Methyltransferase type 11

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HMP7_LEIBR

TriTrypDb:

LbrM.34.2180 , LBRM2903_340029000

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMP7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMP7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.495
CLV_NRD_NRD_1	13	15	PF00675	0.725
CLV_NRD_NRD_1	139	141	PF00675	0.451
CLV_NRD_NRD_1	308	310	PF00675	0.467
CLV_NRD_NRD_1	333	335	PF00675	0.376
CLV_NRD_NRD_1	382	384	PF00675	0.605
CLV_NRD_NRD_1	434	436	PF00675	0.520
CLV_PCSK_FUR_1	432	436	PF00082	0.558
CLV_PCSK_KEX2_1	12	14	PF00082	0.685
CLV_PCSK_KEX2_1	308	310	PF00082	0.475
CLV_PCSK_KEX2_1	332	334	PF00082	0.374
CLV_PCSK_KEX2_1	432	434	PF00082	0.497
CLV_PCSK_SKI1_1	146	150	PF00082	0.694
CLV_PCSK_SKI1_1	227	231	PF00082	0.236
CLV_PCSK_SKI1_1	295	299	PF00082	0.340
CLV_PCSK_SKI1_1	334	338	PF00082	0.453
CLV_PCSK_SKI1_1	384	388	PF00082	0.612
DEG_SPOP_SBC_1	160	164	PF00917	0.502
DOC_ANK_TNKS_1	155	162	PF00023	0.473
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.668
DOC_MAPK_FxFP_2	326	329	PF00069	0.409
DOC_MAPK_gen_1	242	252	PF00069	0.405
DOC_PP2B_LxvP_1	157	160	PF13499	0.619
DOC_PP4_FxxP_1	231	234	PF00568	0.508
DOC_PP4_FxxP_1	326	329	PF00568	0.409
DOC_PP4_FxxP_1	84	87	PF00568	0.462
DOC_USP7_MATH_1	173	177	PF00917	0.703
DOC_USP7_MATH_1	178	182	PF00917	0.699
DOC_USP7_MATH_1	184	188	PF00917	0.598
DOC_USP7_MATH_1	327	331	PF00917	0.378
DOC_USP7_MATH_1	363	367	PF00917	0.412
DOC_USP7_UBL2_3	371	375	PF12436	0.286
DOC_WW_Pin1_4	155	160	PF00397	0.774
DOC_WW_Pin1_4	202	207	PF00397	0.368
DOC_WW_Pin1_4	39	44	PF00397	0.679
DOC_WW_Pin1_4	400	405	PF00397	0.445
DOC_WW_Pin1_4	414	419	PF00397	0.631
DOC_WW_Pin1_4	424	429	PF00397	0.635
DOC_WW_Pin1_4	64	69	PF00397	0.631
LIG_14-3-3_CanoR_1	26	32	PF00244	0.617
LIG_14-3-3_CanoR_1	295	303	PF00244	0.615
LIG_14-3-3_CanoR_1	333	342	PF00244	0.434
LIG_14-3-3_CanoR_1	35	43	PF00244	0.695
LIG_Actin_WH2_2	304	320	PF00022	0.487
LIG_BIR_III_2	385	389	PF00653	0.396
LIG_BRCT_BRCA1_1	221	225	PF00533	0.497
LIG_BRCT_BRCA1_1	97	101	PF00533	0.525
LIG_CSL_BTD_1	425	428	PF09270	0.587
LIG_EH1_1	246	254	PF00400	0.360
LIG_FHA_1	175	181	PF00498	0.689
LIG_FHA_1	283	289	PF00498	0.571
LIG_FHA_1	362	368	PF00498	0.502
LIG_FHA_2	276	282	PF00498	0.462
LIG_FHA_2	296	302	PF00498	0.476
LIG_FHA_2	401	407	PF00498	0.518
LIG_LIR_Apic_2	228	234	PF02991	0.472
LIG_LIR_Apic_2	323	329	PF02991	0.413
LIG_LIR_Gen_1	27	34	PF02991	0.446
LIG_LIR_Gen_1	366	376	PF02991	0.422
LIG_LIR_Gen_1	394	405	PF02991	0.678
LIG_LIR_Gen_1	89	99	PF02991	0.385
LIG_LIR_Nem_3	202	207	PF02991	0.524
LIG_LIR_Nem_3	27	31	PF02991	0.552
LIG_LIR_Nem_3	323	328	PF02991	0.330
LIG_LIR_Nem_3	394	400	PF02991	0.679
LIG_LIR_Nem_3	89	94	PF02991	0.377
LIG_PDZ_Class_3	436	441	PF00595	0.453
LIG_Pex14_2	231	235	PF04695	0.511
LIG_SH2_CRK	357	361	PF00017	0.375
LIG_SH2_GRB2like	274	277	PF00017	0.291
LIG_SH2_SRC	274	277	PF00017	0.438
LIG_SH2_STAP1	303	307	PF00017	0.260
LIG_SH2_STAT3	340	343	PF00017	0.462
LIG_SH2_STAT5	191	194	PF00017	0.572
LIG_SH2_STAT5	274	277	PF00017	0.498
LIG_SH3_1	124	130	PF00018	0.279
LIG_SH3_3	104	110	PF00018	0.368
LIG_SH3_3	124	130	PF00018	0.323
LIG_SH3_3	258	264	PF00018	0.406
LIG_SH3_3	321	327	PF00018	0.547
LIG_SH3_3	434	440	PF00018	0.724
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.326
LIG_SUMO_SIM_par_1	216	222	PF11976	0.343
LIG_SxIP_EBH_1	131	143	PF03271	0.299
LIG_TRFH_1	340	344	PF08558	0.547
LIG_WRC_WIRS_1	28	33	PF05994	0.447
MOD_CDK_SPK_2	39	44	PF00069	0.550
MOD_CK1_1	111	117	PF00069	0.405
MOD_CK1_1	174	180	PF00069	0.649
MOD_CK1_1	194	200	PF00069	0.626
MOD_CK1_1	202	208	PF00069	0.528
MOD_CK1_1	27	33	PF00069	0.516
MOD_CK1_1	289	295	PF00069	0.331
MOD_CK1_1	39	45	PF00069	0.720
MOD_CK2_1	202	208	PF00069	0.352
MOD_CK2_1	414	420	PF00069	0.441
MOD_GlcNHglycan	163	166	PF01048	0.715
MOD_GlcNHglycan	186	189	PF01048	0.654
MOD_GlcNHglycan	193	196	PF01048	0.649
MOD_GlcNHglycan	288	291	PF01048	0.336
MOD_GlcNHglycan	39	42	PF01048	0.538
MOD_GlcNHglycan	6	9	PF01048	0.456
MOD_GSK3_1	155	162	PF00069	0.718
MOD_GSK3_1	174	181	PF00069	0.609
MOD_GSK3_1	190	197	PF00069	0.571
MOD_GSK3_1	282	289	PF00069	0.336
MOD_N-GLC_1	275	280	PF02516	0.412
MOD_N-GLC_2	103	105	PF02516	0.257
MOD_NEK2_1	24	29	PF00069	0.602
MOD_NEK2_1	286	291	PF00069	0.344
MOD_NEK2_1	356	361	PF00069	0.297
MOD_NEK2_1	73	78	PF00069	0.615
MOD_NEK2_1	95	100	PF00069	0.480
MOD_NEK2_2	240	245	PF00069	0.248
MOD_PIKK_1	13	19	PF00454	0.597
MOD_PKA_1	13	19	PF00069	0.450
MOD_PKA_2	13	19	PF00069	0.450
MOD_PKA_2	282	288	PF00069	0.473
MOD_PKA_2	37	43	PF00069	0.620
MOD_PKA_2	46	52	PF00069	0.643
MOD_PKB_1	332	340	PF00069	0.525
MOD_Plk_4	133	139	PF00069	0.565
MOD_Plk_4	199	205	PF00069	0.572
MOD_Plk_4	356	362	PF00069	0.345
MOD_Plk_4	363	369	PF00069	0.409
MOD_Plk_4	90	96	PF00069	0.474
MOD_ProDKin_1	155	161	PF00069	0.777
MOD_ProDKin_1	202	208	PF00069	0.366
MOD_ProDKin_1	39	45	PF00069	0.681
MOD_ProDKin_1	400	406	PF00069	0.448
MOD_ProDKin_1	414	420	PF00069	0.624
MOD_ProDKin_1	424	430	PF00069	0.629
MOD_ProDKin_1	64	70	PF00069	0.631
TRG_ENDOCYTIC_2	204	207	PF00928	0.401
TRG_ENDOCYTIC_2	357	360	PF00928	0.387
TRG_ER_diArg_1	12	14	PF00400	0.452
TRG_ER_diArg_1	124	127	PF00400	0.504
TRG_ER_diArg_1	307	309	PF00400	0.461
TRG_ER_diArg_1	331	334	PF00400	0.407
TRG_ER_diArg_1	431	434	PF00400	0.516
TRG_NLS_MonoExtN_4	139	144	PF00514	0.556
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.293
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L8	Leptomonas seymouri	45%	81%
A0A0S4JDL6	Bodo saltans	28%	100%
A0A1X0P5V1	Trypanosomatidae	43%	100%
A0A3Q8IJ19	Leishmania donovani	75%	83%
A0A422NLY6	Trypanosoma rangeli	40%	100%
A4IBB6	Leishmania infantum	75%	83%
C9ZZD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AF48	Leishmania major	73%	100%
E9B6A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	85%
V5DKB8	Trypanosoma cruzi	40%	100%