Putative ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

poly(A)-specific ribonuclease PARN, putative

Species:

Leishmania braziliensis

UniProt:

A4HMQ8_LEIBR

TriTrypDb:

LbrM.34.2290 , LBRM2903_340030400

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4HMQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ8

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0003676	nucleic acid binding	3	8
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	8
GO:0008408	3'-5' exonuclease activity	6	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.402
CLV_C14_Caspase3-7	592	596	PF00656	0.340
CLV_C14_Caspase3-7	85	89	PF00656	0.402
CLV_NRD_NRD_1	315	317	PF00675	0.276
CLV_NRD_NRD_1	402	404	PF00675	0.300
CLV_NRD_NRD_1	441	443	PF00675	0.304
CLV_NRD_NRD_1	54	56	PF00675	0.304
CLV_NRD_NRD_1	619	621	PF00675	0.317
CLV_PCSK_KEX2_1	194	196	PF00082	0.202
CLV_PCSK_KEX2_1	315	317	PF00082	0.221

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PGE9	Leptomonas seymouri	38%	98%
A0A3R7LZW8	Trypanosoma rangeli	23%	100%
A0A3S7X9D8	Leishmania donovani	67%	100%
A4IBC6	Leishmania infantum	67%	100%
E9AF58	Leishmania major	66%	100%
E9B6B4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%

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