GlcNHglycan	150	153	PF01048	0.308
MOD_GlcNHglycan	233	236	PF01048	0.326
MOD_GlcNHglycan	30	34	PF01048	0.335
MOD_GlcNHglycan	371	374	PF01048	0.373
MOD_GlcNHglycan	392	395	PF01048	0.240
MOD_GlcNHglycan	502	506	PF01048	0.328
MOD_GlcNHglycan	532	535	PF01048	0.268
MOD_GlcNHglycan	661	664	PF01048	0.349
MOD_GSK3_1	138	145	PF00069	0.505
MOD_GSK3_1	172	179	PF00069	0.411
MOD_GSK3_1	216	223	PF00069	0.423
MOD_GSK3_1	297	304	PF00069	0.454
MOD_GSK3_1	416	423	PF00069	0.502
MOD_GSK3_1	481	488	PF00069	0.498
MOD_GSK3_1	512	519	PF00069	0.478
MOD_GSK3_1	535	542	PF00069	0.402
MOD_GSK3_1	577	584	PF00069	0.391
MOD_GSK3_1	622	629	PF00069	0.317
MOD_GSK3_1	65	72	PF00069	0.559
MOD_GSK3_1	98	105	PF00069	0.569
MOD_N-GLC_1	123	128	PF02516	0.288
MOD_N-GLC_1	142	147	PF02516	0.202
MOD_N-GLC_1	568	573	PF02516	0.576
MOD_N-GLC_2	415	417	PF02516	0.202
MOD_NEK2_1	1	6	PF00069	0.369
MOD_NEK2_1	198	203	PF00069	0.416
MOD_NEK2_1	263	268	PF00069	0.504
MOD_NEK2_1	29	34	PF00069	0.464
MOD_NEK2_1	333	338	PF00069	0.511
MOD_NEK2_1	360	365	PF00069	0.419
MOD_NEK2_1	404	409	PF00069	0.402
MOD_NEK2_1	430	435	PF00069	0.521
MOD_NEK2_1	485	490	PF00069	0.470
MOD_NEK2_1	528	533	PF00069	0.408
MOD_NEK2_1	65	70	PF00069	0.529
MOD_NEK2_1	653	658	PF00069	0.280
MOD_NEK2_2	522	527	PF00069	0.419
MOD_NEK2_2	568	573	PF00069	0.547
MOD_NEK2_2	622	627	PF00069	0.285
MOD_PIKK_1	183	189	PF00454	0.441
MOD_PIKK_1	297	303	PF00454	0.402
MOD_PIKK_1	536	542	PF00454	0.504
MOD_PK_1	172	178	PF00069	0.407
MOD_PK_1	69	75	PF00069	0.421
MOD_PKA_1	55	61	PF00069	0.504
MOD_PKA_1	598	604	PF00069	0.378
MOD_PKA_2	176	182	PF00069	0.466
MOD_PKA_2	598	604	PF00069	0.378
MOD_PKA_2	685	691	PF00069	0.476
MOD_Plk_1	123	129	PF00069	0.513
MOD_Plk_1	20	26	PF00069	0.502
MOD_Plk_1	216	222	PF00069	0.414
MOD_Plk_1	246	252	PF00069	0.481
MOD_Plk_1	263	269	PF00069	0.482
MOD_Plk_1	528	534	PF00069	0.454
MOD_Plk_1	568	574	PF00069	0.578
MOD_Plk_4	14	20	PF00069	0.538
MOD_Plk_4	301	307	PF00069	0.591
MOD_Plk_4	417	423	PF00069	0.545
MOD_Plk_4	430	436	PF00069	0.493
MOD_Plk_4	481	487	PF00069	0.448
MOD_Plk_4	548	554	PF00069	0.433
MOD_Plk_4	584	590	PF00069	0.401
MOD_Plk_4	653	659	PF00069	0.504
MOD_Plk_4	69	75	PF00069	0.521
MOD_ProDKin_1	220	226	PF00069	0.440
MOD_ProDKin_1	96	102	PF00069	0.437
MOD_SUMO_for_1	110	113	PF00179	0.402
MOD_SUMO_for_1	597	600	PF00179	0.381
MOD_SUMO_for_1	682	685	PF00179	0.447
TRG_DiLeu_BaEn_2	112	118	PF01217	0.504
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.402
TRG_ENDOCYTIC_2	196	199	PF00928	0.500
TRG_ENDOCYTIC_2	303	306	PF00928	0.504
TRG_ENDOCYTIC_2	451	454	PF00928	0.500
TRG_ENDOCYTIC_2	523	526	PF00928	0.409
TRG_ENDOCYTIC_2	575	578	PF00928	0.462
TRG_ENDOCYTIC_2	582	585	PF00928	0.435
TRG_ENDOCYTIC_2	71	74	PF00928	0.526
TRG_ER_diArg_1	315	317	PF00400	0.423
TRG_ER_diArg_1	402	404	PF00400	0.402
TRG_ER_diArg_1	676	679	PF00400	0.389
TRG_NES_CRM1_1	311	327	PF08389	0.581
TRG_NES_CRM1_1	75	88	PF08389	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGE9	Leptomonas seymouri	38%	98%
A0A3R7LZW8	Trypanosoma rangeli	23%	100%
A0A3S7X9D8	Leishmania donovani	67%	100%
A4IBC6	Leishmania infantum	67%	100%
E9AF58	Leishmania major	66%	100%
E9B6B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%