Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMQ5_LEIBR

TriTrypDb:

LbrM.34.2260 , LBRM2903_340030000

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0005744	TIM23 mitochondrial import inner membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1

Expansion

Sequence features

A4HMQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	97	99	PF00675	0.570
CLV_PCSK_KEX2_1	37	39	PF00082	0.486
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.398
CLV_PCSK_SKI1_1	178	182	PF00082	0.587
DOC_MAPK_MEF2A_6	138	147	PF00069	0.358
DOC_USP7_MATH_1	113	117	PF00917	0.548
DOC_USP7_MATH_1	150	154	PF00917	0.478
DOC_USP7_MATH_1	155	159	PF00917	0.412
DOC_WW_Pin1_4	118	123	PF00397	0.485
DOC_WW_Pin1_4	42	47	PF00397	0.735
LIG_14-3-3_CanoR_1	123	131	PF00244	0.505
LIG_14-3-3_CanoR_1	178	183	PF00244	0.490
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_Clathr_ClatBox_1	133	137	PF01394	0.352
LIG_FHA_1	16	22	PF00498	0.734
LIG_FHA_1	179	185	PF00498	0.348
LIG_FHA_2	209	215	PF00498	0.475
LIG_FHA_2	222	228	PF00498	0.433
LIG_IRF3_LxIS_1	140	146	PF10401	0.358
LIG_LIR_Gen_1	142	152	PF02991	0.561
LIG_LIR_Nem_3	137	143	PF02991	0.503
LIG_NRBOX	73	79	PF00104	0.427
LIG_Pex14_2	176	180	PF04695	0.435
LIG_SH2_CRK	14	18	PF00017	0.755
LIG_SH2_PTP2	144	147	PF00017	0.367
LIG_SH2_STAT5	14	17	PF00017	0.755
LIG_SH2_STAT5	144	147	PF00017	0.558
LIG_SH3_2	162	167	PF14604	0.398
LIG_SH3_3	156	162	PF00018	0.505
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.569
LIG_SUMO_SIM_anti_2	82	87	PF11976	0.316
LIG_SUMO_SIM_par_1	180	187	PF11976	0.353
LIG_SUMO_SIM_par_1	76	82	PF11976	0.224
LIG_TRAF2_1	212	215	PF00917	0.439
LIG_UBA3_1	179	185	PF00899	0.465
MOD_CDC14_SPxK_1	45	48	PF00782	0.732
MOD_CDK_SPK_2	118	123	PF00069	0.383
MOD_CDK_SPxK_1	42	48	PF00069	0.711
MOD_CK1_1	153	159	PF00069	0.538
MOD_CK1_1	2	8	PF00069	0.725
MOD_CK1_1	218	224	PF00069	0.416
MOD_CK1_1	29	35	PF00069	0.711
MOD_CK2_1	123	129	PF00069	0.448
MOD_CK2_1	208	214	PF00069	0.423
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.730
MOD_GlcNHglycan	125	128	PF01048	0.665
MOD_GlcNHglycan	153	156	PF01048	0.726
MOD_GlcNHglycan	195	198	PF01048	0.637
MOD_GlcNHglycan	211	214	PF01048	0.699
MOD_GlcNHglycan	28	31	PF01048	0.475
MOD_GSK3_1	114	121	PF00069	0.503
MOD_GSK3_1	12	19	PF00069	0.682
MOD_GSK3_1	150	157	PF00069	0.535
MOD_GSK3_1	51	58	PF00069	0.714
MOD_NEK2_1	143	148	PF00069	0.508
MOD_NEK2_1	21	26	PF00069	0.552
MOD_NEK2_1	7	12	PF00069	0.573
MOD_PIKK_1	218	224	PF00454	0.416
MOD_PKA_1	37	43	PF00069	0.595
MOD_PKA_2	21	27	PF00069	0.724
MOD_PKA_2	37	43	PF00069	0.591
MOD_PKA_2	62	68	PF00069	0.720
MOD_PKA_2	94	100	PF00069	0.494
MOD_Plk_4	2	8	PF00069	0.717
MOD_ProDKin_1	118	124	PF00069	0.483
MOD_ProDKin_1	42	48	PF00069	0.735
MOD_SUMO_for_1	184	187	PF00179	0.421
MOD_SUMO_rev_2	226	231	PF00179	0.452
TRG_DiLeu_BaEn_1	129	134	PF01217	0.346
TRG_DiLeu_BaEn_2	185	191	PF01217	0.508
TRG_DiLeu_BaEn_4	186	192	PF01217	0.413
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.427
TRG_ENDOCYTIC_2	14	17	PF00928	0.755
TRG_ENDOCYTIC_2	144	147	PF00928	0.529
TRG_NLS_MonoExtC_3	97	103	PF00514	0.354
TRG_NLS_MonoExtN_4	95	102	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF73	Leptomonas seymouri	50%	97%
A0A1X0P5M8	Trypanosomatidae	39%	100%
A0A3Q8IPJ2	Leishmania donovani	70%	93%
A4IBC3	Leishmania infantum	70%	93%
C9ZZC5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AF55	Leishmania major	74%	100%
E9B6B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	93%