DUF4205 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4205), putative

Species:

Leishmania braziliensis

UniProt:

A4HMM7_LEIBR

TriTrypDb:

LbrM.34.1980 , LBRM2903_340026600

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMM7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004843	cysteine-type deubiquitinase activity	5	7
GO:0008233	peptidase activity	3	7
GO:0008234	cysteine-type peptidase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0019783	ubiquitin-like protein peptidase activity	4	7
GO:0101005	deubiquitinase activity	5	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1990380	K48-linked deubiquitinase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.685
CLV_NRD_NRD_1	131	133	PF00675	0.600
CLV_NRD_NRD_1	168	170	PF00675	0.623
CLV_NRD_NRD_1	228	230	PF00675	0.594
CLV_NRD_NRD_1	37	39	PF00675	0.525
CLV_NRD_NRD_1	97	99	PF00675	0.568
CLV_PCSK_KEX2_1	176	178	PF00082	0.734
CLV_PCSK_KEX2_1	228	230	PF00082	0.594
CLV_PCSK_KEX2_1	37	39	PF00082	0.525
CLV_PCSK_KEX2_1	97	99	PF00082	0.568
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.702
CLV_PCSK_SKI1_1	146	150	PF00082	0.630
CLV_PCSK_SKI1_1	350	354	PF00082	0.513
CLV_PCSK_SKI1_1	38	42	PF00082	0.637
CLV_PCSK_SKI1_1	4	8	PF00082	0.665
CLV_PCSK_SKI1_1	424	428	PF00082	0.411
CLV_PCSK_SKI1_1	480	484	PF00082	0.472
CLV_PCSK_SKI1_1	624	628	PF00082	0.411
CLV_PCSK_SKI1_1	675	679	PF00082	0.402
CLV_PCSK_SKI1_1	97	101	PF00082	0.424
DEG_APCC_DBOX_1	37	45	PF00400	0.635
DEG_APCC_DBOX_1	528	536	PF00400	0.513
DEG_SPOP_SBC_1	587	591	PF00917	0.383
DOC_ANK_TNKS_1	76	83	PF00023	0.567
DOC_CDC14_PxL_1	9	17	PF14671	0.673
DOC_PP2B_LxvP_1	522	525	PF13499	0.513
DOC_PP2B_LxvP_1	617	620	PF13499	0.474
DOC_USP7_MATH_1	252	256	PF00917	0.711
DOC_USP7_MATH_1	262	266	PF00917	0.544
DOC_USP7_MATH_1	305	309	PF00917	0.720
DOC_USP7_MATH_1	436	440	PF00917	0.407
DOC_USP7_MATH_1	573	577	PF00917	0.488
DOC_USP7_MATH_1	587	591	PF00917	0.392
DOC_USP7_MATH_1	62	66	PF00917	0.641
DOC_USP7_MATH_1	684	688	PF00917	0.411
DOC_USP7_MATH_1	690	694	PF00917	0.411
DOC_USP7_UBL2_3	141	145	PF12436	0.660
DOC_WW_Pin1_4	150	155	PF00397	0.552
DOC_WW_Pin1_4	182	187	PF00397	0.712
DOC_WW_Pin1_4	216	221	PF00397	0.694
DOC_WW_Pin1_4	230	235	PF00397	0.765
DOC_WW_Pin1_4	588	593	PF00397	0.411
LIG_14-3-3_CanoR_1	180	186	PF00244	0.829
LIG_14-3-3_CanoR_1	228	235	PF00244	0.671
LIG_14-3-3_CanoR_1	242	248	PF00244	0.548
LIG_14-3-3_CanoR_1	529	533	PF00244	0.433
LIG_14-3-3_CanoR_1	61	70	PF00244	0.648
LIG_14-3-3_CanoR_1	675	681	PF00244	0.524
LIG_BRCT_BRCA1_1	334	338	PF00533	0.376
LIG_BRCT_BRCA1_1	490	494	PF00533	0.513
LIG_BRCT_BRCA1_1	589	593	PF00533	0.261
LIG_BRCT_BRCA1_1	660	664	PF00533	0.513
LIG_FHA_1	466	472	PF00498	0.492
LIG_FHA_1	529	535	PF00498	0.353
LIG_FHA_1	621	627	PF00498	0.411
LIG_FHA_1	654	660	PF00498	0.515
LIG_FHA_1	99	105	PF00498	0.606
LIG_FHA_2	197	203	PF00498	0.710
LIG_FHA_2	217	223	PF00498	0.518
LIG_FHA_2	292	298	PF00498	0.716
LIG_FHA_2	411	417	PF00498	0.411
LIG_FHA_2	646	652	PF00498	0.411
LIG_FHA_2	83	89	PF00498	0.507
LIG_GBD_Chelix_1	407	415	PF00786	0.513
LIG_GBD_Chelix_1	489	497	PF00786	0.474
LIG_LIR_Apic_2	478	484	PF02991	0.411
LIG_LIR_Gen_1	335	344	PF02991	0.361
LIG_LIR_Gen_1	455	464	PF02991	0.411
LIG_LIR_Gen_1	491	502	PF02991	0.513
LIG_LIR_Gen_1	612	620	PF02991	0.513
LIG_LIR_Nem_3	335	341	PF02991	0.352
LIG_LIR_Nem_3	491	497	PF02991	0.513
LIG_LIR_Nem_3	612	617	PF02991	0.513
LIG_NRBOX	492	498	PF00104	0.513
LIG_REV1ctd_RIR_1	543	551	PF16727	0.513
LIG_SH2_GRB2like	595	598	PF00017	0.513
LIG_SH2_NCK_1	595	599	PF00017	0.478
LIG_SH2_STAP1	391	395	PF00017	0.411
LIG_SH2_STAP1	559	563	PF00017	0.411
LIG_SH2_STAT5	396	399	PF00017	0.411
LIG_SH2_STAT5	595	598	PF00017	0.387
LIG_SH3_3	110	116	PF00018	0.675
LIG_SH3_3	375	381	PF00018	0.411
LIG_SH3_3	598	604	PF00018	0.342
LIG_SUMO_SIM_anti_2	638	643	PF11976	0.513
LIG_SUMO_SIM_par_1	424	430	PF11976	0.367
LIG_SUMO_SIM_par_1	655	661	PF11976	0.369
LIG_TRAF2_1	220	223	PF00917	0.690
LIG_WRC_WIRS_1	489	494	PF05994	0.513
MOD_CDC14_SPxK_1	153	156	PF00782	0.558
MOD_CDK_SPxK_1	150	156	PF00069	0.543
MOD_CK1_1	182	188	PF00069	0.777
MOD_CK1_1	207	213	PF00069	0.742
MOD_CK1_1	230	236	PF00069	0.721
MOD_CK1_1	243	249	PF00069	0.782
MOD_CK1_1	261	267	PF00069	0.637
MOD_CK1_1	591	597	PF00069	0.373
MOD_CK2_1	216	222	PF00069	0.733
MOD_CK2_1	410	416	PF00069	0.411
MOD_CK2_1	510	516	PF00069	0.265
MOD_CK2_1	82	88	PF00069	0.521
MOD_CMANNOS	606	609	PF00535	0.513
MOD_Cter_Amidation	174	177	PF01082	0.594
MOD_GlcNHglycan	150	153	PF01048	0.713
MOD_GlcNHglycan	181	184	PF01048	0.781
MOD_GlcNHglycan	186	189	PF01048	0.821
MOD_GlcNHglycan	230	233	PF01048	0.713
MOD_GlcNHglycan	242	245	PF01048	0.807
MOD_GlcNHglycan	247	250	PF01048	0.689
MOD_GlcNHglycan	260	263	PF01048	0.609
MOD_GlcNHglycan	334	337	PF01048	0.370
MOD_GlcNHglycan	429	432	PF01048	0.294
MOD_GlcNHglycan	526	529	PF01048	0.351
MOD_GlcNHglycan	582	585	PF01048	0.416
MOD_GlcNHglycan	635	638	PF01048	0.272
MOD_GlcNHglycan	660	663	PF01048	0.433
MOD_GlcNHglycan	667	670	PF01048	0.413
MOD_GlcNHglycan	692	695	PF01048	0.411
MOD_GSK3_1	203	210	PF00069	0.739
MOD_GSK3_1	243	250	PF00069	0.672
MOD_GSK3_1	254	261	PF00069	0.612
MOD_GSK3_1	452	459	PF00069	0.323
MOD_GSK3_1	488	495	PF00069	0.515
MOD_GSK3_1	507	514	PF00069	0.411
MOD_GSK3_1	524	531	PF00069	0.220
MOD_GSK3_1	582	589	PF00069	0.446
MOD_GSK3_1	676	683	PF00069	0.411
MOD_GSK3_1	98	105	PF00069	0.436
MOD_N-GLC_1	596	601	PF02516	0.499
MOD_NEK2_1	148	153	PF00069	0.523
MOD_NEK2_1	181	186	PF00069	0.678
MOD_NEK2_1	203	208	PF00069	0.711
MOD_NEK2_1	247	252	PF00069	0.741
MOD_NEK2_1	344	349	PF00069	0.509
MOD_NEK2_1	40	45	PF00069	0.537
MOD_NEK2_1	427	432	PF00069	0.507
MOD_NEK2_1	492	497	PF00069	0.411
MOD_NEK2_1	537	542	PF00069	0.499
MOD_NEK2_1	593	598	PF00069	0.420
MOD_NEK2_1	633	638	PF00069	0.323
MOD_NEK2_1	653	658	PF00069	0.375
MOD_NEK2_1	680	685	PF00069	0.411
MOD_PIKK_1	262	268	PF00454	0.694
MOD_PIKK_1	465	471	PF00454	0.339
MOD_PKA_1	169	175	PF00069	0.597
MOD_PKA_1	228	234	PF00069	0.585
MOD_PKA_2	179	185	PF00069	0.664
MOD_PKA_2	227	233	PF00069	0.677
MOD_PKA_2	253	259	PF00069	0.836
MOD_PKA_2	471	477	PF00069	0.411
MOD_PKA_2	528	534	PF00069	0.351
MOD_PKA_2	580	586	PF00069	0.358
MOD_PKA_2	610	616	PF00069	0.513
MOD_PKB_1	454	462	PF00069	0.323
MOD_Plk_1	465	471	PF00069	0.261
MOD_Plk_1	54	60	PF00069	0.452
MOD_Plk_2-3	311	317	PF00069	0.680
MOD_Plk_2-3	645	651	PF00069	0.411
MOD_Plk_4	471	477	PF00069	0.411
MOD_Plk_4	488	494	PF00069	0.411
MOD_Plk_4	518	524	PF00069	0.416
MOD_Plk_4	602	608	PF00069	0.362
MOD_Plk_4	676	682	PF00069	0.411
MOD_Plk_4	82	88	PF00069	0.521
MOD_ProDKin_1	150	156	PF00069	0.556
MOD_ProDKin_1	182	188	PF00069	0.711
MOD_ProDKin_1	216	222	PF00069	0.695
MOD_ProDKin_1	230	236	PF00069	0.763
MOD_ProDKin_1	588	594	PF00069	0.411
MOD_SUMO_for_1	78	81	PF00179	0.571
MOD_SUMO_for_1	99	102	PF00179	0.429
TRG_DiLeu_BaEn_1	21	26	PF01217	0.522
TRG_ENDOCYTIC_2	119	122	PF00928	0.620
TRG_ER_diArg_1	453	456	PF00400	0.443
TRG_ER_diArg_1	97	99	PF00400	0.568
TRG_NES_CRM1_1	84	96	PF08389	0.521
TRG_NLS_Bipartite_1	132	150	PF00514	0.488
TRG_NLS_MonoExtC_3	122	128	PF00514	0.456
TRG_NLS_MonoExtC_3	144	149	PF00514	0.648
TRG_NLS_MonoExtN_4	145	150	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	61	66	PF00026	0.641
TRG_Pf-PMV_PEXEL_1	624	628	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	97	102	PF00026	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILT4	Leptomonas seymouri	51%	100%
A0A3S7X9A6	Leishmania donovani	78%	100%
A4IBA5	Leishmania infantum	78%	100%
E9AF29	Leishmania major	78%	100%
E9B685	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%