Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4HMM9_LEIBR

TriTrypDb:

LbrM.34.2000 , LBRM2903_340026900

Length:

694

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	6
GO:0099080	supramolecular complex	2	6
GO:0099081	supramolecular polymer	3	6
GO:0099512	supramolecular fiber	4	6
GO:0099513	polymeric cytoskeletal fiber	5	6
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	4
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4HMM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMM9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	22
GO:0007018	microtubule-based movement	3	22
GO:0009987	cellular process	1	22
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	22
GO:0003774	cytoskeletal motor activity	1	22
GO:0003777	microtubule motor activity	2	22
GO:0003824	catalytic activity	1	8
GO:0005488	binding	1	22
GO:0005515	protein binding	2	22
GO:0005524	ATP binding	5	22
GO:0008017	microtubule binding	5	22
GO:0008092	cytoskeletal protein binding	3	22
GO:0015631	tubulin binding	4	22
GO:0016787	hydrolase activity	2	8
GO:0017076	purine nucleotide binding	4	22
GO:0030554	adenyl nucleotide binding	5	22
GO:0032553	ribonucleotide binding	3	22
GO:0032555	purine ribonucleotide binding	4	22
GO:0032559	adenyl ribonucleotide binding	5	22
GO:0035639	purine ribonucleoside triphosphate binding	4	22
GO:0036094	small molecule binding	2	22
GO:0043167	ion binding	2	22
GO:0043168	anion binding	3	22
GO:0097159	organic cyclic compound binding	2	22
GO:0097367	carbohydrate derivative binding	2	22
GO:0140657	ATP-dependent activity	1	22
GO:1901265	nucleoside phosphate binding	3	22
GO:1901363	heterocyclic compound binding	2	22
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	82	86	PF00656	0.263
CLV_MEL_PAP_1	364	370	PF00089	0.211
CLV_NRD_NRD_1	215	217	PF00675	0.228
CLV_NRD_NRD_1	256	258	PF00675	0.482
CLV_NRD_NRD_1	277	279	PF00675	0.501
CLV_NRD_NRD_1	461	463	PF00675	0.531
CLV_NRD_NRD_1	490	492	PF00675	0.557
CLV_NRD_NRD_1	575	577	PF00675	0.399
CLV_PCSK_FUR_1	488	492	PF00082	0.496
CLV_PCSK_KEX2_1	215	217	PF00082	0.199
CLV_PCSK_KEX2_1	461	463	PF00082	0.530
CLV_PCSK_KEX2_1	490	492	PF00082	0.559
CLV_PCSK_KEX2_1	575	577	PF00082	0.380
CLV_PCSK_KEX2_1	648	650	PF00082	0.434
CLV_PCSK_PC1ET2_1	648	650	PF00082	0.434
CLV_PCSK_SKI1_1	105	109	PF00082	0.298
CLV_PCSK_SKI1_1	143	147	PF00082	0.259
CLV_PCSK_SKI1_1	16	20	PF00082	0.235
CLV_PCSK_SKI1_1	166	170	PF00082	0.237
CLV_PCSK_SKI1_1	316	320	PF00082	0.242
CLV_PCSK_SKI1_1	373	377	PF00082	0.301
CLV_PCSK_SKI1_1	385	389	PF00082	0.212
CLV_PCSK_SKI1_1	413	417	PF00082	0.376
CLV_PCSK_SKI1_1	481	485	PF00082	0.559
CLV_PCSK_SKI1_1	648	652	PF00082	0.409
DEG_SPOP_SBC_1	417	421	PF00917	0.359
DOC_CYCLIN_yClb5_NLxxxL_5	367	375	PF00134	0.260
DOC_MAPK_gen_1	143	153	PF00069	0.291
DOC_MAPK_MEF2A_6	146	155	PF00069	0.259
DOC_MAPK_MEF2A_6	8	15	PF00069	0.314
DOC_PP1_RVXF_1	425	431	PF00149	0.471
DOC_PP4_FxxP_1	379	382	PF00568	0.232
DOC_SPAK_OSR1_1	491	495	PF12202	0.352
DOC_USP7_MATH_1	220	224	PF00917	0.306
DOC_USP7_MATH_1	246	250	PF00917	0.411
DOC_USP7_MATH_1	343	347	PF00917	0.175
DOC_USP7_MATH_1	54	58	PF00917	0.257
DOC_WW_Pin1_4	279	284	PF00397	0.546
DOC_WW_Pin1_4	390	395	PF00397	0.247
DOC_WW_Pin1_4	624	629	PF00397	0.662
LIG_14-3-3_CanoR_1	132	140	PF00244	0.318
LIG_14-3-3_CanoR_1	490	495	PF00244	0.485
LIG_14-3-3_CanoR_1	649	654	PF00244	0.513
LIG_14-3-3_CanoR_1	8	14	PF00244	0.386
LIG_Actin_WH2_2	361	378	PF00022	0.387
LIG_Actin_WH2_2	6	22	PF00022	0.245
LIG_APCC_ABBA_1	158	163	PF00400	0.241
LIG_APCC_ABBA_1	655	660	PF00400	0.266
LIG_APCC_ABBA_1	73	78	PF00400	0.232
LIG_BRCT_BRCA1_1	126	130	PF00533	0.245
LIG_BRCT_BRCA1_1	56	60	PF00533	0.215
LIG_Clathr_ClatBox_1	233	237	PF01394	0.245
LIG_FHA_1	104	110	PF00498	0.214
LIG_FHA_1	370	376	PF00498	0.279
LIG_FHA_1	41	47	PF00498	0.149
LIG_FHA_1	480	486	PF00498	0.620
LIG_FHA_1	605	611	PF00498	0.468
LIG_FHA_2	183	189	PF00498	0.182
LIG_FHA_2	419	425	PF00498	0.453
LIG_FHA_2	484	490	PF00498	0.625
LIG_FHA_2	625	631	PF00498	0.557
LIG_FHA_2	69	75	PF00498	0.271
LIG_IRF3_LxIS_1	209	214	PF10401	0.163
LIG_LIR_Apic_2	301	306	PF02991	0.476
LIG_LIR_Apic_2	378	382	PF02991	0.189
LIG_LIR_Gen_1	106	115	PF02991	0.252
LIG_LIR_Gen_1	127	138	PF02991	0.269
LIG_LIR_Gen_1	583	593	PF02991	0.427
LIG_LIR_Gen_1	61	66	PF02991	0.284
LIG_LIR_Gen_1	659	665	PF02991	0.318
LIG_LIR_Nem_3	106	110	PF02991	0.286
LIG_LIR_Nem_3	127	133	PF02991	0.279
LIG_LIR_Nem_3	583	588	PF02991	0.382
LIG_LIR_Nem_3	61	65	PF02991	0.257
LIG_LIR_Nem_3	656	661	PF02991	0.534
LIG_NRBOX	370	376	PF00104	0.261
LIG_PCNA_yPIPBox_3	162	172	PF02747	0.362
LIG_PDZ_Class_1	689	694	PF00595	0.326
LIG_Pex14_1	294	298	PF04695	0.403
LIG_Pex14_2	62	66	PF04695	0.249
LIG_SH2_CRK	303	307	PF00017	0.332
LIG_SH2_CRK	472	476	PF00017	0.414
LIG_SH2_PTP2	661	664	PF00017	0.267
LIG_SH2_SRC	76	79	PF00017	0.245
LIG_SH2_STAP1	313	317	PF00017	0.340
LIG_SH2_STAP1	399	403	PF00017	0.217
LIG_SH2_STAP1	472	476	PF00017	0.529
LIG_SH2_STAP1	637	641	PF00017	0.543
LIG_SH2_STAP1	658	662	PF00017	0.366
LIG_SH2_STAP1	76	80	PF00017	0.263
LIG_SH2_STAT5	592	595	PF00017	0.516
LIG_SH2_STAT5	64	67	PF00017	0.307
LIG_SH2_STAT5	661	664	PF00017	0.267
LIG_SH3_3	186	192	PF00018	0.224
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.342
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.344
LIG_SUMO_SIM_anti_2	383	390	PF11976	0.229
LIG_SUMO_SIM_anti_2	587	592	PF11976	0.466
LIG_SUMO_SIM_anti_2	659	668	PF11976	0.509
LIG_SUMO_SIM_par_1	659	668	PF11976	0.271
LIG_TRAF2_1	502	505	PF00917	0.424
LIG_TRAF2_1	550	553	PF00917	0.446
LIG_TRAF2_1	627	630	PF00917	0.480
LIG_TYR_ITIM	470	475	PF00017	0.421
LIG_UBA3_1	510	516	PF00899	0.350
MOD_CK1_1	103	109	PF00069	0.243
MOD_CK1_1	218	224	PF00069	0.254
MOD_CK1_1	225	231	PF00069	0.229
MOD_CK1_1	274	280	PF00069	0.632
MOD_CK1_1	282	288	PF00069	0.639
MOD_CK1_1	331	337	PF00069	0.273
MOD_CK1_1	346	352	PF00069	0.246
MOD_CK1_1	369	375	PF00069	0.261
MOD_CK1_1	380	386	PF00069	0.282
MOD_CK1_1	493	499	PF00069	0.587
MOD_CK1_1	58	64	PF00069	0.264
MOD_CK1_1	598	604	PF00069	0.522
MOD_CK1_1	624	630	PF00069	0.532
MOD_CK2_1	153	159	PF00069	0.233
MOD_CK2_1	282	288	PF00069	0.456
MOD_CK2_1	395	401	PF00069	0.244
MOD_CK2_1	418	424	PF00069	0.460
MOD_CK2_1	624	630	PF00069	0.518
MOD_CK2_1	68	74	PF00069	0.273
MOD_Cter_Amidation	573	576	PF01082	0.302
MOD_GlcNHglycan	102	105	PF01048	0.267
MOD_GlcNHglycan	126	129	PF01048	0.232
MOD_GlcNHglycan	174	177	PF01048	0.452
MOD_GlcNHglycan	243	246	PF01048	0.342
MOD_GlcNHglycan	273	276	PF01048	0.612
MOD_GlcNHglycan	284	287	PF01048	0.601
MOD_GlcNHglycan	330	333	PF01048	0.277
MOD_GlcNHglycan	434	437	PF01048	0.515
MOD_GlcNHglycan	569	572	PF01048	0.436
MOD_GlcNHglycan	57	60	PF01048	0.217
MOD_GlcNHglycan	623	626	PF01048	0.474
MOD_GlcNHglycan	639	642	PF01048	0.508
MOD_GSK3_1	211	218	PF00069	0.248
MOD_GSK3_1	220	227	PF00069	0.258
MOD_GSK3_1	339	346	PF00069	0.273
MOD_GSK3_1	36	43	PF00069	0.150
MOD_GSK3_1	362	369	PF00069	0.214
MOD_GSK3_1	377	384	PF00069	0.207
MOD_GSK3_1	395	402	PF00069	0.245
MOD_GSK3_1	479	486	PF00069	0.600
MOD_GSK3_1	54	61	PF00069	0.253
MOD_N-GLC_1	259	264	PF02516	0.595
MOD_N-GLC_1	344	349	PF02516	0.251
MOD_N-GLC_1	369	374	PF02516	0.303
MOD_N-GLC_1	680	685	PF02516	0.473
MOD_N-GLC_1	91	96	PF02516	0.237
MOD_N-GLC_2	530	532	PF02516	0.267
MOD_NEK2_1	211	216	PF00069	0.196
MOD_NEK2_1	253	258	PF00069	0.511
MOD_NEK2_1	298	303	PF00069	0.413
MOD_NEK2_1	415	420	PF00069	0.369
MOD_NEK2_1	432	437	PF00069	0.473
MOD_NEK2_1	567	572	PF00069	0.479
MOD_NEK2_1	604	609	PF00069	0.507
MOD_NEK2_1	621	626	PF00069	0.457
MOD_NEK2_1	664	669	PF00069	0.477
MOD_NEK2_2	40	45	PF00069	0.274
MOD_NEK2_2	483	488	PF00069	0.541
MOD_PIKK_1	222	228	PF00454	0.365
MOD_PIKK_1	392	398	PF00454	0.264
MOD_PIKK_1	560	566	PF00454	0.508
MOD_PIKK_1	68	74	PF00454	0.218
MOD_PK_1	490	496	PF00069	0.433
MOD_PKA_1	215	221	PF00069	0.232
MOD_PKA_1	490	496	PF00069	0.544
MOD_PKA_2	215	221	PF00069	0.247
MOD_PKA_2	366	372	PF00069	0.280
MOD_PKA_2	490	496	PF00069	0.492
MOD_PKA_2	544	550	PF00069	0.461
MOD_PKB_1	488	496	PF00069	0.355
MOD_Plk_1	339	345	PF00069	0.245
MOD_Plk_1	369	375	PF00069	0.251
MOD_Plk_1	399	405	PF00069	0.200
MOD_Plk_1	40	46	PF00069	0.235
MOD_Plk_1	68	74	PF00069	0.245
MOD_Plk_1	680	686	PF00069	0.397
MOD_Plk_1	91	97	PF00069	0.216
MOD_Plk_4	190	196	PF00069	0.241
MOD_Plk_4	248	254	PF00069	0.301
MOD_Plk_4	298	304	PF00069	0.397
MOD_Plk_4	584	590	PF00069	0.478
MOD_Plk_4	680	686	PF00069	0.311
MOD_Plk_4	91	97	PF00069	0.241
MOD_ProDKin_1	279	285	PF00069	0.543
MOD_ProDKin_1	390	396	PF00069	0.247
MOD_ProDKin_1	624	630	PF00069	0.661
MOD_SUMO_for_1	44	47	PF00179	0.279
MOD_SUMO_rev_2	135	142	PF00179	0.290
MOD_SUMO_rev_2	256	265	PF00179	0.536
MOD_SUMO_rev_2	268	273	PF00179	0.503
MOD_SUMO_rev_2	542	550	PF00179	0.461
TRG_DiLeu_BaEn_1	506	511	PF01217	0.502
TRG_DiLeu_BaEn_4	552	558	PF01217	0.567
TRG_DiLeu_BaLyEn_6	370	375	PF01217	0.279
TRG_ENDOCYTIC_2	471	474	PF00928	0.431
TRG_ENDOCYTIC_2	661	664	PF00928	0.469
TRG_ER_diArg_1	13	16	PF00400	0.240
TRG_ER_diArg_1	215	217	PF00400	0.387
TRG_ER_diArg_1	460	462	PF00400	0.493
TRG_ER_diArg_1	490	492	PF00400	0.623
TRG_ER_diArg_1	575	577	PF00400	0.408
TRG_NES_CRM1_1	440	452	PF08389	0.401
TRG_NLS_MonoExtN_4	676	682	PF00514	0.359
TRG_Pf-PMV_PEXEL_1	132	136	PF00026	0.200
TRG_Pf-PMV_PEXEL_1	575	579	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.456

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM1	Leptomonas seymouri	29%	75%
A0A0N1IM30	Leptomonas seymouri	73%	99%
A0A0S4IXS6	Bodo saltans	37%	67%
A0A0S4JN49	Bodo saltans	51%	96%
A0A0S4KM02	Bodo saltans	27%	68%
A0A1X0NYU1	Trypanosomatidae	34%	68%
A0A1X0P5Y8	Trypanosomatidae	59%	100%
A0A3Q8IG88	Leishmania donovani	77%	99%
A0A422MZ05	Trypanosoma rangeli	57%	100%
A0A422NEF2	Trypanosoma rangeli	34%	69%
A0A422NEQ8	Trypanosoma rangeli	26%	92%
A4HCA1	Leishmania braziliensis	31%	78%
A4HHY2	Leishmania braziliensis	27%	100%
A4IBA7	Leishmania infantum	76%	99%
C9ZVT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	68%
C9ZZN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AF32	Leishmania major	75%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	78%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
O43093	Syncephalastrum racemosum	26%	74%
Q7X7H4	Oryza sativa subsp. japonica	26%	73%
V5B8X9	Trypanosoma cruzi	56%	99%
V5DFA7	Trypanosoma cruzi	29%	100%