SH3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Variant SH3 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HMM6_LEIBR

TriTrypDb:

LbrM.34.1970 , LBRM2903_340026500

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HMM6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMM6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.715
CLV_C14_Caspase3-7	411	415	PF00656	0.706
CLV_C14_Caspase3-7	425	429	PF00656	0.644
CLV_NRD_NRD_1	309	311	PF00675	0.341
CLV_NRD_NRD_1	5	7	PF00675	0.756
CLV_NRD_NRD_1	8	10	PF00675	0.686
CLV_PCSK_FUR_1	6	10	PF00082	0.644
CLV_PCSK_KEX2_1	309	311	PF00082	0.357
CLV_PCSK_KEX2_1	5	7	PF00082	0.705
CLV_PCSK_KEX2_1	8	10	PF00082	0.685
CLV_PCSK_SKI1_1	324	328	PF00082	0.357
CLV_PCSK_SKI1_1	349	353	PF00082	0.445
CLV_PCSK_SKI1_1	430	434	PF00082	0.818
DEG_Nend_UBRbox_2	1	3	PF02207	0.632
DOC_ANK_TNKS_1	15	22	PF00023	0.510
DOC_PP4_FxxP_1	229	232	PF00568	0.700
DOC_USP7_MATH_1	114	118	PF00917	0.749
DOC_USP7_MATH_1	235	239	PF00917	0.779
DOC_WW_Pin1_4	193	198	PF00397	0.391
DOC_WW_Pin1_4	218	223	PF00397	0.574
DOC_WW_Pin1_4	437	442	PF00397	0.633
LIG_14-3-3_CanoR_1	136	143	PF00244	0.674
LIG_14-3-3_CanoR_1	152	158	PF00244	0.656
LIG_14-3-3_CanoR_1	192	197	PF00244	0.357
LIG_14-3-3_CanoR_1	434	441	PF00244	0.747
LIG_14-3-3_CanoR_1	447	452	PF00244	0.747
LIG_14-3-3_CanoR_1	462	471	PF00244	0.728
LIG_BRCT_BRCA1_1	225	229	PF00533	0.718
LIG_BRCT_BRCA1_1	353	357	PF00533	0.581
LIG_FHA_1	106	112	PF00498	0.738
LIG_FHA_1	123	129	PF00498	0.672
LIG_FHA_1	136	142	PF00498	0.577
LIG_FHA_1	273	279	PF00498	0.545
LIG_FHA_1	384	390	PF00498	0.621
LIG_FHA_2	30	36	PF00498	0.522
LIG_FHA_2	385	391	PF00498	0.638
LIG_FHA_2	399	405	PF00498	0.614
LIG_FHA_2	409	415	PF00498	0.589
LIG_FHA_2	441	447	PF00498	0.795
LIG_FHA_2	471	477	PF00498	0.752
LIG_Integrin_RGD_1	426	428	PF01839	0.563
LIG_LIR_Apic_2	209	213	PF02991	0.331
LIG_LIR_Apic_2	226	232	PF02991	0.704
LIG_LIR_Apic_2	329	334	PF02991	0.561
LIG_LIR_Gen_1	65	74	PF02991	0.438
LIG_LIR_Gen_1	95	105	PF02991	0.501
LIG_LIR_Nem_3	390	395	PF02991	0.613
LIG_LIR_Nem_3	65	69	PF02991	0.399
LIG_LIR_Nem_3	91	97	PF02991	0.501
LIG_Pex14_2	273	277	PF04695	0.605
LIG_SH2_CRK	331	335	PF00017	0.554
LIG_SH2_NCK_1	331	335	PF00017	0.554
LIG_SH2_PTP2	97	100	PF00017	0.451
LIG_SH2_STAP1	170	174	PF00017	0.391
LIG_SH2_STAP1	358	362	PF00017	0.515
LIG_SH2_STAT3	160	163	PF00017	0.643
LIG_SH2_STAT3	170	173	PF00017	0.438
LIG_SH2_STAT5	331	334	PF00017	0.604
LIG_SH2_STAT5	381	384	PF00017	0.639
LIG_SH2_STAT5	97	100	PF00017	0.563
LIG_SUMO_SIM_anti_2	467	474	PF11976	0.525
LIG_TYR_ITIM	64	69	PF00017	0.438
MOD_CK1_1	109	115	PF00069	0.779
MOD_CK1_1	124	130	PF00069	0.703
MOD_CK1_1	238	244	PF00069	0.744
MOD_CK1_1	329	335	PF00069	0.559
MOD_CK1_1	398	404	PF00069	0.781
MOD_CK1_1	436	442	PF00069	0.649
MOD_CK1_1	464	470	PF00069	0.775
MOD_CK2_1	109	115	PF00069	0.636
MOD_CK2_1	238	244	PF00069	0.541
MOD_CK2_1	398	404	PF00069	0.772
MOD_CK2_1	4	10	PF00069	0.537
MOD_CK2_1	417	423	PF00069	0.704
MOD_GlcNHglycan	100	103	PF01048	0.584
MOD_GlcNHglycan	213	216	PF01048	0.676
MOD_GlcNHglycan	225	228	PF01048	0.710
MOD_GlcNHglycan	238	241	PF01048	0.788
MOD_GlcNHglycan	401	404	PF01048	0.705
MOD_GlcNHglycan	90	93	PF01048	0.361
MOD_GSK3_1	105	112	PF00069	0.665
MOD_GSK3_1	116	123	PF00069	0.664
MOD_GSK3_1	202	209	PF00069	0.336
MOD_GSK3_1	272	279	PF00069	0.553
MOD_GSK3_1	347	354	PF00069	0.588
MOD_GSK3_1	395	402	PF00069	0.756
MOD_GSK3_1	404	411	PF00069	0.731
MOD_GSK3_1	418	425	PF00069	0.758
MOD_GSK3_1	426	433	PF00069	0.730
MOD_GSK3_1	435	442	PF00069	0.689
MOD_GSK3_1	82	89	PF00069	0.379
MOD_N-GLC_1	236	241	PF02516	0.529
MOD_N-GLC_1	287	292	PF02516	0.447
MOD_N-GLC_1	329	334	PF02516	0.534
MOD_N-GLC_1	430	435	PF02516	0.779
MOD_N-GLC_1	82	87	PF02516	0.438
MOD_NEK2_1	120	125	PF00069	0.518
MOD_NEK2_1	146	151	PF00069	0.539
MOD_NEK2_1	153	158	PF00069	0.579
MOD_NEK2_1	287	292	PF00069	0.454
MOD_NEK2_1	357	362	PF00069	0.577
MOD_NEK2_1	4	9	PF00069	0.666
MOD_NEK2_1	417	422	PF00069	0.778
MOD_NEK2_1	44	49	PF00069	0.577
MOD_NEK2_2	316	321	PF00069	0.391
MOD_OFUCOSY	444	451	PF10250	0.549
MOD_PIKK_1	462	468	PF00454	0.555
MOD_PKA_2	135	141	PF00069	0.701
MOD_PKA_2	153	159	PF00069	0.419
MOD_PKA_2	191	197	PF00069	0.357
MOD_PKA_2	4	10	PF00069	0.654
MOD_PKA_2	417	423	PF00069	0.817
MOD_PKA_2	433	439	PF00069	0.664
MOD_PKA_2	44	50	PF00069	0.543
MOD_PKA_2	446	452	PF00069	0.712
MOD_PKA_2	461	467	PF00069	0.779
MOD_Plk_1	178	184	PF00069	0.438
MOD_Plk_1	329	335	PF00069	0.532
MOD_Plk_1	395	401	PF00069	0.666
MOD_Plk_1	72	78	PF00069	0.389
MOD_Plk_2-3	404	410	PF00069	0.744
MOD_Plk_4	116	122	PF00069	0.640
MOD_Plk_4	178	184	PF00069	0.427
MOD_Plk_4	206	212	PF00069	0.240
MOD_Plk_4	467	473	PF00069	0.725
MOD_ProDKin_1	193	199	PF00069	0.391
MOD_ProDKin_1	218	224	PF00069	0.574
MOD_ProDKin_1	437	443	PF00069	0.634
MOD_SUMO_rev_2	238	247	PF00179	0.545
TRG_ENDOCYTIC_2	66	69	PF00928	0.438
TRG_ENDOCYTIC_2	97	100	PF00928	0.451
TRG_ER_diArg_1	309	311	PF00400	0.358
TRG_ER_diArg_1	4	6	PF00400	0.765
TRG_ER_diArg_1	452	455	PF00400	0.786

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT1	Leptomonas seymouri	54%	100%
A0A0S4JH24	Bodo saltans	38%	100%
A0A3Q8IJ10	Leishmania donovani	73%	100%
A0A422NNS8	Trypanosoma rangeli	41%	100%
A4IBA4	Leishmania infantum	73%	100%
E9AF28	Leishmania major	73%	98%
E9B684	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%