Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMP2_LEIBR

TriTrypDb:

LbrM.34.2130 , LBRM2903_340028500

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 12
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HMP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMP2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	80	84	PF00656	0.393
CLV_NRD_NRD_1	101	103	PF00675	0.407
CLV_NRD_NRD_1	195	197	PF00675	0.382
CLV_NRD_NRD_1	24	26	PF00675	0.595
CLV_NRD_NRD_1	97	99	PF00675	0.247
CLV_PCSK_KEX2_1	24	26	PF00082	0.536
CLV_PCSK_KEX2_1	97	99	PF00082	0.247
CLV_PCSK_SKI1_1	196	200	PF00082	0.268
DOC_CKS1_1	38	43	PF01111	0.450
DOC_CYCLIN_RxL_1	193	201	PF00134	0.393
DOC_MAPK_gen_1	231	240	PF00069	0.440
DOC_MAPK_gen_1	24	32	PF00069	0.566
DOC_MAPK_MEF2A_6	234	242	PF00069	0.440
DOC_PP4_FxxP_1	38	41	PF00568	0.440
DOC_USP7_MATH_1	68	72	PF00917	0.443
DOC_WW_Pin1_4	37	42	PF00397	0.450
LIG_14-3-3_CanoR_1	129	138	PF00244	0.585
LIG_14-3-3_CanoR_1	153	157	PF00244	0.562
LIG_APCC_ABBA_1	86	91	PF00400	0.440
LIG_CtBP_PxDLS_1	258	264	PF00389	0.440
LIG_FHA_1	15	21	PF00498	0.498
LIG_FHA_1	56	62	PF00498	0.440
LIG_FHA_2	90	96	PF00498	0.458
LIG_LIR_Gen_1	214	222	PF02991	0.440
LIG_LIR_Gen_1	40	49	PF02991	0.450
LIG_LIR_Nem_3	214	219	PF02991	0.440
LIG_LIR_Nem_3	255	259	PF02991	0.441
LIG_LIR_Nem_3	40	45	PF02991	0.450
LIG_Pex14_2	38	42	PF04695	0.440
LIG_PTB_Apo_2	199	206	PF02174	0.440
LIG_PTB_Apo_2	32	39	PF02174	0.440
LIG_SH2_STAP1	57	61	PF00017	0.440
LIG_SH2_STAT5	132	135	PF00017	0.663
LIG_SH2_STAT5	48	51	PF00017	0.474
LIG_SH2_STAT5	57	60	PF00017	0.414
LIG_SH3_3	105	111	PF00018	0.496
LIG_SH3_4	185	192	PF00018	0.553
LIG_SH3_CIN85_PxpxPR_1	182	187	PF14604	0.708
LIG_TYR_ITIM	55	60	PF00017	0.268
MOD_CK1_1	130	136	PF00069	0.480
MOD_CK1_1	7	13	PF00069	0.637
MOD_CK2_1	242	248	PF00069	0.269
MOD_CK2_1	89	95	PF00069	0.268
MOD_Cter_Amidation	194	197	PF01082	0.416
MOD_Cter_Amidation	95	98	PF01082	0.268
MOD_GlcNHglycan	141	144	PF01048	0.606
MOD_GlcNHglycan	158	161	PF01048	0.506
MOD_GlcNHglycan	209	212	PF01048	0.284
MOD_GlcNHglycan	70	73	PF01048	0.287
MOD_GSK3_1	152	159	PF00069	0.497
MOD_GSK3_1	68	75	PF00069	0.268
MOD_N-GLC_1	89	94	PF02516	0.281
MOD_NEK2_1	156	161	PF00069	0.686
MOD_NEK2_1	198	203	PF00069	0.281
MOD_NEK2_1	205	210	PF00069	0.268
MOD_NEK2_1	212	217	PF00069	0.268
MOD_PIKK_1	127	133	PF00454	0.470
MOD_PIKK_1	185	191	PF00454	0.575
MOD_PKA_2	152	158	PF00069	0.565
MOD_PKA_2	212	218	PF00069	0.268
MOD_PKA_2	4	10	PF00069	0.706
MOD_PKA_2	55	61	PF00069	0.268
MOD_Plk_4	26	32	PF00069	0.534
MOD_Plk_4	72	78	PF00069	0.323
MOD_ProDKin_1	37	43	PF00069	0.281
MOD_SUMO_for_1	243	246	PF00179	0.323
TRG_DiLeu_BaEn_1	95	100	PF01217	0.268
TRG_DiLeu_LyEn_5	95	100	PF01217	0.268
TRG_ENDOCYTIC_2	57	60	PF00928	0.268
TRG_ER_diArg_1	23	25	PF00400	0.647
TRG_ER_diArg_1	97	99	PF00400	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I120	Leptomonas seymouri	83%	100%
A0A0S4JGF6	Bodo saltans	55%	89%
A0A1X0P606	Trypanosomatidae	66%	98%
A0A3Q8IF50	Leishmania donovani	93%	100%
A0A422MNR3	Trypanosoma rangeli	66%	98%
C9ZZE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	91%
E9AF44	Leishmania major	93%	100%
E9AHW1	Leishmania infantum	93%	100%
E9B699	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P49314	Nicotiana plumbaginifolia	29%	94%
Q08937	Nicotiana sylvestris	29%	95%
Q12926	Homo sapiens	24%	77%
Q5R9Z6	Pongo abelii	24%	77%
Q60899	Mus musculus	24%	76%
Q8CH84	Rattus norvegicus	24%	77%
V5BNY3	Trypanosoma cruzi	67%	100%