LeishMANIAdb
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ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-dependent DNA helicase
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HMN1_LEIBR
TriTrypDb:
LbrM.34.2020 , LBRM2903_340027200 * , LBRM2903_340027300 *
Length:
688

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMN1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 104 108 PF00656 0.638
CLV_C14_Caspase3-7 144 148 PF00656 0.576
CLV_MEL_PAP_1 602 608 PF00089 0.505
CLV_NRD_NRD_1 127 129 PF00675 0.558
CLV_NRD_NRD_1 164 166 PF00675 0.869
CLV_NRD_NRD_1 171 173 PF00675 0.757
CLV_NRD_NRD_1 195 197 PF00675 0.640
CLV_NRD_NRD_1 284 286 PF00675 0.612
CLV_NRD_NRD_1 329 331 PF00675 0.680
CLV_NRD_NRD_1 351 353 PF00675 0.715
CLV_NRD_NRD_1 380 382 PF00675 0.749
CLV_NRD_NRD_1 451 453 PF00675 0.597
CLV_PCSK_FUR_1 125 129 PF00082 0.538
CLV_PCSK_FUR_1 282 286 PF00082 0.763
CLV_PCSK_KEX2_1 127 129 PF00082 0.546
CLV_PCSK_KEX2_1 171 173 PF00082 0.859
CLV_PCSK_KEX2_1 180 182 PF00082 0.703
CLV_PCSK_KEX2_1 195 197 PF00082 0.582
CLV_PCSK_KEX2_1 284 286 PF00082 0.688
CLV_PCSK_KEX2_1 328 330 PF00082 0.678
CLV_PCSK_KEX2_1 351 353 PF00082 0.715
CLV_PCSK_KEX2_1 380 382 PF00082 0.749
CLV_PCSK_KEX2_1 451 453 PF00082 0.661
CLV_PCSK_PC1ET2_1 180 182 PF00082 0.824
CLV_PCSK_SKI1_1 120 124 PF00082 0.463
CLV_PCSK_SKI1_1 180 184 PF00082 0.862
CLV_PCSK_SKI1_1 339 343 PF00082 0.687
CLV_PCSK_SKI1_1 460 464 PF00082 0.358
CLV_PCSK_SKI1_1 94 98 PF00082 0.747
DEG_APCC_DBOX_1 12 20 PF00400 0.552
DEG_APCC_DBOX_1 327 335 PF00400 0.406
DEG_SCF_TRCP1_1 141 146 PF00400 0.581
DEG_SPOP_SBC_1 182 186 PF00917 0.853
DEG_SPOP_SBC_1 568 572 PF00917 0.573
DOC_MAPK_gen_1 282 290 PF00069 0.619
DOC_MAPK_gen_1 292 299 PF00069 0.596
DOC_MAPK_gen_1 46 55 PF00069 0.702
DOC_MAPK_gen_1 474 483 PF00069 0.633
DOC_MAPK_gen_1 605 613 PF00069 0.667
DOC_MAPK_MEF2A_6 49 57 PF00069 0.708
DOC_PP1_RVXF_1 118 125 PF00149 0.611
DOC_PP1_RVXF_1 337 344 PF00149 0.685
DOC_PP1_RVXF_1 458 465 PF00149 0.612
DOC_PP4_FxxP_1 311 314 PF00568 0.726
DOC_PP4_FxxP_1 456 459 PF00568 0.447
DOC_USP7_MATH_1 108 112 PF00917 0.471
DOC_USP7_MATH_1 182 186 PF00917 0.853
DOC_USP7_MATH_1 234 238 PF00917 0.826
DOC_USP7_MATH_1 239 243 PF00917 0.743
DOC_USP7_MATH_1 433 437 PF00917 0.635
DOC_USP7_MATH_1 568 572 PF00917 0.600
DOC_USP7_MATH_1 582 586 PF00917 0.770
DOC_USP7_MATH_1 631 635 PF00917 0.729
LIG_14-3-3_CanoR_1 120 125 PF00244 0.490
LIG_14-3-3_CanoR_1 128 136 PF00244 0.608
LIG_14-3-3_CanoR_1 13 22 PF00244 0.554
LIG_14-3-3_CanoR_1 181 191 PF00244 0.815
LIG_14-3-3_CanoR_1 266 270 PF00244 0.720
LIG_14-3-3_CanoR_1 284 289 PF00244 0.478
LIG_14-3-3_CanoR_1 384 391 PF00244 0.478
LIG_14-3-3_CanoR_1 581 591 PF00244 0.659
LIG_14-3-3_CanoR_1 605 611 PF00244 0.733
LIG_APCC_ABBA_1 288 293 PF00400 0.782
LIG_APCC_ABBA_1 53 58 PF00400 0.703
LIG_BIR_II_1 1 5 PF00653 0.721
LIG_BRCT_BRCA1_1 307 311 PF00533 0.713
LIG_BRCT_BRCA1_1 460 464 PF00533 0.625
LIG_BRCT_BRCA1_1 639 643 PF00533 0.725
LIG_Clathr_ClatBox_1 296 300 PF01394 0.753
LIG_FHA_1 247 253 PF00498 0.797
LIG_FHA_1 333 339 PF00498 0.566
LIG_FHA_1 367 373 PF00498 0.484
LIG_FHA_1 491 497 PF00498 0.436
LIG_FHA_1 535 541 PF00498 0.470
LIG_FHA_1 587 593 PF00498 0.712
LIG_FHA_2 142 148 PF00498 0.578
LIG_FHA_2 213 219 PF00498 0.617
LIG_FHA_2 296 302 PF00498 0.478
LIG_FHA_2 417 423 PF00498 0.695
LIG_FHA_2 468 474 PF00498 0.637
LIG_LIR_Apic_2 308 314 PF02991 0.720
LIG_LIR_Gen_1 305 315 PF02991 0.721
LIG_LIR_Gen_1 84 93 PF02991 0.776
LIG_LIR_Nem_3 305 310 PF02991 0.720
LIG_LIR_Nem_3 612 617 PF02991 0.788
LIG_LIR_Nem_3 80 86 PF02991 0.787
LIG_MLH1_MIPbox_1 307 311 PF16413 0.713
LIG_MYND_1 651 655 PF01753 0.815
LIG_NRBOX 491 497 PF00104 0.622
LIG_PCNA_PIPBox_1 312 321 PF02747 0.698
LIG_PCNA_PIPBox_1 450 459 PF02747 0.349
LIG_PCNA_yPIPBox_3 445 457 PF02747 0.355
LIG_Pex14_2 22 26 PF04695 0.624
LIG_Pex14_2 307 311 PF04695 0.713
LIG_Pex14_2 464 468 PF04695 0.600
LIG_PTB_Apo_2 264 271 PF02174 0.453
LIG_PTB_Phospho_1 264 270 PF10480 0.453
LIG_Rb_pABgroove_1 608 616 PF01858 0.785
LIG_REV1ctd_RIR_1 308 313 PF16727 0.718
LIG_SH2_NCK_1 86 90 PF00017 0.794
LIG_SH2_STAT3 270 273 PF00017 0.451
LIG_SH2_STAT5 318 321 PF00017 0.655
LIG_SH2_STAT5 324 327 PF00017 0.559
LIG_SH2_STAT5 64 67 PF00017 0.637
LIG_SH2_STAT5 7 10 PF00017 0.694
LIG_SH3_3 188 194 PF00018 0.589
LIG_SH3_3 251 257 PF00018 0.784
LIG_SH3_3 576 582 PF00018 0.842
LIG_SH3_3 645 651 PF00018 0.602
LIG_SH3_4 221 228 PF00018 0.586
LIG_SUMO_SIM_anti_2 249 256 PF11976 0.665
LIG_SUMO_SIM_anti_2 434 443 PF11976 0.360
LIG_SUMO_SIM_par_1 434 443 PF11976 0.601
LIG_SUMO_SIM_par_1 488 493 PF11976 0.422
LIG_SUMO_SIM_par_1 609 615 PF11976 0.785
LIG_TRAF2_1 298 301 PF00917 0.473
LIG_TRAF2_1 411 414 PF00917 0.587
LIG_TRAF2_1 419 422 PF00917 0.569
LIG_TRAF2_1 598 601 PF00917 0.657
LIG_UBA3_1 349 356 PF00899 0.456
LIG_UBA3_1 527 532 PF00899 0.499
LIG_WRC_WIRS_1 121 126 PF05994 0.473
LIG_WRC_WIRS_1 19 24 PF05994 0.695
LIG_WW_3 91 95 PF00397 0.746
MOD_CK1_1 129 135 PF00069 0.701
MOD_CK1_1 142 148 PF00069 0.733
MOD_CK1_1 150 156 PF00069 0.646
MOD_CK1_1 18 24 PF00069 0.413
MOD_CK1_1 227 233 PF00069 0.693
MOD_CK1_1 3 9 PF00069 0.695
MOD_CK1_1 567 573 PF00069 0.617
MOD_CK1_1 585 591 PF00069 0.663
MOD_CK1_1 632 638 PF00069 0.545
MOD_CK1_1 84 90 PF00069 0.524
MOD_CK2_1 295 301 PF00069 0.701
MOD_CK2_1 416 422 PF00069 0.694
MOD_CK2_1 84 90 PF00069 0.750
MOD_GlcNHglycan 141 144 PF01048 0.586
MOD_GlcNHglycan 156 159 PF01048 0.691
MOD_GlcNHglycan 241 244 PF01048 0.592
MOD_GlcNHglycan 517 520 PF01048 0.763
MOD_GlcNHglycan 566 569 PF01048 0.609
MOD_GlcNHglycan 584 587 PF01048 0.819
MOD_GlcNHglycan 592 595 PF01048 0.536
MOD_GlcNHglycan 620 624 PF01048 0.801
MOD_GlcNHglycan 631 634 PF01048 0.672
MOD_GlcNHglycan 644 647 PF01048 0.565
MOD_GlcNHglycan 680 683 PF01048 0.574
MOD_GSK3_1 126 133 PF00069 0.688
MOD_GSK3_1 139 146 PF00069 0.715
MOD_GSK3_1 14 21 PF00069 0.693
MOD_GSK3_1 150 157 PF00069 0.577
MOD_GSK3_1 212 219 PF00069 0.734
MOD_GSK3_1 295 302 PF00069 0.482
MOD_GSK3_1 318 325 PF00069 0.450
MOD_GSK3_1 367 374 PF00069 0.733
MOD_GSK3_1 423 430 PF00069 0.664
MOD_GSK3_1 564 571 PF00069 0.566
MOD_GSK3_1 581 588 PF00069 0.826
MOD_GSK3_1 627 634 PF00069 0.571
MOD_GSK3_1 674 681 PF00069 0.818
MOD_LATS_1 179 185 PF00433 0.821
MOD_N-GLC_1 674 679 PF02516 0.574
MOD_NEK2_1 1 6 PF00069 0.447
MOD_NEK2_1 217 222 PF00069 0.578
MOD_NEK2_1 371 376 PF00069 0.731
MOD_NEK2_1 490 495 PF00069 0.520
MOD_NEK2_1 627 632 PF00069 0.661
MOD_NEK2_1 642 647 PF00069 0.520
MOD_NEK2_1 81 86 PF00069 0.520
MOD_OFUCOSY 320 326 PF10250 0.385
MOD_PIKK_1 126 132 PF00454 0.673
MOD_PIKK_1 174 180 PF00454 0.862
MOD_PIKK_1 183 189 PF00454 0.705
MOD_PIKK_1 221 227 PF00454 0.584
MOD_PIKK_1 332 338 PF00454 0.678
MOD_PIKK_1 417 423 PF00454 0.708
MOD_PK_1 284 290 PF00069 0.507
MOD_PKA_1 284 290 PF00069 0.507
MOD_PKA_1 380 386 PF00069 0.538
MOD_PKA_2 126 132 PF00069 0.594
MOD_PKA_2 174 180 PF00069 0.798
MOD_PKA_2 265 271 PF00069 0.719
MOD_PKA_2 284 290 PF00069 0.462
MOD_PKA_2 380 386 PF00069 0.538
MOD_PKA_2 416 422 PF00069 0.682
MOD_PKA_2 45 51 PF00069 0.652
MOD_PKA_2 503 509 PF00069 0.402
MOD_PKA_2 534 540 PF00069 0.466
MOD_PKB_1 196 204 PF00069 0.580
MOD_PKB_1 282 290 PF00069 0.502
MOD_PKB_1 328 336 PF00069 0.409
MOD_PKB_1 415 423 PF00069 0.562
MOD_Plk_1 150 156 PF00069 0.850
MOD_Plk_1 423 429 PF00069 0.593
MOD_Plk_1 433 439 PF00069 0.632
MOD_Plk_4 15 21 PF00069 0.461
MOD_Plk_4 265 271 PF00069 0.618
MOD_Plk_4 284 290 PF00069 0.462
MOD_Plk_4 3 9 PF00069 0.695
MOD_Plk_4 367 373 PF00069 0.734
MOD_Plk_4 424 430 PF00069 0.524
MOD_Plk_4 433 439 PF00069 0.509
MOD_Plk_4 458 464 PF00069 0.489
MOD_Plk_4 84 90 PF00069 0.791
MOD_SUMO_for_1 343 346 PF00179 0.697
MOD_SUMO_rev_2 31 39 PF00179 0.677
MOD_SUMO_rev_2 58 65 PF00179 0.688
TRG_DiLeu_BaEn_1 357 362 PF01217 0.722
TRG_DiLeu_BaEn_1 77 82 PF01217 0.506
TRG_DiLeu_BaLyEn_6 649 654 PF01217 0.571
TRG_ENDOCYTIC_2 86 89 PF00928 0.794
TRG_ER_diArg_1 124 127 PF00400 0.755
TRG_ER_diArg_1 194 196 PF00400 0.826
TRG_ER_diArg_1 282 285 PF00400 0.603
TRG_ER_diArg_1 328 330 PF00400 0.678
TRG_ER_diArg_1 350 352 PF00400 0.711
TRG_ER_diArg_1 380 382 PF00400 0.749
TRG_ER_diArg_1 451 453 PF00400 0.393
TRG_NLS_Bipartite_1 165 184 PF00514 0.826
TRG_NLS_MonoExtN_4 163 169 PF00514 0.870
TRG_NLS_MonoExtN_4 171 176 PF00514 0.735

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H7Z3 Leishmania donovani 75% 95%
A4IBA8 Leishmania infantum 75% 95%
E9AF33 Leishmania major 75% 100%
E9B688 Leishmania mexicana (strain MHOM/GT/2001/U1103) 74% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS