Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMQ4_LEIBR

TriTrypDb:

LbrM.34.2250 , LBRM2903_340029900

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.467
CLV_C14_Caspase3-7	270	274	PF00656	0.337
CLV_C14_Caspase3-7	49	53	PF00656	0.500
CLV_NRD_NRD_1	100	102	PF00675	0.547
CLV_NRD_NRD_1	103	105	PF00675	0.544
CLV_NRD_NRD_1	236	238	PF00675	0.493
CLV_NRD_NRD_1	297	299	PF00675	0.368
CLV_NRD_NRD_1	319	321	PF00675	0.351
CLV_NRD_NRD_1	396	398	PF00675	0.426
CLV_NRD_NRD_1	45	47	PF00675	0.649
CLV_PCSK_FUR_1	103	107	PF00082	0.470
CLV_PCSK_FUR_1	394	398	PF00082	0.450
CLV_PCSK_FUR_1	97	101	PF00082	0.526
CLV_PCSK_KEX2_1	103	105	PF00082	0.544
CLV_PCSK_KEX2_1	136	138	PF00082	0.416
CLV_PCSK_KEX2_1	236	238	PF00082	0.491
CLV_PCSK_KEX2_1	297	299	PF00082	0.368
CLV_PCSK_KEX2_1	319	321	PF00082	0.351
CLV_PCSK_KEX2_1	396	398	PF00082	0.522
CLV_PCSK_KEX2_1	43	45	PF00082	0.481
CLV_PCSK_KEX2_1	99	101	PF00082	0.553
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.474
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.416
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.477
CLV_PCSK_PC7_1	99	105	PF00082	0.510
CLV_PCSK_SKI1_1	198	202	PF00082	0.684
CLV_PCSK_SKI1_1	225	229	PF00082	0.391
CLV_PCSK_SKI1_1	372	376	PF00082	0.374
DEG_APCC_DBOX_1	296	304	PF00400	0.371
DEG_APCC_KENBOX_2	154	158	PF00400	0.551
DEG_MDM2_SWIB_1	302	310	PF02201	0.473
DOC_CKS1_1	57	62	PF01111	0.489
DOC_CYCLIN_RxL_1	169	180	PF00134	0.637
DOC_CYCLIN_RxL_1	295	305	PF00134	0.360
DOC_MAPK_gen_1	316	324	PF00069	0.457
DOC_PP2B_LxvP_1	216	219	PF13499	0.599
DOC_PP4_FxxP_1	3	6	PF00568	0.643
DOC_PP4_FxxP_1	57	60	PF00568	0.488
DOC_USP7_MATH_1	184	188	PF00917	0.541
DOC_USP7_MATH_1	189	193	PF00917	0.650
DOC_USP7_MATH_1	199	203	PF00917	0.418
DOC_USP7_MATH_1	348	352	PF00917	0.503
DOC_USP7_MATH_1	356	360	PF00917	0.331
DOC_USP7_MATH_1	48	52	PF00917	0.629
DOC_USP7_UBL2_3	43	47	PF12436	0.727
DOC_WW_Pin1_4	17	22	PF00397	0.785
DOC_WW_Pin1_4	2	7	PF00397	0.557
DOC_WW_Pin1_4	225	230	PF00397	0.538
DOC_WW_Pin1_4	56	61	PF00397	0.610
DOC_WW_Pin1_4	64	69	PF00397	0.620
LIG_14-3-3_CanoR_1	103	112	PF00244	0.469
LIG_14-3-3_CanoR_1	198	204	PF00244	0.568
LIG_14-3-3_CanoR_1	297	301	PF00244	0.418
LIG_14-3-3_CanoR_1	358	368	PF00244	0.425
LIG_14-3-3_CanoR_1	369	379	PF00244	0.451
LIG_14-3-3_CanoR_1	380	386	PF00244	0.518
LIG_14-3-3_CanoR_1	396	401	PF00244	0.572
LIG_14-3-3_CanoR_1	8	14	PF00244	0.540
LIG_AP2alpha_2	220	222	PF02296	0.372
LIG_APCC_ABBA_1	174	179	PF00400	0.593
LIG_BIR_II_1	1	5	PF00653	0.491
LIG_BIR_III_4	27	31	PF00653	0.519
LIG_BRCT_BRCA1_1	298	302	PF00533	0.525
LIG_BRCT_BRCA1_1	53	57	PF00533	0.495
LIG_FHA_1	195	201	PF00498	0.465
LIG_FHA_1	59	65	PF00498	0.774
LIG_FHA_2	233	239	PF00498	0.554
LIG_FHA_2	34	40	PF00498	0.606
LIG_FHA_2	380	386	PF00498	0.466
LIG_FHA_2	70	76	PF00498	0.491
LIG_FHA_2	78	84	PF00498	0.440
LIG_LIR_Apic_2	2	6	PF02991	0.509
LIG_LIR_Apic_2	54	60	PF02991	0.489
LIG_LIR_Gen_1	318	329	PF02991	0.477
LIG_LIR_Nem_3	305	310	PF02991	0.367
LIG_LIR_Nem_3	318	324	PF02991	0.340
LIG_LIR_Nem_3	362	368	PF02991	0.399
LIG_LIR_Nem_3	388	392	PF02991	0.395
LIG_PDZ_Class_3	400	405	PF00595	0.431
LIG_Pex14_2	164	168	PF04695	0.483
LIG_Pex14_2	302	306	PF04695	0.490
LIG_SH2_CRK	307	311	PF00017	0.363
LIG_SH2_CRK	365	369	PF00017	0.369
LIG_SH2_PTP2	321	324	PF00017	0.474
LIG_SH2_SRC	265	268	PF00017	0.304
LIG_SH2_SRC	353	356	PF00017	0.417
LIG_SH2_STAP1	143	147	PF00017	0.455
LIG_SH2_STAP1	206	210	PF00017	0.584
LIG_SH2_STAT5	206	209	PF00017	0.584
LIG_SH2_STAT5	214	217	PF00017	0.357
LIG_SH2_STAT5	321	324	PF00017	0.401
LIG_SH3_1	160	166	PF00018	0.416
LIG_SH3_3	15	21	PF00018	0.707
LIG_SH3_3	160	166	PF00018	0.403
LIG_SH3_3	226	232	PF00018	0.559
LIG_TRAF2_1	382	385	PF00917	0.557
LIG_UBA3_1	121	128	PF00899	0.488
MOD_CDC14_SPxK_1	5	8	PF00782	0.489
MOD_CDK_SPxK_1	2	8	PF00069	0.705
MOD_CK1_1	194	200	PF00069	0.468
MOD_CK1_1	2	8	PF00069	0.597
MOD_CK1_1	359	365	PF00069	0.427
MOD_CK1_1	51	57	PF00069	0.492
MOD_CK1_1	67	73	PF00069	0.677
MOD_CK2_1	150	156	PF00069	0.547
MOD_CK2_1	33	39	PF00069	0.595
MOD_CK2_1	379	385	PF00069	0.374
MOD_DYRK1A_RPxSP_1	225	229	PF00069	0.484
MOD_GlcNHglycan	152	155	PF01048	0.572
MOD_GlcNHglycan	179	182	PF01048	0.638
MOD_GlcNHglycan	186	189	PF01048	0.747
MOD_GlcNHglycan	191	194	PF01048	0.796
MOD_GlcNHglycan	201	204	PF01048	0.473
MOD_GlcNHglycan	361	364	PF01048	0.606
MOD_GlcNHglycan	372	375	PF01048	0.470
MOD_GlcNHglycan	48	51	PF01048	0.609
MOD_GlcNHglycan	72	75	PF01048	0.570
MOD_GlcNHglycan	94	97	PF01048	0.561
MOD_GSK3_1	17	24	PF00069	0.789
MOD_GSK3_1	194	201	PF00069	0.514
MOD_GSK3_1	292	299	PF00069	0.508
MOD_GSK3_1	329	336	PF00069	0.519
MOD_GSK3_1	48	55	PF00069	0.640
MOD_GSK3_1	58	65	PF00069	0.604
MOD_GSK3_1	77	84	PF00069	0.509
MOD_N-GLC_1	339	344	PF02516	0.371
MOD_NEK2_1	177	182	PF00069	0.630
MOD_NEK2_1	329	334	PF00069	0.452
MOD_NEK2_1	370	375	PF00069	0.410
MOD_NEK2_1	77	82	PF00069	0.515
MOD_PIKK_1	292	298	PF00454	0.490
MOD_PKA_1	104	110	PF00069	0.497
MOD_PKA_1	396	402	PF00069	0.447
MOD_PKA_1	46	52	PF00069	0.612
MOD_PKA_2	296	302	PF00069	0.368
MOD_PKA_2	379	385	PF00069	0.505
MOD_PKA_2	396	402	PF00069	0.584
MOD_PKA_2	7	13	PF00069	0.497
MOD_PKB_1	394	402	PF00069	0.486
MOD_PKB_1	44	52	PF00069	0.461
MOD_Plk_1	38	44	PF00069	0.660
MOD_ProDKin_1	17	23	PF00069	0.787
MOD_ProDKin_1	2	8	PF00069	0.558
MOD_ProDKin_1	225	231	PF00069	0.534
MOD_ProDKin_1	56	62	PF00069	0.609
MOD_ProDKin_1	64	70	PF00069	0.619
MOD_SUMO_for_1	42	45	PF00179	0.452
MOD_SUMO_rev_2	39	49	PF00179	0.670
TRG_DiLeu_BaEn_1	305	310	PF01217	0.461
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.552
TRG_DiLeu_LyEn_5	305	310	PF01217	0.461
TRG_ENDOCYTIC_2	214	217	PF00928	0.673
TRG_ENDOCYTIC_2	307	310	PF00928	0.344
TRG_ENDOCYTIC_2	321	324	PF00928	0.348
TRG_ENDOCYTIC_2	365	368	PF00928	0.356
TRG_ER_diArg_1	101	104	PF00400	0.547
TRG_ER_diArg_1	319	321	PF00400	0.349
TRG_ER_diArg_1	322	325	PF00400	0.373
TRG_ER_diArg_1	394	397	PF00400	0.461
TRG_ER_diArg_1	97	100	PF00400	0.556
TRG_NLS_MonoExtC_3	103	109	PF00514	0.492
TRG_NLS_MonoExtN_4	101	108	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMN6	Leptomonas seymouri	60%	92%
A0A0S4JDE7	Bodo saltans	39%	100%
A0A1X0P5P1	Trypanosomatidae	47%	100%
A0A3S5H7Z4	Leishmania donovani	83%	100%
A0A422NM18	Trypanosoma rangeli	47%	100%
A4IBC2	Leishmania infantum	83%	100%
C9ZZC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AF54	Leishmania major	83%	100%
E9B6B0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BJA6	Trypanosoma cruzi	44%	100%