Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HMN5_LEIBR

TriTrypDb:

LbrM.34.2060 , LBRM2903_340027700

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	391	395	PF00656	0.497
CLV_MEL_PAP_1	36	42	PF00089	0.538
CLV_NRD_NRD_1	218	220	PF00675	0.687
CLV_NRD_NRD_1	38	40	PF00675	0.443
CLV_NRD_NRD_1	428	430	PF00675	0.438
CLV_NRD_NRD_1	438	440	PF00675	0.447
CLV_PCSK_KEX2_1	218	220	PF00082	0.687
CLV_PCSK_KEX2_1	37	39	PF00082	0.461
CLV_PCSK_KEX2_1	428	430	PF00082	0.438
CLV_PCSK_KEX2_1	438	440	PF00082	0.447
CLV_PCSK_PC7_1	424	430	PF00082	0.414
CLV_PCSK_SKI1_1	275	279	PF00082	0.648
CLV_PCSK_SKI1_1	412	416	PF00082	0.489
CLV_PCSK_SKI1_1	54	58	PF00082	0.349
DEG_APCC_DBOX_1	411	419	PF00400	0.433
DEG_SCF_FBW7_1	301	307	PF00400	0.512
DEG_SPOP_SBC_1	262	266	PF00917	0.508
DOC_CDC14_PxL_1	80	88	PF14671	0.521
DOC_CKS1_1	248	253	PF01111	0.661
DOC_CKS1_1	301	306	PF01111	0.509
DOC_MAPK_RevD_3	413	429	PF00069	0.411
DOC_PP1_RVXF_1	26	32	PF00149	0.453
DOC_USP7_MATH_1	13	17	PF00917	0.514
DOC_USP7_MATH_1	138	142	PF00917	0.608
DOC_USP7_MATH_1	184	188	PF00917	0.525
DOC_USP7_MATH_1	263	267	PF00917	0.626
DOC_USP7_MATH_1	312	316	PF00917	0.548
DOC_USP7_MATH_1	347	351	PF00917	0.664
DOC_USP7_MATH_1	72	76	PF00917	0.510
DOC_WW_Pin1_4	11	16	PF00397	0.590
DOC_WW_Pin1_4	17	22	PF00397	0.471
DOC_WW_Pin1_4	2	7	PF00397	0.671
DOC_WW_Pin1_4	204	209	PF00397	0.577
DOC_WW_Pin1_4	247	252	PF00397	0.611
DOC_WW_Pin1_4	300	305	PF00397	0.649
DOC_WW_Pin1_4	341	346	PF00397	0.678
LIG_14-3-3_CanoR_1	270	274	PF00244	0.581
LIG_14-3-3_CanoR_1	324	330	PF00244	0.451
LIG_14-3-3_CanoR_1	37	45	PF00244	0.484
LIG_14-3-3_CanoR_1	375	380	PF00244	0.478
LIG_14-3-3_CanoR_1	412	421	PF00244	0.424
LIG_BRCT_BRCA1_1	325	329	PF00533	0.608
LIG_deltaCOP1_diTrp_1	334	340	PF00928	0.509
LIG_FHA_1	146	152	PF00498	0.451
LIG_FHA_1	262	268	PF00498	0.511
LIG_FHA_1	276	282	PF00498	0.569
LIG_FHA_1	3	9	PF00498	0.566
LIG_FHA_1	301	307	PF00498	0.512
LIG_FHA_1	31	37	PF00498	0.493
LIG_FHA_1	376	382	PF00498	0.517
LIG_FHA_1	44	50	PF00498	0.421
LIG_FHA_2	111	117	PF00498	0.613
LIG_FHA_2	168	174	PF00498	0.671
LIG_HP1_1	411	415	PF01393	0.445
LIG_LIR_Apic_2	350	356	PF02991	0.468
LIG_LIR_Gen_1	227	236	PF02991	0.549
LIG_LIR_Gen_1	334	342	PF02991	0.504
LIG_LIR_Nem_3	227	232	PF02991	0.605
LIG_LIR_Nem_3	334	339	PF02991	0.508
LIG_MYND_1	84	88	PF01753	0.528
LIG_MYND_1	9	13	PF01753	0.680
LIG_NRBOX	414	420	PF00104	0.502
LIG_NRBOX	51	57	PF00104	0.441
LIG_PAM2_1	133	145	PF00658	0.451
LIG_PCNA_yPIPBox_3	174	183	PF02747	0.479
LIG_Pex14_2	336	340	PF04695	0.506
LIG_SH2_CRK	233	237	PF00017	0.579
LIG_SH2_NCK_1	229	233	PF00017	0.602
LIG_SH2_STAP1	229	233	PF00017	0.529
LIG_SH3_3	129	135	PF00018	0.521
LIG_SH3_3	278	284	PF00018	0.495
LIG_SH3_3	298	304	PF00018	0.508
LIG_SH3_3	3	9	PF00018	0.615
LIG_SH3_3	78	84	PF00018	0.516
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.472
LIG_SUMO_SIM_par_1	302	309	PF11976	0.661
LIG_SUMO_SIM_par_1	46	53	PF11976	0.532
LIG_TRFH_1	80	84	PF08558	0.514
LIG_UBA3_1	48	54	PF00899	0.368
MOD_CK1_1	108	114	PF00069	0.549
MOD_CK1_1	123	129	PF00069	0.623
MOD_CK1_1	141	147	PF00069	0.429
MOD_CK1_1	16	22	PF00069	0.531
MOD_CK1_1	187	193	PF00069	0.471
MOD_CK1_1	266	272	PF00069	0.689
MOD_CK1_1	319	325	PF00069	0.751
MOD_CK1_1	390	396	PF00069	0.598
MOD_CK1_1	41	47	PF00069	0.500
MOD_CK1_1	89	95	PF00069	0.800
MOD_CK2_1	110	116	PF00069	0.613
MOD_CK2_1	150	156	PF00069	0.386
MOD_CK2_1	175	181	PF00069	0.385
MOD_CK2_1	224	230	PF00069	0.446
MOD_CK2_1	294	300	PF00069	0.668
MOD_CK2_1	317	323	PF00069	0.672
MOD_CMANNOS	335	338	PF00535	0.503
MOD_GlcNHglycan	16	19	PF01048	0.535
MOD_GlcNHglycan	186	189	PF01048	0.498
MOD_GlcNHglycan	257	262	PF01048	0.564
MOD_GlcNHglycan	295	299	PF01048	0.590
MOD_GlcNHglycan	325	328	PF01048	0.621
MOD_GlcNHglycan	349	352	PF01048	0.577
MOD_GlcNHglycan	396	399	PF01048	0.605
MOD_GlcNHglycan	40	43	PF01048	0.387
MOD_GlcNHglycan	400	403	PF01048	0.618
MOD_GlcNHglycan	89	92	PF01048	0.637
MOD_GSK3_1	105	112	PF00069	0.569
MOD_GSK3_1	13	20	PF00069	0.579
MOD_GSK3_1	141	148	PF00069	0.528
MOD_GSK3_1	257	264	PF00069	0.669
MOD_GSK3_1	269	276	PF00069	0.600
MOD_GSK3_1	296	303	PF00069	0.620
MOD_GSK3_1	312	319	PF00069	0.605
MOD_GSK3_1	390	397	PF00069	0.600
MOD_GSK3_1	50	57	PF00069	0.513
MOD_GSK3_1	86	93	PF00069	0.744
MOD_N-GLC_1	184	189	PF02516	0.625
MOD_NEK2_1	109	114	PF00069	0.525
MOD_NEK2_1	56	61	PF00069	0.366
MOD_NEK2_2	221	226	PF00069	0.474
MOD_PIKK_1	141	147	PF00454	0.389
MOD_PIKK_1	212	218	PF00454	0.532
MOD_PKA_1	38	44	PF00069	0.541
MOD_PKA_2	269	275	PF00069	0.569
MOD_PKA_2	312	318	PF00069	0.625
MOD_PKA_2	323	329	PF00069	0.553
MOD_PKA_2	38	44	PF00069	0.541
MOD_Plk_4	138	144	PF00069	0.626
MOD_Plk_4	150	156	PF00069	0.462
MOD_Plk_4	167	173	PF00069	0.409
MOD_Plk_4	263	269	PF00069	0.677
MOD_Plk_4	325	331	PF00069	0.683
MOD_Plk_4	414	420	PF00069	0.502
MOD_ProDKin_1	11	17	PF00069	0.587
MOD_ProDKin_1	2	8	PF00069	0.671
MOD_ProDKin_1	204	210	PF00069	0.574
MOD_ProDKin_1	247	253	PF00069	0.615
MOD_ProDKin_1	300	306	PF00069	0.647
MOD_ProDKin_1	341	347	PF00069	0.685
MOD_SUMO_for_1	191	194	PF00179	0.503
MOD_SUMO_rev_2	20	29	PF00179	0.521
TRG_ENDOCYTIC_2	229	232	PF00928	0.546
TRG_ENDOCYTIC_2	233	236	PF00928	0.524
TRG_ER_diArg_1	217	219	PF00400	0.679
TRG_ER_diArg_1	36	39	PF00400	0.448
TRG_ER_diArg_1	437	439	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSZ3	Leptomonas seymouri	45%	87%
A0A3Q8IHZ9	Leishmania donovani	70%	88%
E9AF37	Leishmania major	69%	100%
E9AHV4	Leishmania infantum	70%	88%
E9B692	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	88%