Short chain dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMN9_LEIBR

TriTrypDb:

LbrM.34.2100 , LBRM2903_340028200

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HMN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMN9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008667	2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity	5	1
GO:0016491	oxidoreductase activity	2	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	1
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	4	1
GO:0004312	fatty acid synthase activity	5	1
GO:0004316	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	5	1
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	1
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	335	337	PF00675	0.749
CLV_NRD_NRD_1	476	478	PF00675	0.700
CLV_PCSK_SKI1_1	107	111	PF00082	0.319
CLV_PCSK_SKI1_1	337	341	PF00082	0.772
CLV_PCSK_SKI1_1	381	385	PF00082	0.535
CLV_PCSK_SKI1_1	72	76	PF00082	0.259
DEG_Nend_Nbox_1	1	3	PF02207	0.541
DEG_SPOP_SBC_1	189	193	PF00917	0.369
DOC_CDC14_PxL_1	392	400	PF14671	0.312
DOC_CYCLIN_RxL_1	167	177	PF00134	0.506
DOC_MAPK_MEF2A_6	153	162	PF00069	0.445
DOC_MAPK_MEF2A_6	34	43	PF00069	0.199
DOC_MAPK_MEF2A_6	359	367	PF00069	0.421
DOC_PP1_RVXF_1	105	111	PF00149	0.415
DOC_PP2B_LxvP_1	215	218	PF13499	0.457
DOC_PP4_FxxP_1	243	246	PF00568	0.525
DOC_USP7_MATH_1	11	15	PF00917	0.323
DOC_USP7_MATH_1	124	128	PF00917	0.423
DOC_USP7_MATH_1	189	193	PF00917	0.415
DOC_USP7_MATH_1	194	198	PF00917	0.398
DOC_USP7_MATH_1	469	473	PF00917	0.336
DOC_USP7_UBL2_3	125	129	PF12436	0.481
DOC_USP7_UBL2_3	327	331	PF12436	0.524
DOC_WW_Pin1_4	250	255	PF00397	0.510
DOC_WW_Pin1_4	329	334	PF00397	0.542
DOC_WW_Pin1_4	340	345	PF00397	0.578
DOC_WW_Pin1_4	351	356	PF00397	0.511
LIG_14-3-3_CanoR_1	226	236	PF00244	0.435
LIG_14-3-3_CanoR_1	317	323	PF00244	0.347
LIG_Actin_WH2_2	168	184	PF00022	0.541
LIG_BRCT_BRCA1_1	396	400	PF00533	0.420
LIG_BRCT_BRCA1_1	46	50	PF00533	0.337
LIG_BRCT_BRCA1_2	396	402	PF00533	0.422
LIG_deltaCOP1_diTrp_1	291	297	PF00928	0.550
LIG_eIF4E_1	210	216	PF01652	0.415
LIG_FHA_1	131	137	PF00498	0.460
LIG_FHA_1	228	234	PF00498	0.538
LIG_FHA_1	310	316	PF00498	0.251
LIG_FHA_1	330	336	PF00498	0.352
LIG_FHA_1	374	380	PF00498	0.320
LIG_FHA_1	417	423	PF00498	0.376
LIG_FHA_1	68	74	PF00498	0.539
LIG_FHA_1	78	84	PF00498	0.493
LIG_FHA_1	95	101	PF00498	0.411
LIG_FHA_2	35	41	PF00498	0.276
LIG_FHA_2	401	407	PF00498	0.329
LIG_FHA_2	448	454	PF00498	0.321
LIG_LIR_Apic_2	242	246	PF02991	0.517
LIG_LIR_Gen_1	291	301	PF02991	0.468
LIG_LIR_Gen_1	40	50	PF02991	0.283
LIG_LIR_Gen_1	93	102	PF02991	0.565
LIG_LIR_Nem_3	291	297	PF02991	0.472
LIG_LIR_Nem_3	377	383	PF02991	0.337
LIG_LIR_Nem_3	390	394	PF02991	0.391
LIG_LIR_Nem_3	40	45	PF02991	0.340
LIG_LIR_Nem_3	93	99	PF02991	0.494
LIG_LYPXL_yS_3	395	398	PF13949	0.309
LIG_MYND_1	465	469	PF01753	0.254
LIG_NRBOX	388	394	PF00104	0.355
LIG_PCNA_TLS_4	112	119	PF02747	0.362
LIG_Pex14_1	387	391	PF04695	0.311
LIG_Pex14_2	28	32	PF04695	0.393
LIG_Pex14_2	400	404	PF04695	0.326
LIG_SH2_NCK_1	252	256	PF00017	0.536
LIG_SH2_STAP1	85	89	PF00017	0.446
LIG_SH2_STAT5	118	121	PF00017	0.508
LIG_SH2_STAT5	145	148	PF00017	0.530
LIG_SH2_STAT5	210	213	PF00017	0.493
LIG_SH2_STAT5	26	29	PF00017	0.369
LIG_SH2_STAT5	288	291	PF00017	0.657
LIG_SH2_STAT5	378	381	PF00017	0.397
LIG_SH2_STAT5	391	394	PF00017	0.319
LIG_SH2_STAT5	427	430	PF00017	0.337
LIG_SH3_3	341	347	PF00018	0.547
LIG_SUMO_SIM_par_1	132	139	PF11976	0.421
LIG_TYR_ITIM	298	303	PF00017	0.267
LIG_TYR_ITIM	393	398	PF00017	0.375
MOD_CDK_SPxxK_3	329	336	PF00069	0.705
MOD_CK1_1	138	144	PF00069	0.374
MOD_CK1_1	228	234	PF00069	0.311
MOD_CK1_1	239	245	PF00069	0.355
MOD_CK1_1	293	299	PF00069	0.403
MOD_CK1_1	407	413	PF00069	0.455
MOD_CK1_1	471	477	PF00069	0.536
MOD_CK2_1	250	256	PF00069	0.376
MOD_CK2_1	400	406	PF00069	0.370
MOD_CK2_1	447	453	PF00069	0.420
MOD_GlcNHglycan	272	276	PF01048	0.588
MOD_GlcNHglycan	406	409	PF01048	0.387
MOD_GlcNHglycan	429	432	PF01048	0.433
MOD_GlcNHglycan	436	439	PF01048	0.432
MOD_GlcNHglycan	442	445	PF01048	0.331
MOD_GlcNHglycan	64	67	PF01048	0.450
MOD_GlcNHglycan	80	83	PF01048	0.299
MOD_GSK3_1	180	187	PF00069	0.386
MOD_GSK3_1	190	197	PF00069	0.426
MOD_GSK3_1	220	227	PF00069	0.283
MOD_GSK3_1	235	242	PF00069	0.306
MOD_GSK3_1	325	332	PF00069	0.601
MOD_GSK3_1	400	407	PF00069	0.420
MOD_GSK3_1	469	476	PF00069	0.526
MOD_N-GLC_1	340	345	PF02516	0.574
MOD_N-GLC_1	349	354	PF02516	0.705
MOD_NEK2_1	108	113	PF00069	0.341
MOD_NEK2_1	309	314	PF00069	0.515
MOD_NEK2_1	400	405	PF00069	0.476
MOD_NEK2_1	44	49	PF00069	0.325
MOD_NEK2_2	124	129	PF00069	0.243
MOD_NEK2_2	408	413	PF00069	0.421
MOD_PIKK_1	210	216	PF00454	0.323
MOD_PKA_2	225	231	PF00069	0.402
MOD_Plk_1	138	144	PF00069	0.328
MOD_Plk_1	224	230	PF00069	0.379
MOD_Plk_1	290	296	PF00069	0.447
MOD_Plk_4	11	17	PF00069	0.345
MOD_Plk_4	239	245	PF00069	0.436
MOD_Plk_4	293	299	PF00069	0.311
MOD_Plk_4	374	380	PF00069	0.486
MOD_Plk_4	394	400	PF00069	0.372
MOD_ProDKin_1	250	256	PF00069	0.376
MOD_ProDKin_1	329	335	PF00069	0.706
MOD_ProDKin_1	340	346	PF00069	0.754
MOD_ProDKin_1	351	357	PF00069	0.652
MOD_SUMO_for_1	467	470	PF00179	0.592
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.312
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.264
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.446
TRG_ENDOCYTIC_2	22	25	PF00928	0.383
TRG_ENDOCYTIC_2	252	255	PF00928	0.518
TRG_ENDOCYTIC_2	300	303	PF00928	0.266
TRG_ENDOCYTIC_2	380	383	PF00928	0.383
TRG_ENDOCYTIC_2	395	398	PF00928	0.358
TRG_Pf-PMV_PEXEL_1	313	318	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ81	Leptomonas seymouri	26%	87%
A0A0N1I1M5	Leptomonas seymouri	63%	98%
A0A0S4IZG2	Bodo saltans	24%	100%
A0A0S4J1I6	Bodo saltans	26%	100%
A0A0S4J9U3	Bodo saltans	29%	100%
A0A1X0P5Q9	Trypanosomatidae	25%	100%
A0A1X0P5W3	Trypanosomatidae	44%	100%
A0A3Q8IM89	Leishmania donovani	26%	100%
A0A3R7K8J6	Trypanosoma rangeli	27%	100%
A0A3R7N7S2	Trypanosoma rangeli	44%	100%
A0A3S5H7D5	Leishmania donovani	24%	100%
A0A3S7X986	Leishmania donovani	85%	100%
A4HMN7	Leishmania braziliensis	25%	100%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	97%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AF39	Leishmania major	25%	100%
E9AF41	Leishmania major	83%	100%
E9AHV6	Leishmania infantum	25%	100%
E9AHV8	Leishmania infantum	85%	100%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BJC7	Trypanosoma cruzi	28%	100%
V5BNY6	Trypanosoma cruzi	43%	100%