Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Importin 1

Species:

Leishmania braziliensis

UniProt:

A4HMQ7_LEIBR

TriTrypDb:

LbrM.34.2280 , LBRM2903_340030300

Length:

919

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4HMQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ7

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006913	nucleocytoplasmic transport	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0034504	protein localization to nucleus	6	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051169	nuclear transport	4	12
GO:0051170	import into nucleus	6	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	12
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051236	establishment of RNA localization	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	1
GO:0005488	binding	1	2
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1
GO:0003824	catalytic activity	1	1
GO:0005515	protein binding	2	1
GO:0016301	kinase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0019899	enzyme binding	3	1
GO:0031267	small GTPase binding	5	1
GO:0051020	GTPase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.501
CLV_C14_Caspase3-7	343	347	PF00656	0.624
CLV_C14_Caspase3-7	588	592	PF00656	0.578
CLV_NRD_NRD_1	22	24	PF00675	0.371
CLV_NRD_NRD_1	384	386	PF00675	0.363
CLV_NRD_NRD_1	496	498	PF00675	0.517
CLV_NRD_NRD_1	908	910	PF00675	0.548
CLV_PCSK_KEX2_1	22	24	PF00082	0.371
CLV_PCSK_KEX2_1	384	386	PF00082	0.363
CLV_PCSK_SKI1_1	161	165	PF00082	0.383
CLV_PCSK_SKI1_1	295	299	PF00082	0.376
CLV_PCSK_SKI1_1	515	519	PF00082	0.520
CLV_PCSK_SKI1_1	549	553	PF00082	0.327
CLV_PCSK_SKI1_1	883	887	PF00082	0.468
DOC_CDC14_PxL_1	165	173	PF14671	0.495
DOC_CDC14_PxL_1	401	409	PF14671	0.426
DOC_CKS1_1	528	533	PF01111	0.278
DOC_CYCLIN_RxL_1	239	249	PF00134	0.239
DOC_CYCLIN_RxL_1	546	554	PF00134	0.337
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.464
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.468
DOC_MAPK_gen_1	187	196	PF00069	0.390
DOC_MAPK_gen_1	384	391	PF00069	0.359
DOC_MAPK_gen_1	56	63	PF00069	0.449
DOC_MAPK_HePTP_8	186	198	PF00069	0.327
DOC_MAPK_MEF2A_6	189	198	PF00069	0.346
DOC_MAPK_MEF2A_6	242	250	PF00069	0.329
DOC_PP1_RVXF_1	159	166	PF00149	0.260
DOC_PP2B_LxvP_1	228	231	PF13499	0.527
DOC_PP2B_LxvP_1	577	580	PF13499	0.446
DOC_USP7_MATH_1	11	15	PF00917	0.464
DOC_USP7_MATH_1	513	517	PF00917	0.466
DOC_USP7_MATH_1	555	559	PF00917	0.468
DOC_USP7_MATH_1	566	570	PF00917	0.428
DOC_USP7_MATH_1	638	642	PF00917	0.509
DOC_USP7_MATH_1	664	668	PF00917	0.401
DOC_USP7_MATH_1	732	736	PF00917	0.554
DOC_USP7_MATH_1	738	742	PF00917	0.497
DOC_USP7_MATH_1	814	818	PF00917	0.495
DOC_USP7_MATH_1	900	904	PF00917	0.432
DOC_USP7_UBL2_3	354	358	PF12436	0.482
DOC_WW_Pin1_4	14	19	PF00397	0.550
DOC_WW_Pin1_4	527	532	PF00397	0.411
DOC_WW_Pin1_4	589	594	PF00397	0.388
DOC_WW_Pin1_4	689	694	PF00397	0.582
DOC_WW_Pin1_4	763	768	PF00397	0.502
LIG_14-3-3_CanoR_1	141	146	PF00244	0.461
LIG_14-3-3_CanoR_1	384	391	PF00244	0.344
LIG_14-3-3_CanoR_1	535	544	PF00244	0.424
LIG_14-3-3_CanoR_1	568	574	PF00244	0.302
LIG_14-3-3_CanoR_1	623	628	PF00244	0.489
LIG_Actin_RPEL_3	469	488	PF02755	0.279
LIG_APCC_ABBA_1	802	807	PF00400	0.380
LIG_APCC_ABBA_1	861	866	PF00400	0.346
LIG_BIR_II_1	1	5	PF00653	0.385
LIG_BIR_III_2	690	694	PF00653	0.510
LIG_BIR_III_4	663	667	PF00653	0.377
LIG_BRCT_BRCA1_1	172	176	PF00533	0.464
LIG_BRCT_BRCA1_1	246	250	PF00533	0.415
LIG_BRCT_BRCA1_1	658	662	PF00533	0.314
LIG_deltaCOP1_diTrp_1	292	300	PF00928	0.362
LIG_EH1_1	190	198	PF00400	0.231
LIG_eIF4E_1	398	404	PF01652	0.422
LIG_FHA_1	158	164	PF00498	0.374
LIG_FHA_1	236	242	PF00498	0.259
LIG_FHA_1	460	466	PF00498	0.469
LIG_FHA_1	528	534	PF00498	0.505
LIG_FHA_1	615	621	PF00498	0.446
LIG_FHA_1	651	657	PF00498	0.467
LIG_FHA_1	857	863	PF00498	0.273
LIG_FHA_2	177	183	PF00498	0.528
LIG_FHA_2	388	394	PF00498	0.394
LIG_FHA_2	586	592	PF00498	0.399
LIG_FHA_2	728	734	PF00498	0.451
LIG_GBD_Chelix_1	118	126	PF00786	0.448
LIG_LIR_Apic_2	337	342	PF02991	0.444
LIG_LIR_Gen_1	207	218	PF02991	0.285
LIG_LIR_Gen_1	256	267	PF02991	0.366
LIG_LIR_Gen_1	321	332	PF02991	0.419
LIG_LIR_Gen_1	436	447	PF02991	0.395
LIG_LIR_Gen_1	461	471	PF02991	0.390
LIG_LIR_Gen_1	597	605	PF02991	0.391
LIG_LIR_Gen_1	624	632	PF02991	0.446
LIG_LIR_Gen_1	659	669	PF02991	0.405
LIG_LIR_Gen_1	677	688	PF02991	0.352
LIG_LIR_Gen_1	734	744	PF02991	0.390
LIG_LIR_LC3C_4	462	467	PF02991	0.390
LIG_LIR_Nem_3	207	213	PF02991	0.378
LIG_LIR_Nem_3	249	254	PF02991	0.371
LIG_LIR_Nem_3	256	262	PF02991	0.352
LIG_LIR_Nem_3	291	297	PF02991	0.365
LIG_LIR_Nem_3	395	401	PF02991	0.436
LIG_LIR_Nem_3	436	442	PF02991	0.480
LIG_LIR_Nem_3	461	467	PF02991	0.398
LIG_LIR_Nem_3	539	544	PF02991	0.498
LIG_LIR_Nem_3	624	628	PF02991	0.355
LIG_LIR_Nem_3	677	683	PF02991	0.477
LIG_LIR_Nem_3	734	740	PF02991	0.388
LIG_NRBOX	452	458	PF00104	0.338
LIG_Pex14_2	621	625	PF04695	0.509
LIG_Pex14_2	821	825	PF04695	0.321
LIG_PTB_Apo_2	619	626	PF02174	0.493
LIG_Rb_pABgroove_1	593	601	PF01858	0.477
LIG_Rb_pABgroove_1	656	664	PF01858	0.323
LIG_SH2_CRK	210	214	PF00017	0.422
LIG_SH2_CRK	737	741	PF00017	0.358
LIG_SH2_NCK_1	737	741	PF00017	0.375
LIG_SH2_SRC	805	808	PF00017	0.425
LIG_SH2_STAT3	916	919	PF00017	0.495
LIG_SH2_STAT5	145	148	PF00017	0.478
LIG_SH2_STAT5	170	173	PF00017	0.408
LIG_SH2_STAT5	40	43	PF00017	0.468
LIG_SH2_STAT5	480	483	PF00017	0.396
LIG_SH2_STAT5	805	808	PF00017	0.425
LIG_SH3_3	111	117	PF00018	0.355
LIG_SH3_3	399	405	PF00018	0.483
LIG_SH3_3	525	531	PF00018	0.403
LIG_SH3_3	764	770	PF00018	0.298
LIG_SH3_3	86	92	PF00018	0.437
LIG_SUMO_SIM_anti_2	148	155	PF11976	0.332
LIG_SUMO_SIM_anti_2	192	199	PF11976	0.355
LIG_SUMO_SIM_anti_2	400	405	PF11976	0.441
LIG_SUMO_SIM_par_1	315	321	PF11976	0.349
LIG_SUMO_SIM_par_1	465	470	PF11976	0.373
LIG_SUMO_SIM_par_1	549	554	PF11976	0.391
LIG_TRAF2_1	281	284	PF00917	0.497
LIG_TRAF2_1	569	572	PF00917	0.345
LIG_TRAF2_1	646	649	PF00917	0.532
LIG_TYR_ITSM	247	254	PF00017	0.487
LIG_UBA3_1	491	498	PF00899	0.438
LIG_UBA3_1	517	525	PF00899	0.436
LIG_UBA3_1	772	778	PF00899	0.403
MOD_CDK_SPxxK_3	689	696	PF00069	0.438
MOD_CK1_1	102	108	PF00069	0.415
MOD_CK1_1	14	20	PF00069	0.404
MOD_CK1_1	209	215	PF00069	0.411
MOD_CK1_1	357	363	PF00069	0.654
MOD_CK1_1	387	393	PF00069	0.336
MOD_CK1_1	459	465	PF00069	0.435
MOD_CK1_1	470	476	PF00069	0.380
MOD_CK1_1	483	489	PF00069	0.422
MOD_CK1_1	686	692	PF00069	0.458
MOD_CK2_1	322	328	PF00069	0.431
MOD_CK2_1	387	393	PF00069	0.384
MOD_CK2_1	40	46	PF00069	0.366
MOD_CK2_1	405	411	PF00069	0.315
MOD_CK2_1	513	519	PF00069	0.509
MOD_CK2_1	566	572	PF00069	0.421
MOD_CK2_1	664	670	PF00069	0.395
MOD_CK2_1	834	840	PF00069	0.541
MOD_CK2_1	900	906	PF00069	0.352
MOD_GlcNHglycan	13	16	PF01048	0.355
MOD_GlcNHglycan	334	337	PF01048	0.490
MOD_GlcNHglycan	386	389	PF01048	0.343
MOD_GlcNHglycan	415	418	PF01048	0.488
MOD_GlcNHglycan	458	461	PF01048	0.400
MOD_GlcNHglycan	640	643	PF01048	0.586
MOD_GlcNHglycan	658	661	PF01048	0.206
MOD_GlcNHglycan	666	669	PF01048	0.387
MOD_GSK3_1	13	20	PF00069	0.531
MOD_GSK3_1	171	178	PF00069	0.524
MOD_GSK3_1	205	212	PF00069	0.309
MOD_GSK3_1	318	325	PF00069	0.391
MOD_GSK3_1	35	42	PF00069	0.448
MOD_GSK3_1	472	479	PF00069	0.499
MOD_GSK3_1	555	562	PF00069	0.401
MOD_GSK3_1	585	592	PF00069	0.443
MOD_GSK3_1	601	608	PF00069	0.307
MOD_GSK3_1	652	659	PF00069	0.454
MOD_GSK3_1	755	762	PF00069	0.588
MOD_GSK3_1	780	787	PF00069	0.404
MOD_GSK3_1	852	859	PF00069	0.551
MOD_LATS_1	352	358	PF00433	0.476
MOD_N-GLC_1	35	40	PF02516	0.454
MOD_N-GLC_1	589	594	PF02516	0.413
MOD_N-GLC_1	621	626	PF02516	0.422
MOD_N-GLC_1	727	732	PF02516	0.483
MOD_N-GLC_1	783	788	PF02516	0.589
MOD_N-GLC_1	794	799	PF02516	0.435
MOD_NEK2_1	171	176	PF00069	0.519
MOD_NEK2_1	205	210	PF00069	0.322
MOD_NEK2_1	244	249	PF00069	0.368
MOD_NEK2_1	35	40	PF00069	0.450
MOD_NEK2_1	413	418	PF00069	0.466
MOD_NEK2_1	465	470	PF00069	0.372
MOD_NEK2_1	573	578	PF00069	0.422
MOD_NEK2_1	594	599	PF00069	0.355
MOD_NEK2_1	621	626	PF00069	0.373
MOD_NEK2_1	65	70	PF00069	0.503
MOD_NEK2_1	650	655	PF00069	0.359
MOD_NEK2_1	681	686	PF00069	0.371
MOD_NEK2_1	780	785	PF00069	0.560
MOD_NEK2_1	867	872	PF00069	0.355
MOD_NEK2_2	732	737	PF00069	0.456
MOD_OFUCOSY	898	904	PF10250	0.329
MOD_PIKK_1	124	130	PF00454	0.474
MOD_PIKK_1	230	236	PF00454	0.462
MOD_PIKK_1	392	398	PF00454	0.418
MOD_PIKK_1	47	53	PF00454	0.492
MOD_PIKK_1	583	589	PF00454	0.525
MOD_PIKK_1	75	81	PF00454	0.449
MOD_PK_1	344	350	PF00069	0.575
MOD_PKA_1	384	390	PF00069	0.349
MOD_PKA_2	384	390	PF00069	0.349
MOD_PKA_2	567	573	PF00069	0.525
MOD_PKA_2	832	838	PF00069	0.552
MOD_Plk_1	205	211	PF00069	0.307
MOD_Plk_1	282	288	PF00069	0.538
MOD_Plk_1	35	41	PF00069	0.562
MOD_Plk_1	392	398	PF00069	0.418
MOD_Plk_1	621	627	PF00069	0.402
MOD_Plk_1	727	733	PF00069	0.411
MOD_Plk_1	794	800	PF00069	0.462
MOD_Plk_1	833	839	PF00069	0.539
MOD_Plk_1	876	882	PF00069	0.584
MOD_Plk_2-3	149	155	PF00069	0.447
MOD_Plk_2-3	834	840	PF00069	0.541
MOD_Plk_4	121	127	PF00069	0.506
MOD_Plk_4	141	147	PF00069	0.421
MOD_Plk_4	149	155	PF00069	0.460
MOD_Plk_4	246	252	PF00069	0.466
MOD_Plk_4	307	313	PF00069	0.390
MOD_Plk_4	318	324	PF00069	0.377
MOD_Plk_4	35	41	PF00069	0.344
MOD_Plk_4	476	482	PF00069	0.529
MOD_Plk_4	483	489	PF00069	0.512
MOD_Plk_4	573	579	PF00069	0.447
MOD_Plk_4	652	658	PF00069	0.398
MOD_Plk_4	683	689	PF00069	0.375
MOD_Plk_4	834	840	PF00069	0.530
MOD_Plk_4	852	858	PF00069	0.409
MOD_Plk_4	99	105	PF00069	0.413
MOD_ProDKin_1	14	20	PF00069	0.555
MOD_ProDKin_1	527	533	PF00069	0.402
MOD_ProDKin_1	589	595	PF00069	0.380
MOD_ProDKin_1	689	695	PF00069	0.576
MOD_ProDKin_1	763	769	PF00069	0.491
MOD_SUMO_rev_2	519	526	PF00179	0.320
MOD_SUMO_rev_2	807	814	PF00179	0.506
TRG_DiLeu_BaEn_1	192	197	PF01217	0.457
TRG_DiLeu_BaEn_1	834	839	PF01217	0.540
TRG_DiLeu_BaLyEn_6	590	595	PF01217	0.366
TRG_ENDOCYTIC_2	210	213	PF00928	0.357
TRG_ENDOCYTIC_2	251	254	PF00928	0.409
TRG_ENDOCYTIC_2	324	327	PF00928	0.390
TRG_ENDOCYTIC_2	398	401	PF00928	0.438
TRG_ENDOCYTIC_2	439	442	PF00928	0.503
TRG_ENDOCYTIC_2	737	740	PF00928	0.361
TRG_ER_diArg_1	348	351	PF00400	0.516
TRG_ER_diArg_1	383	385	PF00400	0.369
TRG_ER_diArg_1	55	58	PF00400	0.452
TRG_NLS_MonoExtC_3	908	914	PF00514	0.486
TRG_NLS_MonoExtN_4	907	913	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.292
TRG_Pf-PMV_PEXEL_1	549	554	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	880	884	PF00026	0.492
TRG_Pf-PMV_PEXEL_1	910	914	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1U2	Leptomonas seymouri	74%	100%
A0A0S4J991	Bodo saltans	38%	100%
A0A1X0P5L5	Trypanosomatidae	47%	100%
A0A3S7X9A3	Leishmania donovani	91%	100%
A0A422NM11	Trypanosoma rangeli	48%	100%
A4IBC5	Leishmania infantum	91%	100%
B8ARW2	Oryza sativa subsp. indica	26%	100%
B9FDR3	Oryza sativa subsp. japonica	26%	100%
C9ZZC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9AF57	Leishmania major	91%	100%
E9B6B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O14089	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O14787	Homo sapiens	26%	100%
P38217	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
Q3SYU7	Bos taurus	25%	100%
Q8BFY9	Mus musculus	25%	100%
Q8H0U4	Arabidopsis thaliana	28%	100%
Q92973	Homo sapiens	25%	100%
Q99LG2	Mus musculus	26%	100%
V5BTG7	Trypanosoma cruzi	47%	100%