U3 small nucleolar RNA-associated protein 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U3 small nucleolar RNA-associated protein 6, putative

Species:

Leishmania braziliensis

UniProt:

A4HML9_LEIBR

TriTrypDb:

LbrM.34.1900 , LBRM2903_340025500 , LBRM2903_340025600

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4HML9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HML9

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	7
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	7
GO:0030490	maturation of SSU-rRNA	9	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0030515	snoRNA binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	661	665	PF00656	0.586
CLV_C14_Caspase3-7	795	799	PF00656	0.613
CLV_NRD_NRD_1	1042	1044	PF00675	0.419
CLV_NRD_NRD_1	141	143	PF00675	0.390
CLV_NRD_NRD_1	207	209	PF00675	0.454
CLV_NRD_NRD_1	212	214	PF00675	0.502
CLV_NRD_NRD_1	401	403	PF00675	0.638
CLV_NRD_NRD_1	425	427	PF00675	0.487
CLV_NRD_NRD_1	552	554	PF00675	0.391
CLV_NRD_NRD_1	560	562	PF00675	0.420
CLV_NRD_NRD_1	676	678	PF00675	0.390
CLV_NRD_NRD_1	705	707	PF00675	0.602
CLV_NRD_NRD_1	708	710	PF00675	0.593
CLV_PCSK_FUR_1	673	677	PF00082	0.474
CLV_PCSK_KEX2_1	1042	1044	PF00082	0.419
CLV_PCSK_KEX2_1	141	143	PF00082	0.390
CLV_PCSK_KEX2_1	212	214	PF00082	0.560
CLV_PCSK_KEX2_1	400	402	PF00082	0.641
CLV_PCSK_KEX2_1	425	427	PF00082	0.661
CLV_PCSK_KEX2_1	462	464	PF00082	0.642
CLV_PCSK_KEX2_1	554	556	PF00082	0.389
CLV_PCSK_KEX2_1	675	677	PF00082	0.403
CLV_PCSK_KEX2_1	68	70	PF00082	0.299
CLV_PCSK_KEX2_1	704	706	PF00082	0.619
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.727
CLV_PCSK_PC1ET2_1	462	464	PF00082	0.599
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.389
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.299
CLV_PCSK_PC1ET2_1	704	706	PF00082	0.576
CLV_PCSK_PC7_1	208	214	PF00082	0.544
CLV_PCSK_SKI1_1	1029	1033	PF00082	0.408
CLV_PCSK_SKI1_1	1043	1047	PF00082	0.388
CLV_PCSK_SKI1_1	468	472	PF00082	0.562
CLV_PCSK_SKI1_1	49	53	PF00082	0.299
CLV_PCSK_SKI1_1	562	566	PF00082	0.472
CLV_PCSK_SKI1_1	608	612	PF00082	0.577
CLV_PCSK_SKI1_1	914	918	PF00082	0.264
DEG_APCC_DBOX_1	913	921	PF00400	0.259
DEG_SCF_FBW7_1	493	500	PF00400	0.471
DEG_SCF_TRCP1_1	798	804	PF00400	0.531
DEG_SPOP_SBC_1	994	998	PF00917	0.591
DOC_CKS1_1	417	422	PF01111	0.576
DOC_CKS1_1	494	499	PF01111	0.615
DOC_CYCLIN_RxL_1	45	55	PF00134	0.299
DOC_CYCLIN_RxL_1	872	884	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	768	774	PF00134	0.399
DOC_CYCLIN_yCln2_LP_2	943	949	PF00134	0.407
DOC_MAPK_gen_1	141	147	PF00069	0.373
DOC_MAPK_gen_1	553	565	PF00069	0.419
DOC_MAPK_gen_1	673	683	PF00069	0.415
DOC_MAPK_gen_1	955	965	PF00069	0.273
DOC_MAPK_MEF2A_6	1043	1052	PF00069	0.439
DOC_MAPK_MEF2A_6	295	302	PF00069	0.389
DOC_MAPK_MEF2A_6	45	54	PF00069	0.299
DOC_MAPK_MEF2A_6	958	967	PF00069	0.275
DOC_MAPK_RevD_3	691	704	PF00069	0.497
DOC_PP1_RVXF_1	642	649	PF00149	0.394
DOC_PP2B_LxvP_1	943	946	PF13499	0.432
DOC_PP4_FxxP_1	271	274	PF00568	0.396
DOC_PP4_MxPP_1	569	572	PF00568	0.648
DOC_SPAK_OSR1_1	644	648	PF12202	0.461
DOC_USP7_MATH_1	140	144	PF00917	0.393
DOC_USP7_MATH_1	332	336	PF00917	0.545
DOC_USP7_MATH_1	432	436	PF00917	0.559
DOC_USP7_MATH_1	479	483	PF00917	0.529
DOC_USP7_MATH_1	508	512	PF00917	0.557
DOC_USP7_MATH_1	572	576	PF00917	0.707
DOC_USP7_MATH_1	582	586	PF00917	0.589
DOC_USP7_MATH_1	619	623	PF00917	0.591
DOC_USP7_MATH_1	783	787	PF00917	0.636
DOC_USP7_MATH_1	929	933	PF00917	0.323
DOC_USP7_MATH_1	947	951	PF00917	0.335
DOC_USP7_UBL2_3	650	654	PF12436	0.344
DOC_USP7_UBL2_3	96	100	PF12436	0.366
DOC_WW_Pin1_4	270	275	PF00397	0.398
DOC_WW_Pin1_4	416	421	PF00397	0.588
DOC_WW_Pin1_4	439	444	PF00397	0.709
DOC_WW_Pin1_4	493	498	PF00397	0.604
DOC_WW_Pin1_4	626	631	PF00397	0.716
DOC_WW_Pin1_4	709	714	PF00397	0.636
DOC_WW_Pin1_4	747	752	PF00397	0.455
LIG_14-3-3_CanoR_1	1033	1038	PF00244	0.427
LIG_14-3-3_CanoR_1	141	147	PF00244	0.373
LIG_14-3-3_CanoR_1	158	166	PF00244	0.399
LIG_14-3-3_CanoR_1	330	338	PF00244	0.553
LIG_14-3-3_CanoR_1	354	360	PF00244	0.395
LIG_14-3-3_CanoR_1	476	482	PF00244	0.522
LIG_14-3-3_CanoR_1	522	526	PF00244	0.746
LIG_14-3-3_CanoR_1	553	560	PF00244	0.408
LIG_14-3-3_CanoR_1	736	744	PF00244	0.654
LIG_14-3-3_CanoR_1	753	759	PF00244	0.390
LIG_14-3-3_CanoR_1	760	768	PF00244	0.338
LIG_14-3-3_CanoR_1	860	865	PF00244	0.422
LIG_14-3-3_CanoR_1	927	936	PF00244	0.504
LIG_APCC_ABBA_1	916	921	PF00400	0.329
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BIR_III_3	1	5	PF00653	0.432
LIG_Clathr_ClatBox_1	51	55	PF01394	0.299
LIG_deltaCOP1_diTrp_1	1015	1023	PF00928	0.341
LIG_deltaCOP1_diTrp_1	144	152	PF00928	0.363
LIG_DLG_GKlike_1	124	131	PF00625	0.376
LIG_FHA_1	1004	1010	PF00498	0.430
LIG_FHA_1	237	243	PF00498	0.493
LIG_FHA_1	30	36	PF00498	0.326
LIG_FHA_1	442	448	PF00498	0.496
LIG_FHA_1	481	487	PF00498	0.548
LIG_FHA_1	494	500	PF00498	0.540
LIG_FHA_1	502	508	PF00498	0.550
LIG_FHA_1	522	528	PF00498	0.560
LIG_FHA_1	554	560	PF00498	0.541
LIG_FHA_1	59	65	PF00498	0.278
LIG_FHA_1	591	597	PF00498	0.619
LIG_FHA_1	695	701	PF00498	0.606
LIG_FHA_1	727	733	PF00498	0.384
LIG_FHA_1	852	858	PF00498	0.342
LIG_FHA_1	911	917	PF00498	0.346
LIG_FHA_1	995	1001	PF00498	0.579
LIG_FHA_2	1034	1040	PF00498	0.373
LIG_FHA_2	26	32	PF00498	0.299
LIG_FHA_2	263	269	PF00498	0.421
LIG_FHA_2	378	384	PF00498	0.492
LIG_FHA_2	636	642	PF00498	0.415
LIG_FHA_2	7	13	PF00498	0.388
LIG_GBD_Chelix_1	530	538	PF00786	0.380
LIG_LIR_Apic_2	268	274	PF02991	0.395
LIG_LIR_Gen_1	593	602	PF02991	0.607
LIG_LIR_Gen_1	844	853	PF02991	0.371
LIG_LIR_Gen_1	959	968	PF02991	0.413
LIG_LIR_Nem_3	1015	1020	PF02991	0.346
LIG_LIR_Nem_3	129	135	PF02991	0.500
LIG_LIR_Nem_3	151	155	PF02991	0.436
LIG_LIR_Nem_3	360	366	PF02991	0.509
LIG_LIR_Nem_3	43	47	PF02991	0.340
LIG_LIR_Nem_3	461	467	PF02991	0.542
LIG_LIR_Nem_3	593	597	PF02991	0.612
LIG_LIR_Nem_3	72	76	PF02991	0.403
LIG_LIR_Nem_3	757	762	PF02991	0.360
LIG_LIR_Nem_3	844	850	PF02991	0.384
LIG_LIR_Nem_3	959	964	PF02991	0.488
LIG_LIR_Nem_3	975	980	PF02991	0.285
LIG_MYND_3	917	921	PF01753	0.327
LIG_NRBOX	195	201	PF00104	0.444
LIG_NRBOX	280	286	PF00104	0.441
LIG_NRBOX	893	899	PF00104	0.302
LIG_PCNA_yPIPBox_3	120	132	PF02747	0.382
LIG_PCNA_yPIPBox_3	193	204	PF02747	0.401
LIG_PCNA_yPIPBox_3	858	872	PF02747	0.301
LIG_Pex14_1	821	825	PF04695	0.294
LIG_Pex14_2	118	122	PF04695	0.371
LIG_Pex14_2	645	649	PF04695	0.388
LIG_Rb_pABgroove_1	976	984	PF01858	0.325
LIG_SH2_CRK	76	80	PF00017	0.358
LIG_SH2_CRK	838	842	PF00017	0.342
LIG_SH2_STAP1	961	965	PF00017	0.406
LIG_SH2_STAT5	1020	1023	PF00017	0.335
LIG_SH2_STAT5	22	25	PF00017	0.299
LIG_SH2_STAT5	366	369	PF00017	0.446
LIG_SH2_STAT5	387	390	PF00017	0.383
LIG_SH2_STAT5	73	76	PF00017	0.299
LIG_SH3_1	624	630	PF00018	0.526
LIG_SH3_3	134	140	PF00018	0.392
LIG_SH3_3	404	410	PF00018	0.560
LIG_SH3_3	44	50	PF00018	0.343
LIG_SH3_3	515	521	PF00018	0.538
LIG_SH3_3	546	552	PF00018	0.467
LIG_SH3_3	624	630	PF00018	0.815
LIG_SH3_3	690	696	PF00018	0.578
LIG_Sin3_3	254	261	PF02671	0.308
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.451
LIG_SUMO_SIM_par_1	30	36	PF11976	0.299
LIG_SUMO_SIM_par_1	432	438	PF11976	0.374
LIG_SUMO_SIM_par_1	49	55	PF11976	0.299
LIG_SUMO_SIM_par_1	523	529	PF11976	0.428
LIG_TRAF2_1	28	31	PF00917	0.299
LIG_TRAF2_1	842	845	PF00917	0.492
LIG_TYR_ITIM	836	841	PF00017	0.338
LIG_UBA3_1	257	264	PF00899	0.376
LIG_UBA3_1	534	542	PF00899	0.448
LIG_UBA3_1	964	972	PF00899	0.381
LIG_WRC_WIRS_1	436	441	PF05994	0.444
LIG_WRC_WIRS_1	822	827	PF05994	0.350
MOD_CDC14_SPxK_1	750	753	PF00782	0.435
MOD_CDK_SPxK_1	709	715	PF00069	0.556
MOD_CDK_SPxK_1	747	753	PF00069	0.448
MOD_CDK_SPxxK_3	416	423	PF00069	0.496
MOD_CK1_1	273	279	PF00069	0.403
MOD_CK1_1	314	320	PF00069	0.452
MOD_CK1_1	333	339	PF00069	0.526
MOD_CK1_1	358	364	PF00069	0.450
MOD_CK1_1	411	417	PF00069	0.577
MOD_CK1_1	435	441	PF00069	0.474
MOD_CK1_1	442	448	PF00069	0.463
MOD_CK1_1	718	724	PF00069	0.496
MOD_CK1_1	790	796	PF00069	0.689
MOD_CK1_1	816	822	PF00069	0.474
MOD_CK1_1	839	845	PF00069	0.488
MOD_CK1_1	995	1001	PF00069	0.478
MOD_CK2_1	1002	1008	PF00069	0.532
MOD_CK2_1	1033	1039	PF00069	0.374
MOD_CK2_1	25	31	PF00069	0.299
MOD_CK2_1	262	268	PF00069	0.419
MOD_CK2_1	6	12	PF00069	0.384
MOD_CK2_1	760	766	PF00069	0.360
MOD_CK2_1	839	845	PF00069	0.488
MOD_GlcNHglycan	1000	1003	PF01048	0.452
MOD_GlcNHglycan	23	26	PF01048	0.315
MOD_GlcNHglycan	275	278	PF01048	0.384
MOD_GlcNHglycan	313	316	PF01048	0.533
MOD_GlcNHglycan	332	335	PF01048	0.453
MOD_GlcNHglycan	392	395	PF01048	0.607
MOD_GlcNHglycan	410	413	PF01048	0.511
MOD_GlcNHglycan	584	587	PF01048	0.578
MOD_GlcNHglycan	613	616	PF01048	0.697
MOD_GlcNHglycan	664	667	PF01048	0.543
MOD_GlcNHglycan	737	740	PF01048	0.499
MOD_GlcNHglycan	762	765	PF01048	0.360
MOD_GlcNHglycan	787	790	PF01048	0.800
MOD_GlcNHglycan	798	801	PF01048	0.563
MOD_GlcNHglycan	803	806	PF01048	0.514
MOD_GlcNHglycan	883	886	PF01048	0.352
MOD_GlcNHglycan	927	930	PF01048	0.386
MOD_GlcNHglycan	931	934	PF01048	0.411
MOD_GlcNHglycan	936	939	PF01048	0.487
MOD_GlcNHglycan	985	988	PF01048	0.492
MOD_GSK3_1	153	160	PF00069	0.373
MOD_GSK3_1	21	28	PF00069	0.315
MOD_GSK3_1	287	294	PF00069	0.397
MOD_GSK3_1	29	36	PF00069	0.355
MOD_GSK3_1	313	320	PF00069	0.532
MOD_GSK3_1	330	337	PF00069	0.698
MOD_GSK3_1	377	384	PF00069	0.419
MOD_GSK3_1	435	442	PF00069	0.560
MOD_GSK3_1	480	487	PF00069	0.615
MOD_GSK3_1	493	500	PF00069	0.510
MOD_GSK3_1	626	633	PF00069	0.763
MOD_GSK3_1	714	721	PF00069	0.593
MOD_GSK3_1	760	767	PF00069	0.282
MOD_GSK3_1	772	779	PF00069	0.501
MOD_GSK3_1	783	790	PF00069	0.579
MOD_GSK3_1	813	820	PF00069	0.712
MOD_GSK3_1	925	932	PF00069	0.322
MOD_GSK3_1	992	999	PF00069	0.471
MOD_N-GLC_1	124	129	PF02516	0.373
MOD_N-GLC_1	734	739	PF02516	0.427
MOD_N-GLC_1	790	795	PF02516	0.549
MOD_NEK2_1	1023	1028	PF00069	0.337
MOD_NEK2_1	262	267	PF00069	0.414
MOD_NEK2_1	300	305	PF00069	0.542
MOD_NEK2_1	437	442	PF00069	0.562
MOD_NEK2_1	592	597	PF00069	0.544
MOD_NEK2_1	611	616	PF00069	0.600
MOD_NEK2_1	669	674	PF00069	0.502
MOD_NEK2_1	734	739	PF00069	0.427
MOD_NEK2_1	881	886	PF00069	0.345
MOD_NEK2_1	910	915	PF00069	0.556
MOD_NEK2_1	925	930	PF00069	0.297
MOD_PIKK_1	153	159	PF00454	0.406
MOD_PIKK_1	348	354	PF00454	0.526
MOD_PIKK_1	418	424	PF00454	0.473
MOD_PIKK_1	726	732	PF00454	0.405
MOD_PKA_1	212	218	PF00069	0.425
MOD_PKA_1	553	559	PF00069	0.401
MOD_PKA_2	140	146	PF00069	0.377
MOD_PKA_2	157	163	PF00069	0.405
MOD_PKA_2	212	218	PF00069	0.427
MOD_PKA_2	355	361	PF00069	0.469
MOD_PKA_2	521	527	PF00069	0.736
MOD_PKA_2	714	720	PF00069	0.523
MOD_PKA_2	735	741	PF00069	0.592
MOD_PKA_2	796	802	PF00069	0.525
MOD_PKA_2	871	877	PF00069	0.433
MOD_PKB_1	346	354	PF00069	0.508
MOD_PKB_1	657	665	PF00069	0.633
MOD_Plk_1	1023	1029	PF00069	0.347
MOD_Plk_1	29	35	PF00069	0.324
MOD_Plk_1	317	323	PF00069	0.599
MOD_Plk_2-3	58	64	PF00069	0.218
MOD_Plk_4	1033	1039	PF00069	0.374
MOD_Plk_4	262	268	PF00069	0.378
MOD_Plk_4	358	364	PF00069	0.571
MOD_Plk_4	377	383	PF00069	0.439
MOD_Plk_4	413	419	PF00069	0.738
MOD_Plk_4	432	438	PF00069	0.466
MOD_Plk_4	442	448	PF00069	0.409
MOD_Plk_4	754	760	PF00069	0.432
MOD_Plk_4	817	823	PF00069	0.381
MOD_Plk_4	852	858	PF00069	0.342
MOD_Plk_4	973	979	PF00069	0.374
MOD_ProDKin_1	270	276	PF00069	0.396
MOD_ProDKin_1	416	422	PF00069	0.583
MOD_ProDKin_1	439	445	PF00069	0.711
MOD_ProDKin_1	493	499	PF00069	0.608
MOD_ProDKin_1	626	632	PF00069	0.716
MOD_ProDKin_1	709	715	PF00069	0.637
MOD_ProDKin_1	747	753	PF00069	0.448
MOD_SUMO_rev_2	223	233	PF00179	0.645
TRG_DiLeu_BaEn_2	113	119	PF01217	0.365
TRG_DiLeu_BaEn_4	845	851	PF01217	0.427
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.360
TRG_DiLeu_BaLyEn_6	280	285	PF01217	0.294
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.299
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.441
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.539
TRG_DiLeu_BaLyEn_6	976	981	PF01217	0.350
TRG_ENDOCYTIC_2	1020	1023	PF00928	0.335
TRG_ENDOCYTIC_2	132	135	PF00928	0.547
TRG_ENDOCYTIC_2	366	369	PF00928	0.446
TRG_ENDOCYTIC_2	76	79	PF00928	0.363
TRG_ENDOCYTIC_2	838	841	PF00928	0.343
TRG_ENDOCYTIC_2	961	964	PF00928	0.408
TRG_ER_diArg_1	140	142	PF00400	0.402
TRG_ER_diArg_1	346	349	PF00400	0.625
TRG_ER_diArg_1	353	356	PF00400	0.410
TRG_ER_diArg_1	552	555	PF00400	0.391
TRG_ER_diArg_1	656	659	PF00400	0.546
TRG_ER_diArg_1	673	676	PF00400	0.420
TRG_NLS_MonoCore_2	702	707	PF00514	0.549
TRG_NLS_MonoExtC_3	708	713	PF00514	0.553
TRG_NLS_MonoExtN_4	703	708	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHB0	Leptomonas seymouri	54%	100%
A0A3Q8II91	Leishmania donovani	78%	100%
A4IB97	Leishmania infantum	78%	100%
E9AF21	Leishmania major	79%	100%
E9B677	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%