DUF115 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMQ2_LEIBR

TriTrypDb:

LbrM.34.2230 , LBRM2903_340029500 , LBRM2903_340029600

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.408
CLV_NRD_NRD_1	184	186	PF00675	0.425
CLV_NRD_NRD_1	442	444	PF00675	0.378
CLV_PCSK_KEX2_1	130	132	PF00082	0.593
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.608
CLV_PCSK_SKI1_1	264	268	PF00082	0.474
CLV_PCSK_SKI1_1	444	448	PF00082	0.444
CLV_PCSK_SKI1_1	49	53	PF00082	0.727
DEG_Nend_Nbox_1	1	3	PF02207	0.719
DEG_SPOP_SBC_1	27	31	PF00917	0.801
DOC_CKS1_1	55	60	PF01111	0.638
DOC_CYCLIN_yClb5_NLxxxL_5	117	125	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	298	304	PF00134	0.505
DOC_MAPK_gen_1	272	281	PF00069	0.387
DOC_MAPK_gen_1	296	302	PF00069	0.458
DOC_MAPK_MEF2A_6	272	281	PF00069	0.402
DOC_MAPK_MEF2A_6	327	334	PF00069	0.453
DOC_MAPK_MEF2A_6	342	349	PF00069	0.377
DOC_PP1_RVXF_1	184	191	PF00149	0.452
DOC_PP2B_LxvP_1	298	301	PF13499	0.562
DOC_PP2B_LxvP_1	316	319	PF13499	0.282
DOC_PP4_FxxP_1	375	378	PF00568	0.380
DOC_PP4_FxxP_1	85	88	PF00568	0.452
DOC_USP7_MATH_1	26	30	PF00917	0.757
DOC_USP7_MATH_1	437	441	PF00917	0.467
DOC_WW_Pin1_4	305	310	PF00397	0.305
DOC_WW_Pin1_4	54	59	PF00397	0.650
LIG_14-3-3_CanoR_1	451	455	PF00244	0.348
LIG_APCC_ABBA_1	347	352	PF00400	0.443
LIG_BIR_III_4	25	29	PF00653	0.801
LIG_BRCT_BRCA1_1	215	219	PF00533	0.612
LIG_deltaCOP1_diTrp_1	220	227	PF00928	0.479
LIG_deltaCOP1_diTrp_1	388	393	PF00928	0.467
LIG_FHA_1	104	110	PF00498	0.578
LIG_FHA_1	13	19	PF00498	0.525
LIG_FHA_1	248	254	PF00498	0.398
LIG_FHA_1	293	299	PF00498	0.436
LIG_FHA_1	358	364	PF00498	0.405
LIG_FHA_1	437	443	PF00498	0.450
LIG_FHA_1	82	88	PF00498	0.447
LIG_FHA_2	114	120	PF00498	0.371
LIG_FHA_2	216	222	PF00498	0.560
LIG_FHA_2	64	70	PF00498	0.638
LIG_GBD_Chelix_1	423	431	PF00786	0.276
LIG_IBAR_NPY_1	312	314	PF08397	0.454
LIG_LIR_Apic_2	84	88	PF02991	0.458
LIG_LIR_Gen_1	116	125	PF02991	0.533
LIG_LIR_Gen_1	159	168	PF02991	0.429
LIG_LIR_Gen_1	220	230	PF02991	0.474
LIG_LIR_Gen_1	235	244	PF02991	0.485
LIG_LIR_Gen_1	371	378	PF02991	0.382
LIG_LIR_Gen_1	71	80	PF02991	0.486
LIG_LIR_Gen_1	99	109	PF02991	0.478
LIG_LIR_Nem_3	116	121	PF02991	0.528
LIG_LIR_Nem_3	159	163	PF02991	0.402
LIG_LIR_Nem_3	220	226	PF02991	0.461
LIG_LIR_Nem_3	285	291	PF02991	0.414
LIG_LIR_Nem_3	371	377	PF02991	0.367
LIG_LIR_Nem_3	388	393	PF02991	0.217
LIG_LIR_Nem_3	409	414	PF02991	0.396
LIG_LIR_Nem_3	71	77	PF02991	0.500
LIG_LIR_Nem_3	99	105	PF02991	0.465
LIG_PCNA_yPIPBox_3	364	373	PF02747	0.482
LIG_PCNA_yPIPBox_3	435	444	PF02747	0.406
LIG_Pex14_1	222	226	PF04695	0.477
LIG_Pex14_2	461	465	PF04695	0.448
LIG_PTB_Apo_2	107	114	PF02174	0.557
LIG_SH2_CRK	175	179	PF00017	0.484
LIG_SH2_CRK	74	78	PF00017	0.542
LIG_SH2_SRC	343	346	PF00017	0.376
LIG_SH2_STAP1	144	148	PF00017	0.407
LIG_SH2_STAP1	175	179	PF00017	0.382
LIG_SH2_STAP1	223	227	PF00017	0.417
LIG_SH2_STAP1	249	253	PF00017	0.450
LIG_SH2_STAP1	83	87	PF00017	0.472
LIG_SH2_STAT5	238	241	PF00017	0.399
LIG_SH2_STAT5	249	252	PF00017	0.402
LIG_SH2_STAT5	260	263	PF00017	0.318
LIG_SH2_STAT5	314	317	PF00017	0.458
LIG_SH2_STAT5	372	375	PF00017	0.361
LIG_SH2_STAT5	381	384	PF00017	0.398
LIG_SH2_STAT5	392	395	PF00017	0.435
LIG_SH2_STAT5	406	409	PF00017	0.347
LIG_SH2_STAT5	65	68	PF00017	0.658
LIG_SH2_STAT5	83	86	PF00017	0.292
LIG_SH3_3	411	417	PF00018	0.451
LIG_SH3_3	442	448	PF00018	0.422
LIG_TRAF2_1	218	221	PF00917	0.518
LIG_TRAF2_1	66	69	PF00917	0.534
LIG_TYR_ITAM	157	178	PF00017	0.439
LIG_TYR_ITIM	158	163	PF00017	0.423
LIG_UBA3_1	1	7	PF00899	0.497
LIG_UBA3_1	178	186	PF00899	0.488
LIG_UBA3_1	315	322	PF00899	0.457
LIG_WRPW_2	461	464	PF00400	0.299
MOD_CK1_1	29	35	PF00069	0.726
MOD_CK2_1	215	221	PF00069	0.495
MOD_CK2_1	365	371	PF00069	0.406
MOD_CK2_1	377	383	PF00069	0.371
MOD_CK2_1	63	69	PF00069	0.502
MOD_CMANNOS	387	390	PF00535	0.390
MOD_GlcNHglycan	274	277	PF01048	0.518
MOD_GSK3_1	243	250	PF00069	0.425
MOD_GSK3_1	64	71	PF00069	0.660
MOD_N-GLC_1	292	297	PF02516	0.398
MOD_NEK2_1	105	110	PF00069	0.518
MOD_NEK2_1	113	118	PF00069	0.570
MOD_NEK2_1	18	23	PF00069	0.673
MOD_NEK2_1	253	258	PF00069	0.391
MOD_NEK2_1	292	297	PF00069	0.434
MOD_PIKK_1	100	106	PF00454	0.577
MOD_PIKK_1	247	253	PF00454	0.359
MOD_PIKK_1	358	364	PF00454	0.285
MOD_PKA_2	397	403	PF00069	0.568
MOD_PKA_2	43	49	PF00069	0.802
MOD_PKA_2	450	456	PF00069	0.382
MOD_Plk_1	113	119	PF00069	0.635
MOD_Plk_1	199	205	PF00069	0.479
MOD_Plk_1	213	219	PF00069	0.617
MOD_Plk_4	174	180	PF00069	0.513
MOD_Plk_4	221	227	PF00069	0.422
MOD_Plk_4	243	249	PF00069	0.385
MOD_Plk_4	343	349	PF00069	0.425
MOD_Plk_4	437	443	PF00069	0.268
MOD_Plk_4	56	62	PF00069	0.662
MOD_ProDKin_1	305	311	PF00069	0.314
MOD_ProDKin_1	54	60	PF00069	0.642
MOD_SUMO_for_1	111	114	PF00179	0.612
MOD_SUMO_rev_2	95	103	PF00179	0.457
TRG_DiLeu_BaEn_1	263	268	PF01217	0.517
TRG_DiLeu_BaLyEn_6	442	447	PF01217	0.519
TRG_ENDOCYTIC_2	144	147	PF00928	0.435
TRG_ENDOCYTIC_2	160	163	PF00928	0.403
TRG_ENDOCYTIC_2	175	178	PF00928	0.494
TRG_ENDOCYTIC_2	223	226	PF00928	0.461
TRG_ENDOCYTIC_2	230	233	PF00928	0.423
TRG_ENDOCYTIC_2	238	241	PF00928	0.410
TRG_ENDOCYTIC_2	314	317	PF00928	0.458
TRG_ENDOCYTIC_2	372	375	PF00928	0.366
TRG_ENDOCYTIC_2	74	77	PF00928	0.488
TRG_ER_diArg_1	33	36	PF00400	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8S2	Leptomonas seymouri	83%	100%
A0A0S4J1D8	Bodo saltans	25%	86%
A0A0S4JF65	Bodo saltans	57%	100%
A0A1X0P745	Trypanosomatidae	69%	100%
A0A3R7NH73	Trypanosoma rangeli	69%	100%
A0A3S7X999	Leishmania donovani	88%	100%
A4IBC0	Leishmania infantum	88%	100%
C9ZZC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9AF52	Leishmania major	86%	100%
E9B6A8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BNX6	Trypanosoma cruzi	69%	100%