Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMN6_LEIBR

TriTrypDb:

LbrM.34.2070 , LBRM2903_340027800

Length:

544

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMN6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	244	248	PF00656	0.561
CLV_C14_Caspase3-7	404	408	PF00656	0.510
CLV_C14_Caspase3-7	442	446	PF00656	0.574
CLV_MEL_PAP_1	37	43	PF00089	0.569
CLV_NRD_NRD_1	535	537	PF00675	0.618
CLV_NRD_NRD_1	67	69	PF00675	0.624
CLV_NRD_NRD_1	71	73	PF00675	0.506
CLV_PCSK_FUR_1	68	72	PF00082	0.629
CLV_PCSK_KEX2_1	521	523	PF00082	0.541
CLV_PCSK_KEX2_1	535	537	PF00082	0.524
CLV_PCSK_KEX2_1	70	72	PF00082	0.541
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.601
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.613
CLV_PCSK_SKI1_1	165	169	PF00082	0.468
CLV_PCSK_SKI1_1	177	181	PF00082	0.287
CLV_PCSK_SKI1_1	273	277	PF00082	0.413
CLV_PCSK_SKI1_1	356	360	PF00082	0.281
CLV_Separin_Metazoa	474	478	PF03568	0.517
DEG_APCC_DBOX_1	164	172	PF00400	0.510
DOC_CKS1_1	197	202	PF01111	0.499
DOC_CYCLIN_RxL_1	174	184	PF00134	0.465
DOC_CYCLIN_yCln2_LP_2	385	391	PF00134	0.361
DOC_MAPK_DCC_7	347	357	PF00069	0.281
DOC_MAPK_gen_1	220	230	PF00069	0.474
DOC_MAPK_gen_1	86	95	PF00069	0.420
DOC_MAPK_MEF2A_6	223	230	PF00069	0.327
DOC_MAPK_MEF2A_6	494	503	PF00069	0.467
DOC_PP2B_LxvP_1	335	338	PF13499	0.360
DOC_USP7_MATH_1	18	22	PF00917	0.420
DOC_USP7_MATH_1	299	303	PF00917	0.308
DOC_USP7_MATH_1	399	403	PF00917	0.734
DOC_USP7_MATH_1	529	533	PF00917	0.636
DOC_WW_Pin1_4	196	201	PF00397	0.511
DOC_WW_Pin1_4	292	297	PF00397	0.325
DOC_WW_Pin1_4	384	389	PF00397	0.477
DOC_WW_Pin1_4	414	419	PF00397	0.645
LIG_14-3-3_CanoR_1	191	196	PF00244	0.525
LIG_14-3-3_CanoR_1	211	221	PF00244	0.383
LIG_14-3-3_CanoR_1	301	305	PF00244	0.301
LIG_14-3-3_CanoR_1	522	530	PF00244	0.663
LIG_14-3-3_CanoR_1	89	94	PF00244	0.521
LIG_APCC_ABBA_1	171	176	PF00400	0.330
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BRCT_BRCA1_1	37	41	PF00533	0.451
LIG_BRCT_BRCA1_1	483	487	PF00533	0.392
LIG_DLG_GKlike_1	191	198	PF00625	0.542
LIG_eIF4E_1	174	180	PF01652	0.346
LIG_eIF4E_1	28	34	PF01652	0.445
LIG_eIF4E_1	483	489	PF01652	0.448
LIG_FHA_1	113	119	PF00498	0.360
LIG_FHA_1	202	208	PF00498	0.367
LIG_FHA_1	301	307	PF00498	0.306
LIG_FHA_1	330	336	PF00498	0.413
LIG_FHA_1	96	102	PF00498	0.434
LIG_FHA_2	242	248	PF00498	0.526
LIG_FHA_2	368	374	PF00498	0.421
LIG_FHA_2	502	508	PF00498	0.480
LIG_FHA_2	529	535	PF00498	0.635
LIG_LIR_Apic_2	194	200	PF02991	0.519
LIG_LIR_Gen_1	129	138	PF02991	0.538
LIG_LIR_Gen_1	278	287	PF02991	0.366
LIG_LIR_Gen_1	514	525	PF02991	0.535
LIG_LIR_LC3C_4	224	228	PF02991	0.403
LIG_LIR_Nem_3	514	520	PF02991	0.624
LIG_LRP6_Inhibitor_1	350	356	PF00058	0.299
LIG_NRBOX	317	323	PF00104	0.281
LIG_PCNA_yPIPBox_3	183	196	PF02747	0.458
LIG_PCNA_yPIPBox_3	339	349	PF02747	0.255
LIG_SH2_CRK	106	110	PF00017	0.468
LIG_SH2_SRC	505	508	PF00017	0.513
LIG_SH2_STAP1	174	178	PF00017	0.455
LIG_SH2_STAT3	234	237	PF00017	0.372
LIG_SH2_STAT3	36	39	PF00017	0.376
LIG_SH2_STAT5	197	200	PF00017	0.494
LIG_SH2_STAT5	240	243	PF00017	0.328
LIG_SH2_STAT5	280	283	PF00017	0.325
LIG_SH2_STAT5	348	351	PF00017	0.255
LIG_SH2_STAT5	36	39	PF00017	0.366
LIG_SH2_STAT5	492	495	PF00017	0.372
LIG_SH3_2	296	301	PF14604	0.362
LIG_SH3_3	293	299	PF00018	0.426
LIG_SH3_3	362	368	PF00018	0.360
LIG_SH3_3	412	418	PF00018	0.653
LIG_SUMO_SIM_anti_2	176	182	PF11976	0.411
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.367
LIG_SUMO_SIM_par_1	226	233	PF11976	0.338
LIG_SUMO_SIM_par_1	382	387	PF11976	0.498
LIG_TRAF2_1	467	470	PF00917	0.675
LIG_TRAF2_1	531	534	PF00917	0.663
LIG_TRAF2_2	200	205	PF00917	0.280
LIG_UBA3_1	138	147	PF00899	0.484
LIG_WRC_WIRS_1	138	143	PF05994	0.524
MOD_CK1_1	137	143	PF00069	0.532
MOD_CK1_1	212	218	PF00069	0.367
MOD_CK1_1	392	398	PF00069	0.690
MOD_CK1_1	452	458	PF00069	0.739
MOD_CK2_1	137	143	PF00069	0.492
MOD_CK2_1	147	153	PF00069	0.530
MOD_CK2_1	18	24	PF00069	0.440
MOD_CK2_1	263	269	PF00069	0.449
MOD_CK2_1	367	373	PF00069	0.405
MOD_CK2_1	399	405	PF00069	0.728
MOD_CK2_1	464	470	PF00069	0.702
MOD_CK2_1	501	507	PF00069	0.463
MOD_CK2_1	521	527	PF00069	0.433
MOD_CK2_1	528	534	PF00069	0.642
MOD_Cter_Amidation	66	69	PF01082	0.476
MOD_GlcNHglycan	121	124	PF01048	0.428
MOD_GlcNHglycan	20	23	PF01048	0.513
MOD_GlcNHglycan	211	214	PF01048	0.405
MOD_GlcNHglycan	250	253	PF01048	0.558
MOD_GlcNHglycan	30	33	PF01048	0.493
MOD_GlcNHglycan	394	398	PF01048	0.615
MOD_GlcNHglycan	427	430	PF01048	0.564
MOD_GlcNHglycan	447	450	PF01048	0.726
MOD_GlcNHglycan	483	486	PF01048	0.305
MOD_GlcNHglycan	523	526	PF01048	0.595
MOD_GSK3_1	133	140	PF00069	0.509
MOD_GSK3_1	143	150	PF00069	0.459
MOD_GSK3_1	271	278	PF00069	0.481
MOD_GSK3_1	316	323	PF00069	0.366
MOD_GSK3_1	327	334	PF00069	0.264
MOD_GSK3_1	337	344	PF00069	0.432
MOD_GSK3_1	389	396	PF00069	0.691
MOD_GSK3_1	414	421	PF00069	0.497
MOD_GSK3_1	431	438	PF00069	0.570
MOD_GSK3_1	445	452	PF00069	0.724
MOD_GSK3_1	497	504	PF00069	0.485
MOD_N-GLC_1	126	131	PF02516	0.600
MOD_N-GLC_1	209	214	PF02516	0.419
MOD_N-GLC_1	28	33	PF02516	0.451
MOD_N-GLC_1	389	394	PF02516	0.621
MOD_NEK2_1	133	138	PF00069	0.478
MOD_NEK2_1	27	32	PF00069	0.454
MOD_NEK2_1	275	280	PF00069	0.381
MOD_NEK2_1	282	287	PF00069	0.357
MOD_NEK2_1	316	321	PF00069	0.413
MOD_NEK2_1	327	332	PF00069	0.418
MOD_NEK2_1	520	525	PF00069	0.497
MOD_PIKK_1	275	281	PF00454	0.369
MOD_PIKK_1	320	326	PF00454	0.362
MOD_PIKK_1	35	41	PF00454	0.403
MOD_PK_1	4	10	PF00069	0.497
MOD_PKA_1	147	153	PF00069	0.590
MOD_PKA_1	521	527	PF00069	0.663
MOD_PKA_2	190	196	PF00069	0.526
MOD_PKA_2	300	306	PF00069	0.291
MOD_PKA_2	481	487	PF00069	0.366
MOD_PKA_2	521	527	PF00069	0.610
MOD_Plk_1	126	132	PF00069	0.545
MOD_Plk_1	134	140	PF00069	0.478
MOD_Plk_1	230	236	PF00069	0.370
MOD_Plk_1	418	424	PF00069	0.558
MOD_Plk_1	435	441	PF00069	0.553
MOD_Plk_1	501	507	PF00069	0.442
MOD_Plk_1	95	101	PF00069	0.494
MOD_Plk_2-3	250	256	PF00069	0.534
MOD_Plk_2-3	464	470	PF00069	0.621
MOD_Plk_4	113	119	PF00069	0.357
MOD_Plk_4	134	140	PF00069	0.484
MOD_Plk_4	191	197	PF00069	0.550
MOD_Plk_4	203	209	PF00069	0.391
MOD_Plk_4	271	277	PF00069	0.351
MOD_Plk_4	300	306	PF00069	0.318
MOD_Plk_4	316	322	PF00069	0.150
MOD_ProDKin_1	196	202	PF00069	0.508
MOD_ProDKin_1	292	298	PF00069	0.325
MOD_ProDKin_1	384	390	PF00069	0.496
MOD_ProDKin_1	414	420	PF00069	0.646
MOD_SUMO_rev_2	140	149	PF00179	0.448
MOD_SUMO_rev_2	402	411	PF00179	0.596
TRG_DiLeu_BaEn_1	176	181	PF01217	0.464
TRG_DiLeu_BaEn_2	372	378	PF01217	0.397
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.343
TRG_ENDOCYTIC_2	11	14	PF00928	0.362
TRG_ENDOCYTIC_2	130	133	PF00928	0.476
TRG_ENDOCYTIC_2	280	283	PF00928	0.337
TRG_ENDOCYTIC_2	517	520	PF00928	0.522
TRG_ER_diArg_1	535	538	PF00400	0.675
TRG_ER_diArg_1	97	100	PF00400	0.310
TRG_NLS_MonoCore_2	67	72	PF00514	0.577
TRG_NLS_MonoExtC_3	67	72	PF00514	0.594
TRG_NLS_MonoExtN_4	68	74	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	535	539	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9E6	Leptomonas seymouri	66%	99%
A0A1X0P5Q0	Trypanosomatidae	42%	100%
A0A3R7RFL4	Trypanosoma rangeli	47%	100%
A0A3S7X984	Leishmania donovani	87%	100%
C9ZZF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AF38	Leishmania major	85%	100%
E9AHV5	Leishmania infantum	87%	100%
E9B693	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BTI6	Trypanosoma cruzi	46%	100%