ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMQ0_LEIBR

TriTrypDb:

LbrM.34.2210 , LBRM2903_340029300

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.186
CLV_C14_Caspase3-7	274	278	PF00656	0.292
CLV_C14_Caspase3-7	307	311	PF00656	0.273
CLV_NRD_NRD_1	21	23	PF00675	0.434
CLV_NRD_NRD_1	231	233	PF00675	0.331
CLV_NRD_NRD_1	238	240	PF00675	0.369
CLV_PCSK_KEX2_1	21	23	PF00082	0.425
CLV_PCSK_SKI1_1	240	244	PF00082	0.478
CLV_PCSK_SKI1_1	306	310	PF00082	0.358
CLV_PCSK_SKI1_1	370	374	PF00082	0.328
CLV_PCSK_SKI1_1	500	504	PF00082	0.440
DEG_APCC_DBOX_1	94	102	PF00400	0.440
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DOC_CKS1_1	35	40	PF01111	0.418
DOC_CKS1_1	483	488	PF01111	0.279
DOC_CYCLIN_RxL_1	21	29	PF00134	0.255
DOC_CYCLIN_RxL_1	357	366	PF00134	0.356
DOC_CYCLIN_yClb5_NLxxxL_5	360	368	PF00134	0.368
DOC_MAPK_DCC_7	130	138	PF00069	0.391
DOC_MAPK_DCC_7	95	103	PF00069	0.387
DOC_MAPK_FxFP_2	180	183	PF00069	0.195
DOC_MAPK_gen_1	21	30	PF00069	0.319
DOC_MAPK_gen_1	334	342	PF00069	0.279
DOC_MAPK_MEF2A_6	130	138	PF00069	0.401
DOC_MAPK_MEF2A_6	21	30	PF00069	0.327
DOC_PP1_RVXF_1	2	9	PF00149	0.378
DOC_PP2B_LxvP_1	373	376	PF13499	0.472
DOC_PP4_FxxP_1	180	183	PF00568	0.195
DOC_PP4_FxxP_1	439	442	PF00568	0.445
DOC_USP7_MATH_1	349	353	PF00917	0.302
DOC_USP7_MATH_1	77	81	PF00917	0.369
DOC_USP7_MATH_2	465	471	PF00917	0.399
DOC_WW_Pin1_4	125	130	PF00397	0.364
DOC_WW_Pin1_4	186	191	PF00397	0.292
DOC_WW_Pin1_4	241	246	PF00397	0.283
DOC_WW_Pin1_4	34	39	PF00397	0.475
DOC_WW_Pin1_4	397	402	PF00397	0.565
DOC_WW_Pin1_4	403	408	PF00397	0.694
DOC_WW_Pin1_4	482	487	PF00397	0.335
DOC_WW_Pin1_4	96	101	PF00397	0.420
LIG_14-3-3_CanoR_1	118	126	PF00244	0.419
LIG_14-3-3_CanoR_1	198	204	PF00244	0.474
LIG_14-3-3_CanoR_1	21	27	PF00244	0.360
LIG_14-3-3_CanoR_1	239	245	PF00244	0.297
LIG_BRCT_BRCA1_1	156	160	PF00533	0.432
LIG_BRCT_BRCA1_1	275	279	PF00533	0.292
LIG_BRCT_BRCA1_1	38	42	PF00533	0.255
LIG_BRCT_BRCA1_1	435	439	PF00533	0.385
LIG_BRCT_BRCA1_2	156	162	PF00533	0.441
LIG_EVH1_2	487	491	PF00568	0.404
LIG_FHA_1	166	172	PF00498	0.355
LIG_FHA_1	179	185	PF00498	0.174
LIG_FHA_1	241	247	PF00498	0.452
LIG_FHA_1	27	33	PF00498	0.428
LIG_FHA_1	52	58	PF00498	0.381
LIG_FHA_2	140	146	PF00498	0.545
LIG_FHA_2	199	205	PF00498	0.400
LIG_LIR_Apic_2	178	183	PF02991	0.269
LIG_LIR_Apic_2	436	442	PF02991	0.384
LIG_LIR_Gen_1	223	234	PF02991	0.341
LIG_LIR_Gen_1	400	410	PF02991	0.420
LIG_LIR_Gen_1	426	437	PF02991	0.412
LIG_LIR_Gen_1	58	69	PF02991	0.485
LIG_LIR_Nem_3	116	120	PF02991	0.402
LIG_LIR_Nem_3	181	185	PF02991	0.213
LIG_LIR_Nem_3	223	229	PF02991	0.341
LIG_LIR_Nem_3	357	362	PF02991	0.389
LIG_LIR_Nem_3	383	388	PF02991	0.471
LIG_LIR_Nem_3	39	45	PF02991	0.396
LIG_LIR_Nem_3	400	405	PF02991	0.407
LIG_LIR_Nem_3	426	432	PF02991	0.426
LIG_LIR_Nem_3	58	64	PF02991	0.475
LIG_LIR_Nem_3	80	84	PF02991	0.338
LIG_PCNA_yPIPBox_3	240	254	PF02747	0.306
LIG_PCNA_yPIPBox_3	300	309	PF02747	0.272
LIG_PCNA_yPIPBox_3	489	497	PF02747	0.269
LIG_PDZ_Class_1	520	525	PF00595	0.293
LIG_Pex14_2	42	46	PF04695	0.351
LIG_SH2_CRK	20	24	PF00017	0.391
LIG_SH2_CRK	359	363	PF00017	0.394
LIG_SH2_SRC	330	333	PF00017	0.341
LIG_SH2_STAT3	299	302	PF00017	0.217
LIG_SH2_STAT3	452	455	PF00017	0.538
LIG_SH2_STAT3	48	51	PF00017	0.346
LIG_SH2_STAT5	285	288	PF00017	0.292
LIG_SH2_STAT5	312	315	PF00017	0.352
LIG_SH2_STAT5	338	341	PF00017	0.273
LIG_SH2_STAT5	61	64	PF00017	0.249
LIG_SH3_3	182	188	PF00018	0.267
LIG_SH3_3	239	245	PF00018	0.257
LIG_SH3_3	278	284	PF00018	0.339
LIG_SH3_3	32	38	PF00018	0.343
LIG_SH3_3	402	408	PF00018	0.484
LIG_SH3_3	481	487	PF00018	0.352
LIG_SH3_3	98	104	PF00018	0.328
LIG_SUMO_SIM_anti_2	29	34	PF11976	0.293
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.320
LIG_TRAF2_1	376	379	PF00917	0.402
LIG_TRAF2_1	391	394	PF00917	0.396
LIG_UBA3_1	493	500	PF00899	0.272
LIG_WRC_WIRS_1	471	476	PF05994	0.253
LIG_WRC_WIRS_1	78	83	PF05994	0.297
MOD_CDK_SPK_2	125	130	PF00069	0.425
MOD_CDK_SPxxK_3	125	132	PF00069	0.273
MOD_CDK_SPxxK_3	397	404	PF00069	0.454
MOD_CDK_SPxxK_3	482	489	PF00069	0.288
MOD_CK1_1	12	18	PF00069	0.245
MOD_CK1_1	128	134	PF00069	0.411
MOD_CK1_1	178	184	PF00069	0.307
MOD_CK1_1	348	354	PF00069	0.328
MOD_CK1_1	470	476	PF00069	0.372
MOD_CK2_1	139	145	PF00069	0.540
MOD_CK2_1	388	394	PF00069	0.407
MOD_CK2_1	408	414	PF00069	0.611
MOD_CK2_1	77	83	PF00069	0.315
MOD_CMANNOS	211	214	PF00535	0.319
MOD_GlcNHglycan	12	15	PF01048	0.251
MOD_GlcNHglycan	176	180	PF01048	0.298
MOD_GlcNHglycan	347	350	PF01048	0.331
MOD_GlcNHglycan	351	354	PF01048	0.322
MOD_GlcNHglycan	394	398	PF01048	0.551
MOD_GlcNHglycan	425	428	PF01048	0.580
MOD_GlcNHglycan	476	479	PF01048	0.375
MOD_GlcNHglycan	521	525	PF01048	0.376
MOD_GlcNHglycan	64	67	PF01048	0.373
MOD_GSK3_1	124	131	PF00069	0.356
MOD_GSK3_1	165	172	PF00069	0.469
MOD_GSK3_1	22	29	PF00069	0.286
MOD_GSK3_1	345	352	PF00069	0.311
MOD_GSK3_1	393	400	PF00069	0.587
MOD_GSK3_1	419	426	PF00069	0.540
MOD_GSK3_1	470	477	PF00069	0.291
MOD_GSK3_1	8	15	PF00069	0.256
MOD_N-GLC_1	96	101	PF02516	0.404
MOD_NEK2_1	113	118	PF00069	0.263
MOD_NEK2_1	160	165	PF00069	0.435
MOD_NEK2_1	175	180	PF00069	0.424
MOD_NEK2_1	213	218	PF00069	0.300
MOD_NEK2_1	26	31	PF00069	0.291
MOD_NEK2_1	308	313	PF00069	0.347
MOD_NEK2_1	354	359	PF00069	0.321
MOD_NEK2_1	388	393	PF00069	0.454
MOD_NEK2_1	512	517	PF00069	0.285
MOD_NEK2_1	62	67	PF00069	0.436
MOD_NEK2_1	8	13	PF00069	0.312
MOD_PIKK_1	160	166	PF00454	0.291
MOD_PIKK_1	388	394	PF00454	0.358
MOD_PIKK_1	451	457	PF00454	0.273
MOD_PK_1	271	277	PF00069	0.352
MOD_PKA_2	512	518	PF00069	0.444
MOD_Plk_1	175	181	PF00069	0.270
MOD_Plk_1	349	355	PF00069	0.299
MOD_Plk_1	467	473	PF00069	0.425
MOD_Plk_4	191	197	PF00069	0.289
MOD_Plk_4	26	32	PF00069	0.297
MOD_Plk_4	308	314	PF00069	0.295
MOD_Plk_4	354	360	PF00069	0.335
MOD_Plk_4	380	386	PF00069	0.487
MOD_Plk_4	467	473	PF00069	0.427
MOD_ProDKin_1	125	131	PF00069	0.364
MOD_ProDKin_1	186	192	PF00069	0.292
MOD_ProDKin_1	241	247	PF00069	0.283
MOD_ProDKin_1	34	40	PF00069	0.480
MOD_ProDKin_1	397	403	PF00069	0.563
MOD_ProDKin_1	482	488	PF00069	0.345
MOD_ProDKin_1	96	102	PF00069	0.416
TRG_DiLeu_BaEn_1	467	472	PF01217	0.402
TRG_ENDOCYTIC_2	20	23	PF00928	0.319
TRG_ENDOCYTIC_2	359	362	PF00928	0.376
TRG_ENDOCYTIC_2	61	64	PF00928	0.419
TRG_ER_diArg_1	20	22	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	132	137	PF00026	0.295
TRG_Pf-PMV_PEXEL_1	306	310	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P380	Leptomonas seymouri	54%	99%
A0A0S4JCU0	Bodo saltans	38%	100%
A0A1X0P6I8	Trypanosomatidae	45%	100%
A0A3Q8IG99	Leishmania donovani	73%	100%
A0A3R7KHD1	Trypanosoma rangeli	44%	100%
A4IBB8	Leishmania infantum	73%	100%
E9AF50	Leishmania major	72%	100%
E9B6A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
V5BJB2	Trypanosoma cruzi	44%	100%