NAD(P)-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short chain dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HMN7_LEIBR

TriTrypDb:

LbrM.34.2080 , LBRM2903_340027900

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HMN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMN7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	396	400	PF00656	0.632
CLV_NRD_NRD_1	188	190	PF00675	0.383
CLV_NRD_NRD_1	27	29	PF00675	0.243
CLV_NRD_NRD_1	316	318	PF00675	0.522
CLV_PCSK_KEX2_1	175	177	PF00082	0.389
CLV_PCSK_KEX2_1	27	29	PF00082	0.243
CLV_PCSK_KEX2_1	316	318	PF00082	0.522
CLV_PCSK_KEX2_1	79	81	PF00082	0.609
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.408
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.609
CLV_PCSK_SKI1_1	172	176	PF00082	0.497
CLV_PCSK_SKI1_1	190	194	PF00082	0.397
CLV_PCSK_SKI1_1	254	258	PF00082	0.648
CLV_PCSK_SKI1_1	294	298	PF00082	0.587
CLV_PCSK_SKI1_1	319	323	PF00082	0.605
CLV_PCSK_SKI1_1	344	348	PF00082	0.510
CLV_PCSK_SKI1_1	53	57	PF00082	0.618
CLV_PCSK_SKI1_1	68	72	PF00082	0.593
DEG_APCC_DBOX_1	380	388	PF00400	0.591
DEG_Nend_UBRbox_1	1	4	PF02207	0.616
DOC_CYCLIN_RxL_1	187	195	PF00134	0.234
DOC_MAPK_gen_1	171	182	PF00069	0.163
DOC_MAPK_MEF2A_6	175	182	PF00069	0.165
DOC_PP1_RVXF_1	188	195	PF00149	0.234
DOC_PP2B_LxvP_1	218	221	PF13499	0.213
DOC_PP2B_LxvP_1	23	26	PF13499	0.297
DOC_PP4_FxxP_1	209	212	PF00568	0.205
DOC_USP7_MATH_1	281	285	PF00917	0.418
DOC_USP7_MATH_1	356	360	PF00917	0.337
DOC_USP7_MATH_1	370	374	PF00917	0.584
DOC_USP7_MATH_1	394	398	PF00917	0.494
DOC_USP7_UBL2_3	171	175	PF12436	0.143
DOC_USP7_UBL2_3	2	6	PF12436	0.661
DOC_USP7_UBL2_3	257	261	PF12436	0.265
DOC_WW_Pin1_4	139	144	PF00397	0.288
DOC_WW_Pin1_4	385	390	PF00397	0.653
DOC_WW_Pin1_4	399	404	PF00397	0.519
LIG_14-3-3_CanoR_1	239	245	PF00244	0.299
LIG_14-3-3_CanoR_1	68	77	PF00244	0.248
LIG_Actin_WH2_2	351	366	PF00022	0.196
LIG_BRCT_BRCA1_1	246	250	PF00533	0.266
LIG_BRCT_BRCA1_1	358	362	PF00533	0.359
LIG_BRCT_BRCA1_1	401	405	PF00533	0.499
LIG_BRCT_BRCA1_1	8	12	PF00533	0.652
LIG_BRCT_BRCA1_2	358	364	PF00533	0.359
LIG_eIF4E_1	300	306	PF01652	0.260
LIG_FHA_1	16	22	PF00498	0.249
LIG_FHA_1	214	220	PF00498	0.236
LIG_FHA_1	241	247	PF00498	0.379
LIG_FHA_1	300	306	PF00498	0.215
LIG_FHA_1	411	417	PF00498	0.630
LIG_FHA_2	162	168	PF00498	0.230
LIG_FHA_2	363	369	PF00498	0.496
LIG_FHA_2	54	60	PF00498	0.531
LIG_LIR_Gen_1	103	109	PF02991	0.319
LIG_LIR_Gen_1	353	363	PF02991	0.353
LIG_LIR_Nem_3	103	108	PF02991	0.234
LIG_LIR_Nem_3	191	197	PF02991	0.202
LIG_LIR_Nem_3	251	256	PF02991	0.430
LIG_LIR_Nem_3	353	358	PF02991	0.346
LIG_MLH1_MIPbox_1	401	405	PF16413	0.489
LIG_MYND_3	220	224	PF01753	0.288
LIG_NRBOX	214	220	PF00104	0.213
LIG_PTB_Apo_2	349	356	PF02174	0.297
LIG_SH2_SRC	139	142	PF00017	0.281
LIG_SH2_STAP1	105	109	PF00017	0.319
LIG_SH2_STAP1	329	333	PF00017	0.268
LIG_SH2_STAT5	232	235	PF00017	0.248
LIG_SH2_STAT5	29	32	PF00017	0.238
LIG_SH2_STAT5	404	407	PF00017	0.522
LIG_SUMO_SIM_anti_2	382	388	PF11976	0.522
LIG_SUMO_SIM_par_1	211	217	PF11976	0.207
LIG_SUMO_SIM_par_1	242	249	PF11976	0.239
LIG_SUMO_SIM_par_1	80	86	PF11976	0.242
LIG_TRAF2_1	365	368	PF00917	0.507
LIG_TRAF2_1	380	383	PF00917	0.498
LIG_UBA3_1	219	225	PF00899	0.177
LIG_UBA3_1	270	275	PF00899	0.359
LIG_UBA3_1	360	364	PF00899	0.269
LIG_WRC_WIRS_1	347	352	PF05994	0.375
MOD_CK1_1	142	148	PF00069	0.438
MOD_CK1_1	161	167	PF00069	0.121
MOD_CK1_1	248	254	PF00069	0.549
MOD_CK2_1	161	167	PF00069	0.316
MOD_CK2_1	362	368	PF00069	0.349
MOD_CK2_1	421	427	PF00069	0.473
MOD_GlcNHglycan	112	115	PF01048	0.368
MOD_GlcNHglycan	160	163	PF01048	0.340
MOD_GlcNHglycan	250	253	PF01048	0.551
MOD_GlcNHglycan	284	287	PF01048	0.448
MOD_GlcNHglycan	389	392	PF01048	0.516
MOD_GlcNHglycan	396	399	PF01048	0.428
MOD_GlcNHglycan	89	92	PF01048	0.233
MOD_GSK3_1	110	117	PF00069	0.340
MOD_GSK3_1	240	247	PF00069	0.461
MOD_GSK3_1	248	255	PF00069	0.573
MOD_GSK3_1	346	353	PF00069	0.411
MOD_GSK3_1	53	60	PF00069	0.637
MOD_GSK3_1	83	90	PF00069	0.255
MOD_LATS_1	51	57	PF00433	0.532
MOD_N-GLC_1	340	345	PF02516	0.429
MOD_NEK2_1	192	197	PF00069	0.276
MOD_NEK2_1	244	249	PF00069	0.419
MOD_NEK2_1	288	293	PF00069	0.485
MOD_NEK2_1	305	310	PF00069	0.365
MOD_NEK2_1	350	355	PF00069	0.284
MOD_NEK2_2	252	257	PF00069	0.318
MOD_NEK2_2	329	334	PF00069	0.319
MOD_NEK2_2	370	375	PF00069	0.350
MOD_PIKK_1	114	120	PF00454	0.298
MOD_PIKK_1	192	198	PF00454	0.156
MOD_Plk_1	190	196	PF00069	0.212
MOD_Plk_4	142	148	PF00069	0.294
MOD_Plk_4	240	246	PF00069	0.436
MOD_Plk_4	346	352	PF00069	0.332
MOD_Plk_4	356	362	PF00069	0.324
MOD_Plk_4	411	417	PF00069	0.552
MOD_ProDKin_1	139	145	PF00069	0.359
MOD_ProDKin_1	385	391	PF00069	0.603
MOD_ProDKin_1	399	405	PF00069	0.400
MOD_SUMO_for_1	321	324	PF00179	0.416
TRG_DiLeu_BaEn_1	382	387	PF01217	0.343
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.235
TRG_ENDOCYTIC_2	105	108	PF00928	0.302
TRG_ENDOCYTIC_2	318	321	PF00928	0.438
TRG_ER_diArg_1	26	28	PF00400	0.243
TRG_ER_diArg_1	316	318	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2P0	Leptomonas seymouri	27%	100%
A0A0N0P2S5	Leptomonas seymouri	65%	98%
A0A0N0P2S7	Leptomonas seymouri	28%	86%
A0A0N1HZ81	Leptomonas seymouri	30%	79%
A0A0S4J1I6	Bodo saltans	25%	100%
A0A0S4JBQ4	Bodo saltans	28%	100%
A0A0S4JFU3	Bodo saltans	43%	100%
A0A1B7YCL6	Colletotrichum higginsianum (strain IMI 349063)	27%	100%
A0A1X0NVT8	Trypanosomatidae	30%	88%
A0A1X0NVV6	Trypanosomatidae	25%	86%
A0A1X0P5Q9	Trypanosomatidae	46%	96%
A0A1X0P5W3	Trypanosomatidae	26%	99%
A0A2H3CZZ2	Armillaria gallica	23%	100%
A0A3Q8ID46	Leishmania donovani	30%	87%
A0A3Q8IM89	Leishmania donovani	84%	100%
A0A3R7K071	Trypanosoma rangeli	28%	91%
A0A3R7K8J6	Trypanosoma rangeli	52%	100%
A0A3R7N7S2	Trypanosoma rangeli	30%	100%
A0A3S5H7D5	Leishmania donovani	27%	100%
A0A3S7WQY1	Leishmania donovani	25%	100%
A0A3S7X986	Leishmania donovani	25%	91%
A0A422N2B6	Trypanosoma rangeli	28%	92%
A2RVM0	Arabidopsis thaliana	27%	100%
A4H5Z1	Leishmania braziliensis	26%	100%
A4HDP2	Leishmania braziliensis	24%	100%
A4HDP3	Leishmania braziliensis	30%	100%
A4HMN9	Leishmania braziliensis	25%	91%
A4HUB6	Leishmania infantum	25%	100%
C9ZWC0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	93%
C9ZWC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
C9ZZF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZZF3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	95%
E9AF39	Leishmania major	84%	100%
E9AF41	Leishmania major	25%	91%
E9AH88	Leishmania infantum	27%	88%
E9AH89	Leishmania infantum	29%	87%
E9AHV6	Leishmania infantum	84%	100%
E9AHV8	Leishmania infantum	25%	91%
E9AN15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AX26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AX27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	87%
E9B694	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9B696	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	91%
O74959	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P59837	Bos taurus	29%	100%
Q08651	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q17QW3	Bos taurus	26%	100%
Q4QAE9	Leishmania major	28%	87%
Q4QHL1	Leishmania major	26%	100%
Q5F389	Gallus gallus	25%	100%
Q5R9W5	Pongo abelii	27%	100%
Q6RVV4	Pisum sativum	29%	100%
Q803A8	Danio rerio	28%	100%
Q8BYK4	Mus musculus	29%	100%
Q8TC12	Homo sapiens	29%	100%
Q91WL8	Mus musculus	26%	100%
Q96NR8	Homo sapiens	29%	100%
Q9ERI6	Mus musculus	26%	100%
Q9HBH5	Homo sapiens	26%	100%
Q9M2E2	Arabidopsis thaliana	25%	100%
Q9NZC7	Homo sapiens	27%	100%
Q9VLU5	Drosophila melanogaster	26%	100%
V5BAF4	Trypanosoma cruzi	30%	92%
V5BJC7	Trypanosoma cruzi	51%	100%
V5BNY6	Trypanosoma cruzi	31%	100%