Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMN2_LEIBR

TriTrypDb:

LbrM.34.2030 , LBRM2903_340027400

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.695
CLV_NRD_NRD_1	160	162	PF00675	0.766
CLV_NRD_NRD_1	182	184	PF00675	0.855
CLV_NRD_NRD_1	207	209	PF00675	0.729
CLV_NRD_NRD_1	332	334	PF00675	0.349
CLV_NRD_NRD_1	80	82	PF00675	0.378
CLV_PCSK_KEX2_1	181	183	PF00082	0.864
CLV_PCSK_KEX2_1	207	209	PF00082	0.729
CLV_PCSK_KEX2_1	241	243	PF00082	0.785
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.785
CLV_PCSK_SKI1_1	324	328	PF00082	0.506
CLV_PCSK_SKI1_1	364	368	PF00082	0.420
CLV_Separin_Metazoa	306	310	PF03568	0.342
DEG_SPOP_SBC_1	106	110	PF00917	0.686
DOC_CYCLIN_RxL_1	377	386	PF00134	0.502
DOC_MAPK_gen_1	309	316	PF00069	0.491
DOC_MAPK_HePTP_8	78	90	PF00069	0.349
DOC_MAPK_MEF2A_6	81	90	PF00069	0.351
DOC_PP1_RVXF_1	109	116	PF00149	0.694
DOC_USP7_MATH_1	150	154	PF00917	0.597
DOC_USP7_MATH_1	255	259	PF00917	0.574
DOC_USP7_MATH_1	281	285	PF00917	0.561
DOC_USP7_MATH_1	392	396	PF00917	0.575
DOC_USP7_MATH_1	399	403	PF00917	0.610
DOC_USP7_MATH_1	479	483	PF00917	0.685
DOC_USP7_MATH_1	98	102	PF00917	0.629
DOC_WW_Pin1_4	171	176	PF00397	0.537
DOC_WW_Pin1_4	251	256	PF00397	0.765
DOC_WW_Pin1_4	390	395	PF00397	0.706
DOC_WW_Pin1_4	403	408	PF00397	0.559
DOC_WW_Pin1_4	452	457	PF00397	0.538
DOC_WW_Pin1_4	62	67	PF00397	0.530
LIG_14-3-3_CanoR_1	181	190	PF00244	0.647
LIG_14-3-3_CanoR_1	191	201	PF00244	0.702
LIG_14-3-3_CanoR_1	242	246	PF00244	0.828
LIG_14-3-3_CanoR_1	300	308	PF00244	0.442
LIG_14-3-3_CanoR_1	383	392	PF00244	0.399
LIG_14-3-3_CanoR_1	446	451	PF00244	0.448
LIG_14-3-3_CanoR_1	480	484	PF00244	0.497
LIG_14-3-3_CanoR_1	97	106	PF00244	0.530
LIG_Actin_WH2_2	367	385	PF00022	0.486
LIG_BRCT_BRCA1_1	129	133	PF00533	0.573
LIG_Clathr_ClatBox_1	439	443	PF01394	0.530
LIG_CSL_BTD_1	466	469	PF09270	0.498
LIG_DCNL_PONY_1	1	4	PF03556	0.423
LIG_DLG_GKlike_1	161	168	PF00625	0.675
LIG_DLG_GKlike_1	446	454	PF00625	0.467
LIG_FHA_1	108	114	PF00498	0.697
LIG_FHA_1	142	148	PF00498	0.604
LIG_FHA_1	174	180	PF00498	0.541
LIG_FHA_1	221	227	PF00498	0.552
LIG_FHA_1	32	38	PF00498	0.604
LIG_FHA_1	463	469	PF00498	0.562
LIG_FHA_1	70	76	PF00498	0.529
LIG_FHA_2	127	133	PF00498	0.693
LIG_FHA_2	214	220	PF00498	0.570
LIG_LIR_Gen_1	18	29	PF02991	0.558
LIG_LIR_Gen_1	303	310	PF02991	0.336
LIG_LIR_Nem_3	18	24	PF02991	0.549
LIG_LIR_Nem_3	303	308	PF02991	0.490
LIG_LIR_Nem_3	465	470	PF02991	0.498
LIG_LYPXL_yS_3	44	47	PF13949	0.551
LIG_Rb_LxCxE_1	289	306	PF01857	0.355
LIG_Rb_pABgroove_1	163	171	PF01858	0.685
LIG_SH2_NCK_1	458	462	PF00017	0.657
LIG_SH2_SRC	421	424	PF00017	0.652
LIG_SH2_STAP1	458	462	PF00017	0.657
LIG_SH2_STAT3	332	335	PF00017	0.353
LIG_SH2_STAT5	68	71	PF00017	0.481
LIG_SH2_STAT5	89	92	PF00017	0.520
LIG_SH3_3	10	16	PF00018	0.569
LIG_SH3_3	43	49	PF00018	0.563
LIG_SH3_3	60	66	PF00018	0.462
LIG_SH3_3	80	86	PF00018	0.481
LIG_SUMO_SIM_anti_2	428	434	PF11976	0.539
LIG_SUMO_SIM_anti_2	53	60	PF11976	0.617
LIG_SxIP_EBH_1	150	162	PF03271	0.522
LIG_TRAF2_1	356	359	PF00917	0.435
LIG_UBA3_1	156	162	PF00899	0.513
LIG_UBA3_1	74	82	PF00899	0.504
MOD_CK1_1	105	111	PF00069	0.689
MOD_CK1_1	127	133	PF00069	0.693
MOD_CK1_1	164	170	PF00069	0.687
MOD_CK1_1	171	177	PF00069	0.630
MOD_CK1_1	184	190	PF00069	0.688
MOD_CK1_1	203	209	PF00069	0.535
MOD_CK1_1	217	223	PF00069	0.618
MOD_CK1_1	234	240	PF00069	0.565
MOD_CK1_1	263	269	PF00069	0.720
MOD_CK1_1	406	412	PF00069	0.678
MOD_CK2_1	126	132	PF00069	0.696
MOD_CK2_1	25	31	PF00069	0.633
MOD_CK2_1	300	306	PF00069	0.439
MOD_GlcNHglycan	100	103	PF01048	0.652
MOD_GlcNHglycan	148	151	PF01048	0.592
MOD_GlcNHglycan	170	173	PF01048	0.565
MOD_GlcNHglycan	196	199	PF01048	0.639
MOD_GlcNHglycan	202	205	PF01048	0.660
MOD_GlcNHglycan	233	236	PF01048	0.583
MOD_GlcNHglycan	237	240	PF01048	0.543
MOD_GlcNHglycan	261	265	PF01048	0.565
MOD_GlcNHglycan	272	275	PF01048	0.530
MOD_GlcNHglycan	281	284	PF01048	0.481
MOD_GlcNHglycan	39	42	PF01048	0.596
MOD_GlcNHglycan	396	399	PF01048	0.697
MOD_GlcNHglycan	408	411	PF01048	0.632
MOD_GlcNHglycan	477	480	PF01048	0.669
MOD_GlcNHglycan	9	12	PF01048	0.531
MOD_GSK3_1	102	109	PF00069	0.589
MOD_GSK3_1	146	153	PF00069	0.692
MOD_GSK3_1	164	171	PF00069	0.571
MOD_GSK3_1	203	210	PF00069	0.686
MOD_GSK3_1	213	220	PF00069	0.617
MOD_GSK3_1	231	238	PF00069	0.573
MOD_GSK3_1	251	258	PF00069	0.661
MOD_GSK3_1	27	34	PF00069	0.674
MOD_GSK3_1	390	397	PF00069	0.645
MOD_GSK3_1	399	406	PF00069	0.634
MOD_GSK3_1	421	428	PF00069	0.534
MOD_GSK3_1	475	482	PF00069	0.649
MOD_GSK3_1	93	100	PF00069	0.572
MOD_N-GLC_1	208	213	PF02516	0.566
MOD_N-GLC_1	339	344	PF02516	0.554
MOD_NEK2_1	168	173	PF00069	0.625
MOD_NEK2_1	194	199	PF00069	0.836
MOD_NEK2_2	102	107	PF00069	0.538
MOD_NEK2_2	286	291	PF00069	0.446
MOD_PIKK_1	192	198	PF00454	0.723
MOD_PIKK_1	220	226	PF00454	0.554
MOD_PIKK_1	383	389	PF00454	0.464
MOD_PIKK_1	399	405	PF00454	0.510
MOD_PIKK_1	421	427	PF00454	0.494
MOD_PIKK_1	50	56	PF00454	0.562
MOD_PK_1	241	247	PF00069	0.697
MOD_PKA_1	161	167	PF00069	0.674
MOD_PKA_1	181	187	PF00069	0.767
MOD_PKA_1	207	213	PF00069	0.568
MOD_PKA_1	241	247	PF00069	0.785
MOD_PKA_2	181	187	PF00069	0.767
MOD_PKA_2	192	198	PF00069	0.630
MOD_PKA_2	207	213	PF00069	0.570
MOD_PKA_2	214	220	PF00069	0.605
MOD_PKA_2	241	247	PF00069	0.847
MOD_PKA_2	479	485	PF00069	0.552
MOD_PKA_2	98	104	PF00069	0.657
MOD_PKB_1	298	306	PF00069	0.332
MOD_Plk_2-3	25	31	PF00069	0.583
MOD_Plk_2-3	438	444	PF00069	0.367
MOD_Plk_4	164	170	PF00069	0.735
MOD_Plk_4	463	469	PF00069	0.565
MOD_Plk_4	479	485	PF00069	0.485
MOD_Plk_4	53	59	PF00069	0.388
MOD_ProDKin_1	171	177	PF00069	0.538
MOD_ProDKin_1	251	257	PF00069	0.765
MOD_ProDKin_1	390	396	PF00069	0.712
MOD_ProDKin_1	403	409	PF00069	0.559
MOD_ProDKin_1	452	458	PF00069	0.541
MOD_ProDKin_1	62	68	PF00069	0.521
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.494
TRG_ENDOCYTIC_2	363	366	PF00928	0.490
TRG_ENDOCYTIC_2	44	47	PF00928	0.551
TRG_ER_diArg_1	180	183	PF00400	0.835
TRG_ER_diArg_1	190	193	PF00400	0.703
TRG_ER_diArg_1	298	301	PF00400	0.415
TRG_ER_diArg_1	308	311	PF00400	0.481
TRG_ER_diArg_1	445	448	PF00400	0.404
TRG_NES_CRM1_1	429	443	PF08389	0.533
TRG_Pf-PMV_PEXEL_1	111	116	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X976	Leishmania donovani	76%	100%
A4IBA9	Leishmania infantum	76%	73%
E9AF34	Leishmania major	71%	94%
E9B689	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%