NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HMM2_LEIBR

TriTrypDb:

LbrM.34.1930 , LBRM2903_340025900

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HMM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HMM2

Function

Biological processes
Term	Name	Level	Count
GO:0006743	ubiquinone metabolic process	5	1
GO:0006744	ubiquinone biosynthetic process	6	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0042180	cellular ketone metabolic process	3	1
GO:0042181	ketone biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901004	ubiquinone-6 metabolic process	6	1
GO:1901006	ubiquinone-6 biosynthetic process	7	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901661	quinone metabolic process	4	1
GO:1901663	quinone biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0044877	protein-containing complex binding	2	1
GO:0003824	catalytic activity	1	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	71	75	PF00656	0.498
CLV_C14_Caspase3-7	98	102	PF00656	0.318
CLV_PCSK_FUR_1	166	170	PF00082	0.342
CLV_PCSK_KEX2_1	168	170	PF00082	0.344
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.344
CLV_PCSK_SKI1_1	200	204	PF00082	0.387
CLV_PCSK_SKI1_1	206	210	PF00082	0.448
CLV_PCSK_SKI1_1	235	239	PF00082	0.343
CLV_PCSK_SKI1_1	271	275	PF00082	0.487
CLV_PCSK_SKI1_1	279	283	PF00082	0.458
CLV_PCSK_SKI1_1	94	98	PF00082	0.306
DEG_APCC_DBOX_1	338	346	PF00400	0.349
DEG_Nend_Nbox_1	1	3	PF02207	0.479
DOC_ANK_TNKS_1	69	76	PF00023	0.432
DOC_CYCLIN_RxL_1	232	243	PF00134	0.363
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.324
DOC_MAPK_gen_1	138	148	PF00069	0.304
DOC_MAPK_gen_1	166	175	PF00069	0.327
DOC_MAPK_gen_1	200	210	PF00069	0.378
DOC_PP1_RVXF_1	277	283	PF00149	0.462
DOC_PP1_SILK_1	143	148	PF00149	0.306
DOC_PP4_FxxP_1	335	338	PF00568	0.334
DOC_USP7_MATH_1	233	237	PF00917	0.348
DOC_WW_Pin1_4	157	162	PF00397	0.354
DOC_WW_Pin1_4	357	362	PF00397	0.481
LIG_14-3-3_CanoR_1	254	261	PF00244	0.348
LIG_14-3-3_CanoR_1	271	276	PF00244	0.248
LIG_14-3-3_CanoR_1	67	77	PF00244	0.496
LIG_deltaCOP1_diTrp_1	131	139	PF00928	0.288
LIG_deltaCOP1_diTrp_1	310	316	PF00928	0.315
LIG_deltaCOP1_diTrp_1	331	335	PF00928	0.323
LIG_EH1_1	90	98	PF00400	0.311
LIG_FHA_1	179	185	PF00498	0.322
LIG_FHA_1	21	27	PF00498	0.468
LIG_FHA_1	255	261	PF00498	0.385
LIG_FHA_1	272	278	PF00498	0.312
LIG_FHA_1	32	38	PF00498	0.314
LIG_FHA_1	49	55	PF00498	0.446
LIG_FHA_2	254	260	PF00498	0.320
LIG_FHA_2	81	87	PF00498	0.344
LIG_LIR_Apic_2	333	338	PF02991	0.342
LIG_LIR_Gen_1	331	338	PF02991	0.327
LIG_LIR_Nem_3	195	201	PF02991	0.327
LIG_LIR_Nem_3	331	335	PF02991	0.323
LIG_LIR_Nem_3	359	365	PF02991	0.400
LIG_SH2_CRK	207	211	PF00017	0.486
LIG_SH2_CRK	50	54	PF00017	0.425
LIG_SH2_GRB2like	116	119	PF00017	0.438
LIG_SH2_GRB2like	365	368	PF00017	0.403
LIG_SH2_SRC	116	119	PF00017	0.420
LIG_SH2_STAP1	198	202	PF00017	0.320
LIG_SH2_STAP1	365	369	PF00017	0.413
LIG_SH2_STAP1	50	54	PF00017	0.425
LIG_SH2_STAT5	201	204	PF00017	0.324
LIG_SH2_STAT5	349	352	PF00017	0.417
LIG_SH2_STAT5	362	365	PF00017	0.448
LIG_SH2_STAT5	50	53	PF00017	0.399
LIG_SH3_3	127	133	PF00018	0.289
LIG_SH3_3	208	214	PF00018	0.386
LIG_SH3_3	272	278	PF00018	0.495
LIG_SH3_5	361	365	PF00018	0.579
LIG_SUMO_SIM_anti_2	172	178	PF11976	0.329
LIG_TRAF2_1	109	112	PF00917	0.344
LIG_WRC_WIRS_1	28	33	PF05994	0.294
MOD_CDC14_SPxK_1	160	163	PF00782	0.343
MOD_CDK_SPxK_1	157	163	PF00069	0.355
MOD_CK1_1	121	127	PF00069	0.346
MOD_CK1_1	357	363	PF00069	0.428
MOD_CK2_1	80	86	PF00069	0.349
MOD_GlcNHglycan	71	74	PF01048	0.411
MOD_GSK3_1	27	34	PF00069	0.340
MOD_GSK3_1	350	357	PF00069	0.408
MOD_GSK3_1	69	76	PF00069	0.499
MOD_NEK2_1	10	15	PF00069	0.644
MOD_NEK2_1	146	151	PF00069	0.350
MOD_NEK2_1	196	201	PF00069	0.350
MOD_NEK2_1	299	304	PF00069	0.536
MOD_NEK2_1	31	36	PF00069	0.328
MOD_NEK2_1	350	355	PF00069	0.422
MOD_PIKK_1	116	122	PF00454	0.405
MOD_PKA_2	185	191	PF00069	0.294
MOD_PKA_2	253	259	PF00069	0.324
MOD_PKA_2	69	75	PF00069	0.542
MOD_Plk_1	194	200	PF00069	0.351
MOD_Plk_4	118	124	PF00069	0.429
MOD_Plk_4	149	155	PF00069	0.324
MOD_Plk_4	180	186	PF00069	0.295
MOD_Plk_4	350	356	PF00069	0.391
MOD_Plk_4	49	55	PF00069	0.306
MOD_ProDKin_1	157	163	PF00069	0.355
MOD_ProDKin_1	357	363	PF00069	0.478
MOD_SUMO_rev_2	340	350	PF00179	0.386
TRG_DiLeu_BaEn_2	345	351	PF01217	0.401
TRG_ENDOCYTIC_2	207	210	PF00928	0.410
TRG_ENDOCYTIC_2	50	53	PF00928	0.326
TRG_Pf-PMV_PEXEL_1	235	240	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7H6	Leptomonas seymouri	91%	99%
A0A0S4JN30	Bodo saltans	74%	99%
A0A1X0P631	Trypanosomatidae	85%	99%
A0A3S7X967	Leishmania donovani	97%	100%
A4IBA0	Leishmania infantum	97%	100%
C9ZZM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	83%	99%
E9AF24	Leishmania major	96%	100%
E9B680	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
P0CB81	Pongo abelii	25%	98%
P0CB82	Pongo pygmaeus	25%	98%
P25284	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	98%
P34943	Bos taurus	28%	97%
Q0MQB3	Gorilla gorilla gorilla	25%	98%
Q0MQB4	Pan troglodytes	25%	98%
Q16795	Homo sapiens	25%	98%
Q559Z0	Dictyostelium discoideum	28%	100%
Q5BK63	Rattus norvegicus	27%	98%
Q9DC69	Mus musculus	28%	98%
V5ATG2	Trypanosoma cruzi	84%	99%